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Results: 8716
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data.
Alberto Romagnoni, Simon Jégou, Kristel Van Steen, Gilles Wainrib, Jean-Pierre Hugot, International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
Oct 29, 2019
Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent...
Alleles Area Under Curve Crohn Disease Decision Trees Deep learning Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Genotyping Techniques Humans INDEL Mutation Logistic Models Male Models Genetic Neural Networks Computer Nonlinear dynamics Polymorphism Single Nucleotide ROC Curve
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Hailiang Huang, Ming Fang, Luke Jostins, Maša Umićević Mirkov, Gabrielle Boucher, Carl A Anderson, Vibeke Andersen, Isabelle Cleynen, Adrian Cortes, François Crins, Mauro D'Amato, Valérie Deffontaine, Julia Dmitrieva, Elisa Docampo, Mahmoud Elansary, Kyle Kai-How Farh, Andre Franke, Ann-Stephan Gori, Philippe Goyette, Jonas Halfvarson, Talin Haritunians, Jo Knight, Ian C Lawrance, Charlie W Lees, Edouard Louis, Rob Mariman, Theo Meuwissen, Myriam Mni, Yukihide Momozawa, Miles Parkes, Sarah L Spain, Emilie Théâtre, Gosia Trynka, Jack Satsangi, Suzanne van Sommeren, Severine Vermeire, Ramnik J Xavier, International Inflammatory Bowel Disease Genetics Consortium, Rinse K Weersma, Richard H Duerr, Christopher G Mathew, John D Rioux, Dermot PB McGovern, Judy H Cho, Michel Georges, Mark J Daly, Jeffrey C Barrett
Mar 19, 2019
Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect millions of people worldwide. Genome-wide association studies have identified 200 inflammatory bowel disease-associated loci, but few...
Adolescent Adult Aged Aged 80 and over Binding Sites Chromatin Colitis Ulcerative Crohn Disease Epigenesis Genetic Female Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Genotype Humans Inflammatory Bowel Diseases Linkage Disequilibrium Male Middle Aged Quantitative Trait Loci Smad3 Protein Transcription Factors Young Adult
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01
Philippe Goyette, Gabrielle Boucher, Dermot Mallon, Eva Ellinghaus, Luke Jostins, Hailiang Huang, Stephan Ripke, Elena S Gusareva, Vito Annese, Stephen L Hauser, Jorge R Oksenberg, Ingo Thomsen, Stephen Leslie, International Inflammatory Bowel Disease Genetics Consortium, Australia and New Zealand IBDGC, Belgium IBD Genetics Consortium, Italian Group for IBD Genetic Consortium, NIDDK Inflammatory Bowel Disease Genetics Consortium, United Kingdom IBDGC, Wellcome Trust Case Control Consortium, Quebec IBD Genetics Consortium, Mark J Daly, Kristel Van Steen, Richard H Duerr, Jeffrey C Barrett, Dermot PB McGovern, L Philip Schumm, James A Traherne, Mary N Carrington, Vasilis Kosmoliaptsis, Tom H Karlsen, Andre Franke, John D Rioux
Aug 11, 2015
Alleles Chromosome Mapping Colitis Ulcerative Crohn Disease Genetic Linkage Genetic Predisposition to Disease Genome-Wide Association Study Genotype Genotyping Techniques HLA-DRB1 Chains Heterozygote Humans Inflammatory Bowel Diseases Major Histocompatibility Complex Phenotype Polymorphism Single Nucleotide
ImmUniverse Consortium
Stefania Vetrano, Gerben Bouma, Robert J Benschop, Thomas Birngruber, Antonio Costanzo, GRAM D'Haens, Loredana Frasca, Rainer Hillenbrand, Lars Iversen, Claus Johansen, Arthur Kaser, Hans JPM Koenen, Christa Noehammer, Laurent Peyrin-Biroulet, Jeroen Raes, Leonardo Ricotti, Philip Rosenstiel, Venkata P Satagopam, Stefan Schreiber, Severine Vermeire, Andreas Wollenberg, Stephan Weidinger, Daniel Ziemek, Silvio Danese, ImmUniverse Consortium
Jan 04, 2023
Immune mediated inflammatory diseases (IMIDs) are a heterogeneous group of debilitating, multifactorial and unrelated conditions featured by a dysregulated immune response leading to destructive chronic inflammation. The immune...
Treating children with inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gut characterised by alternating periods of remission and relapse. Whilst the mechanism underlying this disease is yet to be fully understood, old and...
Biologic biomarker Crohn’s Disease Immunosuppressant Monitoring Paediatric inflammatory bowel disease Therapy Treatment Ulcerative colitis Age Factors Biological Products Biosimilar Pharmaceuticals Child Clinical Trials as Topic Colitis Ulcerative Crohn Disease Diet Therapy Fecal Microbiota Transplantation Gastrointestinal Microbiome Humans Immunosuppression Therapy Immunosuppressive Agents Treatment Outcome
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
Christel M Middeldorp, Janine F Felix, Anubha Mahajan, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, Early Growth Genetics (EGG) Consortium, Mark I McCarthy
Jul 18, 2019
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as...
NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease.
T Schwerd, RV Bryant, S Pandey, M Capitani, L Meran, J-B Cazier, J Jung, K Mondal, M Parkes, CG Mathew, K Fiedler, DJ McCarthy, WGS500 Consortium, Oxford IBD cohort study investigators, COLORS in IBD group investigators, UK IBD Genetics Consortium, PB Sullivan, A Rodrigues, SPL Travis, C Moore, J Sambrook, WH Ouwehand, DJ Roberts, J Danesh, INTERVAL Study, RK Russell, DC Wilson, JR Kelsen, R Cornall, LA Denson, S Kugathasan, UG Knaus, EG Serra, CA Anderson, RH Duerr, D Pb McGovern, J Cho, F Powrie, V Sw Li, AM Muise, HH Uhlig
Feb 05, 2018
Genetic defects that affect intestinal epithelial barrier function can present with very early-onset inflammatory bowel disease (VEOIBD). Using whole-genome sequencing, a novel hemizygous defect in NOX1 encoding NAPDH oxidase 1...
Animals Child Child Preschool Colon Genes Modifier Genetic Association Studies Genetic Predisposition to Disease Genome Genotype High-Throughput Nucleotide Sequencing Host-Pathogen Interactions Humans Inflammatory Bowel Diseases Male Mice Mice Inbred C57BL Mutation Missense NADPH Oxidase 1 Polymorphism Single Nucleotide Reactive Oxygen Species
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.
Sun-Gou Ji, Brian D Juran, Sören Mucha, Trine Folseraas, Luke Jostins, Espen Melum, Natsuhiko Kumasaka, Elizabeth J Atkinson, Erik M Schlicht, Jimmy Z Liu, Tejas Shah, Javier Gutierrez-Achury, Kirsten M Boberg, Annika Bergquist, Severine Vermeire, Bertus Eksteen, Peter R Durie, Martti Farkkila, Tobias Müller, Christoph Schramm, Martina Sterneck, Tobias J Weismüller, Daniel N Gotthardt, David Ellinghaus, Felix Braun, Andreas Teufel, Mattias Laudes, Wolfgang Lieb, Gunnar Jacobs, Ulrich Beuers, Rinse K Weersma, Cisca Wijmenga, Hanns-Ulrich Marschall, Piotr Milkiewicz, Albert Pares, Kimmo Kontula, Olivier Chazouillères, Pietro Invernizzi, Elizabeth Goode, Kelly Spiess, Carmel Moore, Jennifer Sambrook, Willem H Ouwehand, David J Roberts, John Danesh, Annarosa Floreani, Aliya F Gulamhusein, John E Eaton, Stefan Schreiber, Catalina Coltescu, Christopher L Bowlus, Velimir A Luketic, Joseph A Odin, Kapil B Chopra, Kris V Kowdley, Naga Chalasani, Michael P Manns, Brijesh Srivastava, George Mells, Richard N Sandford, Graeme Alexander, Daniel J Gaffney, Roger W Chapman, Gideon M Hirschfield, Mariza de Andrade, UK-PSC Consortium, International IBD Genetics Consortium, International PSC Study Group, Simon M Rushbrook, Andre Franke, Tom H Karlsen, Konstantinos N Lazaridis, Carl A Anderson
Nov 21, 2017
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study of PSC...
Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease During Remission
Kazuya Takahashi, Iman Geelani Khwaja, Jocelyn Rachel Schreyer, David Bulmer, Madusha Peiris, Shuji Terai, Qasim Aziz
Mar 16, 2023
Patients with inflammatory bowel disease often experience ongoing pain even after achieving mucosal healing (i.e., post-inflammatory pain). Factors related to the brain-gut axis, such as peripheral and central sensitization...
WSES-AAST guidelines
Belinda De Simone, Justin Davies, Elie Chouillard, Salomone Di Saverio, Frank Hoentjen, Antonio Tarasconi, Massimo Sartelli, Walter L Biffl, Luca Ansaloni, Federico Coccolini, Massimo Chiarugi, Nicola de'Angelis, Ernest E Moore, Yoram Kluger, Fikri Abu-Zidan, Boris Sakakushev, Raul Coimbra, Valerio Celentano, Imtiaz Wani, Tadeja Pintar, Gabriele Sganga, Isidoro Di Carlo, Dario Tartaglia, Manos Pikoulis, Maurizio Cardi, Marc A De Moya, Ari Leppaniemi, Andrew Kirkpatrick, Vanni Agnoletti, Gilberto Poggioli, Paolo Carcoforo, Gian Luca Baiocchi, Fausto Catena
Jun 11, 2021
BACKGROUND: Despite the current therapeutic options for the treatment of inflammatory bowel disease, surgery is still frequently required in the emergency setting, although the number of cases performed seems to have decreased...
WSES-AAST guidelines
Belinda De Simone, Justin Davies, Elie Chouillard, Salomone Di Saverio, Frank Hoentjen, Antonio Tarasconi, Massimo Sartelli, Walter L. Biffl, Luca Ansaloni, Federico Coccolini, Massimo Chiarugi, Nicola de’Angelis, Ernest E. Moore, Yoram Kluger, Fikri Abu-Zidan, Boris Sakakushev, Raul Coimbra, Valerio Celentano, Imtiaz Wani, Tadeja Pintar, Gabriele Sganga, Isidoro Di Carlo, Dario Tartaglia, Manos Pikoulis, Maurizio Cardi, Marc A. De Moya, Ari Leppaniemi, Andrew Kirkpatrick, Vanni Agnoletti, Gilberto Poggioli, Paolo Carcoforo, Gian Luca Baiocchi, Fausto Catena
May 11, 2021
Abstract: Background: Despite the current therapeutic options for the treatment of inflammatory bowel disease, surgery is still frequently required in the emergency setting, although the number of cases performed seems to have...
Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease.
Amit V Khera, Hong-Hee Won, Gina M Peloso, Colm O'Dushlaine, Dajiang Liu, Nathan O Stitziel, Pradeep Natarajan, Akihiro Nomura, Connor A Emdin, Namrata Gupta, Ingrid B Borecki, Rosanna Asselta, Stefano Duga, Piera Angelica Merlini, Adolfo Correa, Thorsten Kessler, James G Wilson, Matthew J Bown, Alistair S Hall, Peter S Braund, David J Carey, Michael F Murray, H Lester Kirchner, Joseph B Leader, Daniel R Lavage, J Neil Manus, Dustin N Hartzel, Nilesh J Samani, Heribert Schunkert, Jaume Marrugat, Roberto Elosua, Ruth McPherson, Martin Farrall, Hugh Watkins, Eric S Lander, Daniel J Rader, John Danesh, Diego Ardissino, Stacey Gabriel, Cristen Willer, Gonçalo R Abecasis, Danish Saleheen, Frederick E Dewey, Sekar Kathiresan, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium Myocardial Infarction Genetics Consortium
Jun 25, 2018
IMPORTANCE: The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyceride-rich lipoproteins from the circulation. Mutations that damage the LPL gene (LPL) lead to lifelong deficiency in enzymatic...
Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease
Lauren E. Mokry, Sirui Zhou, Cong Guo, Robert A. Scott, Luke Devey, Claudia Langenberg, Nick Wareham, Dawn Waterworth, Lon Cardon, Philippe Sanseau, George Davey Smith, J. Brent Richards
Jun 27, 2020
Abstract: Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis...
Clinical course and outcomes of diagnosing Inflammatory Bowel Disease in children 10 years and under
Marco Gasparetto, Graziella Guariso, Laura Visona' Dalla Pozza, Alexander Ross, Robert Heuschkel, Matthias Zilbauer
Sep 29, 2016
BACKGROUND: Most children with Inflammatory Bowel Disease (IBD) are diagnosed between 11 and 16 years of age, commonly presenting with features of typical IBD. Children with onset of gut inflammation under 5 years of age often...
Age children Inflammatory Bowel Disease (IBD) Location outcomes Presentation Severity Adalimumab Adolescent Adrenal Cortex Hormones Age of Onset Anti-Bacterial Agents Anti-Inflammatory Agents Case-Control Studies Child Child Preschool Cohort Studies Colitis Ulcerative Crohn Disease Digestive System Surgical Procedures Disease Progression Female Hematocrit Hemoglobins Hospitalization Humans Inflammatory Bowel Diseases Infliximab Italy Leukocyte Count Logistic Models Male Mesalamine Platelet Count Retrospective Studies Severity of Illness Index Tertiary Care Centers United Kingdom
Improving prediction of disease outcome for inflammatory bowel disease
Introduction: Inflammatory bowel diseases (IBDs) are lifelong conditions causing relapsing inflammation of the intestine. In the absence of a cure, clinical management of IBDs is extremely challenging since they present with a...
Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease
Lauren E Mokry, Sirui Zhou, Cong Guo, Robert A Scott, Luke Devey, Claudia Langenberg, Nick Wareham, Dawn Waterworth, Lon Cardon, Philippe Sanseau, George Davey Smith, J Brent Richards
Jul 23, 2019
Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis is due to...
Alleles Anti-Inflammatory Agents Non-Steroidal Biomarkers Drug Repositioning Genetic Predisposition to Disease Humans Inflammatory Bowel Diseases Interleukin-18 Mendelian Randomization Analysis Odds Ratio Polymorphism Single Nucleotide Receptors Interleukin-18 Severity of Illness Index Treatment Outcome
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01
Philippe Goyette, Gabrielle Boucher, Mallon Dermot, Eva Ellinghaus, Luke Jostins, Hailiang Huang, Stephan Ripke, Elena S Gusareva, Vito Annese, Stephen L Hauser, Jorge R Oksenberg, Ingo Thomsen, Stephen Leslie, Inflammatory Bowel Disease Genetics Consortium International, Mark J Daly, Steen Kristel van, Richard H Duerr, Jeffrey C Barrett, Dermot PB McGovern, L Philip Schumm, James Traherne, Mary N Carrington, Vasilis Kosmoliaptsis, Tom H Karlsen, Andre Franke, John D Rioux
Feb 12, 2015
Mucosal IgG in inflammatory bowel disease - a question of (sub)class?
Immunoglobulins (Igs) form a cornerstone of mucosal immunity. In the gastrointestinal tract, secretory IgA and IgM bind to commensal microorganisms within the intestinal lumen to prevent them from breaching the intestinal...
Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis
Rachel Charlton, Amelia Green, Gavin Shaddick, Julia Snowball, Alison Nightingale, William Tillett, Catherine Smith, Neil McHugh
Jan 12, 2018
Objectives: To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods: A cohort study using data...
Is IL-6 Back in trans Signaling for Inflammatory Bowel Disease?
Delivering early, robust hints of potential efficacy is one of the most daunting challenges in drug development. No matter how good the theoretical and preclinical rationale, in the end it is only a large-scale ‘experiment in...
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic
Nicholas A Kennedy, Gareth-Rhys Jones, Christopher A Lamb, Richard Appleby, Ian Arnott, R Mark Beattie, Stuart Bloom, Alenka J Brooks, Rachel Cooney, Robin J Dart, Cathryn Edwards, Aileen Fraser, Daniel R Gaya, Subrata Ghosh, Kay Greveson, Richard Hansen, Ailsa Hart, A Barney Hawthorne, Bu'Hussain Hayee, Jimmy K Limdi, Charles D Murray, Gareth C Parkes, Miles Parkes, Kamal Patel, Richard C Pollok, Nick Powell, Chris S Probert, Tim Raine, Shaji Sebastian, Christian Selinger, Philip J Smith, Catherine Stansfield, Lisa Younge, James O Lindsay, Peter M Irving, Charlie W Lees
Apr 30, 2020
The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we have rapidly mobilised inflammatory...
Consensus for genes to be included on cancer panel tests offered by UK genetics services
Amy Taylor, Angela F Brady, Ian M Frayling, Helen Hanson, Marc Tischkowitz, Clare Turnbull, Lucy Side, UK Cancer Genetics Group (UK-CGG)
May 18, 2018
Genetic testing for hereditary cancer predisposition has evolved rapidly in recent years with the discovery of new genes, but there is much debate over the clinical utility of testing genes for which there are currently limited...
Effectiveness and safety of vedolizumab in inflammatory bowel disease patients aged 60 and over
Hajir Ibraheim, Mark A Samaan, Ashish Srinivasan, Oliver Brain, Jonathan Digby-Bell, Peter M Irving, Irena Norman, Issrah Jawad, Julia Biedermann, Ana Ibarra, Klaartje Bel Kok, Gareth Parkes, Joanna Rimmer, Elisabeta Compot, Miles Parkes, Jonathan Segal, Philip Oppong, Ailsa Hart, Bu'Hussain Hayee, Nick Powell
Feb 03, 2021
BACKGROUND: The GEMINI trials established the efficacy of vedolizumab in moderate-to-severe inflammatory bowel disease (IBD) and demonstrated a favorable safety profile, suggesting it may be advantageous in older patients at...
Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis
Rachel Charlton, Amelia Green, Gavin Shaddick, Julia Snowball, Alison Nightingale, William Tillett, Catherine Smith, Neil McHugh
Jan 12, 2018
Objectives: To determine the risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis. Methods: A cohort study using data...
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic.
Nicholas A Kennedy, Gareth-Rhys Jones, Christopher A Lamb, Richard Appleby, Ian Arnott, R Mark Beattie, Stuart Bloom, Alenka J Brooks, Rachel Cooney, Robin J Dart, Cathryn Edwards, Aileen Fraser, Daniel R Gaya, Subrata Ghosh, Kay Greveson, Richard Hansen, Ailsa Hart, A Barney Hawthorne, Bu'Hussain Hayee, Jimmy K Limdi, Charles D Murray, Gareth C Parkes, Miles Parkes, Kamal Patel, Richard C Pollok, Nick Powell, Chris S Probert, Tim Raine, Shaji Sebastian, Christian Selinger, Philip J Smith, Catherine Stansfield, Lisa Younge, James O Lindsay, Peter M Irving, Charlie W Lees
Jun 26, 2020
The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we have rapidly mobilised inflammatory...
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