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A Data Representation Model for Personalized Medicine
Personalized medicine exploits the patient data, for example, genetic compositions, and key biomarkers. During the data mining process, the key challenges are the information loss, the data types heterogeneity and the time...
Published by: IGI Global Scientific Publishing
FALF ConvNets
Obtaining efficient Convolutional Neural Networks (CNNs) are imperative to enable their application for a wide variety of tasks (classification, detection, etc.). While several methods have been proposed to solve this problem...
FALF ConvNets
Obtaining efficient Convolutional Neural Networks (CNNs) are imperative to enable their application for a wide variety of tasks (classification, detection, etc.). While several methods have been proposed to solve this problem...
Microfluidic approaches for probing amyloid assembly and behaviour.
The self-assembly of proteins into supramolecular structures and machinery underpins biological activity in living systems. Misassembled, misfolded and aggregated protein structures can, by contrast, have deleterious activity...
Waterpipe tobacco smoking (WTS) control policies
Hala Alaouie, Sumithra Krishnamurthy Reddiar, Malak Tleis, Lama El Kadi, Rima A Afifi, Rima Nakkash
Mar 03, 2022
INTRODUCTION: The Framework Convention on Tobacco Control (FCTC) offers guidance on evidence-based policies to reduce tobacco consumption and its burden of disease. Recently, it has provided guidance for alternative tobacco...
Addiction Global Health Public Policy /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells.
Padmapriya Ponnuswamy, Jeremie Joffre, Olivier Herbin, Bruno Esposito, Ludivine Laurans, Christoph J Binder, Thomas F Tedder, Lynda Zeboudj, Xavier Loyer, Andreas Giraud, Yujiao Zhang, Alain Tedgui, Ziad Mallat, Hafid Ait-Oufella
Jun 21, 2018
Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B...
Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices.
Pavan Kumar Challa, Quentin Peter, Maya A Wright, Yuewen Zhang, Kadi L Saar, Jacqueline A Carozza, Justin LP Benesch, Tuomas PJ Knowles
Aug 18, 2020
Optical detection has become a convenient and scalable approach to read out information from microfluidic systems. For the study of many key biomolecules, however, including peptides and proteins, which have low fluorescence...
Waterpipe tobacco smoking (WTS) control policies
Hala Alaouie, Sumithra Krishnamurthy Reddiar, Malak Tleis, Lama El Kadi, Rima A Afifi, Rima Nakkash
Mar 03, 2022
INTRODUCTION: The Framework Convention on Tobacco Control (FCTC) offers guidance on evidence-based policies to reduce tobacco consumption and its burden of disease. Recently, it has provided guidance for alternative tobacco...
Addiction Global Health Public Policy /dk/atira/pure/subjectarea/asjc/3300/3306 name=Health(social science) /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Implementation of E-Learning Holistic Education in First Middle School
The implementation of e-learning holistic education has been widely carried out, but few have studied it related to aspects of the development of the use of communication and information technology in the world of education. Due...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.
Kadi L Saar, Yingbo Zhang, Thomas Müller, Challa P Kumar, Sean Devenish, Andrew Lynn, Urszula Łapińska, Xiaoting Yang, Sara Linse, Tuomas PJ Knowles
Apr 16, 2018
The ability to apply highly controlled electric fields within microfluidic devices is valuable as a basis for preparative and analytical processes. A challenge encountered in the context of such approaches in conductive media...
Rapid two-dimensional characterisation of proteins in solution.
Kadi L Saar, Quentin Peter, Thomas Müller, Pavan K Challa, Therese W Herling, Tuomas PJ Knowles
Apr 03, 2019
Microfluidic platforms provide an excellent basis for working with heterogeneous samples and separating biomolecular components at high throughput, with high recovery rates and by using only very small sample volumes. To date...
Rapid two-dimensional characterisation of proteins in solution
Kadi L. Saar, Quentin Peter, Thomas Müller, Pavan K. Challa, Therese W. Herling, Tuomas P. J. Knowles
Jun 30, 2020
Abstract: Microfluidic platforms provide an excellent basis for working with heterogeneous samples and separating biomolecular components at high throughput, with high recovery rates and by using only very small sample volumes....
Gingival fibroblasts protect against experimental abdominal aortic aneurysm development and rupture through tissue inhibitor of metalloproteinase-1 production.
Andreas Giraud, Lynda Zeboudj, Marie Vandestienne, Jérémie Joffre, Bruno Esposito, Stéphane Potteaux, José Vilar, Daniela Cabuzu, Johannes Kluwe, Sylvie Seguier, Alain Tedgui, Ziad Mallat, Antoine Lafont, Hafid Ait-Oufella
Apr 09, 2019
AIMS: Abdominal aortic aneurysm (AAA), frequently diagnosed in old patients, is characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix destruction. Despite improvement...
abdominal aortic aneurysm Cell therapy Gingival fibroblasts Metalloproteases Remodelling Angiotensin II Animals Aorta Abdominal Aortic Aneurysm Abdominal Aortic Rupture Disease Models Animal Extracellular Matrix FIBROBLASTS Gingiva Mice Inbred C57BL Mice Knockout Protective Agents Tissue Inhibitor of Metalloproteinase-1 Transforming Growth Factor beta
The Dendritic Cell Receptor DNGR-1 Promotes the Development of Atherosclerosis in Mice.
Yacine Haddad, Charlotte Lahoute, Marc Clément, Ludivine Laurans, Sarvenaz Metghalchi, Lynda Zeboudj, Andreas Giraud, Xavier Loyer, Marie Vandestienne, Julien Wain-Hobson, Bruno Esposito, Stephane Potteaux, Hafid Ait-Oufella, Alain Tedgui, Ziad Mallat, Soraya Taleb
Jun 21, 2018
RATIONALE: Necrotic core formation during the development of atherosclerosis is associated with a chronic inflammatory response and promotes accelerated plaque development and instability. However, the molecular links between...
Selective EGF-Receptor Inhibition in CD4+ T Cells Induces Anergy and Limits Atherosclerosis.
Lynda Zeboudj, Mikael Maître, Lea Guyonnet, Ludivine Laurans, Jeremie Joffre, Jeremie Lemarie, Simon Bourcier, Wared Nour-Eldine, Coralie Guérin, Jonas Friard, Abdelilah Wakkach, Elizabeth Fabre, Alain Tedgui, Ziad Mallat, Pierre-Louis Tharaux, Hafid Ait-Oufella
Jun 20, 2018
BACKGROUND: Several epidermal growth factor receptor (EGFR) inhibitors have been successfully developed for the treatment of cancer, limiting tumor growth and metastasis. EGFR is also expressed by leukocytes, but little is...
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation.
Maria J Matos, Claudio D Navo, Tuuli Hakala, Xhenti Ferhati, Ana Guerreiro, David Hartmann, Barbara Bernardim, Kadi L Saar, Ismael Compañón, Francisco Corzana, Tuomas PJ Knowles, Gonzalo Jiménez-Osés, Gonçalo JL Bernardes
Apr 05, 2019
Quaternized vinyl- and alkynyl-pyridine reagents were shown to react in an ultrafast and selective manner with several cysteine-tagged proteins at near-stoichiometric quantities. We have demonstrated that this method can...
Selective EGFR (Epidermal Growth Factor Receptor) Deletion in Myeloid Cells Limits Atherosclerosis-Brief Report.
Lynda Zeboudj, Andréas Giraud, Lea Guyonnet, Yujiao Zhang, Ludivine Laurans, Bruno Esposito, Jose Vilar, Anna Chipont, Nikolina Papac-Milicevic, Christoph J Binder, Alain Tedgui, Ziad Mallat, Pierre-Louis Tharaux, Hafid Ait-Oufella
Apr 09, 2019
OBJECTIVE: To determine the consequences of specific inhibition of EGFR (epidermal growth factor receptor) in myeloid cells in atherosclerosis development. APPROACH AND RESULTS: Atherosclerotic lesion size was significantly...
Atherosclerosis foam cells Inflammation MACROPHAGES Mice Animals Atherosclerosis Bone Marrow Transplantation CD36 Antigens Cytoskeleton Diet High-Fat Disease Models Animal ErbB Receptors Gene Deletion Interleukin-6 MACROPHAGES Male Mice Knockout Necrosis Plaque Atherosclerotic Receptors LDL Tumor Necrosis Factor-alpha Whole-Body Irradiation
Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution.
William E Arter, Catherine K Xu, Marta Castellana-Cruz, Therese W Herling, Georg Krainer, Kadi L Saar, Janet R Kumita, Christopher M Dobson, Tuomas PJ Knowles
Feb 24, 2021
Oligomers comprised of misfolded proteins are implicated as neurotoxins in the pathogenesis of protein misfolding conditions such as Parkinson's and Alzheimer's diseases. Structural, biophysical, and biochemical characterization...
On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.
Yuewen Zhang, Emma V Yates, Liu Hong, Kadi L Saar, Georg Meisl, Christopher M Dobson, Tuomas PJ Knowles
May 16, 2018
Investigations of protein folding, unfolding and stability are critical for the understanding of the molecular basis of biological structure and function. We describe here a microfluidic approach to probe the unfolding of...
Genetic Depletion or Hyperresponsiveness of Natural Killer Cells Do Not Affect Atherosclerosis Development.
Wared Nour-Eldine, Jérémie Joffre, Kazem Zibara, Bruno Esposito, Andréas Giraud, Lynda Zeboudj, José Vilar, Megumi Terada, Patrick Bruneval, Eric Vivier, Hafid Ait-Oufella, Ziad Mallat, Sophie Ugolini, Alain Tedgui
Jun 21, 2018
RATIONALE: Chronic inflammation is central in the development of atherosclerosis. Both innate and adaptive immunities are involved. Although several studies have evaluated the functions of natural killer (NK) cells in...
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