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Results: 13981
Metabolic basis to Sherpa altitude adaptation.
James A Horscroft, Aleksandra O Kotwica, Verena Laner, James A West, Philip J Hennis, Denny ZH Levett, David J Howard, Bernadette O Fernandez, Sarah L Burgess, Zsuzsanna Ament, Edward T Gilbert-Kawai, André Vercueil, Blaine D Landis, Kay Mitchell, Monty G Mythen, Cristina Branco, Randall S Johnson, Martin Feelisch, Hugh E Montgomery, Julian L Griffin, Michael PW Grocott, Erich Gnaiger, Daniel S Martin, Andrew J Murray
May 16, 2017
Altitude Hypoxia metabolism Mitochondria Skeletal muscle Adaptation Physiological Adult Altitude Atmospheric Pressure Citric Acid Cycle Energy Metabolism Ethnicity Fatty Acids Female Gene Frequency Glucose Glycolysis Humans Hypoxia Male Mitochondria Muscle Muscle Skeletal Nepal Nitric oxide Oxidative Phosphorylation Oxidative Stress Oxygen Consumption PPAR alpha Polymorphism Single Nucleotide Tibet
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
HR Warren, E Evangelou, CP Cabrera, H Gao, M Ren, B Mifsud, I Ntalla, P Surendran, C Liu, JP Cook, AT Kraja, F Drenos, M Loh, N Verweij, J Marten, I Karaman, MPS Lepe, PF O'Reilly, J Knight, H Snieder, N Kato, J He, ES Tai, MA Said, D Porteous, M Alver, N Poulter, M Farrall, RT Gansevoort, S Padmanabhan, R Mägi, A Stanton, J Connell, SJL Bakker, A Metspalu, DC Shields, S Thom, M Brown, P Sever, T Esko, C Hayward, P van der Harst, D Saleheen, R Chowdhury, JC Chambers, DI Chasman, A Chakravarti, C Newton-Cheh, CM Lindgren, D Levy, JS Kooner, B Keavney, M Tomaszewski, NJ Samani, JMM Howson, MD Tobin, PB Munroe, GB Ehret, LV Wain, International Consortium of Blood Pressure (ICBP) 1000G Analyses, BIOS Consortium, Lifelines Cohort Study, Understanding Society Scientific Group, CHD Exome+ Consortium, ExomeBP Consortium, T2D-GENES Consortium, GoT2DGenes Consortium, Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, UK Biobank CardioMetabolic Consortium BP working group
Mar 08, 2017
Factors affecting the electrocardiographic QT interval in malaria
Xin Hui S Chan, Yan Naung Win, Ilsa L Haeusler, Jireh Y Tan, Shanghavie Loganathan, Sompob Saralamba, Shu Kiat S Chan, Elizabeth A Ashley, Karen I Barnes, Rita Baiden, Peter U Bassi, Abdoulaye Djimde, Grant Dorsey, Stephan Duparc, Borimas Hanboonkunupakarn, Feiko O Ter Kuile, Marcus V G Lacerda, Amit Nasa, François H Nosten, Cyprian O Onyeji, Sasithon Pukrittayakamee, André M Siqueira, Joel Tarning, Walter R J Taylor, Giovanni Valentini, Michèle van Vugt, David Wesche, Nicholas P J Day, Christopher L-H Huang, Josep Brugada, Ric N Price, Nicholas J White
Apr 05, 2020
BACKGROUND:Electrocardiographic QT interval prolongation is the most widely used risk marker for ventricular arrhythmia potential and thus an important component of drug cardiotoxicity assessments. Several antimalarial medicines...
Published by: PLoS Medicine
An Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors.
Eric L Harshfield, Albert Koulman, Daniel Ziemek, Luke Marney, Eric B Fauman, Dirk S Paul, David Stacey, Asif Rasheed, Jung-Jin Lee, Nabi Shah, Sehrish Jabeen, Atif Imran, Shahid Abbas, Zoubia Hina, Nadeem Qamar, Nadeem Hayyat Mallick, Zia Yaqoob, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Irshad Hussain Qureshi, Muhammad Ishaq, Philippe Frossard, John Danesh, Danish Saleheen, Adam S Butterworth, Angela M Wood, Julian L Griffin
Mar 28, 2019
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid...
The Bangladesh Risk of Acute Vascular Events (BRAVE) Study
Rajiv Chowdhury, Dewan S Alam, Ismail Ibrahim Fakir, Sheikh Daud Adnan, Aliya Naheed, Ishrat Tasmin, Md Mostafa Monower, Farzana Hossain, Fatema Mahjabin Hossain, Md Mostafizur Rahman, Sadia Afrin, Anjan Kumar Roy, Minara Akter, Sima Akter Sume, Ajoy Kumer Biswas, Lisa Pennells, Praveen Surendran, Robin D Young, Sarah A Spackman, Khaled Hasan, Eric Harshfield, Nasir Sheikh, Richard Houghton, Danish Saleheen, Joanna MM Howson, Adam S Butterworth, Cardiology Research Group, Rubhana Raqib, Abdulla Al Shafi Majumder, John Danesh, Emanuele Di Angelantonio
Jun 05, 2015
CALIFA, the Calar Alto Legacy Integral Field Area survey
SF Sánchez, R Garciá-Benito, S Zibetti, CJ Walcher, B Husemann, MA Mendoza, L Galbany, J Falcón-Barroso, D Mast, J Aceituno, JAL Aguerri, J Alves, AL Amorim, Y Ascasibar, D Barrado-Navascues, J Barrera-Ballesteros, S Bekeraitè, J Bland-Hawthorn, M Cano Diáz, R Cid Fernandes, O Cavichia, C Cortijo, H Dannerbauer, M Demleitner, A Diáz, RJ Dettmar, A De Lorenzo-Cáceres, A Del Olmo, A Galazzi, B Garciá-Lorenzo, A Gil De Paz, R González Delgado, L Holmes, J Iglésias-Páramo, C Kehrig, A Kelz, RC Kennicutt, B Kleemann, EAD Lacerda, R López Fernández, AR López Sánchez, M Lyubenova, R Marino, I Márquez, J Mendez-Abreu, M Mollá, A Monreal-Ibero, R Ortega Minakata, JP Torres-Papaqui, E Pérez, FF Rosales-Ortega, MM Roth, P Sánchez-Blázquez, U Schilling, K Spekkens, N Vale Asari, RCE Van Den Bosch, G Van De Ven, JM Vilchez, V Wild, L Wisotzki, A Ylldlrlm, B Ziegler
Jul 15, 2016
Large genome-wide association study identifies three novel risk variants for restless legs syndrome
Maria Didriksen, Muhammad Sulaman Nawaz, Joseph Dowsett, Steven Bell, Christian Erikstrup, Ole B. Pedersen, Erik Sørensen, Poul J. Jennum, Kristoffer S. Burgdorf, Brendan Burchell, Adam S. Butterworth, Nicole Soranzo, David B. Rye, Lynn Marie Trotti, Prabhjyot Saini, Lilja Stefansdottir, Sigurdur H. Magnusson, Gudmar Thorleifsson, Thordur Sigmundsson, Albert P. Sigurdsson, Katja van den Hurk, Franke Quee, Michael W. T. Tanck, Willem H. Ouwehand, David J. Roberts, Eric J. Earley, Michael P. Busch, Alan E. Mast, Grier P. Page, John Danesh, Emanuele Di Angelantonio, Hreinn Stefansson, Henrik Ullum, Kari Stefansson
Nov 25, 2020
Needs of Young African Neurosurgeons and Residents
Ulrick S. Kanmounye, Faith C. Robertson, Nqobile S. Thango, Alvin Nah Doe, Nourou Dine Adeniran Bankole, Pape Aicha Ginette, Solomon Ondoma, James A. Balogun, Isabella Opoku, Luxwell Jokonya, Thioub Mbaye, Zarina A. Shabhay, Ahmed M. Ashour, Ana Cristina Veiga Silva, Beverly Cheserem, Claire Karekezi, Fahd Derkaoui Hassani, Nesrine Mentri, Tsegazeab Laeke, Abenezer Tirsit Aklilu, Samuila Sanoussi, Aaron Musara, Jeff Ntalaja, Peter Ssenyonga, Souad Bakhti, Najia El Abbadi, Muhammad Raji Mahmud, Nasser M. F. El-Ghandour, Amro Al-Habib, Angelos G. Kolias, Franco Servadei, Graham Fieggen, Mahmood Qureshi, Ignatius Esene, CAANS Young Neurosurgeons Committee and WFNS Young Neurosurgeons Committee
Jun 11, 2021
Introduction: Africa has many untreated neurosurgical cases due to limited access to safe, affordable, and timely care. In this study, we surveyed young African neurosurgeons and trainees to identify challenges to training and...
Rare variant analyses across multiethnic cohorts identify novel genes for refractive error.
Anthony M Musolf, Annechien EG Haarman, Robert N Luben, Jue-Sheng Ong, Karina Patasova, Rolando Hernandez Trapero, Joseph Marsh, Ishika Jain, Riya Jain, Paul Zhiping Wang, Deyana D Lewis, Milly S Tedja, Adriana I Iglesias, Hengtong Li, Cameron S Cowan, Consortium for Refractive Error and Myopia (CREAM), Ginevra Biino, Alison P Klein, Priya Duggal, David A Mackey, Caroline Hayward, Toomas Haller, Andres Metspalu, Juho Wedenoja, Olavi Pärssinen, Ching-Yu Cheng, Seang-Mei Saw, Dwight Stambolian, Pirro G Hysi, Anthony P Khawaja, Veronique Vitart, Christopher J Hammond, Cornelia M van Duijn, Virginie JM Verhoeven, Caroline CW Klaver, Joan E Bailey-Wilson
Feb 09, 2023
Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. Individuals with strong positive or negative values of SER require spectacles or...
CEERS Epoch 1 NIRCam Imaging
Micaela B. Bagley, Steven L. Finkelstein, Anton M. Koekemoer, Henry C. Ferguson, Pablo Arrabal Haro, Mark Dickinson, Jeyhan S. Kartaltepe, Casey Papovich, Pablo G. Pérez-González, Nor Pirzkal, Rachel S. Somerville, Christopher N. A. Willmer, Guang Yang, L. Y. Aaron yung, Adriano Fontana, Andrea Grazian, Norman A. Grogin, Michaela Hirschmann, Lisa J. Kewley, Allison Kirkpatrick, Dale D. Kocevski, Jennifer M. Lotz, Aubrey Medrano, Alexa M. Morales, Laura Pentericci, Swara Ravindranath, Jonathan R. Trump, Antonello Calabrò, M. C. Cooper, Luca Costantin, Alexander de la Vega, Bryan Hilbert, Taylor A. Hutchison, Rebecca L. Larson, Ray A. Lucas, Elizabeth J. McGrath, Russell Ryan, Xin Wang, Stijn Wuyts, Stephen Wilkins
Mar 27, 2023
We present the data release and data reduction process for the Epoch 1 NIRCam observations for the Cosmic Evolution Early Release Science Survey (CEERS). These data consist of NIRCam imaging in six broadband filters (F115W...
Altering the availability or proximity of food, alcohol, and tobacco products to change their selection and consumption.
Gareth J Hollands, Patrice Carter, Sumayya Anwer, Sarah E King, Susan A Jebb, David Ogilvie, Ian Shemilt, Julian PT Higgins, Theresa M Marteau
Sep 06, 2019
BACKGROUND: Overconsumption of food, alcohol, and tobacco products increases the risk of non-communicable diseases. Interventions to change characteristics of physical micro-environments where people may select or consume these...
Proteome-Wide Prediction of Acetylation Substrates
Amrita Basu
Jan 01, 0001
Eukaryotic DNA is found packaged with proteins and RNA, which forms a substance called chromatin. This packaging is dynamic and regulates access to DNA for essential cellular processes such as transcription, replication, and...
Published by: Rockefeller University
The Role of Lysogenic Bacteriophage in Virulence and Survival of Streptococcus Pyogenes
Chad W Euler
Jan 01, 0001
This thesis investigates the interactions of lysogenic bacteriophage with Streptococcus pyogenes. We were specifically interested in elucidating novel ways in which the prophage influence GrAS virulence and survival either...
Published by: Rockefeller University
Trans-abdominal in vivo placental vessel occlusion using High Intensity Focused Ultrasound.
Caroline J Shaw, Ian Rivens, John Civale, Kimberley J Botting, Gail Ter Haar, Dino A Giussani, Christoph C Lees
Nov 22, 2018
Pre-clinically, High Intensity Focused Ultrasound (HIFU) has been shown to safely and effectively occlude placental blood vessels in the acute setting, when applied through the uterus. However, further development of the...
<sup>13</sup>C-glucose-fructose labeling reveals comparable exogenous CHO oxidation during exercise when consuming 120 g/h in fluid, gel, jelly chew, or coingestion
Mark A. Hearris, Jamie N. Pugh, Carl Langan-Evans, Stephen J. Mann, Louise Burke, Trent Stellingwerff, Javier T. Gonzalez, James P. Morton
Jun 01, 2022
We examined the effects of carbohydrate (CHO) delivery form on exogenous CHO oxidation, gastrointestinal discomfort, and exercise capacity. In a randomized repeated-measures design [after 24 h of high CHO intake (8 g·kg...
n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes
Frank Qian, Andres V Ardisson Korat, Fumiaki Imamura, Matti Marklund, Nathan Tintle, Jyrki K Virtanen, Xia Zhou, Julie K Bassett, Heidi Lai, Yoichiro Hirakawa, Kuo-Liong Chien, Alexis C Wood, Maria Lankinen, Rachel A Murphy, Cecilia Samieri, Kamalita Pertiwi, Vanessa D de Mello, Weihua Guan, Nita G Forouhi, Nick Wareham, InterAct Consortium Frank B Hu, Ulf Riserus, Lars Lind, William S Harris, Aladdin H Shadyab, Jennifer G Robinson, Lyn M Steffen, Allison Hodge, Graham G Giles, Toshiharu Ninomiya, Matti Uusitupa, Jaakko Tuomilehto, Jaana Lindström, Markku Laakso, David S Siscovick, Catherine Helmer, Johanna M Geleijnse, Jason HY Wu, Amanda Fretts, Rozenn N Lemaitre, Renata Micha, Dariush Mozaffarian, Qi Sun, Fatty Acids and Outcomes Research Consortium (FORCE)
Feb 11, 2021
Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia.
Pirro G Hysi, Hélène Choquet, Anthony P Khawaja, Robert Wojciechowski, Milly S Tedja, Jie Yin, Mark J Simcoe, Karina Patasova, Omar A Mahroo, Khanh K Thai, Phillippa M Cumberland, Ronald B Melles, Virginie JM Verhoeven, Veronique Vitart, Ayellet Segre, Richard A Stone, Nick Wareham, Alex W Hewitt, David A Mackey, Caroline CW Klaver, Stuart MacGregor, Consortium for Refractive Error and Myopia, Peng T Khaw, Paul J Foster, UK Eye and Vision Consortium, Jeremy A Guggenheim, 23andMe Inc., Jugnoo S Rahi, Eric Jorgenson, Christopher J Hammond
Jan 14, 2021
Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the molecular mechanisms that underlie abnormal eye development and impaired...
Polygenic basis and biomedical consequences of telomere length variation
Veryan Codd, Qingning Wang, Elias Allara, Crispin Musicha, Stephen Kaptoge, Svetlana Stoma, Tao Jiang, Stephen E. Hamby, Peter S. Braund, Vasiliki Bountziouka, Charley A. Budgeon, Matthew Denniff, Chloe Swinfield, Manolo Papakonstantinou, Shilpi Sheth, Dominika E. Nanus, Sophie C. Warner, Minxian Wang, Amit V. Khera, James Eales, Willem H. Ouwehand, John R. Thompson, Emanuele Di Angelantonio, Angela M. Wood, Adam S. Butterworth, John N. Danesh, Christopher P. Nelson, Nilesh J. Samani
Oct 06, 2021
Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.
Eric L Harshfield, Eric B Fauman, David Stacey, Dirk S Paul, Daniel Ziemek, Rachel MY Ong, John Danesh, Adam S Butterworth, Asif Rasheed, Taniya Sattar, Zameer-ul-Asar, Imran Saleem, Zoubia Hina, Unzila Ishtiaq, Nadeem Qamar, Nadeem Hayat Mallick, Zia Yaqub, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Anjum Jalal, Shahid Abbas, Philippe Frossard, Danish Saleheen, Angela M Wood, Julian L Griffin, Albert Koulman
Sep 02, 2021
BACKGROUND: Genetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase the risk of cardiovascular and metabolic diseases. However, how changes in individual lipid species...
DeepZipper
R Morgan, B Nord, K Bechtol, SJ González, E Buckley-Geer, A Möller, JW Park, AG Kim, S Birrer, M Aguena, J Annis, S Bocquet, D Brooks, A Carnero Rosell, M Carrasco Kind, J Carretero, R Cawthon, LN Da Costa, TM Davis, J De Vicente, P Doel, I Ferrero, D Friedel, J Frieman, J García-Bellido, M Gatti, E Gaztanaga, G Giannini, D Gruen, RA Gruendl, G Gutierrez, DL Hollowood, K Honscheid, DJ James, K Kuehn, N Kuropatkin, MAG Maia, R Miquel, A Palmese, F Paz-Chinchón, MES Pereira, A Pieres, AA Plazas Malagón, K Reil, A Roodman, E Sanchez, M Smith, E Suchyta, MEC Swanson, G Tarle, C To
Mar 09, 2022
Large-scale astronomical surveys have the potential to capture data on large
numbers of strongly gravitationally lensed supernovae (LSNe). To facilitate
timely analysis and spectroscopic follow-up before the supernova fades, an...
Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition.
SG Yammine, I Huybrechts, C Biessy, L Dossus, S Panico, MJ Sánchez, V Benetou, R Turzanski-Fortner, V Katzke, A Idahl, G Skeie, K Standahl Olsen, A Tjønneland, J Halkjær, S Colorado-Yohar, AK Heath, E Sonestedt, H Sartor, MB Schulze, D Palli, M Crous-Bou, A Dorronsoro, K Overvad, A Barricarte Gurrea, G Severi, RCH Vermeulen, TM Sandanger, RC Travis, T Key, P Amiano, B Van Guelpen, M Johansson, M Sund, R Tumino, N Wareham, C Sacerdote, V Krogh, P Brennan, E Riboli, E Weiderpass, MJ Gunter, V Chajès
Feb 17, 2023
Robot-Assisted Versus Laparoscopic Distal Pancreatectomy in Patients with Resectable Pancreatic Cancer
Jeffrey W Chen, Tess ME van Ramshorst, Sanne Lof, Bilal Al-Sarireh, Bergthor Bjornsson, Ugo Boggi, Fernando Burdio, Giovanni Butturini, Riccardo Casadei, Andrea Coratti, Mathieu D'Hondt, Safi Dokmak, Bjørn Edwin, Alessandro Esposito, Jean M Fabre, Giovanni Ferrari, Fadhel S Ftériche, Giuseppe K Fusai, Bas Groot Koerkamp, Thilo Hackert, Asif Jah, Jin-Young Jang, Emanuele F Kauffmann, Tobias Keck, Alberto Manzoni, Marco V Marino, Quintus Molenaar, Elizabeth Pando, Patrick Pessaux, Andrea Pietrabissa, Zahir Soonawalla, Robert P Sutcliffe, Lea Timmermann, Steven White, Vincent S Yip, Alessandro Zerbi, Mohammad Abu Hilal, Marc G Besselink, European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS)
Apr 10, 2023
BACKGROUND: Robot-assisted distal pancreatectomy (RDP) is increasingly used as an alternative to laparoscopic distal pancreatectomy (LDP) in patients with resectable pancreatic cancer but comparative multicenter studies...
Healthcare databases in europe for studying medicine use and safety during pregnancy
Rachel A. Charlton, Amanda J. Neville, Sue Jordan, Anna Pierini, Christine Damase-Michel, Kari Klungsøyr, Anne-Marie Nybo Andersen, Anne Vinkel Hansen, Rosa Gini, Jens H. J. Bos, Aurora Puccini, Caroline Hurault-Delarue, Caroline J. Brooks, L.T.W. De Jong-Van Den Berg, Corinne S. de Vries
Jun 01, 2014
Purpose: The aim of this study was to describe a number of electronic healthcare databases in Europe in terms of the population covered, the source of the data captured and the availability of data on key variables required for...
Ursinus College Alumni Journal, August 1967
Richard P. Richter, Donald C. Estes, Lucille Hunt Bone, Roger P. Staiger, Raymond V. Gurzynski, Blanche B. Schultz, George R. Freeland, Robert D. Meier, Claude C. Erb, Susan S. Koch, Lawrence Romane, Donald L. Helfferich, Allan Lake Rice, Lester Coleman, Robert McRae
Jan 01, 0001
Exposure '67 Ursinus Viewpoint at commencement time: Means to an end; Toward freedom; Liberal morality; Open-minded attitude; Quality vs. quantity From the President What makes Suzy a language dud? The paradox of urbia: an...
Ursinus College Collegeville Pennsylvania alumni Deaths Marriages Reimert Hall Freeland Hall Robert McRae Lester Coleman Robert D. Myers Rosa Wessel tennis baseball track team Robert Shaw Higher Education Social History United States History
Published by: Ursinus College
Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice
Benjamin G Challis, Andrew S Powlson, Ruth T Casey, Carla Pearson, Brian Y Lam, Marcella Ma, Deborah Pitfield, Giles SH Yeo, Edmund Godfrey, Heok K Cheow, V Krishna Chatterjee, Nicholas R Carroll, Ashley Shaw, John R Buscombe, Helen L Simpson
Dec 08, 2017
OBJECTIVE: In adults with hyperinsulinaemic hypoglycaemia (HH), in particular those with insulinoma, the optimal diagnostic and management strategies remain uncertain. Here, we sought to characterise the biochemical and...
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