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A Teaching Suggestion in the COVID-19 Disease Pandemic Period
The effect of the COVID-19 pandemic shows that schools must adapt new approaches in order to continue to provide teaching and learning at schools. To achieve this, students must be equipped to learn in a multifaceted...
Published by: IGI Global Scientific Publishing
Exact and Heuristic Algorithms for the Carrier-Vehicle Traveling Salesman Problem
This paper presents new structural properties for the Carrier-Vehicle Traveling Salesman Problem. The authors provide a new mixed integer second order conic optimization formulation, with associated optimality cuts based on the...
An Early Developmental Marker of Deficit versus Nondeficit Schizophrenia.
Brian Kirkpatrick, Özlem Gürbüz Oflezer, Mehtap Delice Arslan, Gary Hack, Emilio Fernandez-Egea
Sep 16, 2019
People with schizophrenia and primary negative symptoms (deficit schizophrenia) differ from those without such symptoms (nondeficit schizophrenia) on risk factors, course of illness, other signs and symptoms, treatment response...
Exact and Heuristic Algorithms for the Carrier-Vehicle Traveling Salesman Problem
This paper presents new structural properties for the Carrier-Vehicle Traveling Salesman Problem. The authors provide a new mixed integer second order conic optimization formulation, with associated optimality cuts based on the...
Bayesian Particle Instance Segmentation for Electron Microscopy Image Quantification.
Automating the analysis portion of materials characterization by electron microscopy (EM) has the potential to accelerate the process of scientific discovery. To this end, we present a Bayesian deep-learning model for semantic...
3-D Inorganic Crystal Structure Generation and Property Prediction via Representation Learning
Generative models have been successfully used to synthesize completely novel images, text, music and speech. As such, they present an exciting opportunity for the design of new materials for functional applications. So far...
Computational Investigation of RNA A-Bulges Related to the Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism.
Mutations in the human tau gene result in alternative splicing of the tau protein, which causes frontotemporal dementia and Parkinsonism. One disease mechanism is linked to the stability of a hairpin within the...
Comparative Reviews vs. Regular Consumer Reviews
This study proposes and evaluates the effect of “mixed” comparative reviews on review value and compares the results with “separate” comparative and regular reviews. A total of 201 subjects have participated in the experiment...
Published by: IGI Global Scientific Publishing
Low-Cost Microfabrication Tool Box
Microsystems are key enabling technologies, with applications found in almost every industrial field, including in vitro diagnostic, energy harvesting, automotive, telecommunication, drug screening, etc. Microsystems, such as...
Low-Cost Microfabrication Tool Box.
Jérôme Charmet, Rui Rodrigues, Ender Yildirim, Pavan Kumar Challa, Benjamin Roberts, Robert Dallmann, Yudan Whulanza
Apr 14, 2020
Microsystems are key enabling technologies, with applications found in almost every industrial field, including in vitro diagnostic, energy harvesting, automotive, telecommunication, drug screening, etc. Microsystems, such as...
Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions.
Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K Peter R Nilsson, Derya R Shimshek, Philipp J Kahle, Yvonne S Eisele, Mathias Jucker
Oct 05, 2020
Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS). The clinical heterogeneity of these diseases is thought to be attributed to...
Water-stable zirconium-based metal-organic framework material with high-surface area and gas-storage capacities.
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus
Gonca Bayraktar, PingAn Yuanxiang, Alessandro D. Confettura, Guilherme M. Gomes, Syed A. Raza, Oliver Stork, Shoji Tajima, Isao Suetake, Anna Karpova, Ferah Yildirim, Michael R. Kreutz
Feb 09, 2021
Abstract: DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that...
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus
Gonca Bayraktar, PingAn Yuanxiang, Alessandro D. Confettura, Guilherme M. Gomes, Syed A. Raza, Oliver Stork, Shoji Tajima, Isao Suetake, Anna Karpova, Ferah Yildirim, Michael R. Kreutz
Oct 09, 2020
Abstract: DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that...
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus.
Gonca Bayraktar, PingAn Yuanxiang, Alessandro D Confettura, Guilherme M Gomes, Syed A Raza, Oliver Stork, Shoji Tajima, Isao Suetake, Anna Karpova, Ferah Yildirim, Michael R Kreutz
Jul 29, 2021
DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that protein...
Age-dependent formation of TMEM106B amyloid filaments in human brains.
Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J Garringer, Ruben Vidal, Grace I Hallinan, Kathy L Newell, Airi Tarutani, Shigeo Murayama, Masayuki Miyazaki, Yuko Saito, Mari Yoshida, Kazuko Hasegawa, Tammaryn Lashley, Tamas Revesz, Gabor G Kovacs, John van Swieten, Masaki Takao, Masato Hasegawa, Bernardino Ghetti, Maria Grazia Spillantini, Benjamin Ryskeldi-Falcon, Alexey G Murzin, Michel Goedert, Sjors HW Scheres
May 12, 2022
Many age-dependent neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β, α-synuclein and...
Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures.
Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M Häsler, Manuel Schweighauser, Thomas V Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Philipp J Kahle, Derya R Shimshek, Henner Koch, Mathias Jucker, Gaye Tanriöver
Sep 27, 2021
BACKGROUND: Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of the...
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies
Marc Emmenegger, Elena De Cecco, Marian Hruska‐Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa‐Vergniory, Andrès Gonzalez‐Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Ronald Melki, Philipp J Kahle, Simone Hornemann, Tuomas P J Knowles, Mark R Cookson, Magdalini Polymenidou, Mathias Jucker, Adriano Aguzzi
Jul 28, 2021
Published by: EMBO molecular medicine
Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant.
Motaharehsadat Heydarian, Prajakta Oak, Xin Zhang, Nona Kamgari, Alida Kindt, Markus Koschlig, Tina Pritzke, Erika Gonzalez-Rodriguez, Kai Förster, Rory E Morty, Friederike Häfner, Christoph Hübener, Andreas W Flemmer, Ali Oender Yildirim, Deepti Sudheendra, Xuefei Tian, Agnese Petrera, Holger Kirsten, Peter Ahnert, Nick Morrell, Tushar J Desai, Jennifer Sucre, Edda Spiekerkoetter, Anne Hilgendorff
Nov 03, 2022
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
Marc Emmenegger, Elena De Cecco, Marian Hruska-Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa-Vergniory, Andrès Gonzalez-Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Ronald Melki, Philipp J Kahle, Simone Hornemann, Tuomas PJ Knowles, Mark R Cookson, Magdalini Polymenidou, Mathias Jucker, Adriano Aguzzi
Sep 24, 2021
While the initial pathology of Parkinson's disease and other α-synucleinopathies is often confined to circumscribed brain regions, it can spread and progressively affect adjacent and distant brain locales. This process may be...
Age-dependent formation of TMEM106B amyloid filaments in human brains.
Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J Garringer, Ruben Vidal, Grace I Hallinan, Kathy L Newell, Airi Tarutani, Shigeo Murayama, Masayuki Miyazaki, Yuko Saito, Mari Yoshida, Kazuko Hasegawa, Tammaryn Lashley, Tamas Revesz, Gabor G Kovacs, John van Swieten, Masaki Takao, Masato Hasegawa, Bernardino Ghetti, Maria Grazia Spillantini, Benjamin Ryskeldi-Falcon, Alexey G Murzin, Michel Goedert, Sjors HW Scheres
May 11, 2022
Many age-dependent neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β, α-synuclein and...
Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study.
Lourdes Ortiz-Fernández, Güher Saruhan-Direskeneli, Fatma Alibaz-Oner, Sema Kaymaz-Tahra, Patrick Coit, Xiufang Kong, Allan P Kiprianos, Robert T Maughan, Sibel Z Aydin, Kenan Aksu, Gokhan Keser, Sevil Kamali, Murat Inanc, Jason Springer, Servet Akar, Fatos Onen, Nurullah Akkoc, Nader A Khalidi, Curry Koening, Omer Karadag, Sedat Kiraz, Lindsy Forbess, Carol A Langford, Carol A McAlear, Zeynep Ozbalkan, Sule Yavuz, Gozde Yildirim Çetin, Nilufer Alpay-Kanitez, Sharon Chung, Askin Ates, Yasar Karaaslan, Kathleen McKinnon-Maksimowicz, Paul A Monach, Hüseyin TE Ozer, Emire Seyahi, Izzet Fresko, Ayse Cefle, Philip Seo, Kenneth J Warrington, Mehmet A Ozturk, Steven R Ytterberg, Veli Cobankara, Ahmet Mesut Onat, Nurşen Duzgun, Muge Bıcakcıgil, Sibel P Yentür, Lindsay Lally, Angelo A Manfredi, Elena Baldissera, Eren Erken, Ayten Yazici, Bünyamin Kısacık, Timuçin Kaşifoğlu, Ediz Dalkilic, David Cuthbertson, Christian Pagnoux, Antoine Sreih, Guillermo Reales, Chris Wallace, Jonathan D Wren, Deborah S Cunninghame-Graham, Timothy J Vyse, Ying Sun, Huiyong Chen, Peter C Grayson, Enrico Tombetti, Lindi Jiang, Justin C Mason, Peter A Merkel, Haner Direskeneli, Amr H Sawalha
Nov 26, 2020
Takayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five different populations. We discovered HLA...
Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients
Niccolò Buetti, Alexis Tabah, Ambre Loiodice, Stéphane Ruckly, Abdullah Tarik Aslan, Giorgia Montrucchio, Andrea Cortegiani, Nese Saltoglu, Bircan Kayaaslan, Firdevs Aksoy, Akova Murat, Özlem Akdoğan, Kemal Tolga Saracoglu, Cem Erdogan, Marc Leone, Ricard Ferrer, José-Artur Paiva, Yoshiro Hayashi, Mahesh Ramanan, Andrew Conway Morris, François Barbier, Jean-François Timsit, Jeffrey Lipman, Edward Litton, Anna Maria Palermo, Timothy Yap, Ege Eroglu, Koji Hosokawa, Hideki Yoshida, Shigeki Fujitani, Farid Zand, Ata Mahmoodpoor, Seyed Mohammad Nasirodin Tabatabaei, Omar Elrabi, Ghaleb A Almekhlafi, Gabriela Vidal, Marta Aparicio, Irene Alonzo, Silvio A Namendys-Silva, Mariana Hermosillo, Roberto Alejandro Castillo, Liesbet De Bus, Jan De Waele, Isabelle Hollevoet, Nicolas De Schryver, Nicolas Serck, Pedja Kovacevic, Biljana Zlojutro, Etienne Ruppe, Philippe Montravers, Thierry Dulac, Jérémy Castanera, Alexandre Massri, Charlotte Guesdon, Pierre Garcon, Matthieu Duprey, François Philippart, Marc Tran, Cédric Bruel, Pierre Kalfon, Gaëtan Badre, Sophie Demeret, Loïc Le Guennec, Matteo Bassetti, Daniele Giacobbe, Gabriele Sales, Ivan Daroui, Giovanni Lodi, Mariachiara Ippolito, Davide Bellina, Andrea Di Guardo, Monica Rocco, Silvia Fiorelli, Adam Mikstacki, Mariusz Peichota, Iwona Pietraszek-Grzywaczewska, Pedro Póvoa, Andriy Krystopchuk, Ana Teresa, António Manuel Pereira de Figueiredo, Isabel Botelho, Vasco Costa, Rui Pedro Cunha, Alexey Gritsan, Vladislav Belskiy, Mikhail Furman, Maria Martinez, Vanessa Casares, Maria Pilar Gracia Arnillas, Rosana Munoz Bermudez, Alejandro Ubeda, Maria Salgado, Emilio Maseda, Alejandro Suarez De La Rica, Miguel Angel Blasco-Navalpotro, Alberto Orejas Gallego, Josef Prazak, JL Pagani, S Abed-Maillard, Arzu Topeli Iskit, Selcuk Mehtap, Solakoğlu Ceyhun, Ayşe Kaya Kalem, Ibrahim Kurt, Murat Telli, Barcin Ozturk, Nurcan Baykam, Ridvan Karaali, Iftihar Koksal, Yeliz Bilir, Seda Guzeldag, Gulden Ersoz, Guliz Evik, Yasar Bayindir, Yasemin Ersoy, Ari Ercole, Ashok Raj, Artemis Zormpa, George Tinaslanidis, Reena Khade, Ashraf Roshdy, Santhana Kannan, Supriya Antrolikar, Nicholas Marsden, Ben Attwood, Jamie Patel, Mohan Gurjar, Carol Dsilva, Jagadish Chandran, Bashir El Sanousi, Elfayadh Saidahmed, Hytham KS Hamid
Oct 18, 2022
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