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Practice-Based Views on Key Success Elements in University-Industry Collaborative Activities
Research on university – industry collaboration ideologies, operations and activities for improvement of effective cooperation in industry 4.0 era. Utilizing over 65 years of experience on effective collaboration, inc. advisory...
Published by: IGI Global Scientific Publishing
Enhancement of Power Output by using Alginate Immobilized Algae in Biophotovoltaic Devices.
We report for the first time a photosynthetically active algae immobilized in alginate gel within a fuel cell design for generation of bioelectricity. The algal-alginate biofilm was utilized within a biophotovoltaics (BPV)...
Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation.
David Fernandez-Antoran, Gabriel Piedrafita, Kasumi Murai, Swee Hoe Ong, Albert Herms, Christian Frezza, Philip H Jones
Jul 23, 2019
As humans age, normal tissues, such as the esophageal epithelium, become a patchwork of mutant clones. Some mutations are under positive selection, conferring a competitive advantage over wild-type cells. We speculated that...
NFE2L2 TP53 cell competition cell tracing DIFFERENTIATION ionizing radiation Mitochondria Oxidative Stress Somatic mutation stem cell aging Animals antioxidants Cell Differentiation Cell Proliferation Cells Cultured Epithelial Cells esophagus Humans Mice Mice Transgenic Mutation NF-E2-Related Factor 2 Oxidation-Reduction Oxidative Stress RADIATION Ionizing Receptors Estrogen Tumor Suppressor Protein p53
Retaining Clients in B2B E-Marketplaces
Business-to-business (B2B) e-marketplaces serve local small and medium-sized enterprises (SMEs) by assisting them in connecting with potential overseas buyers. They leverage multiple channels to connect with and bring potential...
Published by: IGI Global Scientific Publishing
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
Kasumi Murai, Stefan Dentro, Swee Hoe Ong, Roshan Sood, David Fernandez-Antoran, Albert Herms, Vasiliki Kostiou, Irina Abnizova, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Nov 20, 2022
Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost universal. However, how p53 mutant clones expand and...
Optimised spectral effects of programmable LED arrays (PLA)s on bioelectricity generation from algal-biophotovoltaic devices
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Emilie Abby, Stefan C Dentro, Michael WJ Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones
Feb 16, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this...
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations.
Kasumi Murai, Greta Skrupskelyte, Gabriel Piedrafita, Michael Hall, Vasiliki Kostiou, Swee Hoe Ong, Tibor Nagy, Alex Cagan, David Goulding, Allon M Klein, Benjamin A Hall, Philip H Jones
Nov 19, 2018
RNAmut
Muxin Gu, Maximillian Zwiebel, Swee Hoe Ong, Nick Boughton, Josep Nomdedeu, Faisal Basheer, Yasuhito Nannya, Pedro M Quiros, Seishi Ogawa, Mario Cazzola, Roland Rad, Adam P Butler, MS Vijayabaskar, George S Vassiliou
Dec 17, 2019
Acute myeloid leukemia (AML) is an aggressive malignancy of haematopoietic stem cells driven by a well-defined set of somatic mutations.1,2 Identifying the mutations driving individual cases is important for assigning the...
Understanding the Usability of a Literature-Based Discovery System Among Clinical Researchers in Sarawak, Malaysia
The rapid increase in scientific publications makes it difficult for researchers to keep up with the latest literature and to explore new research directions. The literature-based discovery (LBD) systems aim to resolve this...
Published by: IGI Global Scientific Publishing
Optimised spectral effects of programmable LED arrays (PLA)s on bioelectricity generation from algal-biophotovoltaic devices.
KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.
Yan Zi Au, Muxin Gu, Etienne De Braekeleer, Malgorzata Gozdecka, Demetrios Aspris, Yusuke Tarumoto, Jonathan Cooper, Jason Yu, Swee Hoe Ong, Xi Chen, Konstantinos Tzelepis, Brian JP Huntly, George Vassiliou, Kosuke Yusa
Aug 14, 2020
Histone acetyltransferases (HATs) catalyze the transfer of an acetyl group from acetyl-CoA to lysine residues of histones and play a central role in transcriptional regulation in diverse biological processes. Dysregulation of...
Apoptosis Biomarkers Tumor Cell Differentiation Cell Line Tumor Disease Management Epigenesis Genetic Gene Knockout Techniques Gene Rearrangement Genetic Association Studies Genetic Predisposition to Disease Histone Acetyltransferases Histone-Lysine N-Methyltransferase Histones Humans Leukemia Myeloid Acute Myeloid Cells Myeloid-Lymphoid Leukemia Protein Oncogene Proteins Fusion Promoter Regions Genetic Protein Binding
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Emilie Abby, Stefan C Dentro, Michael WJ Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones
Feb 19, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this...
Selection of oncogenic mutant clones in normal human skin varies with body site.
Joanna C Fowler, Charlotte King, Christopher Bryant, Michael Hall, Roshan Sood, Swee Hoe Ong, Eleanor Earp, David Fernandez-Antoran, Jonas Koeppel, Stefan C Dentro, David Shorthouse, Amer Durrani, Kate Fife, Edward Rytina, Doreen Milne, Amit Roshan, Krishnaa Mahububani, Kourosh Saeb-Parsy, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Oct 23, 2020
Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high and low risk sites. The density of mutations varied by...
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.
Bartomeu Colom, Maria P Alcolea, Gabriel Piedrafita, Michael WJ Hall, Agnieszka Wabik, Stefan C Dentro, Joanna C Fowler, Albert Herms, Charlotte King, Swee Hoe Ong, Roshan K Sood, Moritz Gerstung, Inigo Martincorena, Benjamin A Hall, Philip H Jones
Apr 28, 2020
ADAM10 Protein Amyloid Precursor Protein Secretases Animals Cell Lineage Diethylnitrosamine Epithelium esophagus Female High-Throughput Nucleotide Sequencing Male Membrane Proteins Mice Inbred C57BL Mice Transgenic Mutation Receptor Notch1 Receptor Notch2 Reproducibility of Results Tumor Suppressor Protein p53
Engineering chloroplast development in rice through cell‐specific control of endogenous genetic circuits
Dong‐Yeon Lee, Lei Hua, Roxana Khoshravesh, Rita Giuliani, Indrajit Kumar, Asaph Cousins, Tammy L. Sage, Julian M. Hibberd, Thomas P. Brutnell
Aug 18, 2021
Summary: The engineering of C4 photosynthetic activity into the C3 plant rice has the potential to nearly double rice yields. To engineer a two‐cell photosynthetic system in rice, the rice bundle sheath (BS) must be rewired to...
Original Article Original Articles C4 photosynthesis dCas9‐mediated transcriptional activation rice bundle sheath chloroplast development
Published by: Plant Biotechnology Journal
Bromocarbons in the tropical coastal and open ocean atmosphere during the 2009 Prime Expedition Scientific Cruise (PESC-09)
MS Mohd Nadzir, SM Phang, MR Abas, N Abdul Rahman, A Abu Samah, WT Sturges, DE Oram, GP Mills, EC Leedham, JA Pyle, NRP Harris, AD Robinson, MJ Ashfold, MI Mead, MT Latif, MF Khan, AM Amiruddin, N Banan, MM Hanafiah
Mar 20, 2015
Systematic Review and Meta-Analysis of Randomised Trials to Ascertain Fatal Gastrointestinal Bleeding Events Attributable to Preventive Low-Dose Aspirin
Peter C Elwood, Gareth Morgan, Julieta Galante, John WK Chia, Sunil Dolwani, J Michael Graziano, Mark Kelson, Angel Lanas, Marcus Longley, Ceri J Phillips, Janet Pickering, Stephen E Roberts, Swee S Soon, Will Steward, Delyth Morris, Alison L Weightman
Feb 15, 2019
BACKGROUND: Aspirin has been shown to lower the incidence and the mortality of vascular disease and cancer but its wider adoption appears to be seriously impeded by concerns about gastrointestinal (GI) bleeding. Unlike heart...
Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore.
Pei Sze Ng, Rick ACM Boonen, Eldarina Wijaya, Chan Eng Chong, Milan Sharma, Sabine Knaup, Shivaani Mariapun, Weang Kee Ho, Joanna Lim, Sook-Yee Yoon, Nur Aishah Mohd Taib, Mee Hoong See, Jingmei Li, Swee Ho Lim, Ern Yu Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Veronique Kiat-Mien Tan, Rob Martinus van Dam, Kartini Rahmat, Cheng Har Yip, Sara Carvalho, Craig Luccarini, Caroline Baynes, Alison M Dunning, Antonis Antoniou, Haico Van Attikum, Douglas F Easton, Mikael Hartman, Soo Hwang Teo
May 13, 2021
BACKGROUND: Rare protein-truncating variants (PTVs) in partner and localiser of BRCA2 (PALB2) confer increased risk to breast cancer, but relatively few studies have reported the prevalence in South-East Asian populations. Here...
Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore
Pei Sze Ng, Rick ACM Boonen, Eldarina Wijaya, Chan Eng Chong, Milan Sharma, Sabine Knaup, Shivaani Mariapun, Weang Kee Ho, Joanna Lim, Sook-Yee Yoon, Nur Aishah Mohd Taib, Mee Hoong See, Jingmei Li, Swee Ho Lim, Ern Yu Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Veronique Kiat-Mien Tan, Rob Martinus van Dam, Kartini Rahmat, Cheng Har Yip, Sara Carvalho, Craig Luccarini, Caroline Baynes, Alison M Dunning, Antonis Antoniou, Haico Van Attikum, Douglas F Easton, Mikael Hartman, Soo Hwang Teo
Apr 07, 2021
Germline breast cancer susceptibility genes, tumor characteristics, and survival
Peh Joo Ho, Alexis J. Khng, Hui Wen Loh, Weang-Kee Ho, Cheng Har Yip, Nur Aishah Mohd-Taib, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Tan, Swee Ho Lim, Suniza Jamaris, Yirong Sim, Fuh Yong Wong, Joanne Ngeow, Elaine Hsuen Lim, Mei Chee Tai, Eldarina Azfar Wijaya, Soo Chin Lee, Ching Wan Chan, Shaik Ahmad Buhari, Patrick M. Y. Chan, Juliana J. C. Chen, Jaime Chin Mui Seah, Wai Peng Lee, Chi Wei Mok, Geok Hoon Lim, Evan Woo, Sung-Won Kim, Jong Won Lee, Min Hyuk Lee, Sue K. Park, Alison M. Dunning, Douglas F. Easton, Marjanka K. Schmidt, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Dec 15, 2021
Abstract: Background: Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility...
Germline breast cancer susceptibility genes, tumor characteristics, and survival.
Peh Joo Ho, Alexis J Khng, Hui Wen Loh, Weang-Kee Ho, Cheng Har Yip, Nur Aishah Mohd-Taib, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Tan, Swee Ho Lim, Suniza Jamaris, Yirong Sim, Fuh Yong Wong, Joanne Ngeow, Elaine Hsuen Lim, Mei Chee Tai, Eldarina Azfar Wijaya, Soo Chin Lee, Ching Wan Chan, Shaik Ahmad Buhari, Patrick MY Chan, Juliana JC Chen, Jaime Chin Mui Seah, Wai Peng Lee, Chi Wei Mok, Geok Hoon Lim, Evan Woo, Sung-Won Kim, Jong Won Lee, Min Hyuk Lee, Sue K Park, Alison M Dunning, Douglas F Easton, Marjanka K Schmidt, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Jan 10, 2022
BACKGROUND: Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility genes on...
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