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Results: 479
Proximal femoral canal shape is more accurately assessed on AP hip radiographs than AP pelvis radiographs in primary hip osteoarthritis
Christian Merle, Wenzel Waldstein, Jennifer S Gregory, Simon R Goodyear, Richard M Aspden, Peter R Aldinger, David W Murray, Harinderjit S Gill
Jan 01, 0001
The objectives of the present study were to determine (1) whether differences in the radiographic appearance of the of the proximal femoral canal exist on corresponding AP pelvis and AP hip radiographs, and (2) whether...
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.
Alexandra K Davies, Daniel N Itzhak, James R Edgar, Tara L Archuleta, Jennifer Hirst, Lauren P Jackson, Margaret S Robinson, Georg HH Borner
Dec 13, 2018
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic...
Proximal femoral canal shape is more accurately assessed on AP hip radiographs than AP pelvis radiographs in primary hip osteoarthritis
Christian Merle, Wenzel Waldstein, Jennifer S Gregory, Simon R Goodyear, Richard M Aspden, Peter R Aldinger, David W Murray, Harinderjit S Gill
Jan 01, 0001
The objectives of the present study were to determine (1) whether differences in the radiographic appearance of the of the proximal femoral canal exist on corresponding AP pelvis and AP hip radiographs, and (2) whether...
Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.
Jennifer Hirst, Georg HH Borner, James Edgar, Marco Y Hein, Matthias Mann, Frank Buchholz, Robin Antrobus, Margaret S Robinson
Feb 13, 2019
The AP-5 complex is a recently identified but evolutionarily ancient member of the family of heterotetrameric adaptor proteins (AP complexes). It is associated with two proteins that are mutated in patients with hereditary...
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex.
Adaptor protein complex 5 (AP-5) and its partners, SPG11 and SPG15, are recruited onto late endosomes and lysosomes. Here we show that recruitment of AP-5/SPG11/SPG15 is enhanced in starved cells and occurs by coincidence...
Adaptor Proteins Vesicular Transport Carrier Proteins Endosomes HEK293 Cells HeLa Cells Humans Lysosomes Mechanistic Target of Rapamycin Complex 1 Models Biological Monomeric GTP-Binding Proteins Multiprotein Complexes Nucleotides Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Protein Domains Proteins
Prediction of three-dimensional femoral offset from AP pelvis radiographs in primary hip osteoarthritis
C Merle, W Waldstein, Elise Pegg, M R Streit, T Gotterbarm, P R Aldinger, D W Murray, H S Gill
Aug 01, 2013
BACKGROUND: In pre-operative planning for total hip arthroplasty (THA), femoral offset (FO) is frequently underestimated on AP pelvis radiographs as a result of inaccurate patient positioning, imprecise magnification, and...
Prediction of three-dimensional femoral offset from AP pelvis radiographs in primary hip osteoarthritis
C Merle, W Waldstein, Elise Pegg, M R Streit, T Gotterbarm, P R Aldinger, D W Murray, H S Gill
Aug 01, 2013
BACKGROUND: In pre-operative planning for total hip arthroplasty (THA), femoral offset (FO) is frequently underestimated on AP pelvis radiographs as a result of inaccurate patient positioning, imprecise magnification, and...
The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Nikolai Schleussner, Olaf Merkel, Mariantonia Costanza, Huan-Chang Liang, Franziska Hummel, Chiara Romagnani, Pawel Durek, Ioannis Anagnostopoulos, Michael Hummel, Korinna Jöhrens, Antonia Niedobitek, Patrick R Griffin, Roberto Piva, Henrike L Sczakiel, Wilhelm Woessmann, Christine Damm-Welk, Christian Hinze, Dagmar Stoiber, Bernd Gillissen, Suzanne D Turner, Eva Kaergel, Linda von Hoff, Michael Grau, Georg Lenz, Bernd Dörken, Claus Scheidereit, Lukas Kenner, Martin Janz, Stephan Mathas
Mar 20, 2018
Transcription factor AP-1 is constitutively activated and IRF4 drives growth and survival in ALK+ and ALK- anaplastic large cell lymphoma (ALCL). Here we demonstrate high-level BATF and BATF3 expression in ALCL. Both BATFs bind...
Basic-Leucine Zipper Transcription Factors Binding Sites CRISPR-Cas Systems Carrier Proteins Cell Death Cell Line Tumor Cell Survival Cytokines Gene Editing Gene Expression Regulation Neoplastic Gene Knockdown Techniques Humans Lymphoma Large-Cell Anaplastic Protein Binding Protein Kinase Inhibitors RNA Small Interfering T-Lymphocyte Subsets Th17 Cells Transcription Factor AP-1 Transcriptome
A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers.
Shanna L Bowman, Linh Le, Yueyao Zhu, Dawn C Harper, Anand Sitaram, Alexander C Theos, Elena V Sviderskaya, Dorothy C Bennett, Graça Raposo-Benedetti, David J Owen, Megan K Dennis, Michael S Marks
Apr 12, 2021
Membrane transport carriers fuse with target membranes through engagement of cognate vSNAREs and tSNAREs on each membrane. How vSNAREs are sorted into transport carriers is incompletely understood. Here we show that VAMP7, the...
A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2.
Panagiota Vardaka, Teresa Lozano, Christopher Bot, Jonathan Ellery, Sarah K Whiteside, Charlotte J Imianowski, Stuart Farrow, Simon Walker, Hanneke Okkenhaug, Jie Yang, Klaus Okkenhaug, Paula Kuo, Rahul Roychoudhuri
Oct 15, 2020
Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and cancer...
The WDR11 complex facilitates the tethering of AP-1-derived vesicles.
Paloma Navarro Negredo, James R Edgar, Paul T Manna, Robin Antrobus, Margaret S Robinson
Jul 20, 2018
Vesicluar transport of proteins from endosomes to the trans-Golgi network (TGN) is an essential cellular pathway, but much of its machinery is still unknown. A screen for genes involved in endosome-to-TGN trafficking produced...
Adaptor Protein Complex 1 Autoantigens CRISPR-Cas Systems Cytoplasmic Vesicles Endosomes GTPase-Activating Proteins HEK293 Cells HeLa Cells Humans Membrane Proteins Microscopy Fluorescence Multiprotein Complexes Protein Binding Protein Transport Proto-Oncogene Proteins RNA Interference trans-Golgi Network
Myosin VI is required for sorting of AP-1B-dependent cargo to the basolateral domain in polarized MDCK cells.
In polarized epithelial cells, newly synthesized membrane proteins are delivered on specific pathways to either the apical or basolateral domains, depending on the sorting motifs present in these proteins. Because myosin VI has...
Adaptor Protein Complex 1 Amino Acid Motifs Animals Cell Cycle Proteins Cell Line Cell Polarity Dogs Endosomes Humans Membrane Glycoproteins Membrane Transport Proteins Mutagenesis Site-Directed Myosin Heavy Chains Protein Isoforms Protein Transport Transcription Factor TFIIIA Viral Envelope Proteins
A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2
Panagiota Vardaka, Teresa Lozano, Christopher Bot, Jonathan Ellery, Sarah K. Whiteside, Charlotte J. Imianowski, Stuart Farrow, Simon Walker, Hanneke Okkenhaug, Jie Yang, Klaus Okkenhaug, Paula Kuo, Rahul Roychoudhuri
Nov 03, 2020
Abstract: Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and...
Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting.
Paloma Navarro Negredo, James R Edgar, Antoni G Wrobel, Nathan R Zaccai, Robin Antrobus, David J Owen, Margaret S Robinson
Sep 11, 2018
Acidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles (CCVs), and also facilitate down-regulation of MHC-I by HIV-1 Nef. To find acidic cluster sorting machinery, we performed a gene-trap...
Adaptor Protein Complex 1 Adaptor Protein Complex mu Subunits CRISPR-Cas Systems Clathrin-Coated Vesicles Flow Cytometry Gene Knockdown Techniques Genotype HEK293 Cells HIV-1 HeLa Cells Histocompatibility Antigens Class I Host-Pathogen Interactions Humans Models Molecular Mutation Phenotype Protein Binding Protein Interaction Domains and Motifs Protein Transport Structure-Activity Relationship Time Factors Transfection nef Gene Products Human Immunodeficiency Virus
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Rahul Roychoudhuri, David Clever, Peng Li, Yoshiyuki Wakabayashi, Kylie M Quinn, Christopher A Klebanoff, Yun Ji, Madhusudhanan Sukumar, Robert L Eil, Zhiya Yu, Rosanne Spolski, Douglas C Palmer, Jenny H Pan, Shashank J Patel, Derek C Macallan, Giulia Fabozzi, Han-Yu Shih, Yuka Kanno, Akihiko Muto, Jun Zhu, Luca Gattinoni, John J O'Shea, Klaus Okkenhaug, Kazuhiko Igarashi, Warren J Leonard, Nicholas P Restifo
Jun 27, 2018
T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is...
Adaptive Immunity Animals Basic-Leucine Zipper Transcription Factors CD8-Positive T-Lymphocytes Cell Differentiation Cells Cultured Enhancer Elements Genetic Gene Expression Regulation Immunologic Memory Lymphocyte Activation Mice Mice Inbred C57BL Mice Knockout Oncogene Protein p65(gag-jun) Signal Transduction Transcription Factor AP-1 Vaccinia vaccinia virus
B cell Fcγ receptor IIb modulates atherosclerosis in male and female mice by controlling adaptive germinal center and innate B1-cell responses
J Bagchi-Chakraborty, A Francis, T Bray, L Masters, D Tsiantoulas, M Nus, J Harrison, M Broekhuizen, J Leggat, MR Clatworthy, M Espeli, KGC Smith, CJ Binder, Z Mallat, AP Sage
May 17, 2019
Mobility and Trajectory-Based Technique for Monitoring Asymptomatic Patients
Asymptomatic patients (AP) travel through neighborhoods in communities. The mobility dynamics of the AP makes it hard to tag them with specific interests. The lack of efficient monitoring systems can enable the AP to infect...
Published by: IGI Global Scientific Publishing
The fifth adaptor protein complex.
Jennifer Hirst, Lael D Barlow, Gabriel Casey Francisco, Daniela A Sahlender, Matthew NJ Seaman, Joel B Dacks, Margaret S Robinson
Jan 24, 2018
Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have been identified, which are present in most eukaryotes. We report the...
A substitution effect between price clustering and size clustering in credit default swaps
In a perfectly liquid market, investors’ optimal allocation decisions refer to maximizing all three dimensions of liquidity, namely immediacy, width and depth. To the extent that investors fail to accommodate size (depth) along...
Return reversals and the compass rose
We study the occurrence and visibility of the compass rose pattern in high frequency data from individual equity options contracts. We show that the compass rose pattern in options contracts is more complex than portrayed in...
A substitution effect between price clustering and size clustering in credit default swaps
In a perfectly liquid market, investors’ optimal allocation decisions refer to maximizing all three dimensions of liquidity, namely immediacy, width and depth. To the extent that investors fail to accommodate size (depth) along...
The impact of a premium based tick size on equity option liquidity
On June 2, 2009, NYSE LIFFE Amsterdam reduced the tick size for options trading at prices below €0.20 from €0.05 to €0.01 and on April 1, 2010, the exchange increased the price threshold to €0.50. We study the effect of that...
Trade size clustering and the cost of trading at the London Stock Exchange
For the London Stock Exchange, this paper investigates differences in trading costs between market maker (off-book) and order book trades, in the context of clustering in trade sizes and prices. We report several substantial...
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