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Editorial.
I am delighted to be writing this editorial at such an exciting time in the history of this journal. This tenth volume sees a re-launch under a new title, which reflects our new aims and scope. The Journal brings together...
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2-Aminoethoxydiphenylborate (2-APB) inhibits release of phosphatidylserine-exposing extracellular vesicles from platelets
Abstract: Activated, procoagulant platelets shed phosphatidylserine (PS)-exposing extracellular vesicles (EVs) from their surface in a Ca2+- and calpain-dependent manner. These PS-exposing EVs are prothrombotic and...
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Protease‐activated receptor antagonists prevent thrombosis when dual antiplatelet therapy is insufficient in an occlusive thrombosis microfluidic model
Abstract: Background: Platelet activation and arterial thrombosis on a ruptured atherosclerotic plaque is a major cause of myocardial infarction. Dual antiplatelet therapy (DAPT), the combination of platelet aggregation...
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High extracellular phosphate increases platelet polyphosphate content.
Platelet-derived extracellular polyphosphate (PolyP) is a major mediator of thrombosis. PolyP is a linear chain of inorganic phosphate (Pi) and is stored in platelet dense granules. Pi enters cells from the extracellular fluid...
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Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
MT Harper, AW Poole
May 28, 2020
Platelets enhance thrombin generation at sites of vascular injury by exposing phosphatidylserine during necrosis-like cell death. Anoctamin 6 (Ano6) is required for Ca(2+)-dependent phosphatidylserine exposure and is defective...
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Tightly shut
Abstract: An organic-rich columnar prismatic outer shell layer, which extends far beyond the underlying nacre, has allowed pterioid bivalves (the pearl oysters and their allies) to develop flexible valve margins, allowing a...
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Sims to Address Northwestern District Alumnae Association
Winthrop News Service
Jan 01, 0001
Winthrop College Alumnae Association Northwestern District consisted of the counties of Abbeville, Anderson, Greenville, Greenwood, McCormick, Oconee, and Pickens in South Carolina. The meeting took place on November 2, 1946 in...
Published by: Winthrop University
Extracellular chloride is required for efficient platelet aggregation.
Anion channels perform a diverse range of functions and have been implicated in ATP release, volume regulation, and phosphatidylserine exposure. Platelets have been shown to express several anion channels but their function is...
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Platelet P-selectin triggers rapid surface exposure of tissue factor in monocytes
Abstract: Tissue factor (TF) plays a central role in haemostasis and thrombosis. Following vascular damage, vessel wall TF initiates the extrinsic coagulation cascade. TF can also be exposed by monocytes. Inflammatory or...
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Computational Investigation of Copper Phosphides as Conversion Anodes for Lithium-Ion Batteries
Using first principles structure searching with density-functional theory (DFT) we identify a novel Fm-3m phase of Cu2P and two low-lying metastable structures, an I-43d–Cu3P phase, and a Cm–Cu3P11 phase. The computed pair...
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A double-edged sword
The past year has demonstrated the power of collaborative scientific effort in rapidly developed vaccines to curb the SARS-CoV-2 pandemic and repurposed drugs to improve patient outcomes in severe COVID-19 disease. The morbidity...
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Tightly shut
Abstract: An organic-rich columnar prismatic outer shell layer, which extends far beyond the underlying nacre, has allowed pterioid bivalves (the pearl oysters and their allies) to develop flexible valve margins, allowing a...
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Evidence for Carbonate System Mediated Shape Shift in an Intertidal Predatory Gastropod
Phenotypic plasticity represents an important first-line organism response to newly introduced or changing environmental constraints. Knowledge about structural responses to environmental stressors could thus be an...
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2-Aminoethoxydiphenylborate (2-APB) inhibits release of phosphatidylserine-exposing extracellular vesicles from platelets.
Activated, procoagulant platelets shed phosphatidylserine (PS)-exposing extracellular vesicles (EVs) from their surface in a Ca2+- and calpain-dependent manner. These PS-exposing EVs are prothrombotic and proinflammatory and are...
Published by: Cell Death Discovery

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