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Results: 44
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
JR Grainger, KA Smith, JP Hewitson, HJ McSorley, Y Harcus, KJ Filbey, CAM Finney, EJD Greenwood, DP Knox, MS Wilson, Y Belkaid, AY Rudensky, RM Maizels
Sep 20, 2017
Animals Antigens Helminth Benzamides Cell Proliferation Chronic Disease Dioxoles Forkhead Transcription Factors Gene Expression Regulation host-parasite interactions Mice Mice Inbred BALB C Mice Transgenic Nematospiroides dubius Phosphorylation Protein Serine-Threonine Kinases Receptor Transforming Growth Factor-beta Type II Receptors Transforming Growth Factor beta Signal Transduction Smad2 Protein Smad3 Protein Strongylida Infections T-Lymphocytes Regulatory Th1 Cells Th2 Cells Transforming Growth Factor beta
Where Does ’Ayyē Come From? Proclisis and Affix Pleonasm in the Biblical Hebrew Interrogatives ’Ē and ’Ayyē
Abstract
Interrogatives from the base *’ayy- are common throughout Semitic. Two of the reflexes of this base in Biblical Hebrew, ’ē ‘where?’ and ’ayyē ‘where?’, exhibit atypical...
Benjamin Kantor
May 14, 2019
Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer.
BACKGROUND: SPRED1 and 2 are key negative regulators of MAPK signalling in mammalian cells. Here, we investigate the expression and functional role of SPREDs in prostate cancer. METHODS: A transcriptome bank of microdissected...
Adaptor Proteins Signal Transducing Blotting Western Cell Movement Cell Proliferation Cohort Studies Down-Regulation Dual Specificity Phosphatase 1 Humans Intracellular Signaling Peptides and Proteins Male Membrane Proteins Neoplasm Grading Prognosis Prostatic Hyperplasia Prostatic Neoplasms RNA Messenger RNA Small Interfering Real-Time Polymerase Chain Reaction Receptors Interleukin Repressor Proteins Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Tumor Cells Cultured
A comparison of operative and margin outcomes from surgeon learning curves in robot assisted radical prostatectomy in a changing referral practice.
Introduction The aim of this study was to explore the impact of increasing proportions of high risk referrals on surgical margin outcomes of a surgeon's learning curve in robotic prostatectomy. Methods All patients in this study...
Early oncological outcomes Learning Curve Robot assisted radical prostatectomy Adult Aged Humans Learning Curve Male Margins of Excision Middle Aged Neoplasm Staging Prospective Studies Prostatectomy Prostatic Neoplasms Referral and Consultation risk Robotic Surgical Procedures Treatment Outcome United Kingdom
Identification of pathologically insignificant prostate cancer is not accurate in unscreened men.
GL Shaw, BC Thomas, SN Dawson, G Srivastava, SL Vowler, VJ Gnanapragasam, NC Shah, AY Warren, DE Neal
Jun 11, 2018
BACKGROUND: Identification of men harbouring insignificant prostate cancer (PC) is important in selecting patients for active surveillance. Tools have been developed in PSA-screened populations to identify such men based on...
Adenocarcinoma Aged Area Under Curve Biopsy Needle Early Detection of Cancer False Negative Reactions Humans Lymphatic Metastasis Magnetic Resonance Imaging Male Middle Aged Neoplasm Grading Neoplasm Staging Organ Size Patient Selection Predictive Value of Tests Prostate Prostate-specific antigen Prostatic Neoplasms ROC Curve Retrospective Studies Risk Assessment Seminal vesicles Sensitivity and Specificity Tumor Burden Watchful Waiting
Efficient Triplet Exciton Fusion in Molecularly Doped Polymer Light-Emitting Diodes.
D Di, L Yang, JM Richter, L Meraldi, RM Altamimi, AY Alyamani, D Credgington, KP Musselman, JL MacManus-Driscoll, RH Friend
Mar 08, 2017
The hydrogen economy
N MacDowell, N Sunny, N Brandon, H Herzog, AY Ku, W Maas, A Ramirez, DM Reiner, GN Sant, N Shah
Oct 07, 2021
For hydrogen to play a meaningful role in a sustainable energy system, all elements of the value chain must scale coherently. Advocates support electrolytic (green) hydrogen or (blue) hydrogen that relies on methane reformation...
Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis.
Acrylamides Apoptosis Carcinoma Renal Cell Epithelial Cells Gene Expression Regulation Neoplastic Humans In Situ Nick-End Labeling Kidney Neoplasms Kidney Tubules Necrosis Organ Culture Techniques Quinazolinones RNA Messenger Receptor-Interacting Protein Serine-Threonine Kinases Receptors Tumor Necrosis Factor Type I Signal Transduction Sulfonamides Tumor Necrosis Factor-alpha Up-Regulation
Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity
AW Nelson, AJ Groen, JL Miller, AY Warren, KA Holmes, GA Tarulli, WD Tilley, BS Katzenellenbogen, JR Hawse, VJ Gnanapragasam, JS Carroll
Mar 31, 2017
Thrombomodulin in patients with mild to moderate bleeding tendency.
Dino Mehic, Alexander Tolios, Stefanie Hofer, Cihan Ay, Helmuth Haslacher, Kate Downes, Matthias Haimel, Ingrid Pabinger, Johanna Gebhart
Oct 10, 2021
INTRODUCTION: A massive increase of soluble thrombomodulin (sTM) due to variants in the thrombomodulin gene (THBD) has recently been identified as a novel bleeding disorder. AIM: To investigate sTM levels and underlying genetic...
Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype.
JLL Robinson, TE Hickey, AY Warren, SL Vowler, T Carroll, AD Lamb, N Papoutsoglou, DE Neal, WD Tilley, JS Carroll
May 02, 2019
Castration-resistant prostate cancer (CRPC) continues to pose a significant clinical challenge with new generation second-line hormonal therapies affording limited improvement in disease outcome. As the androgen receptor (AR)...
Three-year experience of a dedicated prostate mpMRI pre-biopsy programme and effect on timed cancer diagnostic pathways.
T Barrett, R Slough, N Sushentsev, N Shaida, BC Koo, I Caglic, V Kozlov, AY Warren, V Thankappannair, C Pinnock, N Shah, K Saeb-Parsy, VJ Gnanapragasam, E Sala, C Kastner
Sep 09, 2019
AIM: To evaluate the effect of pre-biopsy magnetic resonance imaging (MRI) on cancer diagnostic times, and to report MRI-directed pathology outcomes. MATERIALS AND METHODS: In total, 1483 patients were referred with prostate...
Hospitalization and Mortality Risk for COVID-19 Cases With SARS-CoV-2 AY.4.2 (VUI-21OCT-01) Compared to Non-AY.4.2 Delta Variant Sublineages.
Tommy Nyberg, Katie Harman, Asad Zaidi, Shaun R Seaman, Nick Andrews, Sophie G Nash, Andre Charlett, Jamie Lopez Bernal, Richard Myers, Natalie Groves, Eileen Gallagher, Saheer Gharbia, Meera Chand, Simon Thelwall, Daniela De Angelis, Gavin Dabrera, Anne M Presanis
Mar 28, 2022
The Financial Impact on Reimbursement of Moderately Hypofractionated Postoperative Radiation Therapy for Breast Cancer
GN Marta, D Ramiah, O Kaidar-Person, A Kirby, C Coles, R Jagsi, T Hijal, G Sancho, Y Zissiadis, J-P Pignol, AY Ho, SH-C Cheng, BV Offersen, I Meattini, P Poortmans
Jan 06, 2021
AIMS: Moderately hypofractionated breast irradiation has been evaluated in several prospective studies, resulting in wide acceptance of shorter treatment protocols for postoperative breast irradiation. Reimbursement for...
Life Without GPR7, the Neuropeptide W1 Receptor: Regulation of Energy Homeostasis by GPR7 and its Endogenous Neuropeptide Ligands
Makoto Ishii
Jan 01, 0001
Classic lesion experiments from the 1940s have established the hypothalamus as playing an essential role in controlling energy homeostasis. Gold-thioglucose (GTG) induces lesions in the ventromedial nucleus of the hypothalamus...
Published by: Rockefeller University
Corrigendum to "Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity" [Mol. Cell Endocrinol. 440 (2016) 138-150].
AW Nelson, AJ Groen, JL Miller, AY Warren, KA Holmes, GA Tarulli, WD Tilley, BS Katzenellenbogen, JR Hawse, VJ Gnanapragasam, JS Carroll
Aug 12, 2019
Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets.
NS Poulter, AY Pollitt, DM Owen, EE Gardiner, RK Andrews, H Shimizu, D Ishikawa, D Bihan, RW Farndale, M Moroi, SP Watson, SM Jung
Mar 16, 2017
Integration of copy number and transcriptomics provides risk stratification in prostate cancer
H Ross-Adams, AD Lamb, MJ Dunning, S Halim, J Lindberg, CM Massie, LA Egevad, R Russell, A Ramos-Montoya, SL Vowler, NL Sharma, J Kay, H Whitaker, J Clark, R Hurst, VJ Gnanapragasam, NC Shah, AY Warren, CS Cooper, AG Lynch, R Stark, IG Mills, H Grönberg, DE Neal, CamCaP Study Group
Jul 21, 2015
Biochemical relapse Gene signature Genomics Personalised medicine Prognosis prostate cancer Risk stratification Adult Aged Aged 80 and over Cluster Analysis Cohort Studies Gene Dosage Gene Expression Profiling Gene Expression Regulation Neoplastic Genome Human Humans Male Middle Aged Prognosis Prostatic Neoplasms RNA Messenger Recurrence Reproducibility of Results Risk Factors Transcriptome
The high-energy Sun - probing the origins of particle acceleration on our nearest star
Abstract As a frequent and energetic particle accelerator, our Sun provides us with an excellent astrophysical laboratory for understanding the fundamental process of particle acceleration. The...
SA Matthews, HAS Reid, D Baker, DS Bloomfield, PK Browning, A Calcines, G Del Zanna, R Erdelyi, L Fletcher, IG Hannah, N Jeffrey, L Klein, S Krucker, E Kontar, DM Long, A MacKinnon, G Mann, M Mathioudakis, R Milligan, VM Nakariakov, M Pesce-Rollins, AY Shih, D Smith, A Veronig, N Vilmer
Mar 09, 2023
Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer
MKH Hong, G Macintyre, DC Wedge, P Van Loo, K Patel, S Lunke, LB Alexandrov, C Sloggett, M Cmero, F Marass, D Tsui, S Mangiola, A Lonie, H Naeem, N Sapre, PM Phal, N Kurganovs, X Chin, M Kerger, AY Warren, D Neal, V Gnanapragasam, N Rosenfeld, JS Pedersen, A Ryan, I Haviv, AJ Costello, NM Corcoran, CM Hovens
Sep 12, 2017
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions
D Shungin, WQ Deng, TV Varga, J Luan, E Mihailov, A Metspalu, GIANT Consortium, AP Morris, NG Forouhi, C Lindgren, PKE Magnusson, NL Pedersen, G Hallmans, AY Chu, AE Justice, M Graff, TW Winkler, LM Rose, C Langenberg, LA Cupples, PM Ridker, NJ Wareham, KK Ong, RJF Loos, DI Chasman, E Ingelsson, TO Kilpeläinen, RA Scott, R Mägi, G Paré, PW Franks
Aug 08, 2017
Body Mass Index Cholesterol HDL Cholesterol LDL European Continental Ancestry Group Female Gene-Environment Interaction Genetic Heterogeneity Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Male obesity Polymorphism Single Nucleotide Quantitative Trait Loci Risk Factors Smoking
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