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Results: 2753
Inability to get up after falling, subsequent time on floor, and summoning help
OBJECTIVES: To describe the incidence and extent of lying on the floor for a long time after being unable to get up from a fall among people aged over 90; to explore their use of call alarm systems in these circumstances....
Risk of osteoarthritis in an incident cohort of people with psoriatic arthritis
Objective. To determine the risk of a diagnosis of osteoarthritis (OA) in patients with psoriatic arthritis (PsA) compared to patients with psoriasis and a general population cohort. Methods. Incident PsA patients aged 18-89...
Place of death for the 'oldest old'
Jane Fleming, Jun Zhao, Morag Farquhar, Carol Brayne, Stephen Barclay, Cambridge City over-75s Cohort (CC75C) study collaboration
Mar 01, 2019
BACKGROUND: Deaths are rising fastest among the oldest old but data on their transitions in place of care at the end of life are scarce. AIM: To examine the place of residence or care of > or =85 year-olds less than a year...
Antiretroviral treatment Long-Term (ALT) cohort
Barbara Castelnuovo, Frank Mubiru, Agnes N Kiragga, Rachel Musomba, Olive Mbabazi, Paul Gonza, Andrew Kambugu, Rosalind Parks Ratanshi
Jun 27, 2018
PURPOSE: Little information is available on patients on antiretroviral treatment (ART) after a long-term period from sub-Saharan Africa, with the longest follow-up and related outcomes being after 10 years on ART. At the...
HIV antiretroviral treatment cohort profile long tern outcomes Adult Alkynes Antiretroviral Therapy Highly Active Benzoxazines CD4 Lymphocyte Count Cyclopropanes Drug Combinations Female Follow-Up Studies HIV Infections HIV-1 Humans Lamivudine Male Nevirapine Prospective Studies RNA Viral Time Uganda Viral Load Zidovudine
Birmingham SLE cohort
Chee-Seng Yee, Li Su, Veronica Toescu, Richard Hickman, Deva Situnayake, Simon Bowman, Vernon Farewell, Caroline Gordon
Jun 12, 2018
OBJECTIVE: The aim of this study was to describe the outcomes and predictors for development of damage in a large inception cohort of SLE patients. METHODS: This was a prospective longitudinal study of a cohort of SLE patients....
SLE damage disease activity inception cohort Mortality Therapy Adrenal Cortex Hormones Adult Aged Aged 80 and over Cohort Studies cyclophosphamide Disability Evaluation Disease Progression Female Follow-Up Studies Humans Longitudinal Studies Lupus Erythematosus Systemic Male Middle Aged Patient Outcome Assessment Prospective Studies Regression Analysis Severity of Illness Index Survival Rate Treatment Outcome United Kingdom
Place of death and end-of-life transitions experienced by very old people with differing cognitive status
Anouk J Perrels, Jane Fleming, Jun Zhao, Stephen Barclay, Morag Farquhar, Hilde M Buiting, Carol Brayne, Cambridge City over-75s Cohort (CC75C) study collaboration
Jun 14, 2019
BACKGROUND: Despite fast-growing 'older old' populations, 'place of care' trajectories for very old people approaching death with or without dementia are poorly described and understood. AIM: To explore end-of-life transitions...
80 and over COGNITIVE IMPAIRMENT Aged Delivery of Health Care Dementia Frail Elderly Homes for the Aged Nursing Homes Patient Transfer residential characteristics Terminal Care Aged 80 and over Cognition Disorders Cohort Studies Female Hospital Mortality Humans Male Nursing Homes Terminal Care Terminally Ill United Kingdom
Risk of type 2 diabetes and cardiovascular disease in an incident cohort of people with psoriatic arthritis
Objectives: To determine the risk of type 2 diabetes (T2D) and cardiovascular diseases in PsA patients compared with the general population and patients with psoriasis.
Methods: Incident PsA patients aged 18-89 years...
cardiovascular disease cohort study psoriasis psoriatic arthritis Type 2 diabetes /dk/atira/pure/subjectarea/asjc/2700/2745 name=Rheumatology /dk/atira/pure/subjectarea/asjc/2700/2736 name=Pharmacology (medical) /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Risk of osteoarthritis in an incident cohort of people with psoriatic arthritis
Objective. To determine the risk of a diagnosis of osteoarthritis (OA) in patients with psoriatic arthritis (PsA) compared to patients with psoriasis and a general population cohort. Methods. Incident PsA patients aged 18-89...
Risk of type 2 diabetes and cardiovascular disease in an incident cohort of people with psoriatic arthritis
Objectives: To determine the risk of type 2 diabetes (T2D) and cardiovascular diseases in PsA patients compared with the general population and patients with psoriasis.
Methods: Incident PsA patients aged 18-89 years...
cardiovascular disease cohort study psoriasis psoriatic arthritis Type 2 diabetes /dk/atira/pure/subjectarea/asjc/2700/2745 name=Rheumatology /dk/atira/pure/subjectarea/asjc/2700/2736 name=Pharmacology (medical) /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Blood Eosinophil Count and Metabolic, Cardiac and Pulmonary Outcomes
Marzyeh Amini, Judith M Vonk, Ali Abbasi, Bram P Prins, Marcel Bruinenberg, Lude Franke, Pim van der Harst, Gerjan Navis, Gerard H Koppelman, Bruce Hr Wolffenbuttel, H Marike Boezen, Harold Snieder, Daniel I Chasman, Behrooz Z Alizadeh
Jun 04, 2018
Blood eosinophil count is associated with a variety of common complex outcomes in epidemiological observation. The aim of this study was to explore the causal association between determined blood eosinophil count and 20 common...
Mendelian randomization Cardiovascular Diseases complex diseases eosinophil count genetic risk score instrumental variable Metabolic Diseases pulmonary diseases Asthma Blood Glucose blood pressure Body Mass Index Cohort Studies Diabetes mellitus Type 2 Female Forced Expiratory Volume Genome-Wide Association Study Glycated Hemoglobin Humans Leukocyte Count Lipids Male Mendelian Randomization Analysis Metabolic Syndrome Pulmonary Disease Chronic Obstructive Quantitative Trait Heritable
The relationship between back pain and mortality in older adults varies with disability and gender
RE Docking, J Fleming, C Brayne, J Zhao, GJ Macfarlane, GT Jones, Cambridge City over-75s Cohort (CC75C) study collaboration
Jan 29, 2020
BACKGROUND: This study aims to determine whether older adults reporting back pain (BP) are at increased risk of premature mortality, specifically, to examine the association with disabling/non-disabling pain separately. METHODS...
Falls in advanced old age
Jane Fleming, Fiona E Matthews, Carol Brayne, Cambridge City over-75s Cohort (CC75C) study collaboration
Jun 16, 2011
BACKGROUND: The "oldest old" are now the fastest growing section of most western populations, yet there are scarcely any data concerning even the common problem of falls amongst the very old. Prospective data collection is...
The oldest old in the last year of life
Jun Zhao, Stephen Barclay, Morag Farquhar, Ann Louise Kinmonth, Carol Brayne, Jane Fleming, Cambridge City over-75s Cohort Study collaboration
Feb 28, 2019
OBJECTIVES: To characterize people of advanced old age in their last year of life and compare those dying in their late 80s with those dying aged 90 and older to inform policy and planning. DESIGN: Retrospective analysis of...
Hepatitis C virus reinfection after successful treatment with direct-acting antiviral therapy in a large population-based cohort.
Carmine Rossi, Zahid A Butt, Stanley Wong, Jane A Buxton, Nazrul Islam, Amanda Yu, Maryam Darvishian, Mark Gilbert, Jason Wong, Nuria Chapinal, Mawuena Binka, Maria Alvarez, Mark W Tyndall, Mel Krajden, Naveed Z Janjua, BC Hepatitis Testers Cohort Team
Nov 15, 2018
BACKGROUND & AIMS: Direct-acting antiviral therapies (DAA) are an important tool for hepatitis C virus (HCV) elimination. However, reinfection among people who inject drugs (PWID) may hamper elimination targets. Therefore, we...
Maternal antecedents of adiposity and studying the transgenerational role of hyperglycemia and insulin (MAASTHI): a prospective cohort study
Giridhara R Babu, Gvs Murthy, R Deepa, Yamuna, Prafulla, H Kiran Kumar, Maithili Karthik, Keerti Deshpande, Sara E Benjamin Neelon, D Prabhakaran, Anura Kurpad, Sanjay Kinra
Jan 10, 2018
BACKGROUND: India is experiencing an epidemic of obesity-hyperglycaemia, which coincides with child bearing age for women. The epidemic can be sustained and augmented through transgenerational transmission of adiposity and...
Birth cohort Gestational diabetes Hyperglycemia Lifecourse epidemiology obesity Protocol Adiposity Adult Birth Weight Blood Glucose Child Preschool Clinical Protocols Female Humans Hyperglycemia india Infant Infant Newborn Insulin Male Maternal Nutritional Physiological Phenomena obesity Pilot Projects Pregnancy Pregnancy Complications prenatal exposure delayed effects Prospective Studies Risk Factors Skinfold Thickness
Epidemiology of back pain in older adults
Rachael E Docking, Jane Fleming, Carol Brayne, Jun Zhao, Gary J Macfarlane, Gareth T Jones, Cambridge City over-75s Cohort Study collaboration
Jun 14, 2019
OBJECTIVES: To determine the prevalence of disabling and non-disabling back pain across age in older adults, and identify risk factors for back pain onset in this age group. METHODS: Participants aged ≥ 75 years answered...
Multiple imputation of missing data in nested case-control and case-cohort studies.
The nested case-control and case-cohort designs are two main approaches for carrying out a substudy within a prospective cohort. This article adapts multiple imputation (MI) methods for handling missing covariates in full-cohort...
Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort
Lisa Vermunt, Graciela Muniz-Terrera, Lea ter Meulen, Colin Veal, Kaj Blennow, Archie Campbell, Isabelle Carrié, Julien Delrieu, Karine Fauria, Gema Huesa Rodríguez, Silvia Ingala, Natalie Jenkins, José Luis Molinuevo, Pierre-Jean Ousset, David Porteous, Niels D. Prins, Alina Solomon, Brian D. Tom, Henrik Zetterberg, Marissa Zwan, Craig W. Ritchie, Philip Scheltens, Gerald Luscan, Anthony J. Brookes, Pieter Jelle Visser
Jan 05, 2021
Abstract: Background: Recruitment is often a bottleneck in secondary prevention trials in Alzheimer disease (AD). Furthermore, screen-failure rates in these trials are typically high due to relatively low prevalence of AD...
Feasibility of a birth-cohort in Pakistan
Yasmeen Anwer, Fahad Abbasi, Ariba Dar, Abdullah Hafeez, Sara Valdebenito, Manuel Eisner, Siham Sikander, Assad Hafeez
Mar 13, 2022
BACKGROUND: Evidence for Better Lives Study Foundational Research (EBLS-FR) is a preliminary endeavor to establish the feasibility of a global birth cohort, and within this feasibility study, piloting the research instrument...
Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort
Lisa Vermunt, Graciela Muniz-Terrera, Lea ter Meulen, Colin Veal, Kaj Blennow, Archie Campbell, Isabelle Carrié, Julien Delrieu, Karine Fauria, Gema Huesa Rodríguez, Silvia Ingala, Natalie Jenkins, José Luis Molinuevo, Pierre-Jean Ousset, David Porteous, Niels D Prins, Alina Solomon, Brian D Tom, Henrik Zetterberg, Marissa Zwan, Craig W Ritchie, Philip Scheltens, Gerald Luscan, Anthony J Brookes, Pieter Jelle Visser, IMI-EPAD collaborators
Jan 20, 2020
BACKGROUND: Recruitment is often a bottleneck in secondary prevention trials in Alzheimer disease (AD). Furthermore, screen-failure rates in these trials are typically high due to relatively low prevalence of AD pathology in...
The European Prevention of Alzheimer’s Dementia (EPAD) Longitudinal Cohort Study
Craig William Ritchie, G. Muniz-Terrera, M. Kivipelto, A. Solomon, B. Tom, J. L. Molinuevo
Nov 25, 2020
Abstract: Background: The European Prevention of Alzheimer’s Dementia (EPAD) Programme is a pan-European project whose objective is to deliver a platform, adaptive, Phase 2 proof of concept (PoC) trial for the secondary...
Analysis of Cardio-Cerebral Crosstalk Events in an Adult Cohort from the CENTER-TBI Study.
Giovanna Maria Dimitri, Erta Beqiri, Marek Czosnyka, Ari Ercole, Peter Smielewski, Pietro Lio, CENTER-TBI High Resolution Substudy Participants and Investigators
Apr 17, 2020
OBJECTIVE: In a previous study, we observed the presence of simultaneous increases in intracranial pressure (ICP) and the heart rate (HR), which we denominated cardio-cerebral crosstalk (CC), and we related the number of such...
Study protocol. A prospective cohort study of unselected primiparous women
Dharmintra Pasupathy, Alison Dacey, Emma Cook, D Stephen Charnock-Jones, Ian R White, Gordon CS Smith
Jun 16, 2011
BACKGROUND: There have been dramatic changes in the approach to screening for aneuploidy over the last 20 years. However, the approach to screening for other complications of pregnancy such as intra-uterine growth restriction...
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