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Business Benefits through Company IT Standardization
Many companies have embarked on IT standardization initiatives with specific benefits in mind, but some projects fail dramatically whereas others are very successful. Our research suggests that successful standardization...
Published by: IGI Global Scientific Publishing
Sex- and sub region-dependent modulation of arcuate kisspeptin neurones by vasopressin and vasoactive intestinal peptide.
Using a Network-Based Analysis Approach to Investigate the Involvement of S. aureus in the Pathogenesis of Granulomatosis with Polyangiitis.
Gregory Rowland, Andreas Kronbichler, Rona Smith, David Jayne, Piet H van der Graaf, Vijayalakshmi Chelliah
Feb 03, 2023
ANCA associated vasculitis Staphylococcus aureus biological processes disease network Granulomatosis with polyangiitis molecular signatures network-based analysis Humans Granulomatosis with polyangiitis Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus Antibodies Antineutrophil Cytoplasmic Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Myeloblastin Staphylococcal Infections Nose Diseases
Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution.
Camille Samson, Pierre Legrand, Mustafa Tekpinar, Jef Rozenski, Mikhail Abramov, Philipp Holliger, Vitor B Pinheiro, Piet Herdewijn, Marc Delarue
Dec 10, 2020
Archaeal DNA polymerases from the B-family (polB) have found essential applications in biotechnology. In addition, some of their variants can accept a wide range of modified nucleotides or xenobiotic nucleotides, such as...
DNA polymerase Crystallography protein expression and purification structural biology xeno-nucleic acid (XNA) Archaeal Proteins Binding Sites Cloning Molecular Crystallography X-Ray DNA Polymerase beta DNA Archaeal Directed Molecular Evolution Escherichia coli Gene Expression Genetic Vectors Hexosephosphates Kinetics Molecular Dynamics Simulation Mutation Nucleic Acid Conformation Nucleotides Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Engineering Protein Interaction Domains and Motifs RNA Archaeal Substrate Specificity Thermococcus
Using a Network-Based Analysis Approach to Investigate the Involvement of <i>S. aureus</i> in the Pathogenesis of Granulomatosis with Polyangiitis.
Gregory Rowland, Andreas Kronbichler, Rona Smith, David Jayne, Piet H van der Graaf, Vijayalakshmi Chelliah
Mar 14, 2023
Chronic nasal carriage of Staphylococcus aureus (SA) has been shown to be significantly higher in GPA patients when compared to healthy subjects, as well as being associated with increased endonasal activity and disease...
Staphylococcus aureus molecular signatures biological processes Granulomatosis with polyangiitis ANCA associated vasculitis network-based analysis disease network Humans Staphylococcal Infections Nose Diseases Antibodies Antineutrophil Cytoplasmic Myeloblastin Methicillin-Resistant Staphylococcus aureus Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Granulomatosis with polyangiitis
Published by: International journal of molecular sciences
Rehabilitation after traumatic brain injury
Maryse C Cnossen, Hester F Lingsma, Olli Tenovuo, Andrew IR Maas, David Menon, Ewout W Steyerberg, Gerard M Ribbers, Suzanne Polinder
Jun 25, 2018
OBJECTIVE: To describe variation in structural and process characteristics of acute in-hospital rehabilitation and referral to post-acute care for patients with traumatic brain injury across Europe. DESIGN: Survey study, of...
Female sexual behavior in mice is controlled by kisspeptin neurons.
Vincent Hellier, Olivier Brock, Michael Candlish, Elodie Desroziers, Mari Aoki, Christian Mayer, Richard Piet, Allan Herbison, William Henry Colledge, Vincent Prévot, Ulrich Boehm, Julie Bakker
Sep 08, 2018
Sexual behavior is essential for the survival of many species. In female rodents, mate preference and copulatory behavior depend on pheromones and are synchronized with ovulation to ensure reproductive success. The neural...
Definition of the hypothalamic GnRH pulse generator in mice.
Jenny Clarkson, Su Young Han, Richard Piet, Timothy McLennan, Grace M Kane, Jamie Ng, Robert W Porteous, Joon S Kim, William H Colledge, Karl J Iremonger, Allan E Herbison
Jun 18, 2018
The pulsatile release of luteinizing hormone (LH) is critical for mammalian fertility. However, despite several decades of investigation, the identity of the neuronal network generating pulsatile reproductive hormone secretion...
GnRH arcuate nucleus Fertility Kisspeptin pulse Action Potentials Animals Arcuate Nucleus of Hypothalamus Female Gonadotropin-Releasing Hormone Kisspeptins Luteinizing Hormone Male Mice Mice Inbred C57BL Mice Transgenic Nerve Net Neurons optogenetics Periodicity Photometry Voltage-Sensitive Dye Imaging
Predicting time-resolved electrophysiological brain networks from structural eigenmodes.
Prejaas Tewarie, Bastian Prasse, Jil Meier, Kanad Mandke, Shaun Warrington, Cornelis J Stam, Matthew J Brookes, Piet Van Mieghem, Stamatios N Sotiropoulos, Arjan Hillebrand
Jun 07, 2022
How temporal modulations in functional interactions are shaped by the underlying anatomical connections remains an open question. Here, we analyse the role of structural eigenmodes, in the formation and dissolution of temporally...
Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens.
Nomogram predicting the probability of spontaneous stone passage in patients presenting with acute ureteric colic.
Chuanyu Gao, Max Peters, Piet Kurver, Thineskrishna Anbarasan, Keerthanaa Jayaraajan, Todd Manning, Sophia Cashman, Arjun Nambiar, Marcus Cumberbatch, Benjamin W Lamb, Robert Pickard, Paul Erotocritou, Daron Smith, Veeru Kasivisvanathan, Taimur T Shah, BURST Collaborative MIMIC Study Group
Jul 27, 2022
OBJECTIVES: To develop a nomogram that could predict spontaneous stone passage (SSP) in patients presenting with acute ureteric colic who are suitable for conservative management. SUBJECT/PATIENTS: A 2517 patient dataset was...
Femtosecond formation dynamics of the spin Seebeck effect revealed by terahertz spectroscopy.
Tom S Seifert, Samridh Jaiswal, Joseph Barker, Sebastian T Weber, Ilya Razdolski, Joel Cramer, Oliver Gueckstock, Sebastian F Maehrlein, Lukas Nadvornik, Shun Watanabe, Chiara Ciccarelli, Alexey Melnikov, Gerhard Jakob, Markus Münzenberg, Sebastian TB Goennenwein, Georg Woltersdorf, Baerbel Rethfeld, Piet W Brouwer, Martin Wolf, Mathias Kläui, Tobias Kampfrath
Mar 06, 2019
Understanding the transfer of spin angular momentum is essential in modern magnetism research. A model case is the generation of magnons in magnetic insulators by heating an adjacent metal film. Here, we reveal the initial steps...
A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
Nikos Papadimitriou, David Muller, Piet A. van den Brandt, Milan Geybels, Chirag J. Patel, Marc J. Gunter, David S. Lopez, Timothy J. Key, Aurora Perez-Cornago, Pietro Ferrari, Paolo Vineis, Elisabete Weiderpass, Heiner Boeing, Antonio Agudo, María-José Sánchez, Kim Overvad, Tilman Kühn, Renee T. Fortner, Domenico Palli, Isabel Drake, Anders Bjartell, Carmen Santiuste, Bas H. Bueno-de-Mesquita, Vittorio Krogh, Anne Tjønneland, Dorthe Furstrand Lauritzen, Aurelio Barricarte Gurrea, José Ramón Quirós, Pär Stattin, Antonia Trichopoulou, Georgia Martimianaki, Anna Karakatsani, Elin Thysell, Ingegerd Johansson, Fulvio Ricceri, Rosario Tumino, Nerea Larrañaga, Kay Tee Khaw, Elio Riboli, Ioanna Tzoulaki, Konstantinos K. Tsilidis
Sep 18, 2020
A Deep Learning Approach Validates Genetic Risk Factors for Late Toxicity After Prostate Cancer Radiotherapy in a REQUITE Multi-National Cohort
Michela Carlotta Massi, Francesca Gasperoni, Francesca Ieva, Anna Maria Paganoni, Paolo Zunino, Andrea Manzoni, Nicola Rares Franco, Liv Veldeman, Piet Ost, Valérie Fonteyne, Christopher J. Talbot, Tim Rattay, Adam Webb, Paul R. Symonds, Kerstie Johnson, Maarten Lambrecht, Karin Haustermans, Gert De Meerleer, Dirk de Ruysscher, Ben Vanneste, Evert Van Limbergen, Ananya Choudhury, Rebecca M. Elliott, Elena Sperk, Carsten Herskind, Marlon R. Veldwijk, Barbara Avuzzi, Tommaso Giandini, Riccardo Valdagni, Alessandro Cicchetti, David Azria, Marie-Pierre Farcy Jacquet, Barry S. Rosenstein, Richard G. Stock, Kayla Collado, Ana Vega, Miguel Elías Aguado-Barrera, Patricia Calvo, Alison M. Dunning, Laura Fachal, Sarah L. Kerns, Debbie Payne, Jenny Chang-Claude, Petra Seibold, Catharine M. L. West, Tiziana Rancati
Oct 29, 2020
Background: REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to reduce side effects and improve QUalITy of lifE in cancer survivors) is an international prospective cohort study. The purpose of this...
A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study.
Nikos Papadimitriou, David Muller, Piet A van den Brandt, Milan Geybels, Chirag J Patel, Marc J Gunter, David S Lopez, Timothy J Key, Aurora Perez-Cornago, Pietro Ferrari, Paolo Vineis, Elisabete Weiderpass, Heiner Boeing, Antonio Agudo, María-José Sánchez, Kim Overvad, Tilman Kühn, Renee T Fortner, Domenico Palli, Isabel Drake, Anders Bjartell, Carmen Santiuste, Bas H Bueno-de-Mesquita, Vittorio Krogh, Anne Tjønneland, Dorthe Furstrand Lauritzen, Aurelio Barricarte Gurrea, José Ramón Quirós, Pär Stattin, Antonia Trichopoulou, Georgia Martimianaki, Anna Karakatsani, Elin Thysell, Ingegerd Johansson, Fulvio Ricceri, Rosario Tumino, Nerea Larrañaga, Kay Tee Khaw, Elio Riboli, Ioanna Tzoulaki, Konstantinos K Tsilidis
Nov 09, 2020
A Deep Learning Approach Validates Genetic Risk Factors for Late Toxicity After Prostate Cancer Radiotherapy in a REQUITE Multi-National Cohort.
Michela Carlotta Massi, Francesca Gasperoni, Francesca Ieva, Anna Maria Paganoni, Paolo Zunino, Andrea Manzoni, Nicola Rares Franco, Liv Veldeman, Piet Ost, Valérie Fonteyne, Christopher J Talbot, Tim Rattay, Adam Webb, Paul R Symonds, Kerstie Johnson, Maarten Lambrecht, Karin Haustermans, Gert De Meerleer, Dirk de Ruysscher, Ben Vanneste, Evert Van Limbergen, Ananya Choudhury, Rebecca M Elliott, Elena Sperk, Carsten Herskind, Marlon R Veldwijk, Barbara Avuzzi, Tommaso Giandini, Riccardo Valdagni, Alessandro Cicchetti, David Azria, Marie-Pierre Farcy Jacquet, Barry S Rosenstein, Richard G Stock, Kayla Collado, Ana Vega, Miguel Elías Aguado-Barrera, Patricia Calvo, Alison M Dunning, Laura Fachal, Sarah L Kerns, Debbie Payne, Jenny Chang-Claude, Petra Seibold, Catharine ML West, Tiziana Rancati
Dec 04, 2020
Background: REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to reduce side effects and improve QUalITy of lifE in cancer survivors) is an international prospective cohort study. The purpose of this...
Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score.
Minh-Phuong Huynh-Le, Roshan Karunamuni, Chun Chieh Fan, Lui Asona, Wesley K Thompson, Maria Elena Martinez, Rosalind A Eeles, Zsofia Kote-Jarai, Kenneth R Muir, Artitaya Lophatananon, Johanna Schleutker, Nora Pashayan, Jyotsna Batra, Henrik Grönberg, David E Neal, Børge G Nordestgaard, Catherine M Tangen, Robert J Macinnis, Alicja Wolk, Demetrius Albanes, Christopher A Haiman, Ruth C Travis, William J Blot, Janet L Stanford, Lorelei A Mucci, Catharine ML West, Sune F Nielsen, Adam S Kibel, Olivier Cussenot, Sonja I Berndt, Stella Koutros, Karina Dalsgaard Sørensen, Cezary Cybulski, Eli Marie Grindedal, Florence Menegaux, Jong Y Park, Sue A Ingles, Christiane Maier, Robert J Hamilton, Barry S Rosenstein, Yong-Jie Lu, Stephen Watya, Ana Vega, Manolis Kogevinas, Fredrik Wiklund, Kathryn L Penney, Chad D Huff, Manuel R Teixeira, Luc Multigner, Robin J Leach, Hermann Brenner, Esther M John, Radka Kaneva, Christopher J Logothetis, Susan L Neuhausen, Kim De Ruyck, Piet Ost, Azad Razack, Lisa F Newcomb, Jay H Fowke, Marija Gamulin, Aswin Abraham, Frank Claessens, Jose Esteban Castelao, Paul A Townsend, Dana C Crawford, Gyorgy Petrovics, Ron HN van Schaik, Marie-Élise Parent, Jennifer J Hu, Wei Zheng, UKGPCS collaborators, APCB (Australian Prostate Cancer BioResource), NC-LA PCaP Investigators, IMPACT Study Steering Committee and Collaborators, Canary PASS Investigators, Profile Study Steering Committee, PRACTICAL Consortium, Ian G Mills, Ole A Andreassen, Anders M Dale, Tyler M Seibert
Jan 12, 2023
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.
Tokhir Dadaev, Edward J Saunders, Paul J Newcombe, Ezequiel Anokian, Daniel A Leongamornlert, Mark N Brook, Clara Cieza-Borrella, Martina Mijuskovic, Sarah Wakerell, Ali Amin Al Olama, Fredrick R Schumacher, Sonja I Berndt, Sara Benlloch, Mahbubl Ahmed, Chee Goh, Xin Sheng, Zhuo Zhang, Kenneth Muir, Koveela Govindasami, Artitaya Lophatananon, Victoria L Stevens, Susan M Gapstur, Brian D Carter, Catherine M Tangen, Phyllis Goodman, Ian M Thompson, Jyotsna Batra, Suzanne Chambers, Leire Moya, Judith Clements, Lisa Horvath, Wayne Tilley, Gail Risbridger, Henrik Gronberg, Markus Aly, Tobias Nordström, Paul Pharoah, Nora Pashayan, Johanna Schleutker, Teuvo LJ Tammela, Csilla Sipeky, Anssi Auvinen, Demetrius Albanes, Stephanie Weinstein, Alicja Wolk, Niclas Hakansson, Catharine West, Alison M Dunning, Neil Burnet, Lorelei Mucci, Edward Giovannucci, Gerald Andriole, Olivier Cussenot, Géraldine Cancel-Tassin, Stella Koutros, Laura E Beane Freeman, Karina Dalsgaard Sorensen, Torben Falck Orntoft, Michael Borre, Lovise Mæhle, Eli Marie Grindedal, David E Neal, Jenny L Donovan, Freddie C Hamdy, Richard M Martin, Ruth C Travis, Tim J Key, Robert J Hamilton, Neil E Fleshner, Antonio Finelli, Sue Ann Ingles, Mariana C Stern, Barry Rosenstein, Sarah Kerns, Harry Ostrer, Yong-Jie Lu, Hong-Wei Zhang, Ninghan Feng, Xueying Mao, Xin Guo, Guomin Wang, Zan Sun, Graham G Giles, Melissa C Southey, Robert J Macinnis, Liesel M Fitzgerald, Adam S Kibel, Bettina F Drake, Ana Vega, Antonio Gómez-Caamaño, Laura Fachal, Robert Szulkin, Martin Eklund, Manolis Kogevinas, Javier Llorca, Gemma Castaño-Vinyals, Kathryn L Penney, Meir Stampfer, Jong Y Park, Thomas A Sellers, Hui-Yi Lin, Janet L Stanford, Cezary Cybulski, Dominika Wokolorczyk, Jan Lubinski, Elaine A Ostrander, Milan S Geybels, Børge G Nordestgaard, Sune F Nielsen, Maren Weisher, Rasmus Bisbjerg, Martin Andreas Røder, Peter Iversen, Hermann Brenner, Katarina Cuk, Bernd Holleczek, Christiane Maier, Manuel Luedeke, Thomas Schnoeller, Jeri Kim, Christopher J Logothetis, Esther M John, Manuel R Teixeira, Paula Paulo, Marta Cardoso, Susan L Neuhausen, Linda Steele, Yuan Chun Ding, Kim De Ruyck, Gert De Meerleer, Piet Ost, Azad Razack, Jasmine Lim, Soo-Hwang Teo, Daniel W Lin, Lisa F Newcomb, Davor Lessel, Marija Gamulin, Tomislav Kulis, Radka Kaneva, Nawaid Usmani, Chavdar Slavov, Vanio Mitev, Matthew Parliament, Sandeep Singhal, Frank Claessens, Steven Joniau, Thomas Van den Broeck, Samantha Larkin, Paul A Townsend, Claire Aukim-Hastie, Manuela Gago-Dominguez, Jose Esteban Castelao, Maria Elena Martinez, Monique J Roobol, Guido Jenster, Ron HN van Schaik, Florence Menegaux, Thérèse Truong, Yves Akoli Koudou, Jianfeng Xu, Kay-Tee Khaw, Lisa Cannon-Albright, Hardev Pandha, Agnieszka Michael, Andrzej Kierzek, Stephen N Thibodeau, Shannon K McDonnell, Daniel J Schaid, Sara Lindstrom, Constance Turman, Jing Ma, David J Hunter, Elio Riboli, Afshan Siddiq, Federico Canzian, Laurence N Kolonel, Loic Le Marchand, Robert N Hoover, Mitchell J Machiela, Peter Kraft, PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Matthew Freedman, Fredrik Wiklund, Stephen Chanock, Brian E Henderson, Douglas F Easton, Christopher A Haiman, Rosalind A Eeles, David V Conti, Zsofia Kote-Jarai
Jul 31, 2018
Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection...
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
Fredrick R Schumacher, Ali Amin Al Olama, Sonja I Berndt, Sara Benlloch, Mahbubl Ahmed, Edward J Saunders, Tokhir Dadaev, Daniel Leongamornlert, Ezequiel Anokian, Clara Cieza-Borrella, Chee Goh, Mark N Brook, Xin Sheng, Laura Fachal, Joe Dennis, Jonathan Tyrer, Kenneth Muir, Artitaya Lophatananon, Victoria L Stevens, Susan M Gapstur, Brian D Carter, Catherine M Tangen, Phyllis J Goodman, Ian M Thompson, Jyotsna Batra, Suzanne Chambers, Leire Moya, Judith Clements, Lisa Horvath, Wayne Tilley, Gail P Risbridger, Henrik Gronberg, Markus Aly, Tobias Nordström, Paul Pharoah, Nora Pashayan, Johanna Schleutker, Teuvo LJ Tammela, Csilla Sipeky, Anssi Auvinen, Demetrius Albanes, Stephanie Weinstein, Alicja Wolk, Niclas Håkansson, Catharine ML West, Alison M Dunning, Neil Burnet, Lorelei A Mucci, Edward Giovannucci, Gerald L Andriole, Olivier Cussenot, Géraldine Cancel-Tassin, Stella Koutros, Laura E Beane Freeman, Karina Dalsgaard Sorensen, Torben Falck Orntoft, Michael Borre, Lovise Mæhle, Eli Marie Grindedal, David E Neal, Jenny L Donovan, Freddie C Hamdy, Richard M Martin, Ruth C Travis, Tim J Key, Robert J Hamilton, Neil E Fleshner, Antonio Finelli, Sue Ann Ingles, Mariana C Stern, Barry S Rosenstein, Sarah L Kerns, Harry Ostrer, Yong-Jie Lu, Hong-Wei Zhang, Ninghan Feng, Xueying Mao, Xin Guo, Guomin Wang, Zan Sun, Graham G Giles, Melissa C Southey, Robert J Macinnis, Liesel M Fitzgerald, Adam S Kibel, Bettina F Drake, Ana Vega, Antonio Gómez-Caamaño, Robert Szulkin, Martin Eklund, Manolis Kogevinas, Javier Llorca, Gemma Castaño-Vinyals, Kathryn L Penney, Meir Stampfer, Jong Y Park, Thomas A Sellers, Hui-Yi Lin, Janet L Stanford, Cezary Cybulski, Dominika Wokolorczyk, Jan Lubinski, Elaine A Ostrander, Milan S Geybels, Børge G Nordestgaard, Sune F Nielsen, Maren Weischer, Rasmus Bisbjerg, Martin Andreas Røder, Peter Iversen, Hermann Brenner, Katarina Cuk, Bernd Holleczek, Christiane Maier, Manuel Luedeke, Thomas Schnoeller, Jeri Kim, Christopher J Logothetis, Esther M John, Manuel R Teixeira, Paula Paulo, Marta Cardoso, Susan L Neuhausen, Linda Steele, Yuan Chun Ding, Kim De Ruyck, Gert De Meerleer, Piet Ost, Azad Razack, Jasmine Lim, Soo-Hwang Teo, Daniel W Lin, Lisa F Newcomb, Davor Lessel, Marija Gamulin, Tomislav Kulis, Radka Kaneva, Nawaid Usmani, Sandeep Singhal, Chavdar Slavov, Vanio Mitev, Matthew Parliament, Frank Claessens, Steven Joniau, Thomas Van den Broeck, Samantha Larkin, Paul A Townsend, Claire Aukim-Hastie, Manuela Gago-Dominguez, Jose Esteban Castelao, Maria Elena Martinez, Monique J Roobol, Guido Jenster, Ron HN van Schaik, Florence Menegaux, Thérèse Truong, Yves Akoli Koudou, Jianfeng Xu, Kay-Tee Khaw, Lisa Cannon-Albright, Hardev Pandha, Agnieszka Michael, Stephen N Thibodeau, Shannon K McDonnell, Daniel J Schaid, Sara Lindstrom, Constance Turman, Jing Ma, David J Hunter, Elio Riboli, Afshan Siddiq, Federico Canzian, Laurence N Kolonel, Loic Le Marchand, Robert N Hoover, Mitchell J Machiela, Zuxi Cui, Peter Kraft, Christopher I Amos, David V Conti, Douglas F Easton, Fredrik Wiklund, Stephen J Chanock, Brian E Henderson, Zsofia Kote-Jarai, Christopher A Haiman, Rosalind A Eeles, Profile Study, Australian Prostate Cancer BioResource (APCB), IMPACT Study, Canary PASS Investigators, Breast and Prostate Cancer Cohort Consortium (BPC3), PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Cancer of the Prostate in Sweden (CAPS), Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS), Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium
Feb 12, 2018
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa...
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
David V Conti, Burcu F Darst, Lilit C Moss, Edward J Saunders, Xin Sheng, Alisha Chou, Fredrick R Schumacher, Ali Amin Al Olama, Sara Benlloch, Tokhir Dadaev, Mark N Brook, Ali Sahimi, Thomas J Hoffmann, Atushi Takahashi, Koichi Matsuda, Yukihide Momozawa, Masashi Fujita, Kenneth Muir, Artitaya Lophatananon, Peggy Wan, Loic Le Marchand, Lynne R Wilkens, Victoria L Stevens, Susan M Gapstur, Brian D Carter, Johanna Schleutker, Teuvo LJ Tammela, Csilla Sipeky, Anssi Auvinen, Graham G Giles, Melissa C Southey, Robert J Macinnis, Cezary Cybulski, Dominika Wokołorczyk, Jan Lubiński, David E Neal, Jenny L Donovan, Freddie C Hamdy, Richard M Martin, Børge G Nordestgaard, Sune F Nielsen, Maren Weischer, Stig E Bojesen, Martin Andreas Røder, Peter Iversen, Jyotsna Batra, Suzanne Chambers, Leire Moya, Lisa Horvath, Judith A Clements, Wayne Tilley, Gail P Risbridger, Henrik Gronberg, Markus Aly, Robert Szulkin, Martin Eklund, Tobias Nordström, Nora Pashayan, Alison M Dunning, Maya Ghoussaini, Ruth C Travis, Tim J Key, Elio Riboli, Jong Y Park, Thomas A Sellers, Hui-Yi Lin, Demetrius Albanes, Stephanie J Weinstein, Lorelei A Mucci, Edward Giovannucci, Sara Lindstrom, Peter Kraft, David J Hunter, Kathryn L Penney, Constance Turman, Catherine M Tangen, Phyllis J Goodman, Ian M Thompson, Robert J Hamilton, Neil E Fleshner, Antonio Finelli, Marie-Élise Parent, Janet L Stanford, Elaine A Ostrander, Milan S Geybels, Stella Koutros, Laura E Beane Freeman, Meir Stampfer, Alicja Wolk, Niclas Håkansson, Gerald L Andriole, Robert N Hoover, Mitchell J Machiela, Karina Dalsgaard Sørensen, Michael Borre, William J Blot, Wei Zheng, Edward D Yeboah, James E Mensah, Yong-Jie Lu, Hong-Wei Zhang, Ninghan Feng, Xueying Mao, Yudong Wu, Shan-Chao Zhao, Zan Sun, Stephen N Thibodeau, Shannon K McDonnell, Daniel J Schaid, Catharine ML West, Neil Burnet, Gill Barnett, Christiane Maier, Thomas Schnoeller, Manuel Luedeke, Adam S Kibel, Bettina F Drake, Olivier Cussenot, Géraldine Cancel-Tassin, Florence Menegaux, Thérèse Truong, Yves Akoli Koudou, Esther M John, Eli Marie Grindedal, Lovise Mæhle, Kay-Tee Khaw, Sue A Ingles, Mariana C Stern, Ana Vega, Antonio Gómez-Caamaño, Laura Fachal, Barry S Rosenstein, Sarah L Kerns, Harry Ostrer, Manuel R Teixeira, Paula Paulo, Andreia Brandão, Stephen Watya, Alexander Lubwama, Jeannette T Bensen, Elizabeth TH Fontham, James Mohler, Jack A Taylor, Manolis Kogevinas, Javier Llorca, Gemma Castaño-Vinyals, Lisa Cannon-Albright, Craig C Teerlink, Chad D Huff, Sara S Strom, Luc Multigner, Pascal Blanchet, Laurent Brureau, Radka Kaneva, Chavdar Slavov, Vanio Mitev, Robin J Leach, Brandi Weaver, Hermann Brenner, Katarina Cuk, Bernd Holleczek, Kai-Uwe Saum, Eric A Klein, Ann W Hsing, Rick A Kittles, Adam B Murphy, Christopher J Logothetis, Jeri Kim, Susan L Neuhausen, Linda Steele, Yuan Chun Ding, William B Isaacs, Barbara Nemesure, Anselm Jm Hennis, John Carpten, Hardev Pandha, Agnieszka Michael, Kim De Ruyck, Gert De Meerleer, Piet Ost, Jianfeng Xu, Azad Razack, Jasmine Lim, Soo-Hwang Teo, Lisa F Newcomb, Daniel W Lin, Jay H Fowke, Christine Neslund-Dudas, Benjamin A Rybicki, Marija Gamulin, Davor Lessel, Tomislav Kulis, Nawaid Usmani, Sandeep Singhal, Matthew Parliament, Frank Claessens, Steven Joniau, Thomas Van den Broeck, Manuela Gago-Dominguez, Jose Esteban Castelao, Maria Elena Martinez, Samantha Larkin, Paul A Townsend, Claire Aukim-Hastie, William S Bush, Melinda C Aldrich, Dana C Crawford, Shiv Srivastava, Jennifer C Cullen, Gyorgy Petrovics, Graham Casey, Monique J Roobol, Guido Jenster, Ron HN van Schaik, Jennifer J Hu, Maureen Sanderson, Rohit Varma, Roberta McKean-Cowdin, Mina Torres, Nicholas Mancuso, Sonja I Berndt, Stephen K Van Den Eeden, Douglas F Easton, Stephen J Chanock, Michael B Cook, Fredrik Wiklund, Hidewaki Nakagawa, John S Witte, Rosalind A Eeles, Zsofia Kote-Jarai, Christopher A Haiman
Dec 01, 2020
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases...