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Efficiency and Equity in the Spatial Planning of Primary Schools
The shrinking populations of many regions in Portugal have led to a debate on the criteria which should guide the restructuring of public services at the local scale, and namely how to balance raising per capita costs with...
Published by: IGI Global Scientific Publishing
A novel approach to improve GNSS Precise Point Positioning during strong ionospheric scintillation
Bruno C. Vani, Biagio Forte, João F. G. Monico, Susan Skone, Milton Hirokazu Shimabukuro, Alison de O. Moraes, I. P. Portella, H. A. Marques
May 01, 2019
At equatorial latitudes, ionospheric scintillation is the major limitation in achieving high-accuracy GNSS positioning. This is because scintillation affects the tracking ability of GNSS receivers causing losses of lock and...
Ionospheric scintillation Mitigation precise point positioning (PPP) scintillation-induced error /dk/atira/pure/subjectarea/asjc/2200/2203 name=Automotive Engineering /dk/atira/pure/subjectarea/asjc/2200/2202 name=Aerospace Engineering /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
A scalable insect cell-based production process of the human recombinant BMX for in-vitro covalent ligand high-throughput screening.
Bárbara B Sousa, Marcos FQ Sousa, Marta C Marques, João D Seixas, José A Brito, Pedro M Matias, Gonçalo JL Bernardes, António Roldão
Sep 15, 2020
Bone Marrow Tyrosine kinase in the chromosome X (BMX) is a TEC family kinase associated with numerous pathological pathways in cancer cells. Covalent inhibition of BMX activity holds promise as a therapeutic approach against...
A novel approach to improve GNSS Precise Point Positioning during strong ionospheric scintillation
Bruno C. Vani, Biagio Forte, João F. G. Monico, Susan Skone, Milton Hirokazu Shimabukuro, Alison de O. Moraes, I. P. Portella, H. A. Marques
May 01, 2019
At equatorial latitudes, ionospheric scintillation is the major limitation in achieving high-accuracy GNSS positioning. This is because scintillation affects the tracking ability of GNSS receivers causing losses of lock and...
Ionospheric scintillation Mitigation precise point positioning (PPP) scintillation-induced error /dk/atira/pure/subjectarea/asjc/2200/2203 name=Automotive Engineering /dk/atira/pure/subjectarea/asjc/2200/2202 name=Aerospace Engineering /dk/atira/pure/subjectarea/asjc/2600/2604 name=Applied Mathematics /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
An N-Acetyl Cysteine Ruthenium Tricarbonyl Conjugate Enables Simultaneous Release of CO and Ablation of Reactive Oxygen Species.
Principles for Engineering Social Interaction in Asynchronous Mobile Games
Since their first appearance, mobile devices have had exponential technological growth and have gained other functionalities besides standard calls and messaging services. With the advent of smartphones, the mobile gaming market...
Published by: IGI Global Scientific Publishing
The need for widely available genomic testing in rare eye diseases
Graeme C Black, Panagiotis Sergouniotis, Andrea Sodi, Bart P Leroy, Caroline Van Cauwenbergh, Petra Liskova, Karen Grønskov, Artur Klett, Susanne Kohl, Gita Taurina, Marius Sukys, Lonneke Haer-Wigman, Katarzyna Nowomiejska, João Pedro Marques, Dorothée Leroux, Frans PM Cremers, Elfride De Baere, Hélène Dollfus, ERN-EYE study group
May 17, 2021
BACKGROUND: Rare Eye Diseases (RED) are the leading cause of visual impairment and blindness for children and young adults in Europe. This heterogeneous group of conditions includes over 900 disorders ranging from relatively...
Physiological demands of a swimming-based video game
Pooya Soltani, Pedro Figueiredo, João Ribeiro, Ricardo J. Fernandes, João Paulo Vilas-Boas
Dec 31, 2017
Active video games (exergames) may provide short-term increase in energy expenditure. We explored the effects of gender and prior experience on aerobic and anaerobic energy systems contributions, and the activity profiles of...
Risk Management in Information Systems Projects
Information technologies (IT) and information systems (IS) are the backbone of any developed business, and organizations without them cannot compete. In recent decades, many best practices standards, and guides have been made...
Published by: IGI Global Scientific Publishing
Physiological demands of a swimming-based video game
Pooya Soltani, Pedro Figueiredo, João Ribeiro, Ricardo J. Fernandes, João Paulo Vilas-Boas
Dec 31, 2017
Active video games (exergames) may provide short-term increase in energy expenditure. We explored the effects of gender and prior experience on aerobic and anaerobic energy systems contributions, and the activity profiles of...
Selective Inhibition of Bruton's Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors.
Bárbara B Sousa, Cátia Rebelo de Almeida, Ana F Barahona, Raquel Lopes, Ana Martins-Logrado, Marco Cavaco, Vera Neves, Luís AR Carvalho, Carlos Labão-Almeida, Ana R Coelho, Marta Leal Bento, Ricardo MRM Lopes, Bruno L Oliveira, Miguel ARB Castanho, Peter Neumeister, Alexander Deutsch, Gregory I Vladimer, Nikolaus Krall, Cristina João, Francisco Corzana, João D Seixas, Rita Fior, Gonçalo JL Bernardes
Nov 15, 2022
Bruton's tyrosine kinase (BTK) is a member of the TEC-family kinases and crucial for the proliferation and differentiation of B-cells. We evaluated the therapeutic potential of a covalent inhibitor (JS25) with nanomolar potency...
Decision-Making Model to Assess Organizational Climate in Healthcare Organizations
Organizational climate impacts on the employee's well-being, commitment, and positive behavior. Most studies to assess climate in healthcare organizations use qualitative and/or statistical methods. Here, the authors propose a...
Published by: IGI Global Scientific Publishing
A Multi-Criteria Decision-Making Model for Selecting a Maturity Model
This paper proposes a decision model for a maturity model choice problem via the multiple-criteria decision analysis method. The authors implemented the model in FITradeoff decision support system to select a project management...
Published by: IGI Global Scientific Publishing
Knowledge Sharing in Catholic Organizations
This study examines knowledge sharing in Catholic organizations. The authors adopt Schein's organizational culture theory that facilitates, or inhibits, knowledge sharing in organizations. Thus, they address the phenomenon at...
Published by: IGI Global Scientific Publishing
Isolated Taylor Bubbles in Co-Current with Shear Thinning CMC Solutions in Microchannels—A Numerical Study
Slug flow is a multiphase flow pattern characterized by the occurrence of long gas bubbles (Taylor bubbles) separated by liquid slugs. This multiphase flow regime is present in many and diversified natural and industrial...
Ana I Moreira, Luís AM Rocha, João Carneiro, José DP Araújo, João BLM Campos, João M Miranda
Feb 21, 2020
Vocal Acoustic Analysis
Vocal acoustic analysis is becoming a useful tool for the classification and recognition of laryngological pathologies. This technique enables a non-invasive and low-cost assessment of voice disorders, allowing a more efficient...
Published by: IGI Global Scientific Publishing
Impact of the geometry of inclusions at the micro-scale on the overall stochastic properties
In this contribution, the establishment of relationships between the microstructure of the material and the macroscopic properties is numerically investigated. The material under study is composed by inclusions randomly...
Biology and pathology of the uterine microenvironment and its natural killer cells.
Tissues are the new frontier of discoveries in immunology. Cells of the immune system are an integral part of tissue physiology and immunity. Determining how immune cells inhabit, housekeep, and defend gut, lung, brain, liver...
Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors.
João D Seixas, Bárbara B Sousa, Marta C Marques, Ana Guerreiro, Rui Traquete, Tiago Rodrigues, Inês S Albuquerque, Marcos FQ Sousa, Ana R Lemos, Pedro MF Sousa, Tiago M Bandeiras, Di Wu, Shelby K Doyle, Carol V Robinson, Angela N Koehler, Francisco Corzana, Pedro M Matias, Gonçalo JL Bernardes
Oct 01, 2021
The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with single-digit nanomolar potency with...
A Systematic Literature Review on Hospitality Analytics
With the growth of data generated by all systems involved in a hotel, terms like big data and business analytics (BA) gain strength within the hotel industry. Business analytics can be used in hospitality management to increase...
Published by: IGI Global Scientific Publishing
A Novel Multi-Criteria Local Latin Hypercube Refinement System for Commutation Angle Improvement in IPMSMs
The commutation angle, γ, of an interior permanent magnet synchronous motor's (IPMSM) vector diagram, plays an important role in compensating the back electromotive force (back-EMF); both under phase current variations and an...
AC machines commutation angle mapping drives electric vehicles field weakening Finite element analysis inverter latin hypercube sampling Optimisation permanent magnet synchronous machines /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/subjectarea/asjc/2200/2207 name=Control and Systems Engineering /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering
Organization of residential space, site function variability, and seasonality of activities among MIS 5 Iberian Neandertals.
Whether ethnoarcheological models of hunter-gatherer mobility, landscape use, and structuration of the inhabited space are relevant to the archeology of Neandertals and the Middle Paleolithic remains controversial. The thin...
Testicular organoid generation by a novel in vitro three-layer gradient system.
A system that models the testicular microenvironment and spermatogonial stem-cell (SSC) niche in vitro has not been produced yet. Here, we developed and characterized a novel three-dimensional multilayer model, the Three-Layer...
3D culture De novo morphogenesis Germ Cells Seminiferous tubules-like structures Sertoli Cells Testicular organoid Animals Blood-Testis Barrier Cell Differentiation Interleukin-1alpha Male Organoids Rats Sprague-Dawley Seminiferous Tubules Sertoli Cells Spermatozoa Testis Tissue Engineering Tretinoin Tumor Necrosis Factor-alpha
Developing local RG
Abstract: In this paper we study various forms of RG and apply these to the BFSS model of N coincident D0-branes. Firstly, as a warm-up, we perform standard Wilsonian RG, investigating the conditions under which supersymmetry is...
Biological, Psychological, and Social Determinants of Depression
Depression is one of the leading causes of disability, and, if left unmanaged, it can increase the risk for suicide. The evidence base on the determinants of depression is fragmented, which makes the interpretation of...
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