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Bioengineering solutions for ureteric disorders
Konstantinos Kapetanos, Alexander Light, Niyukta Thakare, Krishnaa Mahbubani, Kasra Saeb-Parsy, Kourosh Saeb-Parsy
May 15, 2022
OBJECTIVES: To summarise the causes of ureteric damage and the current standard of care, discussing the risks and benefits of available therapeutic options. We then focus on the current and future solutions that can be provided...
The Role of Ischemia/Reperfusion Injury in Early Hepatic Allograft Dysfunction.
Liver transplantation (LT) is the only available curative treatment for patients with end-stage liver disease. Early allograft dysfunction (EAD) is a life-threatening complication of LT and is thought to be mediated in large...
Advances in the generation of bioengineered bile ducts.
Alexander W Justin, Kourosh Saeb-Parsy, Athina E Markaki, Ludovic Vallier, Fotios Sampaziotis
Jan 30, 2018
Modeling human tumor-immune environments in vivo for the preclinical assessment of immunotherapies.
Bethany Bareham, Nikitas Georgakopoulos, Alba Matas-Céspedes, Michelle Curran, Kourosh Saeb-Parsy
Sep 08, 2021
Despite the significant contributions of immunocompetent mouse models to the development and assessment of cancer immunotherapies, they inadequately represent the genetic and biological complexity of corresponding human cancers....
Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.
Acute kidney injury (AKI) remains a major problem in critically unwell children and young adults. Ischaemia reperfusion (IR) injury is a major contributor to the development of AKI in a significant proportion of these cases and...
Mitochondria as Therapeutic Targets in Transplantation.
Kourosh Saeb-Parsy, Jack L Martin, Dominic M Summers, Christopher JE Watson, Thomas Krieg, Michael P Murphy
Sep 28, 2020
Advances in surgical procedures, technology, and immune suppression have transformed organ transplantation. However, the metabolic changes that occur during organ retrieval, storage, and implantation have been relatively...
Immunological considerations and challenges for regenerative cellular therapies.
Sandra Petrus-Reurer, Marco Romano, Sarah Howlett, Joanne Louise Jones, Giovanna Lombardi, Kourosh Saeb-Parsy
Jun 16, 2021
The central goal of regenerative medicine is to replace damaged or diseased tissue with cells that integrate and function optimally. The capacity of pluripotent stem cells to produce unlimited numbers of differentiated cells is...
Immunological considerations and challenges for regenerative cellular therapies
Sandra Petrus-Reurer, Marco Romano, Sarah Howlett, Joanne Louise Jones, Giovanna Lombardi, Kourosh Saeb-Parsy
Jun 25, 2021
Abstract: The central goal of regenerative medicine is to replace damaged or diseased tissue with cells that integrate and function optimally. The capacity of pluripotent stem cells to produce unlimited numbers of differentiated...
Phenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes.
Laurence SC Lok, Thomas W Dennison, Krishnaa M Mahbubani, Kourosh Saeb-Parsy, Edwin R Chilvers, Menna R Clatworthy
Sep 05, 2019
B Lymphocyte-Derived CCL7 Augments Neutrophil and Monocyte Recruitment, Exacerbating Acute Kidney Injury.
Akimichi Inaba, Zewen K Tuong, Alexandra M Riding, Rebeccah J Mathews, Jack L Martin, Kourosh Saeb-Parsy, Menna R Clatworthy
Jul 22, 2020
Ureteric complications in recipients of kidneys from donation after circulatory death donors.
Trina-Jo Mah, Dermot H Mallon, Oliver Brewster, Kourosh Saeb-Parsy, Andrew J Butler, J Andrew Bradley, Vasilis Kosmoliaptsis
Mar 29, 2017
DCD kidney transplantation ureteric complications Adolescent Adult Aged Aged 80 and over Brain Death Child Child Preschool Constriction Pathologic Female Follow-Up Studies Glomerular Filtration Rate Humans Incidence Kidney Function Tests Kidney Transplantation Male Middle Aged Postoperative Complications Prognosis Retrospective Studies Risk Factors Tissue Donors Tissue and Organ Procurement United Kingdom Ureter Urologic Diseases Young Adult
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation.
Fotios Sampaziotis, Miguel Cardoso de Brito, Pedro Madrigal, Alessandro Bertero, Kourosh Saeb-Parsy, Filipa AC Soares, Elisabeth Schrumpf, Espen Melum, Tom H Karlsen, J Andrew Bradley, William Th Gelson, Susan Davies, Alastair Baker, Arthur Kaser, Graeme J Alexander, Nicholas RF Hannan, Ludovic Vallier
Jun 23, 2015
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.
Edward T Chouchani, Victoria R Pell, Andrew M James, Lorraine M Work, Kourosh Saeb-Parsy, Christian Frezza, Thomas Krieg, Michael P Murphy
Feb 16, 2016
Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker.
Hiran A Prag, Duvaraka Kula-Alwar, Laura Pala, Stuart T Caldwell, Timothy E Beach, Andrew M James, Kourosh Saeb-Parsy, Thomas Krieg, Richard C Hartley, Michael P Murphy
Aug 17, 2020
Many mitochondrial metabolites and bioactive molecules contain two carboxylic acid moieties that make them unable to cross biological membranes. Hence, there is considerable interest in facilitating the uptake of these molecules...
Risk for arterial thrombosis after liver transplantation with hepatic artery reconstruction.
Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury.
Anja V Gruszczyk, Alva M Casey, Andrew M James, Hiran A Prag, Nils Burger, Georgina R Bates, Andrew R Hall, Fay M Allen, Thomas Krieg, Kourosh Saeb-Parsy, Michael P Murphy
Jul 25, 2022
Use of human splenocytes in an innovative humanised mouse model for prediction of immunotherapy-induced cytokine release syndrome.
Alba Matas-Céspedes, Lee Brown, Krishnaa T Mahbubani, Bethany Bareham, Jackie Higgins, Michelle Curran, Lolke de Haan, Jean-Martin Lapointe, Richard Stebbings, Kourosh Saeb-Parsy
Nov 17, 2020
OBJECTIVES: Humanised mice have emerged as valuable models for pre-clinical testing of the safety and efficacy of immunotherapies. Given the variety of models available, selection of the most appropriate humanised mouse model is...
Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids.
Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy, Meritxell Huch
Mar 28, 2020
BACKGROUND:Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previously...
Published by: BMC developmental biology
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.
Tomas Castro-Dopico, Thomas W Dennison, John R Ferdinand, Rebeccah J Mathews, Aaron Fleming, Dean Clift, Benjamin J Stewart, Chenzhi Jing, Konstantina Strongili, Larisa I Labzin, Edward JM Monk, Kourosh Saeb-Parsy, Clare E Bryant, Simon Clare, Miles Parkes, Menna R Clatworthy
Feb 18, 2019
Inflammatory bowel disease is a chronic, relapsing condition with two subtypes, Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies (GWASs) in UC implicate a FCGR2A variant that alters the binding...
Fcγ receptors IL-1β IgG inflammatory bowel disease type 17 immunity Animals Antibodies Bacterial Colitis Colitis Ulcerative Dextran Sulfate Gastrointestinal Microbiome Gene Expression Regulation Genotype Humans Immunoglobulin G Inflammation Interleukin-1beta Interleukin-8 Intestinal Mucosa MACROPHAGES Mice Phagocytes RNA Messenger Reactive Oxygen Species Receptors IgG Th17 Cells
Recent Advancements and Applications of Human Immune System Mice in Preclinical Immuno-Oncology.
Michelle Curran, Maelle Mairesse, Alba Matas-Céspedes, Bethany Bareham, Giovanni Pellegrini, Ardi Liaunardy, Edward Powell, Rebecca Sargeant, Emanuela Cuomo, Richard Stebbings, Catherine J Betts, Kourosh Saeb-Parsy
Jan 20, 2020
Significant advances in immunotherapies have resulted in the increasing need of predictive preclinical models to improve immunotherapeutic drug development, treatment combination, and to prevent or minimize toxicity in clinical...
Successful Transplantation of Human Kidneys Deemed Untransplantable but Resuscitated by Ex Vivo Normothermic Machine Perfusion
clinical research/practice kidney transplantation/nephrology organ acceptance organ perfusion and preservation Adult Aged Female Graft Rejection Humans Kidney Function Tests Kidney Transplantation Liver Male Organ Preservation Outcome Assessment Health Care Perfusion Tissue Donors Tissue Survival Tissue and Organ Procurement
Diversity of the CD4 T Cell Alloresponse
Jason M Ali, Margaret C Negus, Thomas M Conlon, Ines G Harper, M Saeed Qureshi, Reza Motallebzadeh, Richard Willis, Kourosh Saeb-Parsy, Eleanor M Bolton, J Andrew Bradley, Gavin J Pettigrew
Dec 21, 2015
Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue.
Olivia C Tysoe, Alexander W Justin, Teresa Brevini, Si Emma Chen, Krishnaa T Mahbubani, Anna K Frank, Hajer Zedira, Espen Melum, Kourosh Saeb-Parsy, Athina E Markaki, Ludovic Vallier, Fotios Sampaziotis
Jun 17, 2019
Pediatric liver transplantation is often required as a consequence of biliary disorders because of the lack of alternative treatments for repairing or replacing damaged bile ducts. To address the lack of availability of...
Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant.
Ines G Harper, Jason M Ali, Simon JF Harper, Elizabeth Wlodek, Jawaher Alsughayyir, Margaret C Negus, M Saeed Qureshi, Reza Motalleb-Zadeh, Kourosh Saeb-Parsy, Eleanor M Bolton, J Andrew Bradley, Menna R Clatworthy, Thomas M Conlon, Gavin J Pettigrew
Mar 18, 2016
Adaptive Immunity Allografts Animals Autoantibodies B-Lymphocytes CD4-Positive T-Lymphocytes Cell Differentiation Graft Rejection Graft vs Host Disease Histocompatibility Antigens Class I Histocompatibility Antigens Class II Immunity Humoral Killer Cells Natural Mice Inbred BALB C Models Immunological Peptides Plasma Cells Receptors Antigen B-Cell Tissue Donors Transplantation Homologous
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