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Results: 64
Developing and Comparing Data Mining Algorithms That Work Best for Predicting Student Performance
Learning data analytics improves the learning field in higher education using educational data for extracting useful patterns and making better decision. Identifying potential at-risk students may help instructors and academic...
Published by: IGI Global Scientific Publishing
Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters
DA Rhodes, Hung-Chang Chen, James C Williamson, Alfred Hill, Jack Yuan, Sam Smith, Harriet Rhodes, John Trowsdale, Paul J Lehner, Thomas Herrmann, Matthias Eberl
Jul 04, 2018
Activation of human Vγ9/Vδ2 T cells by ‘phosphoantigens’ (pAg), the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP) and the endogenous isoprenoid intermediate isopentenyl pyrophosphate (IPP)...
1 Underpinning research 1.1 Normal biological development and functioning 2.1 Biological and endogenous factors 2 Aetiology Generic Health Relevance ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter Subfamily G Member 1 ATP Binding Cassette Transporter Subfamily G Member 2 Antigen Presentation Antigens CD Butyrophilins Diphosphates HLA Antigens HeLa Cells Humans Interferon-gamma Lymphocyte Activation Neoplasm Proteins Protein Stability Receptors Antigen T-Cell gamma-delta T-Lymphocytes
E-Banking Adoption by Algerian Bank Customers
This study aimed to identify the factors affecting customers' adoption and use of e-banking services in Algeria. For this purpose, a theoretical model—based on the technology acceptance model (TAM) and the unified theory of...
Published by: IGI Global Scientific Publishing
Host-Parasite Interrelations: Bacterial Adherence to and Invasion of Epithelial Cells
Debra Bessen
Jan 01, 0001
Enteroinvasive Escherichia coli (EIEC) preferentially invaded multinucleated ReLa cells which arose naturally in monolayer cultures at a low frequency. Data suggests that enhancement of the penetration step accounts partly for...
Published by: Rockefeller University
DFC
Knowledge discovery data (KDD) is a research theme evolving to exploit a large data set collected every day from various fields of computing applications. The underlying idea is to extract hidden knowledge from a data set. It...
Published by: IGI Global Scientific Publishing
Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle.
John A Halsall, Simon Andrews, Felix Krueger, Charlotte E Rutledge, Gabriella Ficz, Wolf Reik, Bryan M Turner
Apr 12, 2021
Chromatin configuration influences gene expression in eukaryotes at multiple levels, from individual nucleosomes to chromatin domains several Mb long. Post-translational modifications (PTM) of core histones seem to be involved...
Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(ii)
M. Li, H. Ge, R.L. Arrowsmith, V. Mirabello, S.W. Botchway, W. Zhu, S.I. Pascu, T.D. James
Oct 14, 2014
Copper ions are essential for many biological processes. However, high concentrations of copper can be detrimental to the cell or organism. A novel naphthalimide derivative bearing a monoboronic acid group (BNP) was...
An Alternative View of the Templates and Functions of RNA Polymerase II
Julija Filipovska
Jan 01, 0001
R N A polymerase II (pol II) has been implicated in the RNA-templated RNA synthesis during replication of some Viroids and Hepatitis Delta Virus (HDV). In this study HDV RNA-templated pol II transcription was examined in vitro...
Published by: Rockefeller University
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.
Talia R Pettigrew, Rachel J Porter, Stephen J Walsh, Michael P Housden, Nelson YS Lam, Jason S Carroll, Jeremy S Parker, David R Spring, Ian Paterson
Jan 08, 2020
The aplyronines are a family of highly cytotoxic marine natural products with potential application in targeted cancer chemotherapy. To address the severe supply issue, function-oriented molecular editing of their macrolactone...
Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9.
Mathilde Mathieu, Nathalie Névo, Mabel Jouve, José Ignacio Valenzuela, Mathieu Maurin, Frederik J Verweij, Roberta Palmulli, Danielle Lankar, Florent Dingli, Damarys Loew, Eric Rubinstein, Gaëlle Boncompain, Franck Perez, Clotilde Théry
Sep 05, 2021
Despite their roles in intercellular communications, the different populations of extracellular vesicles (EVs) and their secretion mechanisms are not fully characterized: how and to what extent EVs form as intraluminal vesicles...
Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(ii)
M. Li, H. Ge, R.L. Arrowsmith, V. Mirabello, S.W. Botchway, W. Zhu, S.I. Pascu, T.D. James
Oct 14, 2014
Copper ions are essential for many biological processes. However, high concentrations of copper can be detrimental to the cell or organism. A novel naphthalimide derivative bearing a monoboronic acid group (BNP) was...
Operation of a TCA cycle subnetwork in the mammalian nucleus.
Eleni Kafkia, Amparo Andres-Pons, Kerstin Ganter, Markus Seiler, Tom S Smith, Anna Andrejeva, Paula Jouhten, Filipa Pereira, Catarina Franco, Anna Kuroshchenkova, Sergio Leone, Ritwick Sawarkar, Rebecca Boston, James Thaventhiran, Judith B Zaugg, Kathryn S Lilley, Christophe Lancrin, Martin Beck, Kiran Raosaheb Patil
Oct 01, 2022
Nucleic acid and histone modifications critically depend on the tricarboxylic acid (TCA) cycle for substrates and cofactors. Although a few TCA cycle enzymes have been reported in the nucleus, the corresponding pathways are...
Hydrothermal conversion of one-photon-fluorescent poly-(4-vinylpyridine) into two-photon-fluorescent carbon nanodots
Katherine Lawrence, Fengjie Xia, Rory L Arrowsmith, Haobo Ge, Geoffrey W Nelson, John S Foord, Monica Felipe-Sotelo, Nick D M Evans, John M. Mitchels, Stephen E Flower, Stanley W Botchway, Daniel Wolverson, Gazi Aliev, Tony D James, Sofia I. Pascu, Frank Marken
Oct 07, 2014
A novel two-photon-fluorescent N,O-heteroatom-rich carbon nanomaterial has been synthesized and characterized. The new carbon nanoparticles were produced by hydro-thermal conversion from a one-photon-fluorescent...
Tetherin is an exosomal tether.
Exosomes are extracellular vesicles that are released when endosomes fuse with the plasma membrane. They have been implicated in various functions in both health and disease, including intercellular communication, antigen...
Self-assembled lipoplexes of short interfering RNA (siRNA) using spermine-based fatty acid amide guanidines
Four guanidine derivatives of N4,N9-diacylated spermine have been designed, synthesized, and characterized. These guanidine-containing cationic lipids bound siRNA and formed nanoparticles. Two cationic lipids with C18...
IonFlow
INTRODUCTION: Inductively coupled plasma mass spectrometry (ICP-MS) experiments generate complex multi-dimensional data sets that require specialist data analysis tools. OBJECTIVE: Here we describe tools to facilitate analysis...
dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts.
Vadim Demichev, Lukasz Szyrwiel, Fengchao Yu, Guo Ci Teo, George Rosenberger, Agathe Niewienda, Daniela Ludwig, Jens Decker, Stephanie Kaspar-Schoenefeld, Kathryn Lilley, Michael Mülleder, Alexey I Nesvizhskii, Markus Ralser
Jul 08, 2022
The dia-PASEF technology uses ion mobility separation to reduce signal interferences and increase sensitivity in proteomic experiments. Here we present a two-dimensional peak-picking algorithm and generation of optimized...
IonFlow
Abstract: Introduction: Inductively coupled plasma mass spectrometry (ICP-MS) experiments generate complex multi-dimensional data sets that require specialist data analysis tools. Objective: Here we describe tools to facilitate...
Self-assembled lipoplexes of short interfering RNA (siRNA) using spermine-based fatty acid amide guanidines
Four guanidine derivatives of N4,N9-diacylated spermine have been designed, synthesized, and characterized. These guanidine-containing cationic lipids bound siRNA and formed nanoparticles. Two cationic lipids with C18...
Inadequate BiP availability defines endoplasmic reticulum stress.
Milena Vitale, Anush Bakunts, Andrea Orsi, Federica Lari, Laura Tadè, Alberto Danieli, Claudia Rato, Caterina Valetti, Roberto Sitia, Andrea Raimondi, John C Christianson, Eelco van Anken
Apr 05, 2019
How endoplasmic reticulum (ER) stress leads to cytotoxicity is ill-defined. Previously we showed that HeLa cells readjust homeostasis upon proteostatically driven ER stress, triggered by inducible bulk expression of secretory...
BiP/GRP78 ER stress Cell Biology chaperones Endoplasmic Reticulum human proteotoxicity Unfolded Protein Response Endoplasmic Reticulum Chaperone BiP Endoplasmic reticulum stress Endoplasmic Reticulum-Associated Degradation Epithelial Cells HeLa Cells HEAT-SHOCK PROTEINS Humans Proteostasis Unfolded Protein Response
IonFlow
Abstract: Introduction: Inductively coupled plasma mass spectrometry (ICP-MS) experiments generate complex multi-dimensional data sets that require specialist data analysis tools. Objective: Here we describe tools to facilitate...
Embedded Microbubbles for Acoustic Manipulation of Single Cells and Microfluidic Applications.
Nino F Läubli, Michael S Gerlt, Alexander Wüthrich, Renard TM Lewis, Naveen Shamsudhin, Ulrike Kutay, Daniel Ahmed, Jürg Dual, Bradley J Nelson
Aug 11, 2021
Acoustically excited microstructures have demonstrated significant potential for small-scale biomedical applications by overcoming major microfluidic limitations. Recently, the application of oscillating microbubbles has...
Proteome-Wide Survey of Cysteine Oxidation by Using a Norbornene Probe.
Lisa J Alcock, Maike Langini, Kai Stühler, Marc Remke, Michael V Perkins, Gonçalo JL Bernardes, Justin M Chalker
Feb 19, 2020
Rapid detection of cysteine oxidation in living cells is critical in advancing our understanding of responses to reactive oxygen species (ROS) and oxidative stress. Accordingly, there is a need to develop chemical probes that...
Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway.
Luther J Davis, Nicholas A Bright, James R Edgar, Michael DJ Parkinson, Lena Wartosch, Judith Mantell, Andrew A Peden, J Paul Luzio
Apr 23, 2021
To provide insights into the kiss-and-run and full fusion events resulting in endocytic delivery to lysosomes, we investigated conditions causing increased tethering and pore formation between late endocytic organelles in HeLa...
Hydrothermal conversion of one-photon-fluorescent poly-(4-vinylpyridine) into two-photon-fluorescent carbon nanodots
Katherine Lawrence, Fengjie Xia, Rory L Arrowsmith, Haobo Ge, Geoffrey W Nelson, John S Foord, Monica Felipe-Sotelo, Nick D M Evans, John M. Mitchels, Stephen E Flower, Stanley W Botchway, Daniel Wolverson, Gazi Aliev, Tony D James, Sofia I. Pascu, Frank Marken
Oct 07, 2014
A novel two-photon-fluorescent N,O-heteroatom-rich carbon nanomaterial has been synthesized and characterized. The new carbon nanoparticles were produced by hydro-thermal conversion from a one-photon-fluorescent...
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