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The Human Cell Atlas.
Aviv Regev, Sarah A Teichmann, Eric S Lander, Ido Amit, Christophe Benoist, Ewan Birney, Bernd Bodenmiller, Peter Campbell, Piero Carninci, Menna Clatworthy, Hans Clevers, Bart Deplancke, Ian Dunham, James Eberwine, Roland Eils, Wolfgang Enard, Andrew Farmer, Lars Fugger, Berthold Göttgens, Nir Hacohen, Muzlifah Haniffa, Martin Hemberg, Seung Kim, Paul Klenerman, Arnold Kriegstein, Ed Lein, Sten Linnarsson, Emma Lundberg, Joakim Lundeberg, Partha Majumder, John C Marioni, Miriam Merad, Musa Mhlanga, Martijn Nawijn, Mihai Netea, Garry Nolan, Dana Pe'er, Anthony Phillipakis, Chris P Ponting, Stephen Quake, Wolf Reik, Orit Rozenblatt-Rosen, Joshua Sanes, Rahul Satija, Ton N Schumacher, Alex Shalek, Ehud Shapiro, Padmanee Sharma, Jay W Shin, Oliver Stegle, Michael Stratton, Michael JT Stubbington, Fabian J Theis, Matthias Uhlen, Alexander van Oudenaarden, Allon Wagner, Fiona Watt, Jonathan Weissman, Barbara Wold, Ramnik Xavier, Nir Yosef, Human Cell Atlas Meeting Participants
Feb 16, 2018
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in...
EmptyDrops
Aaron TL Lun, Samantha Riesenfeld, Tallulah Andrews, The Phuong Dao, Tomas Gomes, participants in the 1st Human Cell Atlas Jamboree, John C Marioni
May 28, 2019
Droplet-based single-cell RNA sequencing protocols have dramatically increased the throughput of single-cell transcriptomics studies. A key computational challenge when processing these data is to distinguish libraries for real...
The human body at cellular resolution
HuBMAP Consortium
Nov 29, 2019
Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program...
The human body at cellular resolution
Shin Lin, Amanda Posgai, Mark Atkinson, Aviv Regev, Jennifer Rood, Orit Rozenblatt-Rosen, Leslie Gaffney, Anna Hupalowska, Rahul Satija, Nils Gehlenborg, Jay Shendure, Julia Laskin, Pehr Harbury, Nicholas A. Nystrom, Jonathan C. Silverstein, Ziv Bar-Joseph, Kun Zhang, Katy Börner, Yiing Lin, Richard Conroy, Dena Procaccini, Ananda L. Roy, Ajay Pillai, Marishka Brown, Zorina S. Galis, Long Cai, Cole Trapnell, Dana Jackson, Michael P. Snyder, Garry Nolan, William James Greenleaf, Sylvia Plevritis, Sara Ahadi, Stephanie A. Nevins, Hayan Lee, Christian Martijn Schuerch, Sarah Black, Vishal Gautham Venkataraaman, Ed Esplin, Aaron Horning, Amir Bahmani, Xin Sun, Sanjay Jain, James Hagood, Gloria Pryhuber, Peter Kharchenko, Bernd Bodenmiller, Todd Brusko, Michael Clare-Salzler, Harry Nick, Kevin Otto, Clive Wasserfall, Marda Jorgensen, Maigan Brusko, Sergio Maffioletti, Richard M. Caprioli, Jeffrey M. Spraggins, Danielle Gutierrez, Nathan Heath Patterson, Elizabeth K. Neumann, Raymond Harris, Mark deCaestecker, Agnes B. Fogo, Raf van de Plas, Ken Lau, Guo-Cheng Yuan, Qian Zhu, Ruben Dries, Peng Yin, Sinem K. Saka, Jocelyn Y. Kishi, Yu Wang, Isabel Goldaracena, DongHye Ye, Kristin E. Burnum-Johnson, Paul D. Piehowski, Charles Ansong, Ying Zhu, Tushar Desai, Jay Mulye, Peter Chou, Monica Nagendran, Sarah A. Teichmann, Benedict Paten, Robert F. Murphy, Jian Ma, Vladimir Yu. Kiselev, Carl Kingsford, Allyson Ricarte, Maria Keays, Sushma A. Akoju, Matthew Ruffalo, Margaret Vella, Chuck McCallum, Leonard E. Cross, Samuel H. Friedman, Randy Heiland, Bruce Herr, Paul Macklin, Ellen M. Quardokus, Lisel Record, James P. Sluka, Griffin M. Weber, Philip D. Blood, Alexander J. Ropelewski, William E. Shirey, Robin M. Scibek, Paula Mabee, W. Christopher Lenhardt, Kimberly Robasky, Stavros Michailidis, John Marioni, Andrew Butler, Tim Stuart, Eyal Fisher, Shila Ghazanfar, Gokcen Eraslan, Tommaso Biancalani, Eeshit D. Vaishnav, Ananda Roy, Zorina Galis, Pothur Srinivas, Aaron Pawlyk, Salvatore Sechi, Elizabeth Wilder, James Anderson
Oct 08, 2020
Abstract: Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular...
A cell atlas of human thymic development defines T cell repertoire formation.
Jong-Eun Park, Rachel A Botting, Cecilia Domínguez Conde, Dorin-Mirel Popescu, Marieke Lavaert, Daniel J Kunz, Issac Goh, Emily Stephenson, Roberta Ragazzini, Elizabeth Tuck, Anna Wilbrey-Clark, Kenny Roberts, Veronika R Kedlian, John R Ferdinand, Xiaoling He, Simone Webb, Daniel Maunder, Niels Vandamme, Krishnaa T Mahbubani, Krzysztof Polanski, Lira Mamanova, Liam Bolt, David Crossland, Fabrizio de Rita, Andrew Fuller, Andrew Filby, Gary Reynolds, David Dixon, Kourosh Saeb-Parsy, Steven Lisgo, Deborah Henderson, Roser Vento-Tormo, Omer A Bayraktar, Roger A Barker, Kerstin B Meyer, Yvan Saeys, Paola Bonfanti, Sam Behjati, Menna R Clatworthy, Tom Taghon, Muzlifah Haniffa, Sarah A Teichmann
Mar 19, 2020
The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell...
Mapping human development at single-cell resolution.
Human development is regulated by spatiotemporally restricted molecular programmes and is pertinent to many areas of basic biology and human medicine, such as stem cell biology, reproductive medicine and childhood cancer....
The International Human Epigenome Consortium
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal...
Search for charged-lepton-flavour violation in $Z$-boson decays with the
ATLAS detector
ATLAS Collaboration
Jul 28, 2021
Leptons with essentially the same properties apart from their mass are
grouped into three families (or flavours). The number of leptons of each
flavour is conserved in interactions, but this is not imposed by...
Search for squarks and gluinos in final states with same-sign leptons
and jets using 139 fb$^{-1}$ of data collected with the ATLAS detector
ATLAS Collaboration
Jun 04, 2021
A search for supersymmetric partners of gluons and quarks is presented,
involving signatures with jets and either two isolated leptons (electrons or
muons) with the same electric charge, or at least three isolated leptons....
Cell Atlas technologies and insights into tissue architecture.
Since Robert Hooke first described the existence of 'cells' in 1665, scientists have sought to identify and further characterise these fundamental units of life. While our understanding of cell location, morphology and function...
Test of the universality of $τ$ and $μ$ lepton couplings in
$W$-boson decays from $t\bar{t}$ events with the ATLAS detector
ATLAS Collaboration
Jul 28, 2021
The Standard Model of particle physics encapsulates our current best
understanding of physics at the smallest scales. A fundamental axiom of this
theory is the universality of the couplings of the different generations...
The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs
Typhoid fever is estimated to cause between 11.9-26.9 million infections globally each year with 129,000-216,510 deaths. Access to improved water sources have reduced disease incidence in parts of the world but the use of...
Measurements of $t\bar{t}$ differential cross-sections of highly boosted
top quarks decaying to all-hadronic final states in $pp$ collisions at
$\sqrt{s}=13\,$ TeV using the ATLAS detector
ATLAS Collaboration
Jun 15, 2020
Measurements are made of differential cross-sections of highly boosted
pair-produced top quarks as a function of top-quark and $t\bar{t}$ system
kinematic observables using proton--proton collisions at a center-of-mass
energy of...
Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) Scales after Traumatic Brain Injury
Ali Teymoori, Anastasia Gorbunova, Fardzadeh E. Haghish, Ruben Real, Marina Zeldovich, Yi-Jhen Wu, Suzanne Polinder, Thomas Asendorf, David Menon, CENTER-TBI Investigators and Participants CENTER-TBI Investigators and Participants, Nicole v. Steinbüchel
Mar 25, 2020
Background: The dimensionality of depression and anxiety instruments have recently been a source of controversy. Objectives and Design: In a European-wide sample of patients after Traumatic Brain Injury (TBI), we aim to examine...
Functional proteomic atlas of HIV infection in primary human CD4+ T cells.
Adi Naamati, James C Williamson, Edward JD Greenwood, Sara Marelli, Paul J Lehner, Nicholas J Matheson
Mar 28, 2019
Viruses manipulate host cells to enhance their replication, and the identification of cellular factors targeted by viruses has led to key insights into both viral pathogenesis and cell biology. In this study, we develop an HIV...
HIV human immunology infectious disease Inflammation magnetic cell selection microbiology primary human CD4+ T cell Proteomics Virus CD4-Positive T-Lymphocytes Cell Separation Cluster Analysis DNA-Binding Proteins Fragile X Mental Retardation Protein Gene Expression Regulation Green Fluorescent Proteins HIV Infections HIV-1 Humans Hydrogen-Ion Concentration Lentivirus Lymphocyte Activation Magnetics Methyltransferases Protein Binding Protein Tyrosine Phosphatase Non-Receptor Type 22 Proteome Proteomics Streptavidin Virus Replication vif Gene Products Human Immunodeficiency Virus
The Human Lung Cell Atlas
Herbert B Schiller, Daniel T Montoro, Lukas M Simon, Emma L Rawlins, Kerstin B Meyer, Maximilian Strunz, Felipe A Vieira Braga, Wim Timens, Gerard H Koppelman, GR Scott Budinger, Janette K Burgess, Avinash Waghray, Maarten van den Berge, Fabian J Theis, Aviv Regev, Naftali Kaminski, Jayaraj Rajagopal, Sarah A Teichmann, Alexander V Misharin, Martijn C Nawijn
Dec 12, 2019
Expression Atlas update
Irene Papatheodorou, Pablo Moreno, Jonathan Manning, Alfonso Muñoz-Pomer Fuentes, Nancy George, Silvie Fexova, Nuno A Fonseca, Anja Füllgrabe, Matthew Green, Ni Huang, Laura Huerta, Haider Iqbal, Monica Jianu, Suhaib Mohammed, Lingyun Zhao, Andrew F Jarnuczak, Simon Jupp, John Marioni, Kerstin Meyer, Robert Petryszak, Cesar Augusto Prada Medina, Carlos Talavera-López, Sarah Teichmann, Juan Antonio Vizcaino, Alvis Brazma
Dec 19, 2019
Expression Atlas is EMBL-EBI's resource for gene and protein expression. It sources and compiles data on the abundance and localisation of RNA and proteins in various biological systems and contexts and provides open access to...
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
Linh T Bui, Nichelle I Winters, Mei-I Chung, Chitra Joseph, Austin J Gutierrez, Arun C Habermann, Taylor S Adams, Jonas C Schupp, Sergio Poli, Lance M Peter, Chase J Taylor, Jessica B Blackburn, Bradley W Richmond, Andrew G Nicholson, Doris Rassl, William A Wallace, Ivan O Rosas, R Gisli Jenkins, Naftali Kaminski, Jonathan A Kropski, Nicholas E Banovich, Human Cell Atlas Lung Biological Network
Jul 28, 2021
Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyze the transcriptomes of 611,398 single cells isolated from healthy and CLD lungs to...
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation.
E Madissoon, A Wilbrey-Clark, R J Miragaia, K Saeb-Parsy, K T Mahbubani, N Georgakopoulos, P Harding, K Polanski, N Huang, K Nowicki-Osuch, R C Fitzgerald, K W Loudon, J R Ferdinand, M R Clatworthy, A Tsingene, S van Dongen, M Dabrowska, M Patel, M J T Stubbington, S A Teichmann, O Stegle, K B Meyer
Feb 02, 2020
BACKGROUND:The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate high-quality data for the delivery of such an atlas. However, delays...
Published by: Genome biology, volume 21, issue 1
Navigating Motivation
Gabriele Chierchia, Marisa Przyrembel, Franca Parianen Lesemann, Steven Bosworth, Dennis Snower, Tania Singer
Feb 10, 2021
Research from psychology, neurobiology and behavioral economics indicates that a binary view of motivation, based on approach and avoidance, may be too reductive. Instead, a literature review suggests that at least seven...
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
E. Madissoon, A. Wilbrey-Clark, R. J. Miragaia, K. Saeb-Parsy, K. T. Mahbubani, N. Georgakopoulos, P. Harding, K. Polanski, N. Huang, K. Nowicki-Osuch, R. C. Fitzgerald, K. W. Loudon, J. R. Ferdinand, M. R. Clatworthy, A. Tsingene, S. van Dongen, M. Dabrowska, M. Patel, M. J. T. Stubbington, S. A. Teichmann, O. Stegle, K. B. Meyer
Jun 06, 2020
Abstract: Background: The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate high-quality data for the delivery of such an atlas....
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation.
E Madissoon, A Wilbrey-Clark, RJ Miragaia, K Saeb-Parsy, KT Mahbubani, N Georgakopoulos, P Harding, K Polanski, N Huang, K Nowicki-Osuch, RC Fitzgerald, KW Loudon, JR Ferdinand, MR Clatworthy, A Tsingene, S van Dongen, M Dabrowska, M Patel, MJT Stubbington, SA Teichmann, O Stegle, KB Meyer
Jan 06, 2020
BACKGROUND: The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate high-quality data for the delivery of such an atlas. However, delays...
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
E. Madissoon, A. Wilbrey-Clark, R. J. Miragaia, K. Saeb-Parsy, K. T. Mahbubani, N. Georgakopoulos, P. Harding, K. Polanski, N. Huang, K. Nowicki-Osuch, R. C. Fitzgerald, K. W. Loudon, J. R. Ferdinand, M. R. Clatworthy, A. Tsingene, S. van Dongen, M. Dabrowska, M. Patel, M. J. T. Stubbington, S. A. Teichmann, O. Stegle, K. B. Meyer
Dec 30, 2020
Abstract: Background: The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate high-quality data for the delivery of such an atlas....
Cell-based therapeutic strategies for multiple sclerosis.
Neil J Scolding, Marcelo Pasquini, Stephen C Reingold, Jeffrey A Cohen, International Conference on Cell-Based Therapies for Multiple Sclerosis, International Conference on Cell-Based Therapies for Multiple Sclerosis, International Conference on Cell-Based Therapies for Multiple Sclerosis
Jan 15, 2018
The availability of multiple disease-modifying medications with regulatory approval to treat multiple sclerosis illustrates the substantial progress made in therapy of the disease. However, all are only partially effective in...
Clinical Trials medical ethics multiple sclerosis and neuroinflammation remyelination Stem Cells Hematopoietic Stem Cell Transplantation Humans Induced Pluripotent Stem Cells Mesenchymal Stem Cell Transplantation Multiple Sclerosis Myelin Sheath Oligodendroglia Regeneration Stem Cell Transplantation Stem Cells Transplantation Autologous
BigBrain 3D atlas of cortical layers
Konrad Wagstyl, Stéphanie Larocque, Guillem Cucurull, Claude Lepage, Joseph Paul Cohen, Sebastian Bludau, Nicola Palomero-Gallagher, Lindsay B. Lewis, Thomas Funck, Hannah Spitzer, Timo Dickscheid, Paul C. Fletcher, Adriana Romero, Karl Zilles, Katrin Amunts, Yoshua Bengio, Alan C. Evans
Apr 15, 2020
Histological atlases of the cerebral cortex, such as those made famous by Brodmann and von Economo, are invaluable for understanding human brain microstructure and its relationship with functional organization in the brain....
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