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Results: 1166
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
A Tang-Dynasty Manual of Governance and the East Asian Vernaculars
Peter KORNICKI
Feb 21, 2020
The Essentials of Government in the Zhenguan Era (Zhenguan zhengyao) is a text that was compiled in the Tang dynasty after the death of the founding emperor, Taizong (r. 626-649). It circulated widely throughout East Asia but...
In vivo, genome-wide profiling of endogenously tagged chromatin-binding proteins with spatial and temporal resolution using NanoDam in Drosophila.
Jocelyn LY Tang, Robert Krautz, Oriol Llorà-Batlle, Anna E Hakes, Paul M Fox, Andrea H Brand
Dec 09, 2022
NanoDam is a technique for genome-wide profiling of the binding targets of any endogenously tagged chromatin-binding protein in vivo, without the need for antibodies, crosslinking, or immunoprecipitation. Here, we explain the...
Transformed-FNV
Existing force models for a vertical surface-piercing cylinder require water depth integration from the seabed to the free surface to determine the total inline force. However, acquiring the full wave kinematics profiles beneath...
Hybrid composites of aligned discontinuous carbon fibers and self-reinforced polypropylene under tensile loading
Jun Tang, Yentl Swolfs, Marco Longana, HaNa Yu, Michael R Wisnom, Stepan Lomov, Larissa Gorbatikh
Aug 31, 2019
Highly aligned discontinuous fiber composites have demonstrated mechanical properties comparable to those of unidirectional continuous fiber composites. However, their ductility is still limited by the intrinsic brittleness of...
Transformed-FNV
Existing force models for a vertical surface-piercing cylinder require water depth integration from the seabed to the free surface to determine the total inline force. However, acquiring the full wave kinematics profiles beneath...
Data Informed Model Test Design With Machine Learning – An Example in Nonlinear Wave Load on a Vertical Cylinder
Tianning Tang, Haoyu Ding, Saishuai Dai, Xi Chen, Paul H. Taylor, Jun Zang, Thomas A.A. Adcock
Apr 01, 2024
Model testing is common in coastal and offshore engineering. The design of such model tests is important such that the maximal information of the underlying physics can be extrapolated with a limited amount of test cases. The...
Hybrid composites of aligned discontinuous carbon fibers and self-reinforced polypropylene under tensile loading
Jun Tang, Yentl Swolfs, Marco Longana, HaNa Yu, Michael R Wisnom, Stepan Lomov, Larissa Gorbatikh
Aug 31, 2019
Highly aligned discontinuous fiber composites have demonstrated mechanical properties comparable to those of unidirectional continuous fiber composites. However, their ductility is still limited by the intrinsic brittleness of...
Review of Research on Vision-Based Parking Space Detection Method
Parking space detection is an important part of the automatic parking assistance system. How to use existing sensors to accurately and effectively detect parking spaces is the key problem that has not been solved in the...
Published by: IGI Global Scientific Publishing
A new Gaussian Process based model for non-linear wave loading on vertical cylinders
Tianning Tang, Gerard Ryan, Haoyu Ding, Xi Chen, Jun Zang, Paul H. Taylor, Thomas A.A. Adcock
Mar 31, 2024
We aim to establish a fast and accurate model for fast prediction of nonlinear loading on vertical cylinders such as are typically used for fixed offshore wind turbines. We follow a ‘Stokes-type’ force model and approximate...
A new Gaussian Process based model for non-linear wave loading on vertical cylinders
Tianning Tang, Gerard Ryan, Haoyu Ding, Xi Chen, Jun Zang, Paul H. Taylor, Thomas A.A. Adcock
Mar 31, 2024
We aim to establish a fast and accurate model for fast prediction of nonlinear loading on vertical cylinders such as are typically used for fixed offshore wind turbines. We follow a ‘Stokes-type’ force model and approximate...
Analysis of shroud and disk heat transfer in aero-engine compressor rotors
Richard Jackson, Hui Tang, James Scobie, Oliver Pountney, Carl Sangan, Mike Owen, Gary Lock
Sep 30, 2021
Heat transfer within the rotating compressor cavity of an aero-engine is predominantly governed by buoyancy, which can be characterized by the Grashof number. Unsteady and unstable buoyancy-induced flow structures influence...
/dk/atira/pure/subjectarea/asjc/2100/2104 name=Nuclear Energy and Engineering /dk/atira/pure/subjectarea/asjc/2100/2103 name=Fuel Technology /dk/atira/pure/subjectarea/asjc/2200/2202 name=Aerospace Engineering /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Data Informed Model Test Design With Machine Learning – An Example in Nonlinear Wave Load on a Vertical Cylinder
Tianning Tang, Haoyu Ding, Saishuai Dai, Xi Chen, Paul H. Taylor, Jun Zang, Thomas A.A. Adcock
Apr 01, 2024
Model testing is common in coastal and offshore engineering. The design of such model tests is important such that the maximal information of the underlying physics can be extrapolated with a limited amount of test cases. The...
Analysis of shroud and disk heat transfer in aero-engine compressor rotors
Richard Jackson, Hui Tang, James Scobie, Oliver Pountney, Carl Sangan, Mike Owen, Gary Lock
Sep 30, 2021
Heat transfer within the rotating compressor cavity of an aero-engine is predominantly governed by buoyancy, which can be characterized by the Grashof number. Unsteady and unstable buoyancy-induced flow structures influence...
/dk/atira/pure/subjectarea/asjc/2100/2104 name=Nuclear Energy and Engineering /dk/atira/pure/subjectarea/asjc/2100/2103 name=Fuel Technology /dk/atira/pure/subjectarea/asjc/2200/2202 name=Aerospace Engineering /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Thermal Tactile Perception
Using thermal tactile sensing mechanism based on semi-infinite body model, and combining with the advantages of maximum proportional controller, fuzzy and PID controller, a thermal tactile perception and reproduction experiment...
Published by: IGI Global Scientific Publishing
A spiropyran with low pK<sub>a</sub> for tracking DNA G-quadruplexes and revealing the dissipation of ΔΨm with senescence using an in-situ switching strategy
Xinrong Tian, Jin Li, Yanhui Zhang, Ying Gao, Muhammad Wasim Afzal, Aoli Wang, Tony D. James, Yinjuan Bai, Yuan Guo
May 15, 2022
The in-situ fluorescence triggering of bioprobes only using endogenous bioforces is an ideal non-destructive real-time detection method, which is of particular interest to improve the accuracy of clinical diagnosis and...
Fluorescent probes G-Quadruplexes Membrane potential of mitochondria Senescence Senescent cells /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3105 name=Instrumentation /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/2500/2506 name=Metals and Alloys /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Rahul Roychoudhuri, David Clever, Peng Li, Yoshiyuki Wakabayashi, Kylie M Quinn, Christopher A Klebanoff, Yun Ji, Madhusudhanan Sukumar, Robert L Eil, Zhiya Yu, Rosanne Spolski, Douglas C Palmer, Jenny H Pan, Shashank J Patel, Derek C Macallan, Giulia Fabozzi, Han-Yu Shih, Yuka Kanno, Akihiko Muto, Jun Zhu, Luca Gattinoni, John J O'Shea, Klaus Okkenhaug, Kazuhiko Igarashi, Warren J Leonard, Nicholas P Restifo
Jun 27, 2018
T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is...
Adaptive Immunity Animals Basic-Leucine Zipper Transcription Factors CD8-Positive T-Lymphocytes Cell Differentiation Cells Cultured Enhancer Elements Genetic Gene Expression Regulation Immunologic Memory Lymphocyte Activation Mice Mice Inbred C57BL Mice Knockout Oncogene Protein p65(gag-jun) Signal Transduction Transcription Factor AP-1 Vaccinia vaccinia virus
A spiropyran with low pK<sub>a</sub> for tracking DNA G-quadruplexes and revealing the dissipation of ΔΨm with senescence using an in-situ switching strategy
Xinrong Tian, Jin Li, Yanhui Zhang, Ying Gao, Muhammad Wasim Afzal, Aoli Wang, Tony D. James, Yinjuan Bai, Yuan Guo
May 15, 2022
The in-situ fluorescence triggering of bioprobes only using endogenous bioforces is an ideal non-destructive real-time detection method, which is of particular interest to improve the accuracy of clinical diagnosis and...
Fluorescent probes G-Quadruplexes Membrane potential of mitochondria Senescence Senescent cells /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3105 name=Instrumentation /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/2500/2506 name=Metals and Alloys /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco-Serna, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo
Feb 17, 2022
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...
Eriodictyol protects skin cells from UVA irradiation-induced photodamage by inhibition of the MAPK signaling pathway
Muhammad Farrukh Nisar, Tiantian Liu, Mei Wang, Shida Chen, Li Chang, Vega Widya Karisma, Weixu, Qingchun Diao, Mei Xue, Xueyong Tang, Charareh Pourzand, Jing Yang, J L Zhong
Jan 31, 2022
Solar UVA irradiation-generated reactive oxygen species (ROS) induces the expression of matrix metalloproteinase 1 (MMP-1), leading to photoaging, however the molecular mechanism remains unclear. In the present study, we...
Anti-photoaging COL-1 Eriodictyol MAPK MMP-1 ROS TIMP-1 UVA /dk/atira/pure/subjectarea/asjc/3100/3108 name=Radiation /dk/atira/pure/subjectarea/asjc/3600/3614 name=Radiological and Ultrasound Technology /dk/atira/pure/subjectarea/asjc/1300/1304 name=Biophysics /dk/atira/pure/subjectarea/asjc/2700/2741 name=Radiology Nuclear Medicine and imaging
Eriodictyol protects skin cells from UVA irradiation-induced photodamage by inhibition of the MAPK signaling pathway
Muhammad Farrukh Nisar, Tiantian Liu, Mei Wang, Shida Chen, Li Chang, Vega Widya Karisma, Weixu, Qingchun Diao, Mei Xue, Xueyong Tang, Charareh Pourzand, Jing Yang, J L Zhong
Jan 31, 2022
Solar UVA irradiation-generated reactive oxygen species (ROS) induces the expression of matrix metalloproteinase 1 (MMP-1), leading to photoaging, however the molecular mechanism remains unclear. In the present study, we...
Anti-photoaging COL-1 Eriodictyol MAPK MMP-1 ROS TIMP-1 UVA /dk/atira/pure/subjectarea/asjc/3100/3108 name=Radiation /dk/atira/pure/subjectarea/asjc/3600/3614 name=Radiological and Ultrasound Technology /dk/atira/pure/subjectarea/asjc/1300/1304 name=Biophysics /dk/atira/pure/subjectarea/asjc/2700/2741 name=Radiology Nuclear Medicine and imaging
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