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Novel Adamantanyl-Based Thiadiazolyl Pyrazoles Targeting EGFR in Triple-Negative Breast Cancer.
Anusha Sebastian, Vijay Pandey, Chakrabhavi Dhananjaya Mohan, Yi Ting Chia, Shobith Rangappa, Jessin Mathai, CP Baburajeev, Shardul Paricharak, Lewis H Mervin, Krishna C Bulusu, Julian E Fuchs, Andreas Bender, Shuhei Yamada, Basappa, Peter E Lobie, Kanchugarakoppal S Rangappa
Sep 05, 2018
The epidermal growth factor receptor (EGFR) is a validated therapeutic target for triple-negative breast cancer (TNBC). In the present study, we synthesize novel adamantanyl-based thiadiazolyl pyrazoles by introducing the...
Automatic Detection of Microaneurysms in Fundus Images
Early detection and treatment of diabetic retinopathy can delay blindness and improve quality of life for diabetic patients. It is difficult to detect early symptoms of diabetic retinopathy, which is presented by few...
Systems & Software Design Computer Science and Information Technology Systems and Software Engineering
Published by: IGI Global Scientific Publishing
Distinct subpopulations of mechanosensory chordotonal organ neurons elicit grooming of the fruit fly antennae.
Stefanie Hampel, Katharina Eichler, Daichi Yamada, Davi D Bock, Azusa Kamikouchi, Andrew M Seeds
Jan 18, 2021
Diverse mechanosensory neurons detect different mechanical forces that can impact animal behavior. Yet our understanding of the anatomical and physiological diversity of these neurons and the behaviors that they influence is...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Aug 26, 2021
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer.
Somatic cell nuclear transfer (SCNT) provides a unique opportunity to directly produce a cloned animal from a donor cell, and it requires the use of skillful techniques. Additionally, the efficiencies of cloning have remained...
Sodium-ion battery cathodes Na2FeP<sub>2</sub>O<sub>7</sub> and Na2MnP<sub>2</sub>O<sub>7</sub>
Na-ion batteries are currently the focus of significant research activity due to the relative abundance of sodium and its consequent cost advantages. Recently, the pyrophosphate family of cathodes has attracted considerable...
Sodium-ion battery cathodes Na2FeP<sub>2</sub>O<sub>7</sub> and Na2MnP<sub>2</sub>O<sub>7</sub>
Na-ion batteries are currently the focus of significant research activity due to the relative abundance of sodium and its consequent cost advantages. Recently, the pyrophosphate family of cathodes has attracted considerable...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Oct 14, 2020
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants.
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Mar 27, 2020
The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically important...
Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect.
Given the potential for myocardial stem cell transplantation as a promising treatment for heart failure, numerous clinical trials have been conducted and its usefulness has been clearly confirmed. However, the low rate of...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Oct 12, 2020
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Oct 26, 2020
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation.
Shuhei Hosomi, Joep Grootjans, Markus Tschurtschenthaler, Niklas Krupka, Juan D Matute, Magdalena B Flak, Eduardo Martinez-Naves, Manuel Gomez Del Moral, Jonathan N Glickman, Mizuki Ohira, Lewis L Lanier, Arthur Kaser, Richard Blumberg
Dec 12, 2017
Endoplasmic reticulum (ER) stress is commonly observed in intestinal epithelial cells (IEC) and can, if excessive, cause spontaneous intestinal inflammation as shown by mice with IEC-specific deletion of X-box binding protein-1...
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants
Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto
Feb 25, 2021
Abstract: The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically...
Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation.
Shuhei Hosomi, Joep Grootjans, Markus Tschurtschenthaler, Niklas Krupka, Juan D Matute, Magdalena B Flak, Eduardo Martinez-Naves, Manuel Gomez Del Moral, Jonathan N Glickman, Mizuki Ohira, Lewis L Lanier, Arthur Kaser, Richard Blumberg
Feb 18, 2019
Endoplasmic reticulum (ER) stress is commonly observed in intestinal epithelial cells (IECs) and can, if excessive, cause spontaneous intestinal inflammation as shown by mice with IEC-specific deletion of X-box-binding protein 1...
Establishing the Japan-Store House of Animal Radiobiology Experiments (J-SHARE), a large-scale necropsy and histopathology archive providing international access to important radiobiology data
Paul Schofield, Takamitsu Morioka, Benjamin Blyth, Tatsuhiko Imaoka, Mayumi Nishimura, Hiroshi Takeshita, Takeo Shimomura, Jun Ohtake, Atsuro Ishida, Paul Schofield, Bernd Grosche, Ulrike Kulka, Yutaka Yamada, Shizuko Kakinuma
Aug 09, 2019
Purpose: Projects evaluating the effects of radiation, within the National Institutes of Quantum and Radiological Science and Technology (QST), National Institute of Radiological Sciences (NIRS), have focused on risk analyses...
Animal experiments archive DATABASE Pathology tissue specimen Access to Information Animal Experimentation Animals archives Carcinogenesis Databases Factual Histology Humans Japan Medical Records Mice Neoplasms Neoplasms Radiation-Induced Program Development Radiobiology Research Research Design Risk Assessment
GRAPPA 2021 Pilot Grant Award Reports
Fazira R Kasiem, Daisuke Yamada, Josefina Marin, Marijn Vis, William Tillett, Samuel T Hwang, Enrique R Soriano, Oliver FitzGerald, April W Armstrong
Nov 30, 2023
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) pilot grant awards help support young researchers starting their careers while also encouraging them to develop a focus on psoriatic disease....
Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.
Tsuyoshi Fukushima, Yosuke Tanaka, Fiona K Hamey, Chih-Hsiang Chang, Toshihiko Oki, Shuhei Asada, Yasutaka Hayashi, Takeshi Fujino, Taishi Yonezawa, Reina Takeda, Kimihito Cojin Kawabata, Tomofusa Fukuyama, Terumasa Umemoto, Keiyo Takubo, Hitoshi Takizawa, Susumu Goyama, Yasushi Ishihama, Hiroaki Honda, Berthold Göttgens, Toshio Kitamura
Dec 16, 2019
Quiescent hematopoietic stem cells (HSCs) are typically dormant, and only a few quiescent HSCs are active. The relationship between "dormant" and "active" HSCs remains unresolved. Here we generate a G0 marker (G0M) mouse line...
CDK G(0) phase HSC Calcium Cell Cycle dormancy Hematopoietic stem cell p27 Animals Biomarkers Calcium Cell Proliferation Cell Self Renewal Cytoplasm Female Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Hematopoietic Stem Cells Male Mice Mice Inbred C57BL Resting Phase Cell Cycle Single-Cell Analysis
GRAPPA 2021 Pilot Grant Award Reports
Fazira R Kasiem, Daisuke Yamada, Josefina Marin, Marijn Vis, William Tillett, Samuel T Hwang, Enrique R Soriano, Oliver FitzGerald, April W Armstrong
Nov 30, 2023
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) pilot grant awards help support young researchers starting their careers while also encouraging them to develop a focus on psoriatic disease....
Anterior cingulate cortex connectivity is associated with suppression of behavior in a rat model of chronic pain.
Laurel Morris, Christian Sprenger, Ken Koda, Daniela de la Mora, Tomomi Yamada, Hiroaki Mano, Yuto Kashiwagi, Yoshichika Yoshioka, Yasuhide Morioka, BJ Seymour
Sep 24, 2018
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.
Itsunari Minami, Kohei Yamada, Tomomi G Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji
May 28, 2019
Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem cells, are potentially useful in regenerative therapies for heart disease. For medical applications, clinical-grade cardiac cells...
Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage.
Zewen K Tuong, Andrew Lewandowski, Jennifer A Bridge, Jazmina LG Cruz, Miko Yamada, Duncan Lambie, Richard Lewandowski, Raymond J Steptoe, Graham R Leggatt, Fiona Simpson, Ian H Frazer, H Peter Soyer, James W Wells
Feb 03, 2020
Actinic Keratosis (AK), Intraepidermal Carcinoma (IEC), and Squamous Cell Carcinoma (SCC) are generally considered to be advancing stages of the same disease spectrum. However, while AK often regress spontaneously, and IEC often...
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