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Results: 12090
Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis.
Nicola E Owen, Graeme J Alexander, Sambit Sen, Katherine Bunclark, Gary Polwarth, Joanna Pepke-Zaba, Anthony P Davenport, Nicholas W Morrell, Paul D Upton
May 07, 2020
BACKGROUND: BMP9, originating from the liver, and BMP10 are circulating BMPs that preserve vascular endothelial integrity. We assessed BMP9, BMP10 and soluble endoglin (sEng) levels and their relationships to liver disease...
BMP10 Bone morphogenetic protein 9 cirrhosis ELISA Endoglin Adult Aged Animals Biopsy Bone Morphogenetic Proteins Case-Control Studies Cell Line Disease Models Animal Down-Regulation Endoglin Female Growth Differentiation Factor 2 Hepatopulmonary Syndrome Humans Hypertension Pulmonary Liver Cirrhosis Male Mice Mice Knockout Middle Aged Severity of Illness Index Young Adult
Precise Installation of Diazo-Tagged Side-Chains on Proteins to Enable In Vitro and In-Cell Site-Specific Labeling.
Barbara Bernardim, Lavinia Dunsmore, He Li, Brad Hocking, Reyes Nuñez-Franco, Claudio D Navo, Gonzalo Jiménez-Osés, Antonio CB Burtoloso, Gonçalo JL Bernardes
May 11, 2020
The chemistry of diazo compounds has generated a huge breadth of applications in the field of organic synthesis. Their versatility combined with their tunable reactivity, stability, and chemoselectivity makes diazo compounds...
Macromolecular X-ray structure determination using weak, single-wavelength anomalous data.
Gábor Bunkóczi, Airlie J McCoy, Nathaniel Echols, Ralf W Grosse-Kunstleve, Paul D Adams, James M Holton, Randy J Read, Thomas C Terwilliger
May 11, 2020
We describe a likelihood-based method for determining the substructure of anomalously scattering atoms in macromolecular crystals that allows successful structure determination by single-wavelength anomalous diffraction (SAD)...
Stable task information from an unstable neural population
Michael E Rule, Adrianna R Loback, Dhruva V Raman, Laura N Driscoll, Christopher D Harvey, Timothy O'Leary
Jul 31, 2020
Over days and weeks, neural activity representing an animal’s position and movement in sensorimotor cortex has been found to continually reconfigure or ‘drift’ during repeated trials of learned tasks, with no obvious change in...
Increasing incidence of group B streptococcus neonatal infections in the Netherlands is associated with clonal expansion of CC17 and CC23.
Dorota Jamrozy, Merijn W Bijlsma, Marcus C de Goffau, Diederik van de Beek, Taco W Kuijpers, Julian Parkhill, Arie van der Ende, Stephen D Bentley
Aug 03, 2020
Group B streptococcus (GBS) is the leading cause of neonatal invasive disease worldwide. In the Netherlands incidence of the disease increased despite implementation of preventive guidelines. We describe a genomic analysis of...
Maternal-to-fetal allopurinol transfer and xanthine oxidase suppression in the late gestation pregnant rat.
Andrew D Kane, Emily J Camm, Hans G Richter, Ciara Lusby, Deodata Tijsseling, Joepe J Kaandorp, Jan B Derks, Susan E Ozanne, Dino A Giussani
Aug 12, 2020
Fetal brain hypoxic injury remains a concern in high-risk delivery. There is significant clinical interest in agents that may diminish neuronal damage during birth asphyxia, such as in allopurinol, an inhibitor of the prooxidant...
Robust rapid-setting antibacterial liquid bandages.
Carlos AP Bastos, William D Thom, Beth Reilly, Iris L Batalha, Maedee L Burge Rogers, Ian S McCrone, Nuno Faria, Jonathan J Powell
Aug 18, 2020
Bandaging is a steadfast but time-consuming component of wound care with limited technical advancements to date. Bandages must be changed and infection risk managed. Rapid-set liquid bandages are efficient alternatives but lack...
Discovery of Eurytrema Eggs in Sediment from a Colonial Period Latrine in Taiwan.
Hui-Yuan Yeh, Chieh-Fu Jeff Cheng, ChingJung Huang, Xiaoya Zhan, Weng Kin Wong, Piers D Mitchell
Feb 09, 2020
In this study we take a closer look at the diseases that afflicted Japanese police officers who were stationed in a remote mountainous region of Taiwan from 1921 to 1944. Samples were taken from the latrine at the Huabanuo...
Published by: The Korean journal of parasitology
Decision-making flexibility in New Caledonian crows, young children and adult humans in a multi-dimensional tool-use task.
Rachael Miller, Romana Gruber, Anna Frohnwieser, Martina Schiestl, Sarah A Jelbert, Russell D Gray, Markus Boeckle, Alex H Taylor, Nicola S Clayton
Feb 27, 2020
The ability to make profitable decisions in natural foraging contexts may be influenced by an additional requirement of tool-use, due to increased levels of relational complexity and additional work-effort imposed by tool-use...
Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.
MF Michelle Sim, Elisa Persiani, Md Mesbah Uddin Talukder, George D Mcilroy, Ahlima Roumane, J Michael Edwardson, Justin J Rochford
Mar 02, 2020
Seipin deficiency causes severe congenital generalized lipodystrophy (CGL) and metabolic disease. However, how seipin regulates adipocyte development and function remains incompletely understood. We previously showed that seipin...
1-Acylglycerol-3-Phosphate O-Acyltransferase 3T3-L1 Cells Acyltransferases Adipocytes Adipogenesis Adipose Tissue Animals Cell Differentiation Diabetes mellitus Type 2 GTP-Binding Protein gamma Subunits Gene Expression Regulation HEK293 Cells Humans Lipid Metabolism Mice Mice Inbred C3H Microscopy Atomic Force Mutation
Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo.
Clare E Buckley, Rachel E Moore, Anna Reade, Anna R Goldberg, Orion D Weiner, Jonathan DW Clarke
Mar 22, 2018
We demonstrate the utility of the phytochrome system to rapidly and reversibly recruit proteins to specific subcellular regions within specific cells in a living vertebrate embryo. Light-induced heterodimerization using the...
ZnSe quantum dots modified with a Ni(cyclam) catalyst for efficient visible-light driven CO2 reduction in water.
Moritz F Kuehnel, Constantin D Sahm, Gaia Neri, Jonathan R Lee, Katherine L Orchard, Alexander J Cowan, Erwin Reisner
Mar 27, 2018
A precious metal and Cd-free photocatalyst system for efficient CO2 reduction in water is reported. The hybrid assembly consists of ligand-free ZnSe quantum dots (QDs) as a visible-light photosensitiser combined with a...
Supramolecular glyco-poly-cyclodextrin functionalized thin-layer manganese dioxide for targeted stimulus-responsive bioimaging
Huan Wang, Ying Liu, Chao Xu, Xi Wang, Guo-Rong Chen, Tony D. James, Yi Zang, Jia Li, Xiang Ma, Xiao-Peng He
Apr 18, 2018
We have developed a supramoleuclar imaging probe based on thin-layer manganese dioxide functionalized with a fluorescent, multivalent glyco-poly-cycolodextrin for the targeted, stimulus-responsive bioimaging of cancer...
Exploring the pseudo-ductility of aligned hybrid discontinuous composites using controlled fibre-type arrangements
Pseudo-ductility presents a potential means for preventing catastrophic failure in composite materials; large deformations will prevent brittle fracture and provide warning before final failure. This work explores how the...
Elevated Aspergillus-specific antibody levels among HIV infected Ugandans with pulmonary tuberculosis.
Richard Kwizera, Rosalind Parkes-Ratanshi, Iain D Page, Christine Sekaggya-Wiltshire, Joseph Musaazi, Jan Fehr, Barbara Castelnuovo, Andrew Kambugu, David W Denning
May 16, 2018
Humans Aspergillus Tuberculosis Pulmonary HIV Infections Immunoglobulin E Immunoglobulin G Antibodies Fungal Antitubercular Agents CD4 Lymphocyte Count Prospective Studies Antibody Specificity Adult Uganda Female Male Coinfection
Published by: BMC pulmonary medicine
Schizophrenia-risk and urban birth are associated with proteomic changes in neonatal dried blood spots.
Jason D Cooper, Sureyya Ozcan, Renee M Gardner, Nitin Rustogi, Susanne Wicks, Geertje F van Rees, F Markus Leweke, Christina Dalman, Håkan Karlsson, Sabine Bahn
May 23, 2018
In the present study, we tested whether there were proteomic differences in blood between schizophrenia patients after the initial onset of the disorder and controls; and whether those differences were also present at birth...
Physical descriptions of the bacterial nucleoid at large scales, and their biological implications.
Vincenzo G Benza, Bruno Bassetti, Kevin D Dorfman, Vittore F Scolari, Krystyna Bromek, Pietro Cicuta, Marco Cosentino Lagomarsino
May 25, 2018
Recent experimental and theoretical approaches have attempted to quantify the physical organization (compaction and geometry) of the bacterial chromosome with its complement of proteins (the nucleoid). The genomic DNA exists in...
Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling.
Josephine Pickworth, Alexander Rothman, James Iremonger, Helen Casbolt, Kay Hopkinson, Peter M Hickey, Santhi Gladson, Sheila Shay, Nicholas W Morrell, Sheila E Francis, James D West, Allan Lawrie
Jun 20, 2018
Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in patients with heritable and idiopathic pulmonary arterial hypertension (PAH). Circulating levels of interleukin-1 (IL-1) are raised in patients and...
Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations
Eyram Adjogatse, Peter Erskine, Stephen A. Wells, John M. Kelly, Jonathan D. Wilden, A. W.Edith Chan, David Selwood, Alun Coker, Steve Wood, Jonathan B. Cooper
Sep 01, 2018
Two of the world’s most neglected tropical diseases, human African trypanosomiasis (HAT) and Chagas disease, are caused by protozoan parasites of the genus Trypanosoma. These organisms possess specialized metabolic pathways...
The rational design of affinity attenuated OmCI for the purification of Complement C5
Alex Macpherson, Xiaofeng Liu, Neesha Dedi, Jeffery Kennedy, Bruce Carrington, Oliver Durrant, Sam Heywood, Jean Van Den Elsen, Alastair D G Lawson
Sep 07, 2018
Complement component C5 is the target of the monoclonal antibody Eculizumab, and the focus of a sustained drug discovery effort to prevent complement-induced inflammation in a range of autoimmune diseases. The immune evasion...
Surface Crystallization of Liquid Au-Si and Its Impact on Catalysis.
Federico Panciera, Jerry Tersoff, Andrew D Gamalski, Mark C Reuter, Dmitri Zakharov, Eric A Stach, Stephan Hofmann, Frances M Ross
Dec 17, 2018
In situ transmission electron microscopy reveals that an atomically thin crystalline phase at the surface of liquid Au-Si is stable over an unexpectedly wide range of conditions. By measuring the surface structure as a function...
Sedentary Behavior Research Network (SBRN) - Terminology Consensus Project process and outcome.
Mark S Tremblay, Salomé Aubert, Joel D Barnes, Travis J Saunders, Valerie Carson, Amy E Latimer-Cheung, Sebastien FM Chastin, Teatske M Altenburg, Mai JM Chinapaw, SBRN Terminology Consensus Project Participants
Jul 18, 2018
BACKGROUND: The prominence of sedentary behavior research in health science has grown rapidly. With this growth there is increasing urgency for clear, common and accepted terminology and definitions. Such standardization is...
Fungal Endophyte Alternaria tenuissima Can Affect Growth and Selenium Accumulation in Its Hyperaccumulator Host Astragalus bisulcatus
Stormy D. Lindblom, Ami L. Wangeline, Jose R. Valdez Barillas, Berthal Devilbiss, Sirine C. Fakra, Elizabeth A. H. Pilon-Smits
Aug 01, 2018
Endophytes can enhance plant stress tolerance by promoting growth and affecting elemental accumulation, which may be useful in phytoremediation. In earlier studies, up to 35% elemental selenium (Se0 ) was found in Se...
Published by: Digital Commons @ Texas A&M University-San Antonio
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