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Study on E-Commerce Adoption in SMEs Under the Institutional Perspective
This article investigates and discusses the institutional factors influencing decisions of e-commerce adoption in Saudi small and medium enterprises (SMEs) from the temporal view. This article has been conducted in two phases: a...
Published by: IGI Global Scientific Publishing
Combined Computational and Intracellular Peptide Library Screening
To date, most research into the inhibition of oncogenic transcriptional regulator, Activator Protein 1 (AP-1), has focused on heterodimers of cJun and cFos. However, the Fra1 homologue remains an important cancer target. Here we...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases
Fengzhe Xu, Yuanqing Fu, Ting-yu Sun, Zengliang Jiang, Zelei Miao, Menglei Shuai, Wanglong Gou, Chu-wen Ling, Jian Yang, Jun Wang, Yu-ming Chen, Ju-Sheng Zheng
Oct 08, 2020
Abstract: Background: Interest in the interplay between host genetics and the gut microbiome in complex human diseases is increasing, with prior evidence mainly being derived from animal models. In addition, the shared and...
Combined Computational and Intracellular Peptide Library Screening
To date, most research into the inhibition of oncogenic transcriptional regulator, Activator Protein 1 (AP-1), has focused on heterodimers of cJun and cFos. However, the Fra1 homologue remains an important cancer target. Here we...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases.
Fengzhe Xu, Yuanqing Fu, Ting-yu Sun, Zengliang Jiang, Zelei Miao, Menglei Shuai, Wanglong Gou, Chu-wen Ling, Jian Yang, Jun Wang, Yu-ming Chen, Ju-Sheng Zheng
Oct 08, 2021
BACKGROUND: Interest in the interplay between host genetics and the gut microbiome in complex human diseases is increasing, with prior evidence mainly being derived from animal models. In addition, the shared and distinct...
Bidirectional Mendelian randomization analyses Disease-microbiome features gut microbiome Host genetics Adult Aged Animals Case-Control Studies Disease Female Gastrointestinal Microbiome Genome-Wide Association Study Humans Leukemia Myelogenous Chronic BCR-ABL Positive Lupus Erythematosus Systemic Male Middle Aged
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
A Calibrated Linguistic Semantic Based on Group Consensus Decision Making for FMEA of Industrial Internet Platform
Failure mode and effects analysis (FMEA) is a powerful risk management tool and engineering technique for eliminating potential failures. This paper aims to improve FMEA by introducing the calibrated linguistic semantic (CIS)...
Published by: IGI Global Scientific Publishing
Study on Transient Gap Resonance with Consideration of the Motion of Floating Body
In this paper, the transient fluid resonance phenomenon inside a narrow gap between two adjacent boxes excited by the incident focused waves with various spectral peak periods and focused wave amplitudes is simulated by...
Focused waves free-surface amplification Heave motion OpenFOAM transient gap resonance Wave loads /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Multi-Feature Video Recommendation Based on Hypergraph Convolution for Mobile Edge Environment
With the massive growth of edge devices, how to provide users with video recommendation services in a mobile edge environment has become a research hotspot. Most traditional video recommendation methods regard the relationship...
Published by: IGI Global Scientific Publishing
Study on Transient Gap Resonance with Consideration of the Motion of Floating Body
In this paper, the transient fluid resonance phenomenon inside a narrow gap between two adjacent boxes excited by the incident focused waves with various spectral peak periods and focused wave amplitudes is simulated by...
Focused waves free-surface amplification Heave motion OpenFOAM transient gap resonance Wave loads /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Electrostatic force driven helium insertion into ammonia and water crystals under pressure
Yihong Bai, Zhen Liu, Jorge Botana, Dadong Yan, Hai-Qing Lin, Jian Sun, Chris J. Pickard, Richard J. Needs, Mao-Sheng Miao
Sep 01, 2020
Abstract: Helium, ammonia and ice are among the major components of giant gas planets, and predictions of their chemical structures are therefore crucial in predicting planetary dynamics. Here we demonstrate a strong driving...
RETAD
Due to the rapid advancement of wireless sensor and location technologies, a large amount of mobile agent trajectory data has become available. Intelligent city systems and video surveillance all benefit from trajectory anomaly...
Published by: IGI Global Scientific Publishing
Does PGA external stenting reduce compliance mismatch in venous grafts?
Zhong-zhao Teng, Guang-yu Ji, Hong-jun Chu, Zhi-Yong Li, Liang-jian Zou, Zhi-yun Xu, Sheng-dong Huang
Jun 16, 2011
L q -spectra of self-affine measures
Abstract: We study L q -spectra of planar self-affine measures generated by diagonal matrices. We introduce a new technique for constructing and understanding examples based on combinatorial estimates for the exponential growth...
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Rahul Roychoudhuri, David Clever, Peng Li, Yoshiyuki Wakabayashi, Kylie M Quinn, Christopher A Klebanoff, Yun Ji, Madhusudhanan Sukumar, Robert L Eil, Zhiya Yu, Rosanne Spolski, Douglas C Palmer, Jenny H Pan, Shashank J Patel, Derek C Macallan, Giulia Fabozzi, Han-Yu Shih, Yuka Kanno, Akihiko Muto, Jun Zhu, Luca Gattinoni, John J O'Shea, Klaus Okkenhaug, Kazuhiko Igarashi, Warren J Leonard, Nicholas P Restifo
Jun 27, 2018
T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is...
Adaptive Immunity Animals Basic-Leucine Zipper Transcription Factors CD8-Positive T-Lymphocytes Cell Differentiation Cells Cultured Enhancer Elements Genetic Gene Expression Regulation Immunologic Memory Lymphocyte Activation Mice Mice Inbred C57BL Mice Knockout Oncogene Protein p65(gag-jun) Signal Transduction Transcription Factor AP-1 Vaccinia vaccinia virus
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco-Serna, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo
Feb 17, 2022
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...
Sustainable Construction of Higher Education MOOCs Using CNN Feature Extraction
The attention time of students studying in MOOC (Massive Open Online Courses) classroom was analyzed to optimize and further improve their performance. On this basis, a student class model based on convolutional neural networks...
Published by: IGI Global Scientific Publishing
Optimization Design of High-Dimensional Parameters MIMO Antenna in Semantic-Based Mobile Applications
To ensure the quality of semantic communication, an optimization scheme for multiple-input and multiple-output (MIMO) antenna design using in semantic-based mobile is proposed and verified. The scheme is based on a modified...
Published by: IGI Global Scientific Publishing
An M-Learning Model in the Context of the Blended Synchronous Learning Environment
Mobile learning provides more flexibility and holds considerable promise for improving the learning process and promoting lifelong learning. In order to reduce the sense of isolation felt by the learners, this research...
Published by: IGI Global Scientific Publishing
Novel Bilinear Fusion Network Based on Multimodal Data for Student Distracted Behavior Recognition
Jian Zhang
Jan 01, 2023
As governments, education departments, and academic accreditation bodies have begun to encourage schools to develop evidence-based decision-making and innovation systems, learning analysis techniques have shown great advantages...
Published by: IGI Global Scientific Publishing
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