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Basic Study on Scale-Free Networks and Targeted Antivirus Prophylaxis Supported by Information Communication Tools
With the aim of slowing the spread of infectious disease in the earliest phase of an outbreak, we performed visual simulations using scale-free networks focused on circumstances such as “normal” daily life, pandemic outbreaks...
Published by: IGI Global Scientific Publishing
Assessment of Reference Architectures and Reference Models for Ambient Assisted Living Systems
The innovation and development of software systems in the Ambient Assisted Living (AAL) domain have brought huge challenges for academia and software industry as well. Despite the existence of architectural models that can be...
Published by: IGI Global Scientific Publishing
The unusual case of plastic deformation and high dislocation densities with the cold sintering of the piezoelectric ceramic K0.5Na0.5NbO3
K0.5Na0.5NbO3 (KNN) can be readily densified using the cold sintering process, but despite observing high relative permittivity, the ferroelectric hysteresis is strongly suppressed along with a major suppression in the...
The unusual case of plastic deformation and high dislocation densities with the cold sintering of the piezoelectric ceramic K0.5Na0.5NbO3
K0.5Na0.5NbO3 (KNN) can be readily densified using the cold sintering process, but despite observing high relative permittivity, the ferroelectric hysteresis is strongly suppressed along with a major suppression in the...
Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics.
Danyang Zhang, Remigijus Lape, Saher A Shaikh, Bianka K Kohegyi, Jake F Watson, Ondrej Cais, Terunaga Nakagawa, Ingo H Greger
Apr 17, 2023
AMPA glutamate receptors (AMPARs) mediate excitatory neurotransmission throughout the brain. Their signalling is uniquely diversified by brain region-specific auxiliary subunits, providing an opportunity for the development of...
Published by: Nature Communications
MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis.
Rinako Nakagawa, Rebecca Leyland, Michael Meyer-Hermann, Dong Lu, Martin Turner, Giuseppina Arbore, Tri Giang Phan, Robert Brink, Elena Vigorito
May 24, 2019
MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
Martin D Knolle, Shau Bing Chin, Batika MJ Rana, Alexandros Englezakis, Rinako Nakagawa, Padraic G Fallon, Anna Git, Andrew NJ McKenzie
Oct 09, 2018
Group-2 innate lymphoid cells (ILC2) play critical roles in the initiation and maintenance of type-2 immune responses, predominantly through their production of the type-2 cytokines IL-5, IL-9, and IL-13. ILC2 are essential for...
Octopaminergic neurons have multiple targets in Drosophila larval mushroom body calyx and can modulate behavioral odor discrimination.
JY Hilary Wong, Bo Angela Wan, Tom Bland, Marcella Montagnese, Alex D McLachlan, Cahir J O'Kane, Shuo Wei Zhang, Liria M Masuda-Nakagawa
Nov 09, 2020
Estimating HIV Incidence, Time to Diagnosis, and the Undiagnosed HIV Epidemic Using Routine Surveillance Data.
Ard van Sighem, Fumiyo Nakagawa, Daniela De Angelis, Chantal Quinten, Daniela Bezemer, Eline Op de Coul, Matthias Egger, Frank de Wolf, Christophe Fraser, Andrew Phillips
Aug 16, 2018
BACKGROUND: Estimates of the size of the undiagnosed HIV-infected population are important to understand the HIV epidemic and to plan interventions, including "test-and-treat" strategies. METHODS: We developed a multi-state...
Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2.
Daniel J Hodson, Arthur L Shaffer, Wenming Xiao, George W Wright, Roland Schmitz, James D Phelan, Yandan Yang, Daniel E Webster, Lixin Rui, Holger Kohlhammer, Masao Nakagawa, Thomas A Waldmann, Louis M Staudt
Mar 01, 2016
A framework and case study to systematically identify long-term insect abundance and diversity datasets
EM Grames, GA Montgomery, DH Boyes, LV Dicks, ML Forister, TA Matson, S Nakagawa, KS Prendergast, NG Taylor, MW Tingley, DL Wagner, TE White, P Woodcock, CS Elphick
Apr 13, 2022
The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation.
Dong Lu, Rinako Nakagawa, Sandra Lazzaro, Philipp Staudacher, Cei Abreu-Goodger, Tom Henley, Sara Boiani, Rebecca Leyland, Alison Galloway, Simon Andrews, Geoffrey Butcher, Stephen L Nutt, Martin Turner, Elena Vigorito
Jul 19, 2018
A single microRNA (miRNA) can regulate the expression of many genes, though the level of repression imparted on any given target is generally low. How then is the selective pressure for a single miRNA/target interaction...
3' Untranslated Regions Animals Antibody Formation B-Lymphocytes Base Sequence Binding Sites Cell Adhesion Cell Communication Cell Differentiation Gene Expression Regulation Lymphocyte Activation lymphopoiesis Mice Mice Knockout MicroRNAs Myelopoiesis PAX5 Transcription Factor Positive Regulatory Domain I-Binding Factor 1 Proto-Oncogene Proteins T-Lymphocytes Trans-Activators Transcription Factors
A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis.
Toshinori Nakagawa, David J Jörg, Hitomi Watanabe, Seiya Mizuno, Seungmin Han, Tatsuro Ikeda, Yoshiki Omatsu, Keiko Nishimura, Miyako Fujita, Satoru Takahashi, Gen Kondoh, Benjamin D Simons, Shosei Yoshida, Takashi Nagasawa
Oct 08, 2021
Plvap Sox3 Lineage tracing Mice spermatogenic stem cells stem cell heterogeneity Testis Tissue homeostasis Adult Germline Stem Cells Animals Cell Lineage Cell Self Renewal Gene Expression Regulation Developmental Glial Cell Line-Derived Neurotrophic Factor Receptors Male Membrane Proteins Mice Inbred C57BL Mice Inbred DBA Mice Knockout Mitosis Models Biological Phenotype SOXB1 Transcription Factors Spermatogenesis Testis Time Factors
Accuracy of self-report of HIV viral load among people with HIV on antiretroviral treatment.
J Sewell, M Daskalopoulou, F Nakagawa, FC Lampe, S Edwards, N Perry, E Wilkins, R O'Connell, M Jones, S Collins, A Speakman, AN Phillips, AJ Rodger, Sexual Transmission Risk and Attitudes (ASTRA) Study Group Antiretrovirals
Mar 27, 2019
OBJECTIVES: The aim of the study was to assess, among people living with HIV, knowledge of their latest HIV viral load (VL) and CD4 count. METHODS: Agreement between self-report and clinic record was assessed among 2771...
CD4 count HIV knowledge HIV viral load accuracy of self-report engagement in care medical record Socioeconomic status Adult Aged Anti-Retroviral Agents CD4 Lymphocyte Count Cross-Sectional Studies Female HIV Infections Humans Male Middle Aged Self Report Surveys and Questionnaires United Kingdom Viral Load Young Adult
Comprehensive molecular characterization of mitochondrial genomes in human cancers
Yuan Yuan, Young Seok Ju, Youngwook Kim, Jun Li, Yumeng Wang, Christopher J. Yoon, Yang Yang, Inigo Martincorena, Chad J. Creighton, John N. Weinstein, Yanxun Xu, Leng Han, Hyung-Lae Kim, Hidewaki Nakagawa, Keunchil Park, Peter J. Campbell, Han Liang
Feb 04, 2021
Abstract: Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium...
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer.
Michael A Jacobetz, Derek S Chan, Albrecht Neesse, Tashinga E Bapiro, Natalie Cook, Kristopher K Frese, Christine Feig, Tomoaki Nakagawa, Meredith E Caldwell, Heather I Zecchini, Martijn P Lolkema, Ping Jiang, Anne Kultti, Curtis B Thompson, Daniel C Maneval, Duncan I Jodrell, Gregory I Frost, HM Shepard, Jeremy N Skepper, David A Tuveson
Sep 03, 2020
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study examines the role of an abundant extracellular matrix...
Animals Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Carcinoma Pancreatic Ductal Cell Adhesion Molecules Deoxycytidine Doxorubicin Drug Delivery Systems Drug Resistance Neoplasm Hyaluronic Acid Hyaluronoglucosaminidase Immunohistochemistry Kaplan-Meier Estimate Mice Mice Transgenic Pancreatic Neoplasms Recombinant Proteins Tissue Array Analysis Treatment Outcome Gemcitabine
Comprehensive molecular characterization of mitochondrial genomes in human cancers.
Yuan Yuan, Young Seok Ju, Youngwook Kim, Jun Li, Yumeng Wang, Christopher J Yoon, Yang Yang, Inigo Martincorena, Chad J Creighton, John N Weinstein, Yanxun Xu, Leng Han, Hyung-Lae Kim, Hidewaki Nakagawa, Keunchil Park, Peter J Campbell, Han Liang, PCAWG Consortium
Aug 02, 2021
Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium, which...
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Yiqun Zhang, Fengju Chen, Nuno A Fonseca, Yao He, Masashi Fujita, Hidewaki Nakagawa, Zemin Zhang, Alvis Brazma, PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group, Chad J Creighton, PCAWG Consortium
Feb 04, 2021
The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing...
Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage.
Jeremy P Koelmel, Wan Y Tan, Yang Li, John A Bowden, Atiye Ahmadireskety, Andrew C Patt, David J Orlicky, Ewy Mathé, Nicholas M Kroeger, David C Thompson, Jason A Cochran, Jaya Prakash Golla, Aikaterini Kandyliari, Ying Chen, Georgia Charkoftaki, Joy D Guingab-Cagmat, Hiroshi Tsugawa, Anmol Arora, Kirill Veselkov, Shunji Kato, Yurika Otoki, Kiyotaka Nakagawa, Richard A Yost, Timothy J Garrett, Vasilis Vasiliou
Nov 23, 2021
Alcoholic fatty liver disease (AFLD) is characterized by lipid accumulation and inflammation and can progress to cirrhosis and cancer in the liver. AFLD diagnosis currently relies on histological analysis of liver biopsies....
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.
Yu Kitadate, David J Jörg, Moe Tokue, Ayumi Maruyama, Rie Ichikawa, Soken Tsuchiya, Eri Segi-Nishida, Toshinori Nakagawa, Aya Uchida, Chiharu Kimura-Yoshida, Seiya Mizuno, Fumihiro Sugiyama, Takuya Azami, Masatsugu Ema, Chiyo Noda, Satoru Kobayashi, Isao Matsuo, Yoshiakira Kanai, Takashi Nagasawa, Yukihiko Sugimoto, Satoru Takahashi, Benjamin D Simons, Shosei Yoshida
Jan 17, 2019
biophysical modeling density homeostasis Fibroblast Growth Factors mitogen competition open niche Spermatogenesis Stem Cells Animals Cell Differentiation Cell Self Renewal Fibroblast Growth Factor 5 Glial Cell Line-Derived Neurotrophic Factor Receptors Homeostasis Male Mice Mice Inbred C57BL Mice Knockout Mitogens Spermatogenesis Spermatozoa Stem Cells
State-of-the-art global models underestimate impacts from climate extremes.
Jacob Schewe, Simon N Gosling, Christopher Reyer, Fang Zhao, Philippe Ciais, Joshua Elliott, Louis Francois, Veronika Huber, Heike K Lotze, Sonia I Seneviratne, Michelle TH van Vliet, Robert Vautard, Yoshihide Wada, Lutz Breuer, Matthias Büchner, David A Carozza, Jinfeng Chang, Marta Coll, Delphine Deryng, Allard de Wit, Tyler D Eddy, Christian Folberth, Katja Frieler, Andrew D Friend, Dieter Gerten, Lukas Gudmundsson, Naota Hanasaki, Akihiko Ito, Nikolay Khabarov, Hyungjun Kim, Peter Lawrence, Catherine Morfopoulos, Christoph Müller, Hannes Müller Schmied, René Orth, Sebastian Ostberg, Yadu Pokhrel, Thomas AM Pugh, Gen Sakurai, Yusuke Satoh, Erwin Schmid, Tobias Stacke, Jeroen Steenbeek, Jörg Steinkamp, Qiuhong Tang, Hanqin Tian, Derek P Tittensor, Jan Volkholz, Xuhui Wang, Lila Warszawski
Mar 15, 2019
Global impact models represent process-level understanding of how natural and human systems may be affected by climate change. Their projections are used in integrated assessments of climate change. Here we test, for the first...
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture.
Eva G Álvarez, Jonas Demeulemeester, Paula Otero, Clemency Jolly, Daniel García-Souto, Ana Pequeño-Valtierra, Jorge Zamora, Marta Tojo, Javier Temes, Adrian Baez-Ortega, Bernardo Rodriguez-Martin, Ana Oitaben, Alicia L Bruzos, Mónica Martínez-Fernández, Kerstin Haase, Sonia Zumalave, Rosanna Abal, Jorge Rodríguez-Castro, Aitor Rodriguez-Casanova, Angel Diaz-Lagares, Yilong Li, Keiran M Raine, Adam P Butler, Iago Otero, Atsushi Ono, Hiroshi Aikata, Kazuaki Chayama, Masaki Ueno, Shinya Hayami, Hiroki Yamaue, Kazuhiro Maejima, Miguel G Blanco, Xavier Forns, Carmen Rivas, Juan Ruiz-Bañobre, Sofía Pérez-Del-Pulgar, Raúl Torres-Ruiz, Sandra Rodriguez-Perales, Urtzi Garaigorta, Peter J Campbell, Hidewaki Nakagawa, Peter Van Loo, Jose MC Tubio
Jan 10, 2022
Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. Here, using multiplatform sequencing technologies, we identify and characterize a...
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture.
Eva G Álvarez, Jonas Demeulemeester, Paula Otero, Clemency Jolly, Daniel García-Souto, Ana Pequeño-Valtierra, Jorge Zamora, Marta Tojo, Javier Temes, Adrian Baez-Ortega, Bernardo Rodriguez-Martin, Ana Oitaben, Alicia L Bruzos, Mónica Martínez-Fernández, Kerstin Haase, Sonia Zumalave, Rosanna Abal, Jorge Rodríguez-Castro, Aitor Rodriguez-Casanova, Angel Diaz-Lagares, Yilong Li, Keiran M Raine, Adam P Butler, Iago Otero, Atsushi Ono, Hiroshi Aikata, Kazuaki Chayama, Masaki Ueno, Shinya Hayami, Hiroki Yamaue, Kazuhiro Maejima, Miguel G Blanco, Xavier Forns, Carmen Rivas, Juan Ruiz-Bañobre, Sofía Pérez-Del-Pulgar, Raúl Torres-Ruiz, Sandra Rodriguez-Perales, Urtzi Garaigorta, Peter J Campbell, Hidewaki Nakagawa, Peter Van Loo, Jose MC Tubio
Dec 15, 2021
Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. Here, using multiplatform sequencing technologies, we identify and characterize a...
Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.
Paul D Adams, Kathleen Aertgeerts, Cary Bauer, Jeffrey A Bell, Helen M Berman, Talapady N Bhat, Jeff M Blaney, Evan Bolton, Gerard Bricogne, David Brown, Stephen K Burley, David A Case, Kirk L Clark, Tom Darden, Paul Emsley, Victoria A Feher, Zukang Feng, Colin R Groom, Seth F Harris, Jorg Hendle, Thomas Holder, Andrzej Joachimiak, Gerard J Kleywegt, Tobias Krojer, Joseph Marcotrigiano, Alan E Mark, John L Markley, Matthew Miller, Wladek Minor, Gaetano T Montelione, Garib Murshudov, Atsushi Nakagawa, Haruki Nakamura, Anthony Nicholls, Marc Nicklaus, Robert T Nolte, Anil K Padyana, Catherine E Peishoff, Susan Pieniazek, Randy J Read, Chenghua Shao, Steven Sheriff, Oliver Smart, Stephen Soisson, John Spurlino, Terry Stouch, Radka Svobodova, Wolfram Tempel, Thomas C Terwilliger, Dale Tronrud, Sameer Velankar, Suzanna C Ward, Gregory L Warren, John D Westbrook, Pamela Williams, Huanwang Yang, Jasmine Young
Mar 02, 2016
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