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Cover Image for G-Force PD View Article
G-Force PD
Roger A Barker, Lorenz Studer, Elena Cattaneo, Jun Takahashi, G-Force PD consortium
Aug 20, 2015
G-Force PD consortium
Cover Image for G-Quadruplexes View Article
G-Quadruplexes
Chun Kit Kwok, Catherine J Merrick
Mar 18, 2019
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
G-quadruplex aptamer biosensing cell imaging next-generation sequencing nucleic acid structure Animals Biomedical Research Biosensing Techniques G-Quadruplexes Humans
Cover Image for THE CONCISE GUIDE TO PHARMACOLOGY 2019/20 View Article
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators
Dec 12, 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective...
Animals Databases Pharmaceutical Humans Ligands Pharmaceutical Preparations Receptors G-Protein-Coupled
Cover Image for Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams View Article
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
Ramya G, Barry Crittenden, Martin Smith, Olivier Camus, Yong-Min Chew, Semali Perera
Apr 01, 2019

A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...

Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide
Cover Image for Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams View Article
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
Ramya G, Barry Crittenden, Martin Smith, Olivier Camus, Yong-Min Chew, Semali Perera
Apr 01, 2019

A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...

Adsorbent foam Adsorption Air Filters Isotherms modelling Polyimide
Cover Image for Remote stereocontrol in [3,3]-sigmatropic rearrangements View Article
Remote stereocontrol in [3,3]-sigmatropic rearrangements
Nathan W G Fairhurst, Mary F Mahon, R H Munday, David R Carbery
Feb 03, 2012
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Cover Image for THE CONCISE GUIDE TO PHARMACOLOGY 2017/18 View Article
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18
Stephen Ph Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators
Nov 16, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access...
CGTP Collaborators
Cover Image for RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia. View Article
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
RNA S. cerevisiae Cell Biology Glycolysis Hypoxia phase separation Cytoplasmic Granules Endoribonucleases Glycolysis RNA Fungal Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins
Cover Image for Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor. View Article
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
LJ Bridge, J Mead, E Frattini, I Winfield, G Ladds
Mar 16, 2018
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
Biased signalling G protein-coupled receptors Mathematical pharmacology ordinary differential equations Receptor theory Algorithms Animals GTP-Binding Proteins Humans Ligands Models Biological Receptors G-Protein-Coupled Signal Transduction
Cover Image for Remote stereocontrol in [3,3]-sigmatropic rearrangements View Article
Remote stereocontrol in [3,3]-sigmatropic rearrangements
Nathan W G Fairhurst, Mary F Mahon, R H Munday, David R Carbery
Feb 03, 2012
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Cover Image for Studies of G Protein-Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches View Article
Studies of G Protein-Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches
Adam Knepp
Jan 01, 0001
G protein-coupled receptors (GPCRs) comprise a large family of related seventransmembrane- helical membrane proteins that bind to specific extracellular ligands, such as hormones or neuromodulators. The active receptor-ligand...
Life Sciences
Published by: Rockefeller University
Cover Image for Evaluating the Evidence for Enclothed Cognition View Article
Evaluating the Evidence for Enclothed Cognition
C. Blaine Horton, Hajo Adam, Adam D. Galinsky
Jul 17, 2023

Enclothed cognition refers to the systematic influence that clothes can have on the wearer’s feelings, thoughts, and behaviors through their symbolic meaning. It has attracted considerable academic and nonacademic interest...

Embodied cognition enclothed cognition Meta-Analysis z-curve analysis
Cover Image for Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders View Article
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
Dora-Maria Rasadean, Bin Sheng, Jyotirmayee Dash, G. Dan Pantos
Jun 23, 2017

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

Circular dichroism DNA G-quadruplex naphthalenediimide structure–activity relationships
Cover Image for Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders View Article
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
Dora-Maria Rasadean, Bin Sheng, Jyotirmayee Dash, G. Dan Pantos
Jun 23, 2017

The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...

Circular dichroism DNA G-quadruplex naphthalenediimide structure–activity relationships
Cover Image for Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk. View Article
Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk.
Adam Hulman, Rebecca K Simmons, Dorte Vistisen, Adam G Tabák, Jacqueline M Dekker, Marjan Alssema, Femke Rutters, Anitra DM Koopman, Thomas PJ Solomon, John P Kirwan, Torben Hansen, Anna Jonsson, Anette Prior Gjesing, Hans Eiberg, Arne Astrup, Oluf Pedersen, Thorkild IA Sørensen, Daniel R Witte, Kristine Færch
May 16, 2018
oral glucose tolerance test gGlucose response curve cardiometabolic risk latent class trajectory analysis
Cover Image for A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions View Article
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019

A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...

Dye sensor Fluorescent sensor functional materials graphitic carbon nitride Mercury sensing
Cover Image for A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions View Article
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019

A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...

Dye sensor Fluorescent sensor functional materials graphitic carbon nitride Mercury sensing
Cover Image for Estimation of Poisson’s Ratio and Variation of Tensile Yield Strength of Composite Clay Balls Used in Pebble Matrix Filtration View Article
Estimation of Poisson’s Ratio and Variation of Tensile Yield Strength of Composite Clay Balls Used in Pebble Matrix Filtration
J Rajapakse, C Gallage, Biyanvilage G, G Madabhushi, RA Fenner
Apr 25, 2017
composite clay balls Poisson ratio particle image velocimetry tensile yield strength pebble matrix filtration filter media
Cover Image for Evaluating the Evidence for Enclothed Cognition View Article
Evaluating the Evidence for Enclothed Cognition
C. Blaine Horton, Hajo Adam, Adam D. Galinsky
Jul 17, 2023

Enclothed cognition refers to the systematic influence that clothes can have on the wearer’s feelings, thoughts, and behaviors through their symbolic meaning. It has attracted considerable academic and nonacademic interest...

Embodied cognition enclothed cognition Meta-Analysis z-curve analysis
Cover Image for Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds to G-Quadruplex DNA and RNA View Article
Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds to G-Quadruplex DNA and RNA
James Edwards-Smallbone, Anders L Jensen, Lydia E Roberts, Francis Isidore G Totañes, Sarah R Hart, Catherine J Merrick
Mar 08, 2022
In the early-diverging protozoan parasite Plasmodium, few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of...
Cellular and Infection Microbiology Plasmodium Malaria G-quadruplex Telomere proteomics of isolated chromatin fragments GBP2
Cover Image for Fungal G-protein-coupled receptors: View Article
Fungal G-protein-coupled receptors:
Neil Brown, Sanne Schrevens, Patrick van Dijck, Gustavo Goldman
Apr 01, 2018
G-protein signalling pathways are involved in sensing the environment, enabling fungi to coordinate cell function, metabolism and development with their surroundings, thereby promoting their survival, propagation and virulence....
Cover Image for Fungal G-protein-coupled receptors: View Article
Fungal G-protein-coupled receptors:
Neil Brown, Sanne Schrevens, Patrick van Dijck, Gustavo Goldman
Apr 01, 2018
G-protein signalling pathways are involved in sensing the environment, enabling fungi to coordinate cell function, metabolism and development with their surroundings, thereby promoting their survival, propagation and virulence....
Cover Image for A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase View Article
A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase
Sam Groom, Nina K Blum, Alexandra E Conibear, Alexander Disney, Rob Hill, Stephen M Husbands, Yangmei Li, Lawrence Toll, Andrea Kliewer, Stefan Schulz, Graeme Henderson, Eamonn Kelly, Chris P Bailey
Apr 30, 2023

Background and Purpose: G protein-biased μ opioid receptor agonists have the potential to induce less receptor desensitisation and tolerance than balanced opioids. Here, we investigated if the cyclic endomorphin analogue...

G protein-coupled receptor kinases Arrestins Biased agonism Electrophysiology opiates opioids receptor desensitisation
Cover Image for Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure. View Article
Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure.
James H Felce, Sarah L Latty, Rachel G Knox, Susan R Mattick, Yuan Lui, Steven F Lee, David Klenerman, Simon J Davis
May 10, 2018
The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of mostly individual receptors....
BRET G protein-coupled receptors evolution single-molecule imaging stoichiometry Fluorescence Resonance Energy Transfer HEK293 Cells Humans Protein Multimerization Protein Structure Quaternary Protein Structure Secondary Receptors G-Protein-Coupled Rhodopsin
Cover Image for Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. View Article
Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Michael C Chen, Ramreddy Tippana, Natalia A Demeshkina, Pierre Murat, Shankar Balasubramanian, Sua Myong, Adrian R Ferré-D'Amaré
Aug 03, 2018
Guanine-rich nucleic acid sequences challenge the replication, transcription, and translation machinery by spontaneously folding into G-quadruplexes, the unfolding of which requires forces greater than most polymerases can...
Amino Acid Motifs Animals Cattle Crystallography X-Ray DEAD-box RNA Helicases DNA Fluorescence Resonance Energy Transfer G-Quadruplexes Models Molecular Mutation Nucleic Acid Denaturation

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