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Moodle Learning System as an Effective Tool for Implementing the Innovation Policy of the University
The current study examines Moodle learning management system as an effective tool for implementing the innovation policy of the university. For this, the following methods are employed: (1) monitoring of the Best Global...
Published by: IGI Global Scientific Publishing
The Role of Social Networks in the Development of Skills of Professional Communication
The purpose of the present study was to investigate the role of social networks in the formation of professional communication skills. With this aim in view, a number of training approaches initially used in class were adapted...
Published by: IGI Global Scientific Publishing
Ca2+ Release by IP3 Receptors Is Required to Orient the Mitotic Spindle.
The mitotic spindle distributes chromosomes evenly to daughter cells during mitosis. The orientation of the spindle, guided by internal and external cues, determines the axis of cell division and thereby contributes to tissue...
Bend-strength of novel filament wound shear reinforcement
The winding of Fibre Reinforced Polymer (FRP) tows around longitudinal reinforcing bars provides a novel method for the fabrication of reinforcement cages. Complex geometries of internal reinforcement can be fabricated using...
PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1
Rimma Belotserkovskaya, Elisenda Raga Gil, Nicola Lawrence, Richard Butler, Gillian Clifford, Marcus D. Wilson, Stephen P. Jackson
Feb 09, 2021
Abstract: Loss of functional BRCA1 protein leads to defects in DNA double-strand break (DSB) repair by homologous recombination (HR) and renders cells hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors used to...
PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1.
Rimma Belotserkovskaya, Elisenda Raga Gil, Nicola Lawrence, Richard Butler, Gillian Clifford, Marcus D Wilson, Stephen P Jackson
Jan 20, 2020
Loss of functional BRCA1 protein leads to defects in DNA double-strand break (DSB) repair by homologous recombination (HR) and renders cells hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors used to treat...
Challenges and Opportunities for the Large-Scale Chemoenzymatic Glycoengineering of Therapeutic N-Glycosylated Monoclonal Antibodies
Variability in the glycosylation profile of therapeutic monoclonal antibodies (mAbs), due to recombinant production technologies, leads to inconsistencies in effector functions and pharmacokinetic properties, both...
Bend-strength of novel filament wound shear reinforcement
The winding of Fibre Reinforced Polymer (FRP) tows around longitudinal reinforcing bars provides a novel method for the fabrication of reinforcement cages. Complex geometries of internal reinforcement can be fabricated using...
MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance.
Israel Salguero, Rimma Belotserkovskaya, Julia Coates, Matylda Sczaniecka-Clift, Mukerrem Demir, Satpal Jhujh, Marcus D Wilson, Stephen P Jackson
Dec 16, 2019
Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to promote the...
The discovery and maturation of peptide biologics targeting the small G protein Cdc42
George JN Tetley, Natasha P Murphy, Stephane Bonetto, Gabriela Ivanova-Berndt, Jefferson Revell, Helen R Mott, R Neil Cooley, Darerca Owen
Jan 23, 2020
Cdc42 GTPase Kras (KRAS) biologics Cancer cancer therapeutics cell migration Cell Proliferation Cell Signaling cyclic peptide Drug Discovery Nuclear Magnetic Resonance (NMR) peptide conformation Binding Sites Cell Movement Cell Proliferation Cell-Penetrating Peptides Drug Discovery GTP Phosphohydrolases Humans Molecular Structure Neoplasm Invasiveness Neoplasms Peptides Cyclic Signal Transduction cdc42 GTP-Binding Protein ras Proteins
MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
Israel Salguero, Rimma Belotserkovskaya, Julia Coates, Matylda Sczaniecka-Clift, Mukerrem Demir, Satpal Jhujh, Marcus D. Wilson, Stephen P. Jackson
Nov 14, 2020
Abstract: Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to...
LPS-treatment of bovine endometrial epithelial cells causes differential DNA methylation of genes associated with inflammation and endometrial function.
Naveed Jhamat, Adnan Niazi, Yongzhi Guo, Metasu Chanrot, Elena Ivanova, Gavin Kelsey, Erik Bongcam-Rudloff, Göran Andersson, Patrice Humblot
Jun 04, 2021
BACKGROUND: Lipopolysaccharide (LPS) endotoxin stimulates pro-inflammatory pathways and is a key player in the pathological mechanisms involved in the development of endometritis. This study aimed to investigate LPS-induced DNA...
Bovine endometrial epithelial cells Endometritis Implantation Inflammation LPS RRBS Animals Cattle Cells Cultured DNA Methylation Dose-Response Relationship Drug Endometrium Female Gene Expression Profiling Gene Expression Regulation Gene Ontology Gene Regulatory Networks Lipopolysaccharides Promoter Regions Genetic Sequence Analysis DNA
Defective germline reprogramming rewires the spermatogonial transcriptome.
Lina Vasiliauskaitė, Rebecca V Berrens, Ivayla Ivanova, Claudia Carrieri, Wolf Reik, Anton J Enright, Dónal O'Carroll
Dec 18, 2018
Defective germline reprogramming in Piwil4 (Miwi2)- and Dnmt3l-deficient mice results in the failure to reestablish transposon silencing, meiotic arrest and progressive loss of spermatogonia. Here we sought to understand the...
Culture Medium and Sex Drive Epigenetic Reprogramming in Preimplantation Bovine Embryos.
Sebastian Canovas, Elena Ivanova, Meriem Hamdi, Fernando Perez-Sanz, Dimitrios Rizos, Gavin Kelsey, Pilar Coy
Sep 01, 2021
Assisted reproductive technologies impact transcriptome and epigenome of embryos and can result in long-term phenotypic consequences. Whole-genome DNA methylation profiles from individual bovine blastocysts in vivo- and in...
DNA Methylation bovine Embryo epigenetic preimplantation Sexual dimorphism Animals Blastocyst Cattle Cellular Reprogramming Chromosomes Mammalian CpG Islands Culture Media DNA Methylation Epigenesis Genetic Female Fertilization in Vitro Gene Ontology Logistic Models Male Molecular Sequence Annotation principal component analysis Sex Characteristics
Genome-wide assessment of DNA methylation alterations induced by superovulation, sexual immaturity and in vitro follicle growth in mouse blastocysts.
Laura Saucedo-Cuevas, Elena Ivanova, Anamaria-Cristina Herta, Felix Krueger, Katy Billooye, Johan Smitz, Gavin Kelsey, Ellen Anckaert
Feb 17, 2023
BACKGROUND: In their attempt to fulfill the wish of having children, women who suffer from fertility issues often undergo assisted reproductive technologies such as ovarian stimulation, which has been associated with adverse...
Co‐Assembly of Cellulose Nanocrystals and Silk Fibroin into Photonic Cholesteric Films
Abstract: Controlled self‐assembly of bio‐sourced nanocolloids is of high importance for the development of sustainable and low‐cost functional materials but controlling nanocomposite fabrication with both satisfactory optical...
RESEARCH ARTICLE RESEARCH ARTICLES cellulose nanocrystals cholesteric co‐assembly colloidal liquid crystals silk fibroin structural colors
Published by: Advanced Sustainable Systems
Comparing oncology clinical programs by use of innovative designs and expected net present value optimization
Tom Parke, Olga Marchenko, Vladimir Anisimov, Anastasia Ivanova, Christopher Jennison, Inna Perevozskaya, Guochen Song
Jan 01, 0001
Designing an oncology clinical program is more challenging than designing a single study. The standard approaches have been proven to be not very successful during the last decade; the failure rate of Phase 2 and Phase 3...
Effect of Superovulation Treatment on Oocyte's DNA Methylation.
Controlled ovarian stimulation is a necessary step in some assisted reproductive procedures allowing a higher collection of female gametes. However, consequences of this stimulation for the gamete or the offspring have been...
Comparing oncology clinical programs by use of innovative designs and expected net present value optimization
Tom Parke, Olga Marchenko, Vladimir Anisimov, Anastasia Ivanova, Christopher Jennison, Inna Perevozskaya, Guochen Song
Jan 01, 0001
Designing an oncology clinical program is more challenging than designing a single study. The standard approaches have been proven to be not very successful during the last decade; the failure rate of Phase 2 and Phase 3...
DNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition.
The nutritional environment in which the mammalian fetus or infant develop is recognized as influencing the risk of chronic diseases, such as type 2 diabetes and hypertension, in a phenomenon that has become known as...
Insights into herpesvirus assembly from the structure of the pUL7
Benjamin G Butt, Danielle J Owen, Cy M Jeffries, Lyudmila Ivanova, Chris H Hill, Jack W Houghton, Md Firoz Ahmed, Robin Antrobus, Dmitri I Svergun, John J Welch, Colin M Crump, Stephen C Graham
May 11, 2020
focal adhesions human cytomegalovirus (HCMV) infectious disease microbiology molecular biophysics secondary envelopment small-angle X-ray scattering (SAXS) structural biology Virus virus budding HEK293 Cells HeLa Cells Herpes Simplex Herpesvirus 1 Human Humans Models Molecular Phosphoproteins Protein Binding Protein Interaction Domains and Motifs Protein Structure Quaternary Protein Structure Tertiary Viral Matrix Proteins Viral Proteins Virus Assembly Virus Replication trans-Golgi Network
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