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Analyzing Evolution Patterns of Object-Oriented Metrics
Software evolution is mandatory to keep it useful and functional. However, the quality of the evolving software may degrade due to improper incorporation of changes. Quality can be monitored by analyzing the trends of software...
Published by: IGI Global Scientific Publishing
A Text Mining Framework for Analyzing Change Impact and Maintenance Effort of Software Bug Reports
Software practitioners often strive to achieve a “bug-free” software, though, it is a myth. Software Bug Categorization (SBC) models, which assigns levels (viz. “low”, “moderate” or “high”) to a software bug aid effective bug...
Published by: IGI Global Scientific Publishing
Pandemic, Perceived Risk, and Cognitive Dissonance as Antecedents to Need for Cognitive Closure
Ruchika Sachdeva
Jan 01, 2022
The purpose of this article is to examine the influence of pandemic, perceived risk, and cognitive dissonance on the need for cognitive closure. A consumer today wants an aversion towards the ambiguity that is created due to...
Published by: IGI Global Scientific Publishing
Crowd Abnormality Detection Using Optical Flow and GLCM-Based Texture Features
Detection of abnormal crowd behavior is one of the important tasks in real-time video surveillance systems for public safety in public places such as subway, shopping malls, sport complexes and various other public gatherings....
Published by: IGI Global Scientific Publishing
The current structural glycome landscape and emerging technologies.
Carbohydrates represent one of the building blocks of life, along with nucleic acids, proteins and lipids. Although glycans are involved in a wide range of processes from embryogenesis to protein trafficking and pathogen...
Resource-Efficient VM Placement in the Cloud Environment Using Improved Particle Swarm Optimization
Fundamentally, a strategy considering the effective utilization of resources results in the better energy efficiency of the system. The aroused interest of users in cloud computing has led to an increased power consumption...
Published by: IGI Global Scientific Publishing
Automated Selection of Web Form Text Field Values Based on Bayesian Inferences
The deep web is comprised of a large corpus of information hidden behind the searchable web interfaces. Accessing content through searchable interfaces is somehow a challenging task. One of the challenges in accessing the deep...
Published by: IGI Global Scientific Publishing
Understanding the impacts of missense mutations on structures and functions of human cancer-related genes
Sony Malhotra, Ali F Alsulami, Yang Heiyun, Bernardo Montano Ochoa, Harry Jubb, Simon Forbes, Tom L Blundell
Jul 25, 2019
Reflector-Guided Localisation of Non-Palpable Breast Lesions
Umar Wazir, Iham Kasem, Michael J Michell, Tamara Suaris, David Evans, Anmol Malhotra, Kefah Mokbel
May 20, 2021
Wire-guided localisation (WGL) has been the mainstay for localising non-palpable breast lesions before excision. Due to its limitations, various wireless alternatives have been developed. In this prospective study, we evaluate...
Mycobacterial genomics and structural bioinformatics
Vaishali P Waman, Sundeep Chaitanya Vedithi, Sherine E Thomas, Bridget P Bannerman, Asma Munir, Marcin J Skwark, Sony Malhotra, Tom L Blundell
Feb 18, 2019
Of the more than 190 distinct species of Mycobacterium genus, many are economically and clinically important pathogens of humans or animals. Among those mycobacteria that infect humans, three species namely Mycobacterium...
Mycobacterium comparative genomics Drug Resistance Mutation structure-guided drug discovery Animals Bacterial Proteins Computational Biology Drug Discovery Drug Resistance Bacterial Genome Bacterial Humans Molecular Sequence Annotation Mycobacterium Mycobacterium abscessus Mycobacterium leprae Mycobacterium tuberculosis Protein Conformation Proteomics Sequence Analysis DNA
Plasmodium falciparum PhIL1-associated complex plays an essential role in merozoite reorientation and invasion of host erythrocytes.
Ekta Saini, Pradeep Kumar Sheokand, Vaibhav Sharma, Prakhar Agrawal, Inderjeet Kaur, Shailja Singh, Asif Mohmmed, Pawan Malhotra
Sep 20, 2021
The human malaria parasite, Plasmodium falciparum possesses unique gliding machinery referred to as the glideosome that powers its entry into the insect and vertebrate hosts. Several parasite proteins including Photosensitized...
Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae.
Sundeep Chaitanya Vedithi, Carlos Hm Rodrigues, Stephanie Portelli, Marcin J Skwark, Madhusmita Das, David B Ascher, Tom L Blundell, Sony Malhotra
Jan 15, 2020
The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma.
George Couch, James E Redman, Lorenz Wernisch, Richard Newton, Shalini Malhotra, Sanford M Dawsey, Pierre Lao-Sirieix, Rebecca C Fitzgerald
Apr 26, 2016
Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae
Sundeep Chaitanya Vedithi, Sony Malhotra, Marta Acebrón-García-de-Eulate, Modestas Matusevicius, Pedro Henrique Monteiro Torres, Tom L. Blundell
May 21, 2021
Leprosy, caused by Mycobacterium leprae (M. leprae), is treated with a multidrug regimen comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic, bactericidal and anti-inflammatory properties...
Pre-Injury Antiplatelet Therapy and Risk of Adverse Outcomes after Traumatic Brain Injury
François Mathieu, Armaan K Malhotra, Jerry C Ku, Frederick A Zeiler, Jefferson R Wilson, Farhad Pirouzmand, Damon C Scales
Oct 05, 2022
There is an increasing number of trauma patients presenting on pre-injury antiplatelet (AP) agents attributable to an aging population and expanding cardio- or cerebrovascular indications for antithrombotic therapy. The effects...
Modified Transformer Architecture to Explain Black Box Models in Narrative Form
The current XAI techniques present explanations mainly as visuals and structured data. However, these explanations are difficult to interpret for a non-expert user. Here, the use of natural language generation (NLG)-based...
Published by: IGI Global Scientific Publishing
Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer's disease
Michael CB David, Martina Del Giovane, Kathy Y Liu, Benjamin Gostick, James Benedict Rowe, Imafidon Oboh, Robert Howard, Paresh A Malhotra
Jul 25, 2022
BACKGROUND: Dysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer's disease, contributing to cognitive and neuropsychiatric symptoms in some patients. This system offers a potential therapeutic...
HARP
Sundeep Chaitanya Vedithi, Sony Malhotra, Marcin J Skwark, Asma Munir, Marta Acebrón-García-de-Eulate, Vaishali P Waman, Ali Alsulami, David B Ascher, Tom L Blundell
Nov 20, 2020
Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer's disease
Michael CB David, Martina Del Giovane, Kathy Y Liu, Benjamin Gostick, James Rowe, Imafidon Oboh, Robert Howard, Paresh A Malhotra
Jul 19, 2022
BACKGROUND: Dysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer's disease, contributing to cognitive and neuropsychiatric symptoms in some patients. This system offers a potential therapeutic...
Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae.
Sundeep Chaitanya Vedithi, Sony Malhotra, Marta Acebrón-García-de-Eulate, Modestas Matusevicius, Pedro Henrique Monteiro Torres, Tom L Blundell
Jul 09, 2021
Leprosy, caused by Mycobacterium leprae (M. leprae), is treated with a multidrug regimen comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic, bactericidal and anti-inflammatory properties...
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