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Results: 165
Morphological alterations of cultured human colorectal matched tumour and healthy organoids.
Seyed Mohammad Hossein Kashfi, Sheema Almozyan, Nicholas Jinks, Bon-Kyoung Koo, Abdolrahman S Nateri
Jun 13, 2018
Organoids have extensive applications in many fields ranging from modelling human development and disease, personalised medicine, drug screening, etc. Moreover, in the last few years, several studies have evaluated the capacity...
Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.
Jinwook Choi, Jong-Eun Park, Georgia Tsagkogeorga, Motoko Yanagita, Bon-Kyoung Koo, Namshik Han, Joo-Hyeon Lee
Jun 24, 2020
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Laura Broutier, Amanda Andersson-Rolf, Christopher J Hindley, Sylvia F Boj, Hans Clevers, Bon-Kyoung Koo, Meritxell Huch
Jun 28, 2016
Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses.
Myra Hosmillo, Yasmin Chaudhry, Komal Nayak, Frederic Sorgeloos, Bon-Kyoung Koo, Alessandra Merenda, Reidun Lillestol, Lydia Drumright, Matthias Zilbauer, Ian Goodfellow
Apr 19, 2020
Human noroviruses (HuNoV) are a leading cause of viral gastroenteritis worldwide and a significant cause of morbidity and mortality in all age groups. The recent finding that HuNoV can be propagated in B cells and mucosa-derived...
Published by: mBio
Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses.
Myra Hosmillo, Yasmin Chaudhry, Komal Nayak, Frederic Sorgeloos, Bon-Kyoung Koo, Alessandra Merenda, Reidun Lillestol, Lydia Drumright, Matthias Zilbauer, Ian Goodfellow
Feb 19, 2020
Human noroviruses (HuNoV) are a leading cause of viral gastroenteritis worldwide and a significant cause of morbidity and mortality in all age groups. The recent finding that HuNoV can be propagated in B cells and mucosa-derived...
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
Tadasuke Tsukiyama, Juqi Zou, Jihoon Kim, Shohei Ogamino, Yuki Shino, Takamasa Masuda, Alessandra Merenda, Masaki Matsumoto, Yoichiro Fujioka, Tomonori Hirose, Sayuri Terai, Hidehisa Takahashi, Tohru Ishitani, Keiichi I. Nakayama, Yusuke Ohba, Bon-Kyoung Koo, Shigetsugu Hatakeyama
Sep 15, 2020
Tracing oncogene-driven remodelling of the intestinal stem cell niche.
Min Kyu Yum, Seungmin Han, Juergen Fink, Szu-Hsien Sam Wu, Catherine Dabrowska, Teodora Trendafilova, Roxana Mustata, Lemonia Chatzeli, Roberta Azzarelli, Irina Pshenichnaya, Eunmin Lee, Frances England, Jong Kyoung Kim, Daniel E Stange, Anna Philpott, Joo-Hyeon Lee, Bon-Kyoung Koo, Benjamin D Simons
Apr 07, 2021
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
Tadasuke Tsukiyama, Juqi Zou, Jihoon Kim, Shohei Ogamino, Yuki Shino, Takamasa Masuda, Alessandra Merenda, Masaki Matsumoto, Yoichiro Fujioka, Tomonori Hirose, Sayuri Terai, Hidehisa Takahashi, Tohru Ishitani, Keiichi I Nakayama, Yusuke Ohba, Bon-Kyoung Koo, Shigetsugu Hatakeyama
Sep 15, 2021
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Germán Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Jan 28, 2022
RNF43/ZNRF3 negatively regulate WNT signalling. Both genes are mutated in several types of cancers, however, their contribution to liver disease is unknown. Here we describe that hepatocyte-specific loss of Rnf43/Znrf3 results...
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Germán Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Feb 18, 2022
RNF43/ZNRF3 negatively regulate WNT signalling. Both genes are mutated in several types of cancers, however, their contribution to liver disease is unknown. Here we describe that hepatocyte-specific loss of Rnf43/Znrf3 results...
Adult Animals Carcinoma Hepatocellular Cell Differentiation Cell Proliferation Fatty Liver Gene Deletion Gene Expression Regulation Hepatocytes Hepatomegaly Humans Hyperplasia Lipid Droplets Lipid Metabolism lipidomics Liver Liver Neoplasms Liver Regeneration Mice Prognosis Ubiquitin-Protein Ligases
DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.
Kate Joanne Howell, Judith Kraiczy, Komal M Nayak, Marco Gasparetto, Alexander Ross, Claire Lee, Tim N Mak, Bon-Kyoung Koo, Nitin Kumar, Trevor Lawley, Anupam Sinha, Philip Rosenstiel, Robert Heuschkel, Oliver Stegle, Matthias Zilbauer
Jan 24, 2018
BACKGROUND & AIMS: We analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about pathogenesis....
epigenetics Gut microbiota Human Intestinal Organoids Intestinal Epithelium Adolescent Age Factors Biopsy Case-Control Studies Colitis Ulcerative Colon Sigmoid Crohn Disease DNA Methylation Diagnosis Differential England Epigenesis Genetic Epithelial Cells Female Gastrointestinal Microbiome Gene Expression Profiling Genome-Wide Association Study Humans Ileum Intestinal Mucosa Male Organoids Predictive Value of Tests Prognosis Prospective Studies Ribotyping Time Factors Tissue Culture Techniques Transcription Genetic Transcriptome
DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.
Judith Kraiczy, Komal M Nayak, Kate J Howell, Alexander Ross, Jessica Forbester, Camilla Salvestrini, Roxana Mustata, Sally Perkins, Amanda Andersson-Rolf, Esther Leenen, Anke Liebert, Ludovic Vallier, Philip C Rosenstiel, Oliver Stegle, Gordon Dougan, Robert Heuschkel, Bon-Kyoung Koo, Matthias Zilbauer
May 31, 2018
intestinal cell lines intestinal development Intestinal Epithelium intestinal gene regulation intestinal stem cell Cell Differentiation Cells Cultured Clustered Regularly Interspaced Short Palindromic Repeats DNA Methylation Epigenesis Genetic Epithelial Cells Humans Intestinal Mucosa Organoids Transcriptome
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.
Seungmin Han, Juergen Fink, David J Jörg, Eunmin Lee, Min Kyu Yum, Lemonia Chatzeli, Sebastian R Merker, Manon Josserand, Teodora Trendafilova, Amanda Andersson-Rolf, Catherine Dabrowska, Hyunki Kim, Ronald Naumann, Ji-Hyun Lee, Nobuo Sasaki, Richard Lester Mort, Onur Basak, Hans Clevers, Daniel E Stange, Anna Philpott, Jong Kyoung Kim, Benjamin D Simons, Bon-Kyoung Koo
Jul 24, 2019
Lgr5 Troy biophysical modeling deep tissue imaging gastric corpus isthmus stem cell Intestine punctuated neutral drift Single-cell RNA-seq two stem cell compartments unbiased genetic labeling Adult stem cells Biomarkers Cell Differentiation Cell Lineage Cell Self Renewal Cells Cultured Gastric Mucosa Humans Ki-67 Antigen Sequence Analysis RNA Single-Cell Analysis Stathmin Stem Cell Niche Stomach
Porcine Sapelovirus Uses α2,3-Linked Sialic Acid on GD1a Ganglioside as a Receptor.
Deok-Song Kim, Kyu-Yeol Son, Kyung-Min Koo, Ji-Yun Kim, Mia Madel Alfajaro, Jun-Gyu Park, Myra Hosmillo, Mahmoud Soliman, Yeong-Bin Baek, Eun-Hyo Cho, Ju-Hwan Lee, Mun-Il Kang, Ian Goodfellow, Kyoung-Oh Cho
Jan 18, 2016
The Ursinus Weekly, November 27, 1908
Ursinus then and now Football Post-season bon-fire Department of Music formally opened Noted lecturer coming Societies Personals Alumni notes Seminary notes
Ursinus College Collegeville Pennsylvania newspaper Walter M. Chandler Football YWCA Zwinglian literary society Schaff literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Who Goes to Graduate School? Engineers’ Math Proficiency, College Experience, and Self-Assessment of Skills
$\textbf{Background.}$ Increasing human resources in engineering is a key concern for the United States. While some research has considered pathways to doctoral study, there is not yet clear empirical evidence on the role of...
Isolation and Characterization of Estrogen Receptor- Interacting Proteins
Yun Kyoung Kang
Jan 01, 0001
Estrogen fulfills a variety of physiological roles through its nuclear receptors, estrogen receptors (ERs). The action of ERs is modulated and mediated by diverse interacting cofactors. The initial aim of this thesis work was to...
Published by: Rockefeller University
Ways to Implement Effective Product Placement on YouTube
Wanmo Koo
Jan 01, 2023
In line with marketers' growing use of product placement on YouTube, this study investigates elements of YouTube product placement that can ultimately affect viewers' purchase intention based on the theory of reasoned action...
Published by: IGI Global Scientific Publishing
The Grizzly, September 28, 1999
Erny Hoke, Stephanie Restine, NiPun Suri, Heather W. Gurk, Ann Van Buren, Dan Reimold, Michael Ramsey, Dave Walker, Paige Miller, Mandy Hansen, Susan Patton, Kelly Tessena, Cory Braiterman, Aaron Hampton, Andy Maynard, Fran Shaughnessy
Jan 01, 0001
Cheer on UC at Family Day! Taking to the Ballots Change in Ursinus Security: Good or Bad? Family Day Has Arrived Living Off Campus Just Like Home Campus Unable to Check Messages on Voice Mail Bon Appetite at Back Porch...
Ursinus College Collegeville Pennsylvania newspaper Football field hockey Volleyball Soccer Skippack Family Day telephone service campus security student government cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Symptom Signatures and Diagnostic Timeliness in Cancer Patients
Early diagnosis is an important aspect of contemporary cancer prevention and control strategies, as the majority of patients are diagnosed following symptomatic presentation. The nature of presenting symptoms can critically...
Accelerated galaxy growth and environmental quenching in a protocluster at z=3.24
We present a multiwavelength study of galaxies around D4UD01, a spectroscopically confirmed protocluster at z = 3.24, to investigate environmental trends. 450 galaxies are selected based on KS band detection with photometric...
Mitochondrial redox and TCA cycle metabolite signaling in the heart.
Mitochondria are essential signaling organelles that regulate a broad range of cellular processes and thereby heart function. Multiple mechanisms participate in the communication between mitochondria and the nucleus that...
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