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The Oxymoron of Digitalization
How do small and medium-sized enterprises (SMEs) perceive the prerequisites and critical factors of digitalization? The objective of this article is to map SMEs' digital maturity and their views on how to manage the...
Published by: IGI Global Scientific Publishing
Pulsed SILAC as a Approach for miRNA Targets Identification in Cell Culture.
Daniella E Duque-Guimarães, Juliana de Almeida-Faria, Thomas Prates Ong, Susan E Ozanne
Jul 12, 2018
Pulsed stable isotope labeling by amino acids in cell culture (pSILAC) comprises a variation of the classical SILAC proteomic methodology that enables the identification of short-term proteomic responses such as those elicited...
Reprogramming Human Adult Fibroblasts into GABAergic Interneurons.
Andreas Bruzelius, Srisaiyini Kidnapillai, Janelle Drouin-Ouellet, Tom Stoker, Roger A Barker, Daniella Rylander Ottosson
Jan 28, 2022
Direct reprogramming is an appealing strategy to generate neurons from a somatic cell by forced expression of transcription factors. The generated neurons can be used for both cell replacement strategies and disease modelling....
adult skin cells calbindin direct reprogramming disease-modelling Electrophysiology iN neuronal conversion Adult Brain Diseases Cell Differentiation Cellular Reprogramming Cognitive Dysfunction FIBROBLASTS GABAergic Neurons Gene Expression Regulation Humans Interneurons Neurogenesis Neuroglia Repressor Proteins Skin gamma-Aminobutyric Acid
Influence of Obesity Prevalence on Social Norms and Weight Control Motivation
Fiona Gillison, Vera Killen, Elisabeth Grey, Martyn Standage, Daniella Watson, Stef Kremers
Dec 31, 2022
This cross-sectional survey study explored associations between perceived bodyweight norms, psychological need satisfaction and motivation for weight control among 500 adult residents of two countries with different...
Influence of Obesity Prevalence on Social Norms and Weight Control Motivation
Fiona Gillison, Vera Killen, Elisabeth Grey, Martyn Standage, Daniella Watson, Stef Kremers
Dec 31, 2022
This cross-sectional survey study explored associations between perceived bodyweight norms, psychological need satisfaction and motivation for weight control among 500 adult residents of two countries with different...
Genetic epidemiology of ovarian cancer and prospects for polygenic risk prediction.
Epithelial ovarian cancer (EOC) is a heterogeneous disease with a major heritable component. The different histotypes of invasive disease - high grade serous, clear cell, endometrioid and mucinous - are associated with different...
Reprogramming Human Adult Fibroblasts into GABAergic Interneurons.
Andreas Bruzelius, Srisaiyini Kidnapillai, Janelle Drouin-Ouellet, Tom Stoker, Roger Barker, Daniella Rylander Ottosson
Jan 04, 2022
Direct reprogramming is an appealing strategy to generate neurons from a somatic cell by forced expression of transcription factors. The generated neurons can be used for both cell replacement strategies and disease modelling....
“A disembodied voice over the telephone”
Frankie Brown, Isabella Sanders, Ross Watkins, Elisabeth Grey, Paula Smith, Daniella Springett, Tomas Welsh, Fiona Gillison
May 05, 2023
Objectives: This study explored the experience of delivering care remotely among practitioners in a UK geriatric medicine clinic. Methods: Nine semi-structured interviews were conducted with consultants (n = 5), nurses (n =...
“A disembodied voice over the telephone”
Frankie Brown, Isabella Sanders, Ross Watkins, Elisabeth Grey, Paula Smith, Daniella Springett, Tomas Welsh, Fiona Gillison
May 05, 2023
Objectives: This study explored the experience of delivering care remotely among practitioners in a UK geriatric medicine clinic. Methods: Nine semi-structured interviews were conducted with consultants (n = 5), nurses (n =...
SILAC Mass Spectrometry Profiling
Daniella Duque-Guimarães, Thomas Prates Ong, Juliana de Almeida-Faria, Paul C Guest, Susan E Ozanne
Apr 26, 2018
Stable isotope labelling by amino acids in cell culture (SILAC) is a technique that allows proteomic profiling of cells. In this chapter we describe a protocol for the identification and quantification of newly synthesised...
Cell culture Drug responses Proteomics Psychiatric disorders Stable isotope labelling by amino acids Animals Carbon Isotopes Cell Fractionation Cells Cultured Chromatography High Pressure Liquid Chromatography Liquid Electrophoresis Polyacrylamide Gel Humans Isotope Labeling Lysine Mental Disorders Nerve Tissue Proteins Nitrogen Isotopes Peptide Fragments Proteomics Tandem Mass Spectrometry
Plasma lipids and growth faltering
Gerard Bryan Gonzales, Daniella Brals, Bakary Sonko, Fatou Sosseh, Andrew M Prentice, Sophie E Moore, Albert Koulman
Oct 18, 2021
[Figure: see text].
Published by: Science advances
Neuroergonomic Assessment of Wheelchair Control Using Mobile fNIRS
Shawn Joshi, Roxana Ramirez Herrera, Daniella Nicole Springett, Benjamin David Weedon, Dafne Zuleima Morgado Ramirez, Catherine Holloway, Helen Dawes, Hasan Ayaz
May 04, 2020
For over two centuries, the wheelchair has been one of the most common assistive devices for individuals with locomotor impairments without many modifications. Wheelchair control is a complex motor task that increases both...
Exercise alters the molecular pathways of insulin signaling and lipid handling in maternal tissues of obese pregnant mice.
Barbara Musial, Denise S Fernandez-Twinn, Daniella Duque-Guimaraes, Sarah K Carr, Abigail L Fowden, Susan E Ozanne, Amanda N Sferruzzi-Perri
Aug 19, 2019
Obesity during gestation adversely affects maternal and infant health both during pregnancy and for long afterwards. However, recent work suggests that a period of maternal exercise during pregnancy can improve metabolic health...
The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome.
Michal R Gdula, Tatyana B Nesterova, Greta Pintacuda, Jonathan Godwin, Ye Zhan, Hakan Ozadam, Michael McClellan, Daniella Moralli, Felix Krueger, Catherine M Green, Wolf Reik, Skirmantas Kriaucionis, Edith Heard, Job Dekker, Neil Brockdorff
Jun 17, 2019
The inactive X chromosome (Xi) in female mammals adopts an atypical higher-order chromatin structure, manifested as a global loss of local topologically associated domains (TADs), A/B compartments and formation of two...
Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms.
Denise S Fernandez-Twinn, Maria Z Alfaradhi, Malgorzata S Martin-Gronert, Daniella E Duque-Guimaraes, Ana Piekarz, David Ferland-McCollough, Martin Bushell, Susan E Ozanne
Feb 26, 2020
We determined the effects of maternal diet-induced obesity on offspring adipose tissue insulin signalling and miRNA expression in the aetiology of insulin resistance in later life. Although body composition and glucose tolerance...
Neuroergonomic Assessment of Wheelchair Control Using Mobile fNIRS
Shawn Joshi, Roxana Ramirez Herrera, Daniella Nicole Springett, Benjamin David Weedon, Dafne Zuleima Morgado Ramirez, Catherine Holloway, Helen Dawes, Hasan Ayaz
May 04, 2020
For over two centuries, the wheelchair has been one of the most common assistive devices for individuals with locomotor impairments without many modifications. Wheelchair control is a complex motor task that increases both...
REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.
Janelle Drouin-Ouellet, Shong Lau, Per Ludvik Brattås, Daniella Rylander Ottosson, Karolina Pircs, Daniela A Grassi, Lucy M Collins, Romina Vuono, Annika Andersson Sjöland, Gunilla Westergren-Thorsson, Caroline Graff, Lennart Minthon, Håkan Toresson, Roger A Barker, Johan Jakobsson, Malin Parmar
Nov 27, 2017
Direct conversion of human fibroblasts into mature and functional neurons, termed induced neurons (iNs), was achieved for the first time 6 years ago. This technology offers a promising shortcut for obtaining patient- and...
Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain.
Marcella Birtele, Petter Storm, Yogita Sharma, Janko Kajtez, Jenny Nelander Wahlestedt, Edoardo Sozzi, Fredrik Nilsson, Simon Stott, Xiaoling L He, Bengt Mattsson, Daniella Rylander Ottosson, Roger A Barker, Alessandro Fiorenzano, Malin Parmar
Dec 12, 2022
Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark
Juliana de Almeida-Faria, Daniella E. Duque-Guimarães, Thomas P. Ong, Lucas C. Pantaleão, Asha A. Carpenter, Elena Loche, Laura C. Kusinski, Thomas J. Ashmore, Robin Antrobus, Martin Bushell, Denise S. Fernandez-Twinn, Susan E. Ozanne
Mar 08, 2021
Abstract: Aims/hypothesis: Levels of the microRNA (miRNA) miR-126-3p are programmed cell-autonomously in visceral adipose tissue of adult offspring born to obese female C57BL/6J mice. The spectrum of miR-126-3p targets and thus...
Temperate Earth-sized planets transiting a nearby ultracool dwarf star.
Michaël Gillon, Emmanuël Jehin, Susan M Lederer, Laetitia Delrez, Julien de Wit, Artem Burdanov, Valérie Van Grootel, Adam J Burgasser, Amaury HMJ Triaud, Cyrielle Opitom, Brice-Olivier Demory, Devendra K Sahu, Daniella Bardalez Gagliuffi, Pierre Magain, Didier Queloz
Jul 19, 2021
Star-like objects with effective temperatures of less than 2,700 kelvin are referred to as 'ultracool dwarfs'. This heterogeneous group includes stars of extremely low mass as well as brown dwarfs (substellar objects not massive...
Accuracy of Continuous Glucose Monitoring During Three Closed-Loop Home Studies Under Free-Living Conditions.
Hood Thabit, Lalantha Leelarathna, Malgorzata E Wilinska, Daniella Elleri, Janet M Allen, Alexandra Lubina-Solomon, Emma Walkinshaw, Marietta Stadler, Pratik Choudhary, Julia K Mader, Sibylle Dellweg, Carsten Benesch, Thomas R Pieber, Sabine Arnolds, Simon R Heller, Stephanie A Amiel, David Dunger, Mark L Evans, Roman Hovorka
Jul 14, 2015
Adolescent Adult Blood Glucose Blood Glucose Self-Monitoring Child Cross-Over Studies Diabetes mellitus Type 1 Equipment Design Female Glycated Hemoglobin Humans Hypoglycemia Hypoglycemic Agents Insulin Insulin Infusion Systems Male Middle Aged Reference Values Reproducibility of Results Social Conditions Teach-Back Communication Time Factors
Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark.
Juliana de Almeida-Faria, Daniella E Duque-Guimarães, Thomas P Ong, Lucas C Pantaleão, Asha A Carpenter, Elena Loche, Laura C Kusinski, Thomas J Ashmore, Robin Antrobus, Martin Bushell, Denise S Fernandez-Twinn, Susan E Ozanne
Oct 30, 2020
ER stress glucose metabolism Lunapark Maternal obesity Nutritional programming miR-126-3p 3T3-L1 Cells Adipocytes Adipose Tissue Animals Blood Glucose Disease Models Animal Down-Regulation Endoplasmic reticulum stress Female Homeodomain Proteins Insulin Receptor Substrate Proteins Insulin Resistance Mice Mice Inbred C57BL MicroRNAs obesity Maternal Phenotype Pregnancy prenatal exposure delayed effects Signal Transduction
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease.
Janelle Drouin-Ouellet, Emilie M Legault, Fredrik Nilsson, Karolina Pircs, Julie Bouquety, Florence Petit, Shelby Shrigley, Marcella Birtele, Maria Pereira, Petter Storm, Yogita Sharma, Andreas Bruzelius, Romina Vuono, Malin Kele, Thomas B Stoker, Daniella Rylander Ottosson, Anna Falk, Johan Jakobsson, Roger A Barker, Malin Parmar
Oct 24, 2022
We have developed an efficient approach to generate functional induced dopaminergic (DA) neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of patient fibroblasts with idiopathic Parkinson's...
Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site.
Willy MJM Bogers, Susan W Barnett, Herman Oostermeijer, Ivonne G Nieuwenhuis, Niels Beenhakker, Daniella Mortier, Petra Mooij, Gerrit Koopman, Edmund Remarque, Gregoire Martin, Rachel Pei-Jen Lai, Antu K Dey, Yide Sun, Brian Burke, Guido Ferrari, David Montefiori, Loic Martin, David Davis, Indresh Srivastava, Jonathan L Heeney
Aug 17, 2017
B-cell responses CD4 mimetic CD4 occluded T-cell responses human immunodeficiency virus nonhuman primates vaccines AIDS Vaccines Animals Antibodies Neutralizing Antibody-Dependent Cell Cytotoxicity B-Lymphocytes Binding Sites Antibody CD4 Antigens HIV Antibodies HIV-1 Macaca mulatta T-Lymphocytes Helper-Inducer Vaccination env Gene Products Human Immunodeficiency Virus
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