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Compliance with evidence-based clinical guidelines in the management of acute biliary pancreatitis
Mauro Podda, Gianluca Pellino, Federico Coccolini, Chiara Gerardi, Salomone Di Saverio, Francesco Pata, Benedetto Ielpo, Francesco Virdis, Dimitrios Damaskos, Stavros Gourgiotis, Gaetano Poillucci, Daniela Pacella, Kumar Jayant, Ferdinando Agresta, Massimo Sartelli, Ari Leppaniemi, Yoram Kluger, Fausto Catena, Adolfo Pisanu
Jul 28, 2021
Despite existing evidence-based practice guidelines for the management of biliary acute pancreatitis (AP), the clinical compliance with recommendations is overall poor. Studies in this field have identified significant...
Negotiating Balance
Oscar Adolfo Soto
Jan 01, 0001
When we enter a room with a bed and dresser, we imagine that someone goes there to sleep. When we enter a larger room, with rows of uniform desks facing a whiteboard or lectern, we understand that people go there to learn. In...
Published by: Winthrop University
Highly feminised sex ratio estimations for the world’s third largest nesting aggregation of loggerhead sea turtles
Despite being a fundamental life-history character, there is a paucity of populationwide, data-driven studies of primary sex ratios for any marine turtle species. The Republic of Cape Verde hosts the third-largest nesting...
Sex Ratio climate change Caretta caretta Loggerhead turtle Marine turtle Cape Verde /dk/atira/pure/subjectarea/asjc/1100/1105 name=Ecology, Evolution, Behavior and Systematics /dk/atira/pure/subjectarea/asjc/1100/1103 name=Animal Science and Zoology /dk/atira/pure/subjectarea/asjc/2300/2306 name=Global and Planetary Change /dk/atira/pure/subjectarea/asjc/2300/2303 name=Ecology /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Highly feminised sex ratio estimations for the world’s third largest nesting aggregation of loggerhead sea turtles
Despite being a fundamental life-history character, there is a paucity of populationwide, data-driven studies of primary sex ratios for any marine turtle species. The Republic of Cape Verde hosts the third-largest nesting...
Sex Ratio climate change Caretta caretta Loggerhead turtle Marine turtle Cape Verde /dk/atira/pure/subjectarea/asjc/1100/1105 name=Ecology, Evolution, Behavior and Systematics /dk/atira/pure/subjectarea/asjc/1100/1103 name=Animal Science and Zoology /dk/atira/pure/subjectarea/asjc/2300/2306 name=Global and Planetary Change /dk/atira/pure/subjectarea/asjc/2300/2303 name=Ecology /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Simultaneous single-sample determination of NMNAT isozyme activities in mouse tissues.
Giuseppe Orsomando, Lucia Cialabrini, Adolfo Amici, Francesca Mazzola, Silverio Ruggieri, Laura Conforti, Lucie Janeckova, Michael P Coleman, Giulio Magni
Dec 05, 2017
A novel assay procedure has been developed to allow simultaneous activity discrimination in crude tissue extracts of the three known mammalian nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1) isozymes. These...
Metabolomics Fingerprint Induced by the Intranigral Inoculation of Exogenous Human Alpha-Synuclein Oligomers in a Rat Model of Parkinson's Disease.
Federica Murgia, Luigi Atzori, Ezio Carboni, Maria Laura Santoru, Aran Hendren, Augusta Pisanu, Pierluigi Caboni, Laura Boi, Giuliana Fusco, Anna R Carta
Sep 15, 2020
Parkinson's disease (PD) is considered a synucleinopathy because of the intraneuronal accumulation of aggregated α-synuclein (αSyn). Recent evidence points to soluble αSyn-oligomers (αSynO) as the main cytotoxic species...
Parkinson model Biomarkers gas chromatography mass spectrometry mesencephalic tissue Metabolomics serum α-synuclein oligomers Animals Biomarkers Corpus Striatum Disease Models Animal Dopamine Humans Male Metabolome Metabolomics Neurons Oxidative Stress Parkinson Disease Rats Rats Sprague-Dawley Substantia Nigra ALPHA-SYNUCLEIN
Time-order-errors and duration ranges in the Episodic Temporal Generalization task.
Ezequiel Mikulan, Manuel Bruzzone, Manuel Serodio, Mariano Sigman, Tristán Bekinschtein, Adolfo M García, Lucas Sedeño, Agustín Ibáñez
Mar 16, 2020
The current model of the Episodic Temporal Generalization task, where subjects have to judge whether pairs of auditory stimuli are equal in duration, predicts that results are scale-free and unaffected by the presentation order...
An unaware agenda
Sebastian Moguilner, Adolfo M García, Ezequiel Mikulan, Maria Del Carmen García, Esteban Vaucheret, Yimy Amarillo, Tristan A Bekinschtein, Agustín Ibáñez
Mar 16, 2020
Consciousness impairments have been described as a cornerstone of epilepsy. Generalized seizures are usually characterized by a complete loss of consciousness, whereas focal seizures have more variable degrees of responsiveness....
An Experimental Evaluation of a Teaching Approach for Statistical Process Control in Computer Courses
In organizations that are seeking a high degree of maturity, it is necessary to achieve a statistical control of software processes and to know their behavior and operational performance. The approach adopted for the research...
Published by: IGI Global Scientific Publishing
Docker4Circ
Giulio Ferrero, Nicola Licheri, Lucia Coscujuela Tarrero, Carlo De Intinis, Valentina Miano, Raffaele Adolfo Calogero, Francesca Cordero, Michele De Bortoli, Marco Beccuti
Mar 23, 2020
Recent improvements in cost-effectiveness of high-throughput technologies has allowed RNA sequencing of total transcriptomes suitable for evaluating the expression and regulation of circRNAs, a relatively novel class of...
SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites.
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines.
Gerard Godoy-Tena, Anis Barmada, Octavio Morante-Palacios, Carlos de la Calle-Fabregat, Ricardo Martins-Ferreira, Anna G Ferreté-Bonastre, Laura Ciudad, Adolfo Ruiz-Sanmartín, Mónica Martínez-Gallo, Ricard Ferrer, Juan Carlos Ruiz-Rodriguez, Javier Rodríguez-Ubreva, Roser Vento-Tormo, Esteban Ballestar
Nov 29, 2022
BACKGROUND: COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid...
Intracranial high-γ connectivity distinguishes wakefulness from sleep.
Ezequiel Mikulan, Eugenia Hesse, Lucas Sedeño, Tristán Bekinschtein, Mariano Sigman, María Del Carmen García, Walter Silva, Carlos Ciraolo, Adolfo M García, Agustín Ibáñez
Mar 16, 2020
Neural synchrony in the γ-band is considered a fundamental process in cortical computation and communication and it has also been proposed as a crucial correlate of consciousness. However, the latter claim remains inconclusive...
The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex.
Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone, Luca Picci, Giovanna Mulas, Saturnino Spiga, Maria Scherma, Paola Fadda, Marco Pistis, Nicola Simola, Ezio Carboni, Anna R Carta
Oct 10, 2022
Parkinson's disease (PD) is a complex pathology causing a plethora of non-motor symptoms besides classical motor impairments, including cognitive disturbances. Recent studies in the PD human brain have reported microgliosis in...
Repurposing Pomalidomide as a Neuroprotective Drug
Maria Francesca Palmas, Anna Ena, Chiara Burgaletto, Maria Antonietta Casu, Giuseppina Cantarella, Ezio Carboni, Michela Etzi, Alfonso De Simone, Giuliana Fusco, Maria Cristina Cardia, Francesco Lai, Luca Picci, David Tweedie, Michael T Scerba, Valentina Coroneo, Renato Bernardini, Nigel H Greig, Augusta Pisanu, Anna R Carta
May 25, 2022
Marketed drugs for Parkinson's disease (PD) treat disease motor symptoms but are ineffective in stopping or slowing disease progression. In the quest of novel pharmacological approaches that may target disease progression...
ALPHA-SYNUCLEIN cytokine Drug Repositioning immunomodulation Motor impairment Neuroprotection Animals Cytokines Disease Models Animal Disease Progression Drug Repositioning Humans Microglia Neuroprotective Agents Parkinson Disease Rats Substantia Nigra Thalidomide Tumor Necrosis Factor-alpha ALPHA-SYNUCLEIN
Modeling Parkinson's Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers.
Laura Boi, Augusta Pisanu, Maria Francesca Palmas, Giuliana Fusco, Ezio Carboni, Maria Antonietta Casu, Valentina Satta, Maria Scherma, Elzbieta Janda, Ignazia Mocci, Giovanna Mulas, Anna Ena, Saturnino Spiga, Paola Fadda, Alfonso De Simone, Anna R Carta
Nov 13, 2020
The accumulation of aggregated α-synuclein (αSyn) is a hallmark of Parkinson's disease (PD). Current evidence indicates that small soluble αSyn oligomers (αSynOs) are the most toxic species among the forms of αSyn aggregates...
Parkinson Disease COGNITIVE IMPAIRMENT Microglia motor deficits neurodegeneration Neuroinflammation α-synuclein oligomers Animals Cytokines Disease Models Animal Dopamine Dopaminergic Neurons Humans Inflammation Male Microglia Neurons Parkinson Disease Phagocytosis Phosphorylation Rats Rats Sprague-Dawley Recombinant Proteins Substantia Nigra ALPHA-SYNUCLEIN
Neurotoxin-mediated --potent activation of the axon degeneration regulator SARM1.
Andrea Loreto, Carlo Angeletti, Weixi Gu, Andrew Osborne, Bart Nieuwenhuis, Jonathan Gilley, Peter Arthur-Farraj, Elisa Merlini, Adolfo Amici, Zhenyao Luo, Lauren Hartley-Tassell, Thomas Ve, Laura M Desrochers, Qi Wang, Bostjan Kobe, Giuseppe Orsomando, Michael P Coleman
Jan 28, 2022
Axon loss underlies symptom onset and progression in many neurodegenerative disorders. Axon degeneration in injury and disease is promoted by activation of the nicotinamide adenine dinucleotide (NAD)-consuming enzyme SARM1....
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines.
Gerard Godoy-Tena, Anis Barmada, Octavio Morante-Palacios, Carlos de la Calle-Fabregat, Ricardo Martins-Ferreira, Anna G Ferreté-Bonastre, Laura Ciudad, Adolfo Ruiz-Sanmartín, Mónica Martínez-Gallo, Ricard Ferrer, Juan Carlos Ruiz-Rodriguez, Javier Rodríguez-Ubreva, Roser Vento-Tormo, Esteban Ballestar
Jan 04, 2023
BACKGROUND: COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid...
Heterostructures formed through abraded van der Waals materials.
Darren Nutting, Jorlandio F Felix, Evan Tillotson, Dong-Wook Shin, Adolfo De Sanctis, Hong Chang, Nick Cole, Saverio Russo, Adam Woodgate, Ioannis Leontis, Henry A Fernández, Monica F Craciun, Sarah J Haigh, Freddie Withers
Aug 07, 2020
To fully exploit van der Waals materials and their vertically stacked heterostructures, new mass-scalable production routes which are low cost but preserve the high electronic and optical quality of the single crystals are...
Dynamic neurocognitive changes in interoception after heart transplant.
Paula Celeste Salamone, Lucas Sedeño, Agustina Legaz, Tristán Bekinschtein, Miguel Martorell, Federico Adolfi, Matías Fraile-Vazquez, Nicolás Rodríguez Arriagada, Liliana Favaloro, Margarita Peradejordi, Daniel O Absi, Adolfo M García, Roberto Favaloro, Agustín Ibáñez
Jun 18, 2021
Heart-brain integration dynamics are critical for interoception (i.e. the sensing of body signals). In this unprecedented longitudinal study, we assessed neurocognitive markers of interoception in patients who underwent...
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis.
Donna L Mallery, Chantal L Márquez, William A McEwan, Claire F Dickson, David A Jacques, Madhanagopal Anandapadamanaban, Katsiaryna Bichel, Gregory J Towers, Adolfo Saiardi, Till Böcking, Leo C James
Oct 03, 2018
The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP6, transforming viral stability...
Diagnosis and treatment of acute appendicitis
Salomone Di Saverio, Mauro Podda, Belinda De Simone, Marco Ceresoli, Goran Augustin, Alice Gori, Marja Boermeester, Massimo Sartelli, Federico Coccolini, Antonio Tarasconi, Nicola de’ Angelis, Dieter G. Weber, Matti Tolonen, Arianna Birindelli, Walter Biffl, Ernest E. Moore, Michael Kelly, Kjetil Soreide, Jeffry Kashuk, Richard Ten Broek, Carlos Augusto Gomes, Michael Sugrue, Richard Justin Davies, Dimitrios Damaskos, Ari Leppäniemi, Andrew Kirkpatrick, Andrew B. Peitzman, Gustavo P. Fraga, Ronald V. Maier, Raul Coimbra, Massimo Chiarugi, Gabriele Sganga, Adolfo Pisanu, Gian Luigi de’ Angelis, Edward Tan, Harry Van Goor, Francesco Pata, Isidoro Di Carlo, Osvaldo Chiara, Andrey Litvin, Fabio C. Campanile, Boris Sakakushev, Gia Tomadze, Zaza Demetrashvili, Rifat Latifi, Fakri Abu-Zidan, Oreste Romeo, Helmut Segovia-Lohse, Gianluca Baiocchi, David Costa, Sandro Rizoli, Zsolt J. Balogh, Cino Bendinelli, Thomas Scalea, Rao Ivatury, George Velmahos, Roland Andersson, Yoram Kluger, Luca Ansaloni, Fausto Catena
Jul 01, 2020
Abstract: Background and aims: Acute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different...
Review acute appendicitis Appendicitis guidelines Jerusalem guidelines Consensus conference Alvarado score Appendicitis diagnosis score Adult Appendicitis Score Imaging CT scan appendicitis non-operative management Antibiotics Complicated appendicitis Appendectomy Laparoscopic appendectomy Diagnostic laparoscopy Phlegmon Appendiceal abscess
OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1.
Akhee Sabiha Jahan, Elise Biquand, Raquel Muñoz-Moreno, Agathe Le Quang, Chris Ka-Pun Mok, Ho Him Wong, Qi Wen Teo, Sophie A Valkenburg, Alex WH Chin, Leo Lit Man Poon, Artejan Te Velthuis, Adolfo García-Sastre, Caroline Demeret, Sumana Sanyal
Feb 17, 2020
Deubiquitylases (DUBs) regulate critical signaling pathways at the intersection of host immunity and viral pathogenesis. Although RIG-I activation is heavily dependent on ubiquitylation, systematic analyses of DUBs that regulate...
RIG-I signaling RNA virus deubiquitylases influenza A Innate immune response Ubiquitylation viral subversion strategies A549 Cells Animals Cysteine Endopeptidases Cytosol DEAD Box Protein 58 Deubiquitinating Enzymes Dogs Gene Deletion HEK293 Cells Humans Influenza Human Interferon Regulatory Factor-3 Interferon Type I Madin Darby Canine Kidney Cells Male Mitochondrial Membranes NF-kappa B Proteasome Endopeptidase Complex Protein Multimerization Proteolysis Receptors Immunologic Signal Transduction Viral Nonstructural Proteins
Heterostructures formed through abraded van der Waals materials
Darren Nutting, Jorlandio F. Felix, Evan Tillotson, Dong-Wook Shin, Adolfo De Sanctis, Hong Chang, Nick Cole, Saverio Russo, Adam Woodgate, Ioannis Leontis, Henry A. Fernández, Monica F. Craciun, Sarah J. Haigh, Freddie Withers
Jun 17, 2021
Abstract: To fully exploit van der Waals materials and their vertically stacked heterostructures, new mass-scalable production routes which are low cost but preserve the high electronic and optical quality of the single crystals...
Diagnosis and treatment of acute appendicitis
Salomone Di Saverio, Mauro Podda, Belinda De Simone, Marco Ceresoli, Goran Augustin, Alice Gori, Marja Boermeester, Massimo Sartelli, Federico Coccolini, Antonio Tarasconi, Nicola De' Angelis, Dieter G Weber, Matti Tolonen, Arianna Birindelli, Walter Biffl, Ernest E Moore, Michael Kelly, Kjetil Soreide, Jeffry Kashuk, Richard Ten Broek, Carlos Augusto Gomes, Michael Sugrue, Richard Justin Davies, Dimitrios Damaskos, Ari Leppäniemi, Andrew Kirkpatrick, Andrew B Peitzman, Gustavo P Fraga, Ronald V Maier, Raul Coimbra, Massimo Chiarugi, Gabriele Sganga, Adolfo Pisanu, Gian Luigi De' Angelis, Edward Tan, Harry Van Goor, Francesco Pata, Isidoro Di Carlo, Osvaldo Chiara, Andrey Litvin, Fabio C Campanile, Boris Sakakushev, Gia Tomadze, Zaza Demetrashvili, Rifat Latifi, Fakri Abu-Zidan, Oreste Romeo, Helmut Segovia-Lohse, Gianluca Baiocchi, David Costa, Sandro Rizoli, Zsolt J Balogh, Cino Bendinelli, Thomas Scalea, Rao Ivatury, George Velmahos, Roland Andersson, Yoram Kluger, Luca Ansaloni, Fausto Catena
Apr 15, 2021
BACKGROUND AND AIMS: Acute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different settings and...
acute appendicitis Adult Appendicitis Score Alvarado score Antibiotics Appendectomy Appendiceal abscess Appendicitis diagnosis score Appendicitis guidelines CT scan appendicitis Complicated appendicitis Consensus conference Diagnostic laparoscopy Imaging Jerusalem guidelines Laparoscopic appendectomy non-operative management Phlegmon Abdominal Pain Acute Disease Anti-Bacterial Agents Appendectomy Appendicitis Evidence-Based Medicine Humans laparoscopy Practice Guidelines as Topic
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