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Short-term follow-up of chagasic patients after benzonidazole treatment using multiple serological markers.
Ana Fernández-Villegas, María Jesús Pinazo, Concepción Marañón, M Carmen Thomas, Elizabeth Posada, Bartolomé Carrilero, Manuel Segovia, Joaquim Gascon, Manuel C López
Dec 18, 2020
BACKGROUND: Conventional serological tests, using total soluble proteins or a cocktail of recombinant proteins from T. cruzi as antigens, are highly sensitive for Chagas disease diagnosis. This type of tests, however, does not...
A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons.
Anastasiya Sybirna, Walfred W C Tang, Merrick Pierson Smela, Sabine Dietmann, Wolfram H Gruhn, Ran Brosh, M Azim Surani
Apr 11, 2020
PRDM14 is a crucial regulator of mouse primordial germ cells (mPGCs), epigenetic reprogramming and pluripotency, but its role in the evolutionarily divergent regulatory network of human PGCs (hPGCs) remains unclear. Besides, a...
Published by: Nature Communications
Radiosynthesis of [18F]-Labelled Pro-Nucleotides (ProTides).
Alessandra Cavaliere, Katrin C Probst, Stephen J Paisey, Christopher Marshall, Abdul KH Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D Westwell
Apr 24, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success....
Increased brain age in adults with Prader-Willi syndrome.
Adriana M Azor, James H Cole, Anthony J Holland, Maureen Dumba, Maneesh C Patel, Angelique Sadlon, Anthony P Goldstone, Katherine E Manning
Feb 15, 2019
Prader-Willi syndrome (PWS) is the most common genetic obesity syndrome, with associated learning difficulties, neuroendocrine deficits, and behavioural and psychiatric problems. As the life expectancy of individuals with PWS...
Structural dynamics of a metal-organic framework induced by CO2 migration in its non-uniform porous structure.
Pu Zhao, Hong Fang, Sanghamitra Mukhopadhyay, Aurelia Li, Svemir Rudić, Ian J McPherson, Chiu C Tang, David Fairen-Jimenez, SC Edman Tsang, Simon AT Redfern
Feb 15, 2019
Stimuli-responsive behaviors of flexible metal-organic frameworks (MOFs) make these materials promising in a wide variety of applications such as gas separation, drug delivery, and molecular sensing. Considerable efforts have...
Algorithm based smartphone apps to assess risk of skin cancer in adults
Karoline Freeman, Jacqueline Dinnes, Naomi Chuchu, Yemisi Takwoingi, Sue E Bayliss, Rubeta N Matin, Abhilash Jain, Fiona M Walter, Hywel C Williams, Jonathan J Deeks
Feb 14, 2020
Abstract: Objective: To examine the validity and findings of studies that examine the accuracy of algorithm based smartphone applications (“apps”) to assess risk of skin cancer in suspicious skin lesions. Design: Systematic...
Insulin pump therapy with automated insulin suspension in response to hypoglycemia
Pratik Choudhary, John Shin, Yongyin Wang, Mark L Evans, Peter J Hammond, David Kerr, James Am Shaw, John C Pickup, Stephanie A Amiel
Feb 14, 2020
OBJECTIVE: To evaluate a sensor-augmented insulin pump with a low glucose suspend (LGS) feature that automatically suspends basal insulin delivery for up to 2 h in response to sensor-detected hypoglycemia. RESEARCH DESIGN AND...
How Much Education Is Needed to Delay Women's Age at Marriage and First Pregnancy?
Akanksha A Marphatia, Naomi M Saville, Gabriel S Amable, Dharma S Manandhar, Mario Cortina-Borja, Jonathan C Wells, Alice M Reid
Feb 29, 2020
Background: Early childbirth is associated with adverse maternal and child health outcomes. In South Asia, where women generally marry before having children, public health efforts need to focus on delaying marriage. Female...
Education age at first pregnancy lowland Nepal marriage to first childbearing interval women's marriage age
Published by: Frontiers in public health
Active control of the free surface of a rivulet of a nematic liquid crystal with an electric field
Akhshay S. Bhadwal, Joseph R. L. Cousins, Nigel J. Mottram, Stephen K. Wilson, Brian R. Duffy, Ian C. Sage, Carl V. Brown
Jun 24, 2024
Active control of a rivulet of a nematic liquid crystal is achieved by local modification of the effective viscosity with an applied electric field. Specifically, using the nematic 5CB, control of the free surface of the rivulet...
Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b
Abstract
Background
A key histopathological hallmark of Alzheimer’s disease (AD) is the presence of neurofibrillary tangles of...
Layla Hosseini-Gerami, Elena Ficulle, Neil Humphryes-Kirilov, David C Airey, James Scherschel, Sarubini Kananathan, Brian J Eastwood, Suchira Bose, David A Collier, Emma Laing, David Evans, Howard Broughton, Andreas Bender
Mar 14, 2023
Demographic rates reveal the benefits of protected areas in a long-lived migratory bird.
Characterization of black slags obtained during smelting in the electric arc furnace from SIDERPERU following reduction
Abstract The primary process in an electrical arc furnace (EAF) during industrial steelmaking results in tons of black slags which cause pollution to the environment. In this work, the iron oxides...
HA Cabrera-Tinoco, RA Valencia-Bedregal, LE Borja-Castro, MI Valerio-Cuadros, AGB Dominguez, X Zhao, Y Zhang, C Zheng, NO Moreno, D Zhang, CHW Barnes, LDLS Valladares
Jan 04, 2023
A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma
Hélène Ruffieux, Jérôme Carayol, Radu Popescu, Mary-Ellen Harper, Robert Dent, Wim H. M. Saris, Arne Astrup, Jörg Hager, Anthony C. Davison, Armand Valsesia
Jun 15, 2020
Molecular quantitative trait locus (QTL) analyses are increasingly popular to explore the genetic architecture of complex traits, but existing studies do not leverage shared regulatory patterns and suffer from a large...
The future of human malnutrition
Jonathan C. K. Wells, Akanksha A. Marphatia, Gabriel Amable, Mario Siervo, Henrik Friis, J. Jaime Miranda, Hinke H. Haisma, David Raubenheimer
Oct 09, 2021
Abstract: The major threat to human societies posed by undernutrition has been recognised for millennia. Despite substantial economic development and scientific innovation, however, progress in addressing this global challenge...
A dysfunctional endolysosomal pathway common to two sub-types of demyelinating Charcot–Marie–Tooth disease
James R. Edgar, Anita K. Ho, Matilde Laurá, Rita Horvath, Mary M. Reilly, J. Paul Luzio, Rhys C. Roberts
Oct 18, 2021
Abstract: Autosomal dominant mutations in LITAF are responsible for the rare demyelinating peripheral neuropathy, Charcot–Marie–Tooth disease type 1C (CMT1C). The LITAF protein is expressed in many human cell types and we have...
Digital transformation, for better or worse
J Dąbrowska, A Almpanopoulou, A Brem, H Chesbrough, V Cucino, A Di Minin, F Giones, H Hakala, C Marullo, AL Mention, L Mortara, S Nørskov, PA Nylund, CM Oddo, A Radziwon, P Ritala
Mar 17, 2022
For better or worse, digital technologies are reshaping everything, from customer behaviors and expectations to organizational and manufacturing systems, business models, markets, and ultimately society. To understand this...
Global tree-ring response and inferred climate variation following the mid-thirteenth century Samalas eruption
Abstract The largest explosive volcanic eruption of the Common Era in terms of estimated sulphur yield to the stratosphere was identified in glaciochemical records 40 years ago, and dates to the...
U Büntgen, SH Smith, S Wagner, P Krusic, J Esper, A Piermattei, A Crivellaro, F Reinig, W Tegel, A Kirdyanov, M Trnka, C Oppenheimer
Jun 29, 2022
Introduction of an assessment toolkit associated with increased rate of DLB diagnosis
A. Surendranathan, J. Kane, A. Bentley, S. Barker, R. McNally, C. Bamford, J.-P. Taylor, A. Thomas, I. McKeith, D. Burn, J. T. O’Brien
Feb 20, 2021
Abstract: Background: Dementia with Lewy bodies (DLB) and dementia in Parkinson’s disease (PDD) are recognised to be under-recognised in clinical practice in the UK, with only one third to a half of expected cases diagnosed. We...
A dysfunctional endolysosomal pathway common to two sub-types of demyelinating Charcot–Marie–Tooth disease
James R. Edgar, Anita K. Ho, Matilde Laurá, Rita Horvath, Mary M. Reilly, J. Paul Luzio, Rhys C. Roberts
Oct 15, 2020
Abstract: Autosomal dominant mutations in LITAF are responsible for the rare demyelinating peripheral neuropathy, Charcot–Marie–Tooth disease type 1C (CMT1C). The LITAF protein is expressed in many human cell types and we have...
Senescence of song revealed by a long-term study of the Seychelles warbler ( Acrocephalus sechellensis )
Mathew L. Berg, Sarah C. Beebe, Jan Komdeur, Adam P. A. Cardilini, Raoul F. H. Ribot, Andrew T. D. Bennett, Katherine L. Buchanan
Apr 15, 2021
Abstract: Senescence is widespread in nature, often resulting in diminishing survival or reproduction with age, but its role in age-dependent variation in sexual traits is often poorly understood. One reason is that few studies...
Clinical Utility of microRNAs in Exhaled Breath Condensate as Biomarkers for Lung Cancer.
Carlos Pérez-Sánchez, Nuria Barbarroja, Lucas C Pantaleão, Laura M López-Sánchez, Susan E Ozanne, Bernabé Jurado-Gámez, Enrique Aranda, Chary Lopez-Pedrera, Antonio Rodríguez-Ariza
Apr 26, 2021
This study represents a novel proof of concept of the clinical utility of miRNAs from exhaled breath condensate (EBC) as biomarkers of lung cancer (LC). Genome-wide miRNA profiling and machine learning analysis were performed on...
Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression.
Roberto Bonelli, Brendan RE Ansell, Luca Lotta, Thomas Scerri, Traci E Clemons, Irene Leung, MacTel Consortium, Tunde Peto, Alan C Bird, Ferenc B Sallo, Claudia Langenberg, Melanie Bahlo
Mar 26, 2021
BACKGROUND: Macular telangiectasia type 2 (MacTel) is a rare, heritable and largely untreatable retinal disorder, often comorbid with diabetes. Genetic risk loci subtend retinal vascular calibre and glycine/serine/threonine...
GWAS Mendelian randomisation Metabolomics Retinal disease Serine Biosynthetic Pathways Diabetes mellitus Type 2 Disease Progression Endophenotypes Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Humans Metabolome Polymorphism Single Nucleotide Retinal Telangiectasis Retinal Vessels Serine
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.
Xueyi Shen, David M Howard, Mark J Adams, W David Hill, Toni-Kim Clarke, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Ian J Deary, Heather C Whalley, Andrew M McIntosh
May 08, 2021
Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a...
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