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Results: 2015
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Effects of free heave motion on wave resonance inside a narrow gap between two boxes under wave actions
Fluid resonance inside a narrow gap between two side-by-side boxes is investigated based on an open-source CFD package, OpenFOAM. An upstream box heaves freely under wave actions and a downstream box remains fixed. The focus of...
An Emoji Is Worth a Thousand Words
Face emojis are regularly used in reviews on online shopping sites to add richness and/or levity to the text. However, few researchers have investigated the use of face emojis in consumer reviews. This paper examined the effects...
Published by: IGI Global Scientific Publishing
Risk Analysis in Customer Relationship Management via QRCNN-LSTM and Cross-Attention Mechanism
Risk analysis is an important business decision support task in Customer Relationship Management (CRM), involving the identification of potential risks or challenges that may affect customer satisfaction, retention rates, and...
Published by: IGI Global Scientific Publishing
Effects of free heave motion on wave resonance inside a narrow gap between two boxes under wave actions
Fluid resonance inside a narrow gap between two side-by-side boxes is investigated based on an open-source CFD package, OpenFOAM. An upstream box heaves freely under wave actions and a downstream box remains fixed. The focus of...
Do climate change policies promote or conflict with subjective wellbeing
Miaomiao Liu, Yining Huang, Rosemary Hiscock, Qin Li, Jun Bi, Patrick L. Kinney, Clive E. Sabel
Mar 21, 2016
As public expectations for health rise, health measurements broaden from a focus on death, disease, and disability to wellbeing. However, wellbeing hasn’t been incorporated into the framework of climate change policy...
Chinese city climate change Co-benefits Policy implications Wellbeing /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/subjectarea/asjc/2300/2307 name=Health, Toxicology and Mutagenesis /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Cloning, mapping and molecular characterization of porcine progesterone receptor membrane component 2 (PGRMC2) gene.
Congying Chen, Carole Sargent, Claire Quilter, Zhuqing Yang, Jun Ren, Nabeel Affara, Bertram Brenig, Lusheng Huang
Jun 22, 2020
Progesterone plays an important role in sow reproduction by stimulating classic genomic pathways via nuclear receptors and non-genomic pathways via membrane receptors such a progesterone receptor membrane component 2 (PGRMC2)....
Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle.
Activation of skeletal muscle fibers requires rapid sarcolemmal action potential (AP) conduction to ensure uniform excitation along the fiber length, as well as successful tubular excitation to initiate excitation-contraction...
Identifying a large number of high-yield genes in rice by pedigree analysis, whole genome sequencing and CRISPR-Cas9 gene knockout
Ju Huang, Jing Li, Jun Zhou, Long Wang, Sihai Yang, Laurence Hurst, Wen-Hsiung Li, Dacheng Tian
Aug 07, 2018
Repeated artificial selection of a complex trait facilitates the identification of genes underlying the trait, especially if multiple selected descendant lines are available. Here we developed a pedigree-based approach to...
Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy.
Wenhui Li, Jin Huang, Nan Zhang, Kathrin Weidacker, Jun Li, Valerie Voon, Chuansheng Wang, Chencheng Zhang
Jan 28, 2022
Objective: Abnormal selective attention to drug cues and negative affect is observed in patients with substance dependence, and it is closely associated with drug addiction and relapse. Methadone maintenance is an effective...
Do climate change policies promote or conflict with subjective wellbeing
Miaomiao Liu, Yining Huang, Rosemary Hiscock, Qin Li, Jun Bi, Patrick L. Kinney, Clive E. Sabel
Mar 21, 2016
As public expectations for health rise, health measurements broaden from a focus on death, disease, and disability to wellbeing. However, wellbeing hasn’t been incorporated into the framework of climate change policy...
Chinese city climate change Co-benefits Policy implications Wellbeing /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/subjectarea/asjc/2300/2307 name=Health, Toxicology and Mutagenesis /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Rahul Roychoudhuri, David Clever, Peng Li, Yoshiyuki Wakabayashi, Kylie M Quinn, Christopher A Klebanoff, Yun Ji, Madhusudhanan Sukumar, Robert L Eil, Zhiya Yu, Rosanne Spolski, Douglas C Palmer, Jenny H Pan, Shashank J Patel, Derek C Macallan, Giulia Fabozzi, Han-Yu Shih, Yuka Kanno, Akihiko Muto, Jun Zhu, Luca Gattinoni, John J O'Shea, Klaus Okkenhaug, Kazuhiko Igarashi, Warren J Leonard, Nicholas P Restifo
Jun 27, 2018
T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is...
Adaptive Immunity Animals Basic-Leucine Zipper Transcription Factors CD8-Positive T-Lymphocytes Cell Differentiation Cells Cultured Enhancer Elements Genetic Gene Expression Regulation Immunologic Memory Lymphocyte Activation Mice Mice Inbred C57BL Mice Knockout Oncogene Protein p65(gag-jun) Signal Transduction Transcription Factor AP-1 Vaccinia vaccinia virus
Organisational-Level Assessment of Cloud Computing Adoption
Cloud Computing (CC) is an emerging technology that can potentially revolutionise the application and delivery of IT. There has been little research, however, into the adoption of CC in Small and Medium-Sized Enterprises (SMEs)....
Published by: IGI Global Scientific Publishing
Does PGA external stenting reduce compliance mismatch in venous grafts?
Zhong-zhao Teng, Guang-yu Ji, Hong-jun Chu, Zhi-Yong Li, Liang-jian Zou, Zhi-yun Xu, Sheng-dong Huang
Jun 16, 2011
WGAN-Based Image Denoising Algorithm
Traditional image denoising algorithms are generally based on spatial domains or transform domains to denoise and smooth the image. The denoised images are not exhaustive, and the depth-of-learning algorithm has better denoising...
Published by: IGI Global Scientific Publishing
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco-Serna, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo
Feb 17, 2022
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...
Identifying a large number of high-yield genes in rice by pedigree analysis, whole genome sequencing and CRISPR-Cas9 gene knockout
Ju Huang, Jing Li, Jun Zhou, Long Wang, Sihai Yang, Laurence Hurst, Wen-Hsiung Li, Dacheng Tian
Aug 07, 2018
Repeated artificial selection of a complex trait facilitates the identification of genes underlying the trait, especially if multiple selected descendant lines are available. Here we developed a pedigree-based approach to...
An M-Learning Model in the Context of the Blended Synchronous Learning Environment
Mobile learning provides more flexibility and holds considerable promise for improving the learning process and promoting lifelong learning. In order to reduce the sense of isolation felt by the learners, this research...
Published by: IGI Global Scientific Publishing
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