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Results: 15010
Predicting interval and screen-detected breast cancers from mammographic density defined by different brightness thresholds.
Tuong L Nguyen, Ye K Aung, Shuai Li, Nhut Ho Trinh, Christopher F Evans, Laura Baglietto, Kavitha Krishnan, Gillian S Dite, Jennifer Stone, Dallas R English, Yun-Mi Song, Joohon Sung, Mark A Jenkins, Melissa C Southey, Graham G Giles, John L Hopper
Feb 18, 2019
BACKGROUND: Case-control studies show that mammographic density is a better risk factor when defined at higher than conventional pixel-brightness thresholds. We asked if this applied to interval and/or screen-detected cancers....
Australian women Breast Cancer Interval cancer Mammographic density Mammography Masking effect Nested case–control cohort study Screen-detected Aged Breast Breast Density Breast Neoplasms Case-Control Studies Early Detection of Cancer Female Humans Image Processing Computer-Assisted Mammography Middle Aged Prognosis Prospective Studies Risk Assessment Risk Factors Software
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Farah H Siddiqi, Fiona M Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Rodrigo Ureshino, Thomas Ricketts, Maria Jimenez-Sanchez, Miguel Angel Esteban, Liangxue Lai, Micky D Tortorella, Zhiwei Luo, Hao Liu, Emmanouil Metzakopian, Hugo JR Fernandes, Andrew Bassett, Eric Karran, Bruce L Miller, Angeleen Fleming, David C Rubinsztein
Mar 13, 2019
Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins...
Animals Animals Genetically Modified Autophagy Cell Line Cerebral Cortex Disease Models Animal Drug Repositioning Embryo Mammalian Embryo Nonmammalian Felodipine Female Humans Induced Pluripotent Stem Cells Male Mice Mice Inbred C57BL Mutation Neurodegenerative Diseases Neurons Neuroprotective Agents Primary Cell Culture Swine Swine Miniature Treatment Outcome Zebrafish ALPHA-SYNUCLEIN
Genomic plasticity associated with antimicrobial resistance in Vibrio cholerae.
Jyoti Verma, Satyabrata Bag, Bipasa Saha, Pawan Kumar, Tarini Shankar Ghosh, Mayanka Dayal, Tarosi Senapati, Seema Mehra, Prasanta Dey, Anbumani Desigamani, Dhirendra Kumar, Preety Rana, Bhoj Kumar, Tushar K Maiti, Naresh C Sharma, Rupak K Bhadra, Ankur Mutreja, G Balakrish Nair, Thandavarayan Ramamurthy, Bhabatosh Das
Jun 17, 2019
Antimicrobial resistance Cholera Genome mobile genetic elements Proteome Anti-Bacterial Agents Cholera Conjugation Genetic DNA Transposable Elements Diarrhea Drug Resistance Multiple Bacterial evolution Molecular Feces Gene Transfer Horizontal genetic variation Genome Bacterial Genomic Islands Humans Imipenem india Interspersed Repetitive Sequences Phenotype Plasmids Prophages Proteome Vibrio cholerae Vibrio cholerae O1 whole genome sequencing
Familiarity with, perceptions of and attitudes toward butterflies of urban park users in megacities across East and Southeast Asia
Voon-Ching Lim, Kong-Wah Sing, Kwek Yan Chong, Narong Jaturas, Hui Dong, Ping-Shin Lee, Nguyen Thien Tao, Dzung Trung Le, Timothy C. Bonebrake, Toby P. N. Tsang, Leo Chu, Guo-Jie Brandon-Mong, Wye-Lup Kong, Masashi Soga, John-James Wilson
Apr 17, 2023
Ecology conservation and global change biology RESEARCH ARTICLES Butterflies CONSERVATION human–wildlife interactions megacities nature experiences urban wildlife
Published by: The Royal Society
Uncovering spatiotemporal patterns of atrophy in progressive supranuclear palsy using unsupervised machine learning.
William J Scotton, Cameron Shand, Emily Todd, Martina Bocchetta, David M Cash, Lawren VandeVrede, Hilary Heuer, 4RTNI Consortium PROSPECT Consortium, Alexandra L Young, Neil Oxtoby, Daniel C Alexander, James B Rowe, Huw R Morris, Adam L Boxer, Jonathan D Rohrer, Peter A Wijeratne
Apr 17, 2023
To better understand the pathological and phenotypic heterogeneity of progressive supranuclear palsy and the links between the two, we applied a novel unsupervised machine learning algorithm (Subtype and Stage Inference) to the...
HES5 silencing is an early and recurrent change in prostate tumourigenesis.
Charles E Massie, Inmaculada Spiteri, Helen Ross-Adams, Hayley Luxton, Jonathan Kay, Hayley C Whitaker, Mark J Dunning, Alastair D Lamb, Antonio Ramos-Montoya, Daniel S Brewer, Colin S Cooper, Rosalind Eeles, UK Prostate ICGC Group, Anne Y Warren, Simon Tavaré, David E Neal, Andy G Lynch
Mar 12, 2015
AR ERG HES5 HES6 Notch epigenetics Methylation prostate cancer Basic Helix-Loop-Helix Transcription Factors Carcinogenesis Cell Line Tumor DNA Methylation Epigenesis Genetic Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Male Promoter Regions Genetic Prostatic Neoplasms Repressor Proteins Trans-Activators Transcriptional Regulator ERG
Associations between flavan-3-ol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk)
High-resolution Imaging of PHIBSS z sim 2 Main-sequence Galaxies in CO J = 1 rarr 0
A. D. Bolatto, S. R. Warren, A. K. Leroy, L. J. Tacconi, N. Bouché, N. M. Förster Schreiber, R. Genzel, M. C. Cooper, D. B. Fisher, F. Combes, S. García-Burillo, A. Burkert, F. Bournaud, A. Weiss, A. Saintonge, S. Wuyts, A. Sternberg
Aug 21, 2015
We present Karl Jansky Very Large Array observations of the CO $J=1-0$ transition in a sample of four $z\sim 2$ main-sequence galaxies. These galaxies are in the blue sequence of star-forming galaxies at their redshift, and are...
Manipulation of autophagy in phagocytes facilitates <i>Staphylococcus aureus</i> bloodstream infection
Kate M. O'Keefe, Miesko M. Wilk, John M. Leech, Alison G. Murphy, Maisem Laabei, Ian R. Monk, Ruth C. Massey, Jodi A. Lindsay, Timothy J. Foster, Joan A. Geoghegan, Rachel M. McLoughlin
Sep 01, 2015
The capacity for intracellular survival within phagocytes is likely a critical factor facilitating S. aureus dissemination in the host. To date, the majority of work on S. aureus-phagocyte interactions has focused on neutrophils...
Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors <em>in vitro</em>
Helen A. Paine, Amit Nathubhai, Esther C. Y. Woon, Peter T. Sunderland, Pauline J. Wood, Mary F. Mahon, Matthew D. Lloyd, Andrew S. Thompson, Teemu Haikarainen, Mohit Narwal, Lari Lehtio, Michael D. Threadgill
Sep 01, 2015
Tankyrases-1 and -2 (TNKS-1 and TNKS-2) have three cellular roles which make them important targets in cancer. Using NAD+ as a substrate, they poly(ADP-ribosyl)ate TRF1 (regulating lengths of telomeres), NuMA...
Sequencing and association analysis of the type 1 diabetes - linked region on chromosome 10p12-q11
S Nejentsev, LJ Smink, D Smyth, R Bailey, CE Lowe, F Payne, J Masters, L Godfrey, A Lam, O Burren, H Stevens, S Nutland, NM Walker, A Smith, R Twells, BJ Barratt, C Wright, L French, Y Chen, P Deloukas, J Rogers, I Dunham, JA Todd
Jun 16, 2011
Background: In an effort to locate susceptibility genes for type I diabetes (TID) several genome-wide linkage scans have been undertaken. A chromosomal region designated IDDM10 retained genome-wide significance in a combined...
Bat trait, genetic and pathogen data from large-scale investigations of African fruit bats, Eidolon helvum.
Guidelines for the functional annotation of microRNAs using the Gene Ontology.
Rachael P Huntley, Dmitry Sitnikov, Marija Orlic-Milacic, Rama Balakrishnan, Peter D'Eustachio, Marc E Gillespie, Doug Howe, Anastasia Z Kalea, Lars Maegdefessel, David Osumi-Sutherland, Victoria Petri, Jennifer R Smith, Kimberly Van Auken, Valerie Wood, Anna Zampetaki, Manuel Mayr, Ruth C Lovering
Jan 22, 2016
High-Pressure Transformation of SiO<sub>2</sub> Glass from a Tetrahedral to an Octahedral Network
Anita Zeidler, Kamil Wezka, Ruth F Rowlands, Dean A J Whittaker, Philip S Salmon, Annalisa Polidori, James W E Drewitt, Stefan Klotz, Henry E Fischer, Martin C Wilding, Craig L Bull, Matthew G Tucker, Mark Wilson
Sep 26, 2014
A combination of in situ high-pressure neutron diffraction at pressures up to 17.5(5) GPa and molecular dynamics simulations employing a many-body interatomic potential model is used to investigate the structure of...
Interdependency of subsurface carbon distribution and graphene-catalyst interaction.
Robert S Weatherup, Hakim Amara, Raoul Blume, Bruno Dlubak, Bernhard C Bayer, Mamadou Diarra, Mounib Bahri, Andrea Cabrero-Vilatela, Sabina Caneva, Piran R Kidambi, Marie-Blandine Martin, Cyrile Deranlot, Pierre Seneor, Robert Schloegl, François Ducastelle, Christophe Bichara, Stephan Hofmann
Sep 29, 2014
Diet induces parallel changes to the gut microbiota and problem solving performance in a wild bird
Gabrielle L. Davidson, Niamh Wiley, Amy C. Cooke, Crystal N. Johnson, Fiona Fouhy, Michael S. Reichert, Iván de la Hera, Jodie M. S. Crane, Ipek G. Kulahci, R. Paul Ross, Catherine Stanton, John L. Quinn
Nov 27, 2020
Abstract: The microbial community in the gut is influenced by environmental factors, especially diet, which can moderate host behaviour through the microbiome-gut-brain axis. However, the ecological relevance of...
The contribution of X-linked coding variation to severe developmental disorders.
Hilary C Martin, Eugene J Gardner, Kaitlin E Samocha, Joanna Kaplanis, Nadia Akawi, Alejandro Sifrim, Ruth Y Eberhardt, Ana Lisa Taylor Tavares, Matthew DC Neville, Mari EK Niemi, Giuseppe Gallone, Jeremy McRae, Deciphering Developmental Disorders Study, Caroline F Wright, David R FitzPatrick, Helen V Firth, Matthew E Hurles
Feb 26, 2021
Over 130 X-linked genes have been robustly associated with developmental disorders, and X-linked causes have been hypothesised to underlie the higher developmental disorder rates in males. Here, we evaluate the burden of...
Rapid metal pollutant deposition from the volcanic plume of Kīlauea, Hawai’i
Evgenia Ilyinskaya, Emily Mason, Penny E. Wieser, Lacey Holland, Emma J. Liu, Tamsin A. Mather, Marie Edmonds, Rachel C. W. Whitty, Tamar Elias, Patricia A. Nadeau, David Schneider, James B. McQuaid, Sarah E. Allen, Jason Harvey, Clive Oppenheimer, Christoph Kern, David Damby
Jun 04, 2021
Abstract: Long-lived basaltic volcanic eruptions are a globally important source of environmentally reactive, volatile metal pollutant elements such as selenium, cadmium and lead. The 2018 eruption of Kīlauea, Hawai’i produced...
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite.
Min Zhang, Chengqi Wang, Jenna Oberstaller, Phaedra Thomas, Thomas D Otto, Debora Casandra, Sandhya Boyapalle, Swamy R Adapa, Shulin Xu, Katrina Button-Simons, Matthew Mayho, Julian C Rayner, Michael T Ferdig, Rays HY Jiang, John H Adams
Oct 04, 2021
The emergence and spread of Plasmodium falciparum parasites resistant to front-line antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable gains against the disease of the last decade. Here, we...
The impact of COVID-19 on the management of European protected areas and policy implications
J McGinlay, V Gkoumas, J Holtvoeth, RFA Fuertes, E Bazhenova, A Benzoni, K Botsch, CC Martel, CC Sánchez, I Cervera, G Chaminade, J Doerstel, CJF García, A Jones, M Lammertz, K Lotman, M Odar, T Pastor, C Ritchie, S Santi, M Smolej, FS Rico, H Waterman, T Zwijacz-Kozica, A Kontoleon, PG Dimitrakopoulos, N Jones
Nov 20, 2020
High-resolution dietary reconstruction of victims of the 79 CE Vesuvius eruption at Herculaneum by compound-specific isotope analysis.
Silvia Soncin, Helen M Talbot, Ricardo Fernandes, Alison Harris, Matthew von Tersch, Harry K Robson, Jan K Bakker, Kristine K Richter, Michelle Alexander, Steven Ellis, Gill Thompson, Valeria Amoretti, Massimo Osanna, Marina Caso, Francesco Sirano, Luciano Fattore, Andre C Colonese, Peter Garnsey, Luca Bondioli, Oliver E Craig
Sep 26, 2021
The remains of those who perished at Herculaneum in 79 CE offer a unique opportunity to examine lifeways across an ancient community who lived and died together. Historical sources often allude to differential access to...
International consensus on the prevention of venous and arterial thrombotic events in patients with inflammatory bowel disease.
Pablo A Olivera, Stephane Zuily, Paulo G Kotze, Veronique Regnault, Sameer Al Awadhi, Peter Bossuyt, Richard B Gearry, Subrata Ghosh, Taku Kobayashi, Patrick Lacolley, Edouard Louis, Fernando Magro, Siew C Ng, Alfredo Papa, Tim Raine, Fabio V Teixeira, David T Rubin, Silvio Danese, Laurent Peyrin-Biroulet
Sep 28, 2021
Patients with inflammatory bowel disease (IBD) are at increased risk of thrombotic events. Therapies for IBD have the potential to modulate this risk. The aims of this Evidence-Based Guideline were to summarize available...
Published by: Nature reviews. Gastroenterology & hepatology
Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI.
Kerstin N Timm, Charith Perera, Vicky Ball, John A Henry, Jack J Miller, Matthew Kerr, James A West, Eshita Sharma, John Broxholme, Angela Logan, Dragana Savic, Michael S Dodd, Julian L Griffin, Michael P Murphy, Lisa C Heather, Damian J Tyler
Jan 18, 2021
Doxorubicin (DOX) is a widely used chemotherapeutic agent that can cause serious cardiotoxic side effects culminating in congestive heart failure (HF). There are currently no clinical imaging techniques or biomarkers available...
Should Age-Dependent Absolute Risk Thresholds Be Used for Risk Stratification in Risk-Stratified Breast Cancer Screening?
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth.
Adi L Tarca, Bálint Ármin Pataki, Roberto Romero, Marina Sirota, Yuanfang Guan, Rintu Kutum, Nardhy Gomez-Lopez, Bogdan Done, Gaurav Bhatti, Thomas Yu, Gaia Andreoletti, Tinnakorn Chaiworapongsa, DREAM Preterm Birth Prediction Challenge Consortium, Sonia S Hassan, Chaur-Dong Hsu, Nima Aghaeepour, Gustavo Stolovitzky, Istvan Csabai, James C Costello
Jun 25, 2021
Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM...
Aptamers collaborative competition human transcriptome arrays Machine Learning plasma proteomics predictive modeling preterm labor and delivery spontaneous preterm birth whole blood transcriptomics Adult Asymptomatic Diseases Biomarkers Blood Proteins Cell-Free Nucleic Acids Crowdsourcing Female Gestational Age Humans Infant Newborn Longitudinal Studies pre-eclampsia Pregnancy premature birth Proteomics ROC Curve Transcriptome
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