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Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Risk Assessment Modeling of Urban Railway Investment and Financing Based on Improved SVM Model for Advanced Intelligent Systems
A risk assessment method for urban railway investment and financing based on an improved SVM model under big data is proposed. First, the inner product in the traditional SVM is replaced by a kernel function to obtain a more...
Published by: IGI Global Scientific Publishing
A Hotspot-Aware Personalized News Recommendation Mechanism Based on DistilBERT-TC-MA
Aiming at the problems of existing news recommendation methods, such as inadequate exploration of the semantic information of news, neglecting potential hotspot features of news, and challenging the balance between user...
Published by: IGI Global Scientific Publishing
Numerical investigation of harbor oscillations induced by focused transient wave groups
Focused wave groups are traveling waves characterized by extremely-large transient wave amplitudes and very short durations. These waves usually cause serious damage to marine/offshore structures and coastal infrastructures...
Boussinesq model Focused transient wave groups Harbor oscillations Harbor resonance Maximum runup Resonant intensity /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Numerical investigation of harbor oscillations induced by focused transient wave groups
Focused wave groups are traveling waves characterized by extremely-large transient wave amplitudes and very short durations. These waves usually cause serious damage to marine/offshore structures and coastal infrastructures...
Boussinesq model Focused transient wave groups Harbor oscillations Harbor resonance Maximum runup Resonant intensity /dk/atira/pure/subjectarea/asjc/2300/2305 name=Environmental Engineering /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
A 53-µA-Quiescent 400-mA Load Demultiplexer Based CMOS Multi-Voltage Domain Low Dropout Regulator for RF Energy Harvester.
Balamahesn Poongan, Jagadheswaran Rajendran, Li Yizhi, Selvakumar Mariappan, Pharveen Parameswaran, Narendra Kumar, Masuri Othman, Arokia Nathan
Mar 28, 2023
A low-power capacitorless demultiplexer-based multi-voltage domain low-dropout regulator (MVD-LDO) with 180 nm CMOS technology is proposed in this work. The MVD-LDO has a 1.5 V supply voltage headroom and regulates an output...
Internet of Things demultiplexer radio frequency energy harvester feedback network bandgap voltage reference multi-voltage domain low dropout power management unit system on chip
Published by: Micromachines
Study on Influences of Fringing Reef on Harbor Oscillations Triggered by N-Waves
Influences of topographic variations of the offshore fringing reef on the harbor oscillations excited by incident N-waves with different amplitudes and waveform types are studied for the first time. Both the propagation of...
Fringing-reef topography FUNWAVE-TVD Harbor oscillations N-waves Numerical simulations /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Effects of offshore fringing reefs on the transient harbor resonance excited by solitary waves
In this article, effects of the variation of the offshore reef topography on the transient resonance induced by solitary waves with various wave heights are first investigated. The transient resonance is simulated by a fully...
Effects of offshore fringing reefs on the transient harbor resonance excited by solitary waves
In this article, effects of the variation of the offshore reef topography on the transient resonance induced by solitary waves with various wave heights are first investigated. The transient resonance is simulated by a fully...
Study on Influences of Fringing Reef on Harbor Oscillations Triggered by N-Waves
Influences of topographic variations of the offshore fringing reef on the harbor oscillations excited by incident N-waves with different amplitudes and waveform types are studied for the first time. Both the propagation of...
Fringing-reef topography FUNWAVE-TVD Harbor oscillations N-waves Numerical simulations /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
On hydrodynamic characteristics of transient harbor resonance excited by double solitary waves
The harbor resonance triggered by double solitary waves (DSWs) with different wave parameters (including various wave heights and relative separation distances) is simulated based on the fully nonlinear Boussinesq model...
Provincial Linkage Characteristics of Hog Price in China Based on Linkage Social Network Analysis Method
In order to obtain the visual data of linkage structure and network characteristics of hog price among provinces in China, an improved analysis method of social network correlation was proposed in this article. The lift of...
Published by: IGI Global Scientific Publishing
Penalized likelihood estimation of the proportional hazards model for survival data with interval censoring.
This paper considers the problem of semi-parametric proportional hazards model fitting where observed survival times contain event times and also interval, left and right censoring times. Although this is not a new topic, many...
Energy Financial Risk Management in China Using Complex Network Analysis
Effective energy financial risk management is crucial to ensure that China's economic system can remain stable. This article utilizes the quantile vector autoregressive spillover index model, complex networks, and deep learning...
Published by: IGI Global Scientific Publishing
Measuring gravity wave parameters from a nighttime satellite low-light image based on two-dimensional stockwell transform
Atmospheric gravity waves are a kind of mesoscale disturbance, commonly found in the atmospheric system, that plays a key role in a series of mesospheric dynamic processes. When propagating to the upper atmosphere, the...
Investigation on the effects of Bragg reflection on harbor oscillations
Periodic undulating topographies (such as sandwaves and sandbars) are very common in coastal and estuarine areas. Normally incident water surface waves propagating from open sea to coastal areas may interact strongly with...
On hydrodynamic characteristics of transient harbor resonance excited by double solitary waves
The harbor resonance triggered by double solitary waves (DSWs) with different wave parameters (including various wave heights and relative separation distances) is simulated based on the fully nonlinear Boussinesq model...
A practical grid generation procedure for the design of free-form structures
Computer aided design software enables the rapid conceptual creation of a curved surface geometry, whereas it is neither a convenient nor an obvious task for engineers to create a discrete grid structure on a complex surface...
Topographic influences on transient harbor oscillations excited by N-waves
The main objective of this paper is to comprehensively study influences of the variation of the bottom profile inside the harbor on the transient harbor oscillations excited by normally-incident N-waves. The specific physical...
A practical grid generation procedure for the design of free-form structures
Computer aided design software enables the rapid conceptual creation of a curved surface geometry, whereas it is neither a convenient nor an obvious task for engineers to create a discrete grid structure on a complex surface...
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