Search
Results: 117
Predicting Student Performance to Improve Academic Advising Using the Random Forest Algorithm
The Covid-19 pandemic constrained higher education institutions to switch to online teaching, which led to major changes in students’ learning behavior, affecting their overall performance. Thus, students’ academic performance...
Published by: IGI Global Scientific Publishing
MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints.
Andrea Vergallo, Simone Lista, Yuhai Zhao, Pablo Lemercier, Stefan J Teipel, Marie-Claude Potier, Marie-Odile Habert, Bruno Dubois, Walter J Lukiw, Harald Hampel, INSIGHT-preAD study group, Alzheimer Precision Medicine Initiative (APMI)
Jan 27, 2021
There is substantial experimental evidence for dysregulation of several microRNA (miRNA) expression levels in Alzheimer's disease (AD). MiRNAs modulate critical brain intracellular signaling pathways and are associated with AD...
Genome-Wide Decoding of mRNP and miRNA Maps
Sung Wook Chi
Jan 01, 0001
The limited number of primary transcripts in the genome has promoted interest in the possibility that much of the complexity in the regulation of gene expression may be determined by RNA regulation controlled by RNA-binding...
RNA complexity RNA regulation study mRNP maps miRNA maps HITS-CLIP Nova-RNA interactions Life Sciences
Published by: Rockefeller University
A Network Approach to Understanding miRNA Regulation in Adipose Tissue
Sean O'Connor
Jan 01, 0001
Adipose tissue is a complex organ that is essential for lipid storage and energy homeostasis in mammals. While transcription factors that govern adipogenesis, inflammation, non-shivering thermogenesis, and endocrine function in...
Published by: Rockefeller University
Small RNA Sequencing
Identifying microRNA (miRNA) signatures in animal tissues is an essential first step in studies assessing post-transcriptional regulation of gene expression in health or disease. Small RNA sequencing (sRNA-Seq) is a...
Adverse Intrauterine Environment and Cardiac miRNA Expression.
Placental insufficiency, high altitude pregnancies, maternal obesity/diabetes, maternal undernutrition and stress can result in a poor setting for growth of the developing fetus. These adverse intrauterine environments result in...
Distinct roles of Argonaute in the green alga Chlamydomonas reveal evolutionary conserved mode of miRNA-mediated gene expression.
Betty Y-W Chung, Adrian Valli, Michael J Deery, Francisco J Navarro, Katherine Brown, Silvia Hnatova, Julie Howard, Attila Molnar, David C Baulcombe
Jul 16, 2019
The unicellular green alga Chlamydomonas reinhardtii is evolutionarily divergent from higher plants, but has a fully functional silencing machinery including microRNA (miRNA)-mediated translation repression and mRNA turnover....
Impact of circulating microRNA test (miRNA-371a-3p) on appropriateness of treatment and cost outcomes in patients with Stage I non-seminomatous germ cell tumours.
Aditya Bagrodia, Anna Savelyeva, John T Lafin, Ryan W Speir, Gregory T Chesnut, Anne Lindsay Frazier, Solomon L Woldu, Vitaly Margulis, Matthew J Murray, James F Amatruda, Yair Lotan
Nov 09, 2020
OBJECTIVES: To determine whether utilisation of a serum microRNA (miRNA) test could improve treatment appropriateness and cost-effectiveness for patients with Stage I non-seminomatous germ cell tumours (NSGCTs). PATIENTS AND...
Distinct roles of Argonaute in the green alga Chlamydomonas reveal evolutionary conserved mode of miRNA-mediated gene expression
Betty Y.-W. Chung, Adrian Valli, Michael J. Deery, Francisco J. Navarro, Katherine Brown, Silvia Hnatova, Julie Howard, Attila Molnar, David C. Baulcombe
Jul 30, 2020
Abstract: The unicellular green alga Chlamydomonas reinhardtii is evolutionarily divergent from higher plants, but has a fully functional silencing machinery including microRNA (miRNA)-mediated translation repression and mRNA...
A novel DCL2-dependent miRNA pathway in tomato affects susceptibility to RNA viruses.
Zhengming Wang, Thomas J Hardcastle, Alex Canto Pastor, Wing Hin Yip, Shuoya Tang, David C Baulcombe
Nov 13, 2018
Tomato Dicer-like2 (slDCL2) is a key component of resistance pathways against potato virus X (PVX) and tobacco mosaic virus (TMV). It is also required for production of endogenous small RNAs, including miR6026 and other...
Pulsed SILAC as a Approach for miRNA Targets Identification in Cell Culture.
Daniella E Duque-Guimarães, Juliana de Almeida-Faria, Thomas Prates Ong, Susan E Ozanne
Jul 12, 2018
Pulsed stable isotope labeling by amino acids in cell culture (pSILAC) comprises a variation of the classical SILAC proteomic methodology that enables the identification of short-term proteomic responses such as those elicited...
An Orphan CpG Island Drives Expression of a let-7 miRNA Precursor with an Important Role in Mouse Development.
Martha V Koerner, Kashyap Chhatbar, Shaun Webb, Justyna Cholewa-Waclaw, Jim Selfridge, Dina De Sousa, Bill Skarnes, Barry Rosen, Mark Thomas, Joanna Bottomley, Ramiro Ramires-Solis, Christopher Lelliott, David J Adams, Adrian Bird
Feb 08, 2021
Most human genes are associated with promoters embedded in non-methylated, G + C-rich CpG islands (CGIs). Not all CGIs are found at annotated promoters, however, raising the possibility that many serve as promoters for...
Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring.
Laís Vales Mennitti, Asha AM Carpenter, Elena Loche, Lucas C Pantaleão, Denise S Fernandez-Twinn, Josca M Schoonejans, Heather L Blackmore, Thomas J Ashmore, Luciana Pellegrini Pisani, John A Tadross, Iain Hargreaves, Susan E Ozanne
Jan 28, 2022
OBJECTIVE: This study investigated the effect of maternal obesity on aged-male offspring liver phenotype and hepatic expression of a programmed miRNA. METHODS: A mouse model (C57BL/6 J) of maternal diet-induced obesity was used...
miRBase
miRBase is the central online repository for microRNA (miRNA) nomenclature, sequence data, annotation and target prediction. The current release (10.0) contains 5071 miRNA loci from 58 species, expressing 5922 distinct mature...
A resource of vectors and ES cells for targeted deletion of microRNAs in mice.
The 21-23 nucleotide, single-stranded RNAs classified as microRNAs (miRNA) perform fundamental roles in diverse cellular and developmental processes. In contrast to the situation for protein-coding genes, no public resource of...
Regulation of microRNA during cardiomyocyte maturation in sheep.
Janna L Morrison, Song Zhang, Ross L Tellam, Doug A Brooks, I Caroline McMillen, Enzo R Porrello, Kimberley J Botting
Sep 29, 2016
BACKGROUND: There is a limited capacity to repair damage in the mammalian heart after birth, which is primarily due to the inability of cardiomyocytes to proliferate after birth. This is in contrast to zebrafish and salamander...
Circulating microRNA as a Biomarker for Coronary Artery Disease.
Ibrahim T Fazmin, Zakaria Achercouk, Charlotte E Edling, Asri Said, Kamalan Jeevaratnam
Sep 24, 2020
Coronary artery disease (CAD) is the leading cause of sudden cardiac death in adults, and new methods of predicting disease and risk-stratifying patients will help guide intervention in order to reduce this burden. Current CAD...
Large-scale analysis of microRNA expression, epi-transcriptomic features and biogenesis.
MicroRNAs are important genetic regulators in both animals and plants. They have a range of functions spanning development, differentiation, growth, metabolism and disease. The advent of next-generation sequencing technologies...
A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach.
Niamh Errington, James Iremonger, Josephine A Pickworth, Sokratis Kariotis, Christopher J Rhodes, Alexander MK Rothman, Robin Condliffe, Charles A Elliot, David G Kiely, Luke S Howard, John Wharton, AA Roger Thompson, Nicholas W Morrell, Martin R Wilkins, Dennis Wang, Allan Lawrie
Jul 30, 2021
BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare but life shortening disease, the diagnosis of which is often delayed, and requires an invasive right heart catheterisation. Identifying diagnostic biomarkers may...
miRBase
Sam Griffiths-Jones, Russell J Grocock, Stijn van Dongen, Alex Bateman, Anton J Enright
Nov 16, 2017
The miRBase database aims to provide integrated interfaces to comprehensive microRNA sequence data, annotation and predicted gene targets. miRBase takes over functionality from the microRNA Registry and fulfils three main roles...
Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis.
Henry J Taylor, Yu-Han Hung, Narisu Narisu, Michael R Erdos, Matthew Kanke, Tingfen Yan, Caleb M Grenko, Amy J Swift, Lori L Bonnycastle, Praveen Sethupathy, Francis S Collins, D Leland Taylor
Mar 13, 2023
Genetic studies have identified ≥240 loci associated with the risk of type 2 diabetes (T2D), yet most of these loci lie in non-coding regions, masking the underlying molecular mechanisms. Recent studies investigating mRNA...
Estimating mobility using sparse data
Liisa Loog, Marta Mirazón Lahr, Mirna Kovacevic, Andrea Manica, Anders Eriksson, Mark G Thomas
Mar 20, 2018
METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.
Luca Pandolfini, Isaia Barbieri, Andrew J Bannister, Alan Hendrick, Byron Andrews, Natalie Webster, Pierre Murat, Pia Mach, Rossella Brandi, Samuel C Robson, Valentina Migliori, Andrej Alendar, Mara d'Onofrio, Shankar Balasubramanian, Tony Kouzarides
Apr 05, 2019
7-methylguanosine (m7G) is present at mRNA caps and at defined internal positions within tRNAs and rRNAs. However, its detection within low-abundance mRNAs and microRNAs (miRNAs) has been hampered by a lack of sensitive...
7-methylguanosine G-Quadruplexes METTL1 RNA methylation SAM-dependent methyltransferase cell migration high-throughput sequencing let-7 miRNA biogenesis microRNA A549 Cells Base Sequence Biological Assay Caco-2 Cells Cell Movement Cell Proliferation Guanosine HEK293 Cells Humans Methylation Methyltransferases MicroRNAs Nucleic Acid Conformation RNA processing Post-Transcriptional
MicroRNA targets in Drosophila.
BACKGROUND: The recent discoveries of microRNA (miRNA) genes and characterization of the first few target genes regulated by miRNAs in Caenorhabditis elegans and Drosophila melanogaster have set the stage for elucidation of a...
The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity.
Tsui Han Loo, Xiaoqian Ye, Ruth Jinfen Chai, Mitsuteru Ito, Gisèle Bonne, Anne C Ferguson-Smith, Colin L Stewart
Dec 18, 2019
Here we show that a major muscle specific isoform of the murine LINC complex protein SUN1 is required for efficient muscle regeneration. The nucleoplasmic domain of the isoform specifically binds to and inhibits Drosha, a key...
|
|< |
< |
1 |