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Results: 9014
Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation
CA Fielding, MP Weekes, LV Nobre, E Ruckova, GS Wilkie, JA Paulo, C Chang, NM Suárez, JA Davies, R Antrobus, RJ Stanton, RJ Aicheler, H Nichols, B Vojtesek, J Trowsdale, AJ Davison, SP Gygi, P Tomasec, PJ Lehner, GWG Wilkinson
May 01, 2017
GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography.
Natalie E Adams, Laura E Hughes, Holly N Phillips, Alexander D Shaw, Alexander G Murley, David Nesbitt, Thomas E Cope, W Richard Bevan-Jones, Luca Passamonti, James B Rowe
Jan 08, 2020
To bridge the gap between preclinical cellular models of disease and in vivo imaging of human cognitive network dynamics, there is a pressing need for informative biophysical models. Here we assess dynamic causal models (DCM) of...
Symptom remission at 12-weeks strongly predicts long-term recovery from the first episode of psychosis.
Paola Dazzan, Julia M Lappin, Margaret Heslin, Kim Donoghue, Ben Lomas, Uli Reininghaus, Adanna Onyejiaka, Tim Croudace, Peter B Jones, Robin M Murray, Paul Fearon, Gillian A Doody, Craig Morgan
Nov 22, 2019
clinical outcome Functional outcome Psychosis Remission Schizophrenia Activities of Daily Living Adult Bipolar Disorder Female Follow-Up Studies Humans Logistic Models Male Outcome Assessment Health Care Psychiatric Status Rating Scales Psychotic Disorders Remission Induction Schizophrenia Schizophrenic Psychology United Kingdom Young Adult
Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes.
Zhifen Chen, Haojie Yu, Xu Shi, Curtis R Warren, Luca A Lotta, Max Friesen, Torsten B Meissner, Claudia Langenberg, Martin Wabitsch, Nick Wareham, Mark D Benson, Rob E Gerszten, Chad A Cowan
Nov 25, 2019
Rationale: Genome-wide association studies have identified genetic loci associated with insulin resistance (IR) but pinpointing the causal genes of a risk locus has been challenging. Objective: To identify candidate causal genes...
Adipocytes Adipogenesis Diabetes mellitus Type 2 Insulin Resistance lipid metabolis Adaptor Proteins Signal Transducing Adipocytes Cell Line Dipeptidases Follistatin Genome-Wide Association Study Humans Insulin Receptor Substrate Proteins Insulin Resistance Loss of Function Mutation Lymphokines MAP Kinase Kinase Kinase 1 PPAR gamma Platelet-Derived Growth Factor Quantitative Trait Loci
Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes.
Michael Eiden, Albert Koulman, Mensud Hatunic, James A West, Steven Murfitt, Michael Osei, Claire Adams, Xinzhu Wang, Yajing Chu, Luke Marney, Lee D Roberts, Stephen O'Rahilly, Robert K Semple, David B Savage, Julian L Griffin
Sep 03, 2020
BACKGROUND: Evidence from several recent metabolomic studies suggests that increased concentrations of triacylglycerols with shorter (14-16 carbon atoms), saturated fatty acids are associated with insulin resistance and the risk...
Molecular Characterization and Immuno-Reactivity Patterns of a Novel Plasmodium falciparum Armadillo-Type Repeat Protein, PfATRP.
Emmanuel Amlabu, Philip Ilani, Grace Opoku, Prince B Nyarko, Evelyn Quansah, Laty G Thiam, Manfred Anim, Reuben Ayivor-Djanie, Ojo-ajogu Akuh, Henrietta Mensah-Brown, Julian C Rayner, Gordon A Awandare
May 09, 2020
Nearly half of the genes in the Plasmodium falciparum genome have not yet been functionally investigated. We used homology-based structural modeling to identify multiple copies of Armadillo repeats within one uncharacterized...
Published by: Frontiers in cellular and infection microbiology
Pharmacokinetics of insulin aspart in pump-treated subjects with type 1 diabetes
Putatively novel serotypes and the potential for reduced vaccine effectiveness
C. elegans expressing D76N β2-microglobulin
Giulia Faravelli, Sara Raimondi, Loredana Marchese, Frederick A Partridge, Cristina Soria, P Patrizia Mangione, Diana Canetti, Michele Perni, Francesco A Aprile, Irene Zorzoli, Elia Di Schiavi, David A Lomas, Vittorio Bellotti, David B Sattelle, Sofia Giorgetti
Mar 02, 2020
The availability of a genetic model organism with which to study key molecular events underlying amyloidogenesis is crucial for elucidating the mechanism of the disease and the exploration of new therapeutic avenues. The natural...
Clinical and genetic characterization of AP4B1-associated SPG47.
Darius Ebrahimi-Fakhari, Chi Cheng, Kira Dies, Amelia Diplock, Danielle B Pier, Conor S Ryan, Brendan C Lanpher, Jennifer Hirst, Wendy K Chung, Mustafa Sahin, Elisabeth Rosser, Basil Darras, James T Bennett, CureSPG47
Mar 23, 2018
The hereditary spastic paraplegias (HSPs) are a heterogeneous group of disorders characterized by degeneration of the corticospinal and spinocerebellar tracts leading to progressive spasticity. One subtype, spastic paraplegia...
AP4B1 SPG47 cerebral palsy hereditary spastic paraplegia Intellectual Disability Microcephaly Seizures thin corpus callosum Adaptor Protein Complex 4 Alleles Brain Child Child Preschool Diagnostic Imaging Facies Female Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Magnetic Resonance Imaging Male Mutation Phenotype Spastic Paraplegia Hereditary Symptom Assessment
Nociceptive interneurons control modular motor pathways to promote escape behavior in Drosophila.
Anita Burgos, Ken Honjo, Tomoko Ohyama, Cheng Sam Qian, Grace Ji-Eun Shin, Daryl M Gohl, Marion Silies, W Daniel Tracey, Marta Zlatic, Albert Cardona, Wesley B Grueber
Sep 05, 2018
Rapid and efficient escape behaviors in response to noxious sensory stimuli are essential for protection and survival. Yet, how noxious stimuli are transformed to coordinated escape behaviors remains poorly understood. In...
Absence of cerebrospinal fluid pleocytosis in tuberculous meningitis is a common occurrence in HIV co-infection and a predictor of poor outcomes.
In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.
W Richard Bevan-Jones, Thomas E Cope, P Simon Jones, Luca Passamonti, Young T Hong, Tim Fryer, Robert Arnold, Jonathan P Coles, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Jan 28, 2019
Neuroinflammation occurs in frontotemporal dementia, however its timing relative to protein aggregation and neuronal loss is unknown. Using positron emission tomography and magnetic resonance imaging to quantify these processes...
ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-β copathology.
Carolin Koriath, Tammaryn Lashley, William Taylor, Ronald Druyeh, Athanasios Dimitriadis, Nicola Denning, Julie Williams, Jason D Warren, Nick C Fox, Jonathan M Schott, James B Rowe, John Collinge, Jonathan D Rohrer, Simon Mead
May 30, 2019
INTRODUCTION: Apolipoprotein E (ApoE) is the most important genetic risk factor for Alzheimer's disease (AD), with ApoE4 thought to enhance and accelerate amyloid-β (Aβ) pathology. ApoE4 has recently been described to increase...
Probing the formation of silicon nano-crystals (Si-ncs) using variable energy positron annihilation spectroscopy
A P Knights, J D B Bradley, O Hulko, D V Stevanovic, C J Edwards, Alexis Kallis, Paul G Coleman, I F Crowe, M P Halsall, R M Gwilliam
Jan 01, 0001
We describe preliminary results from studies of the formation of silicon nano-crystals (Si-ncs) embedded in stoichiometric, thermally grown SiO 2 using Variable Energy Positron Annihilation Spectroscopy (VEPAS). We show that the...
The Lantern Vol. 46, No. 2, April 1980
Jack Rosenfeld, Shannon Emery, Joanne McPhillips, Robert Pfeiffer, Mari K. Brown, James Wilson, Terry Waldspurger, Margaret Higgins, Patrick Benjamin Walker, Drew Procaccino, Lori Reinhart, Bruce Dalziel, Marian B. Dugan, Jill Hadley, Shari Slavin, Jeanne E. Hayes
Jan 01, 0001
The Voyage to Man's Destiny If I Could Keep the Times Barstool Blues I Didn't Know Felonious, Friend Cool Ride Georgia Let Us Eat and Drink In a Field New Born Foal Union to Freedom In the Woods ...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
Ursinus College Alumni Journal, November 1963
Richard T. Schellhase, Kay Kerper Schellhase, Lucille Hunt Bone, Charles Hudnut, Roger P. Staiger, Raymond V. Gurzynski, Blanche B. Schultz, Donald L. Helfferich, George W. Hartzell, Thomas J. Beddow
Jan 01, 0001
The President writes A kaleidoscopic view of the student The student looks at himself The faculty comments Modern German literature Founders' Day Spangler portrait unveiled Dr. Helfferich's remarks Board elects two...
Ursinus College Collegeville Pennsylvania alumni Deaths Marriages Henry T. Spangler Theodore R. Schwalm Russell C. Ball Glenn E. Eshbach Roger P. Staiger Werner Ursinus Ruth H. Rothenberger Robert S. Howard field hockey Football G. Sieber Pancoast Higher Education Social History United States History
Published by: Ursinus College
Public participation in decision-making on the coverage of new antivirals for hepatitis C.
Katharina Kieslich, Jeonghoon Ahn, Gabriele Badano, Kalipso Chalkidou, Leonardo Cubillos, Renata Curi Hauegen, Chris Henshall, Carleigh B Krubiner, Peter Littlejohns, Lanting Lu, Steven D Pearson, Annette Rid, Jennifer A Whitty, James Wilson
Jun 24, 2016
Agenda-setting DAAs Direct-acting antivirals Hepatitis C PPI Priority-setting Public and patient involvement Sofosbuvir Antiviral Agents Brazil Community Participation Decision Making England Health Care Rationing Hepatitis C Humans Insurance Coverage insurance health Republic of Korea Sofosbuvir United States
pH-induced reversal of ionic diode polarity in 300 nm thin membranes based on a polymer of intrinsic microporosity
Yuanyang Rong, Qilei Song, Klaus Mathwig, Elena Madrid, Daping He, Ralf G. Niemann, Petra J. Cameron, Sara E C Dale, Simon Bending, Mariolino Carta, Richard Malpass-Evans, Neil B. Mckeown, Frank Marken
Aug 01, 2016
"Ionic diode" (or current rectification) effects are potentially important for a range of applications including water purification. In this preliminary report, we observe novel ionic diode behaviour of thin (300 nm)...
Comparison of inter subject variability and reproducibility of whole brain proton spectroscopy.
Producing wood at least cost to biodiversity
Matthew G Betts, Benjamin T Phalan, Christopher Wolf, Susan C Baker, Christian Messier, Klaus J Puettmann, Rhys Green, Scott H Harris, David P Edwards, David B Lindenmayer, Andrew Balmford
Mar 15, 2021
Forest loss and degradation are the greatest threats to biodiversity worldwide. Rising global wood demand threatens further damage to remaining native forests. Contrasting solutions across a continuum of options have been...
[<sup>18</sup>F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.
Elijah Mak, Antonina Kouli, Negin Holland, Nicolas Nicastro, George Savulich, Ajenthan Surendranathan, Maura Malpetti, Roido Manavaki, Young T Hong, Tim D Fryer, Franklin Aigbirhio, James B Rowe, John T O'Brien, Caroline H Williams-Gray
Oct 07, 2021
Published by: Brain communications
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