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Identifying the immune interactions underlying HLA class I disease associations
Bisrat J Debebe, Lies Boelen, James C Lee, IAVI Protocol C Investigators, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Salim I Khakoo, Sharyne M Donfield, James J Goedert, Becca Asquith, Eduard J Sanders, Omu Anzala, Anatoli Kamali, Pontiano Kaleebu, Etienne Karita, William Kilembe, Mubiana Inambao, Shabir Lakhi, Susan Allen, Eric Hunter, Vinodh A Edward, Pat E Fast, Matt A Price, Jill Gilmour, Jianming Tang
May 28, 2020
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for...
Identifying the immune interactions underlying HLA class I disease associations.
Bisrat J Debebe, Lies Boelen, James C Lee, IAVI Protocol C Investigators, Eduard J Sanders, Omu Anzala, Anatoli Kamali, Pontiano Kaleebu, Etienne Karita, William Kilembe, Mubiana Inambao, Shabir Lakhi, Susan Allen, Eric Hunter, Vinodh A Edward, Pat E Fast, Matt A Price, Jill Gilmour, Jianming Tang, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Salim I Khakoo, Sharyne M Donfield, James J Goedert, Becca Asquith
Jun 19, 2020
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for...
Selective Dealkenylative Functionalization of Styrenes via C-C Bond Cleavage.
As a readily available feedstock, styrene with about 25 million tons of global annual production serves as an important building block and organic synthon for the synthesis of fine chemicals, polystyrene plastics, and...
BSG 2024 IBD guidelines protocol (standard operating procedures).
Ana-Maria Darie, Vasiliki Sinopoulou, Verma Ajay, Klaartje Bel Kok, Kamal V Patel, Jimmy Limdi, Naila Arebi, Philip Smith, Shahida Din, Said Din, Matthew Shale, Sreedhar Subramanian, Polychronis Pavlidis, Rachel Cooney, Dennis McGonagle, Newton A C S Wong, Gordon W Moran, Morris Gordon
Mar 14, 2023
Introduction
In the past 5 years, there have been several advances in the management of inflammatory bowel disease (IBD). We aim for a new guideline to update the most recent guideline published in 2019. We present the...
inflammatory bowel disease health service research IBD clinical IBD BASIC RESEARCH SURGERY FOR IBD Humans Inflammatory Bowel Diseases Prospective Studies Delivery of Health Care Randomized Controlled Trials as Topic
Published by: BMJ open gastroenterology
Catalytic meta-selective C–H functionalization to construct quaternary carbon centres
A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
A Protocol for Producing the Maternal Low-Protein Rat Model
Epidemiological studies have shown that periods of poor nutrition during pregnancy can lead to an increased risk of metabolic and psychiatric disorders in the offspring. In addition, some individuals with disorders such as...
Biomarkers Low-protein model Metabolic programming Preclinical proteomics Schizophrenia Animals Animals Suckling Diet Protein-Restricted Disease Models Animal Female Lactation Pregnancy Pregnancy Complications prenatal exposure delayed effects Protein-Energy Malnutrition Rats Rats Wistar Schizophrenia
Modular and Selective Arylation of Aryl Germanes (C-GeEt3 ) over C-Bpin, C-SiR3 and Halogens Enabled by Light-Activated Gold Catalysis.
Grant J Sherborne, Avetik G Gevondian, Ignacio Funes-Ardoiz, Amit Dahiya, Christoph Fricke, Franziska Schoenebeck
Nov 02, 2020
Selective C sp 2 -C sp 2 couplings are powerful strategies for the rapid and programmable construction of bi- or multiaryls. To this end, the next frontier of synthetic modularity will likely arise from harnessing the...
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
Catalytic meta-selective C–H functionalization to construct quaternary carbon centres
A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary...
Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) Scales after Traumatic Brain Injury
Ali Teymoori, Anastasia Gorbunova, Fardzadeh E. Haghish, Ruben Real, Marina Zeldovich, Yi-Jhen Wu, Suzanne Polinder, Thomas Asendorf, David Menon, CENTER-TBI Investigators and Participants CENTER-TBI Investigators and Participants, Nicole v. Steinbüchel
Mar 25, 2020
Background: The dimensionality of depression and anxiety instruments have recently been a source of controversy. Objectives and Design: In a European-wide sample of patients after Traumatic Brain Injury (TBI), we aim to examine...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Catalytic C(sp3)-H bond activation in tertiary alkylamines.
Jesus Rodrigalvarez, Manuel Nappi, Hiroki Azuma, Nils J Flodén, Matthew E Burns, Matthew J Gaunt
Feb 03, 2021
The development of robust catalytic methods to assemble tertiary alkylamines provides a continual challenge to chemical synthesis. In this regard, transformation of a traditionally unreactive C-H bond, proximal to the nitrogen...
Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell.
David Lando, Srinjan Basu, Tim J Stevens, Andy Riddell, Kai J Wohlfahrt, Yang Cao, Wayne Boucher, Martin Leeb, Liam P Atkinson, Steven F Lee, Brian Hendrich, Dave Klenerman, Ernest D Laue
Feb 28, 2018
Fluorescence imaging and chromosome conformation capture assays such as Hi-C are key tools for studying genome organization. However, traditionally, they have been carried out independently, making integration of the two types...
MAC Protocol Analysis for Wireless Sensor Networks
In wireless sensor networks, MAC protocol is used to achieve efficient, fair and balanced allocation of wireless channel resources and access control of nodes in the network, and to control the communication process of nodes in...
Published by: IGI Global Scientific Publishing
A Study of Tsunami UDP Protocol
Daqing Yun
Jan 01, 0001
Modeling and Optimizing Tsunami UDP Protocol
Published by: Harrisburg University of Science and Technology
OPTIMUM study protocol
Gladymar Perez Chacon, Marie J Estcourt, James Totterdell, Dianne E Campbell, Kirsten P Perrett, Julie A Marsh, Peter C Richmond, Nicholas Wood, Michael S Gold, Patrick G Holt, Claire S Waddington, Thomas L Snelling
Dec 22, 2020
INTRODUCTION: Combination vaccines containing whole-cell pertussis antigens were phased out from the Australian national immunisation programme between 1997 and 1999 and replaced by the less reactogenic acellular pertussis (aP)...
OPTIMUM study protocol
Gladymar Perez Chacon, Marie J Estcourt, James Totterdell, Dianne E Campbell, Kirsten P Perrett, Julie A Marsh, Peter C Richmond, Nicholas Wood, Michael S Gold, Patrick G Holt, Claire S Waddington, Thomas L Snelling
May 16, 2022
INTRODUCTION: Combination vaccines containing whole-cell pertussis antigens were phased out from the Australian national immunisation programme between 1997 and 1999 and replaced by the less reactogenic acellular pertussis (aP)...
Group Size and Matching Protocol in Contests
We investigate the effects of group size and matching protocol in Tullock contest experiments. In a 2x2 factorial design we implement partner and random stranger matching protocols in contests between two and between three...
Circulating vitamin C and digestive system cancers
Susanna C Larsson, Amy M Mason, Mathew Vithayathil, Paul Carter, Siddhartha Kar, Ju-Sheng Zheng, Stephen Burgess
Sep 20, 2022
BACKGROUND & AIMS: Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to...
Massive blood loss protocol 'Code Red' at Papworth Hospital
AIM: To investigate if the massive blood loss protocol 'Code Red' at a specialist cardiothoracic hospital was activated according to local and national guidelines by a closed loop audit. METHODS: Electronic and paper patient...
Group Size and Matching Protocol in Contests
We investigate the effects of group size and matching protocol in Tullock contest experiments. In a 2x2 factorial design we implement partner and random stranger matching protocols in contests between two and between three...
Aliphatic C–H activation with aluminium trichloride–acetyl chloride
The functionalisation of decalin by means of an “aliphatic Friedel–Crafts” reaction was reported over fifty
years ago by Baddeley et al. This protocol is of current relevance in the context of C–H activation and
here we...
years ago by Baddeley et al. This protocol is of current relevance in the context of C–H activation and
here we...
Breast cancer management pathways during the COVID-19 pandemic
Rajiv V Dave, Baek Kim, Alona Courtney, Rachel O'Connell, Tim Rattay, Vicky P Taxiarchi, Jamie J Kirkham, Elizabeth M Camacho, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Ramsey I Cutress, Ashu Gandhi, Cliona C Kirwan, B-MaP-C study collaborative
Apr 14, 2021
BACKGROUND: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. METHODS: This...
The United Kingdom Childhood Cancer Study
UK Childhood Cancer Study Investigators
Feb 21, 2020
An investigation into the possible causes of childhood cancer has been carried out throughout England, Scotland and Wales over the period 1991-1998. All children known to be suffering from one or other type of the disease over...
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