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Effect of Long Term Exposure to Petrol Fumes on Liver Function- A Study in Petrol Pump Attendants
Petrol is an integral part of modern world. Various studies suggest that ingredients of petrol have a toxic effect on various organs. Petrol pump attends are exposed to petrol fumes. This study was conducted in petrol pump...
Published by: IJHS Medical Association
Effect of Long Term Exposure to Petrol Fumes on Liver Function- A Study in Petrol Pump Attendants
Petrol is an integral part of modern world. Various studies suggest that ingredients of petrol have a toxic effect on various organs. Petrol pump attends are exposed to petrol fumes. This study was conducted in petrol pump...
Published by: IJHS Medical Association
Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms.
Can Perceived Ease of Use Improve M-Commerce Adoption?
In India, e-commerce sector is rising at an enormous pace, but even larger share is in the hands of offline retailers till now. A unique type of consumer behaviour has been seen because of the simple accessibility of the...
Published by: IGI Global Scientific Publishing
A new RNASeq-based reference transcriptome for sugar beet and its application in transcriptome-scale analysis of vernalization and gibberellin responses.
Beta vulgaris Cold Temperature Computational Biology Gene Expression Profiling Gene Expression Regulation Plant Gene Regulatory Networks Genotype Gibberellins Molecular Sequence Annotation Molecular Sequence Data Plant Growth Regulators Plant Shoots RNA Messenger RNA Plant Sequence Analysis RNA Transcriptome
A randomised crossover study to compare the cross-sectional and longitudinal approaches to ultrasound-guided peripheral venepuncture in a model.
BACKGROUND: Ultrasound-guided peripheral intravenous access may present an alternative to central or intraosseous access in patients with difficult peripheral veins. Using venepuncture of a phantom model as a proxy, we...
A Technique for Securing Big Data Using K-Anonymization With a Hybrid Optimization Algorithm
The recent techniques built on cloud computing for data processing is scalable and secure, which increasingly attracts the infrastructure to support big data applications. This paper proposes an effective anonymization based...
Published by: IGI Global Scientific Publishing
Decoding Customer Opinion for Products or Brands Using Social Media Analytics
This study uses aspect-level sentiment analysis using lexicon-based approach to analyse online reviews of an Indian brand called Patanjali, which sells many FMCG products under its name. These reviews have been collected from...
Published by: IGI Global Scientific Publishing
p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response.
Hiroyoshi Hattori, Rekin's Janky, Wilfried Nietfeld, Stein Aerts, M Madan Babu, Ashok R Venkitaraman
Feb 13, 2020
The human DNA damage response (DDR) triggers profound changes in gene expression, whose nature and regulation remain uncertain. Although certain micro-(mi)RNA species including miR34, miR-18, miR-16 and miR-143 have been...
AP-1 activator protein-1 DDR DNA damage response DNA damage response E2F1 transcription factor E2F1 FOXM1 forkhead box protein M1 NF-k B nuclear factor-k B NGS next-generation sequencing TF transcription factor TP53 tumour protein p53 clinical outcome computational analysis double stranded DNA breaks DSBs ionizing radiation IR miRNA micro-RNA micro-RNA misc RNA miscellaneous RNA next-generation sequencing p53 scRNA small cytoplasmic RNA snRNA small nuclear RNA snoRNA small nucleolar RNA tRNA transfer RNA Cell Line DNA Damage DNA Repair Gene Expression Regulation Gene Expression Regulation Neoplastic Genome Genome Human Humans MicroRNAs Neoplasms Organ Specificity Tumor Suppressor Protein p53
Molecular determinants underlying functional innovations of TBP and their impact on transcription initiation.
Charles NJ Ravarani, Tilman Flock, Sreenivas Chavali, Madhanagopal Anandapadamanaban, M Madan Babu, Santhanam Balaji
May 20, 2021
Mode-localized accelerometer in the nonlinear Duffing regime with 75 ng bias instability and 95 ng/√Hz noise floor.
Hemin Zhang, Milind Pandit, Guillermo Sobreviela, Madan Parajuli, Dongyang Chen, Jiangkun Sun, Chun Zhao, Ashwin A Seshia
Mar 21, 2022
Mode-localized sensors have attracted attention because of their high parametric sensitivity and first-order common-mode rejection to temperature drift. The high-fidelity detection of resonator amplitude is critical to...
LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein.
Linda Sutherland, Madeleine Ruhe, Daniela Gattegno-Ho, Karanjit Mann, Jennifer Greaves, Magdalena Koscielniak, Stephen Meek, Zen Lu, Martin Waterfall, Ryan Taylor, Anestis Tsakiridis, Helen Brown, Sutherland K Maciver, Anagha Joshi, Michael Clinton, Luke H Chamberlain, Austin Smith, Tom Burdon
Sep 27, 2018
The cytokine leukaemia inhibitory factor (LIF) promotes self-renewal of mouse embryonic stem cells (ESCs) through activation of the transcription factor Stat3. However, the contribution of other ancillary pathways stimulated by...
Persistence of haemostatic response following gene therapy with valoctocogene roxaparvovec in severe haemophilia A.
K John Pasi, Michael Laffan, Savita Rangarajan, Tara M Robinson, Nina Mitchell, Will Lester, Emily Symington, Bella Madan, Xinqun Yang, Benjamin Kim, Glenn F Pierce, Wing Yen Wong
Nov 08, 2021
INTRODUCTION: Valoctocogene roxaparvovec is an investigational AAV5-based factor VIII (FVIII) gene therapy that has demonstrated sustained clinical benefit in people with severe haemophilia A. AIM: To report safety...
Highlights of the thirteenth annual scientific meeting of the Society of Cardiovascular Computed Tomography.
Jonathan R Weir-McCall, Nidhi Madan, Todd C Villines, Leslee J Shaw, Suhny Abbara, Maros Ferencik, Koen Nieman, Ron Blankstein, Brian B Ghoshhajra, Andrew D Choi, Edward Nicol
Dec 20, 2018
The 13th Annual Scientific Meeting of the SCCT, held from July 13 to July 15 in Dallas, TX, was attended by 690 attendees from 39 countries, 55 sessions with 140 speakers, and 18 exhibitors with the abstracts of all scientific...
Multidisciplinary research priorities for the COVID-19 pandemic - Authors' reply.
Rory C O'Connor, Matthew Hotopf, Carol M Worthman, V Hugh Perry, Irene Tracey, Simon Wessely, Louise Arseneault, Clive Ballard, Helen Christensen, Roxane Cohen Silver, Tamsin Ford, Ann John, Thomas Kabir, Kate King, Alan Simpson, Ira Madan, Katherine Cowan, Ed Bullmore, Emily A Holmes
Jul 06, 2020
Progesterone Receptor Attenuates STAT1-Mediated IFN Signaling in Breast Cancer.
Merit L Goodman, Gloria M Trinca, Katherine R Walter, Evangelia K Papachristou, Clive S D'Santos, Tianbao Li, Qi Liu, Zhao Lai, Prabhakar Chalise, Rashna Madan, Fang Fan, Mary A Markiewicz, Victor X Jin, Jason S Carroll, Christy R Hagan
Jul 15, 2019
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.
Bas Brouwers, Edson Mendes de Oliveira, Maria Marti-Solano, Fabiola BF Monteiro, Suli-Anne Laurin, Julia M Keogh, Elana Henning, Rebecca Bounds, Carole A Daly, Shane Houston, Vikram Ayinampudi, Natalia Wasiluk, David Clarke, Bianca Plouffe, Michel Bouvier, M Madan Babu, I Sadaf Farooqi, Jacek Mokrosiński
Apr 14, 2021
The Melanocortin-4 Receptor (MC4R) plays a pivotal role in energy homeostasis. We used human MC4R mutations associated with an increased or decreased risk of obesity to dissect mechanisms that regulate MC4R function. Most...
GPCRs Gα(s) MC4R MSH melanocortin obesity Therapy Weight Loss β-Arrestin Animals Body Weight COS Cells Cell Membrane Chlorocebus aethiops Cyclic AMP Endocytosis Extracellular Signal-Regulated MAP Kinases GTP-Binding Protein alpha Subunits Gs genetic variation HEK293 Cells Humans Models Biological Mutant Proteins Mutation Phosphorylation Protein Multimerization Receptor Melanocortin Type 4 Signal Transduction beta-Arrestins
Textile Production Line Monitoring System Using Wavelet-Regression Neural Network
This paper presents design and experiments for a production line monitoring system. The system is designed based on an existing production line which mapping to the smart grid standards. The Discrete wavelet transform (DWT) and...
Published by: IGI Global Scientific Publishing
Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells.
Joseph Jose Thottacherry, Anita Joanna Kosmalska, Amit Kumar, Amit Singh Vishen, Alberto Elosegui-Artola, Susav Pradhan, Sumit Sharma, Parvinder P Singh, Marta C Guadamillas, Natasha Chaudhary, Ram Vishwakarma, Xavier Trepat, Miguel A Del Pozo, Robert G Parton, Madan Rao, Pramod Pullarkat, Pere Roca-Cusachs, Satyajit Mayor
Jan 06, 2020
Plasma membrane tension regulates many key cellular processes. It is modulated by, and can modulate, membrane trafficking. However, the cellular pathway(s) involved in this interplay is poorly understood. Here we find that...
Common activation mechanism of class A GPCRs.
Qingtong Zhou, Dehua Yang, Meng Wu, Yu Guo, Wanjing Guo, Li Zhong, Xiaoqing Cai, Antao Dai, Wonjo Jang, Eugene I Shakhnovich, Zhi-Jie Liu, Raymond C Stevens, Nevin A Lambert, M Madan Babu, Ming-Wei Wang, Suwen Zhao
Jan 11, 2020
GPCR Activation mechanism allostery Computational Biology Drug Discovery Genetic Diseases human molecular biophysics Signal Transduction structural biology Systems Biology Allosteric Regulation Amino Acid Motifs Binding Sites Humans Ligands Protein Binding Protein Conformation Receptors G-Protein-Coupled Signal Transduction
Multidisciplinary research priorities for the COVID-19 pandemic
Emily A Holmes, Rory C O'Connor, V Hugh Perry, Irene Tracey, Simon Wessely, Louise Arseneault, Clive Ballard, Helen Christensen, Roxane Cohen Silver, Ian Everall, Tamsin Ford, Ann John, Thomas Kabir, Kate King, Ira Madan, Susan Michie, Andrew K Przybylski, Roz Shafran, Angela Sweeney, Carol M Worthman, Lucy Yardley, Katherine Cowan, Claire Cope, Matthew Hotopf, Ed Bullmore
May 19, 2020
The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect on all aspects of society, including mental health and physical health. We explore the psychological, social, and neuroscientific effects of COVID-19...
The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets.
Mariano F Zacarías-Fluck, Toni Jauset, Sandra Martínez-Martín, Jastrinjan Kaur, Sílvia Casacuberta-Serra, Daniel Massó-Vallés, Erika Serrano Del Pozo, Génesis Martín-Fernández, Íñigo González-Larreategui, Sergio López-Estévez, Lamorna Brown-Swigart, Marie-Eve Beaulieu, Jonathan R Whitfield, Babita Madan, David M Virshup, Gerard I Evan, Laura Soucek
May 17, 2021
The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as...
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