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Tsunami wave characteristics in Sendai Bay, Japan, following the 2016 Mw 6.9 Fukushima earthquake
An Chi Cheng, Anawat Suppasri, Mohammad Heidarzadeh, Bruno Adriano, Constance Ting Chua, Fumihiko Imamura
Nov 01, 2023
On 21 November 2016, a Mw 6.9 intraplate earthquake occurred off the Fukushima coast in Japan, triggering a moderate-size tsunami with amplifications and long oscillations along the Sendai Bay coast. Here, we apply a hybrid...
Tsunami wave characteristics in Sendai Bay, Japan, following the 2016 Mw 6.9 Fukushima earthquake
An Chi Cheng, Anawat Suppasri, Mohammad Heidarzadeh, Bruno Adriano, Constance Ting Chua, Fumihiko Imamura
Nov 01, 2023
On 21 November 2016, a Mw 6.9 intraplate earthquake occurred off the Fukushima coast in Japan, triggering a moderate-size tsunami with amplifications and long oscillations along the Sendai Bay coast. Here, we apply a hybrid...
Co-Design of a Trustworthy AI System in Healthcare
This paper documents how an ethically aligned co-design methodology ensures trustworthiness in the early design phase of an artificial intelligence (AI) system component for healthcare. The system explains decisions made...
Roberto V Zicari, Sheraz Ahmed, Julia Amann, Stephan Alexander Braun, John Brodersen, Frédérick Bruneault, James Brusseau, Erik Campano, Megan Coffee, Andreas Dengel, Boris Düdder, Alessio Gallucci, Thomas Krendl Gilbert, Philippe Gottfrois, Emmanuel Goffi, Christoffer Bjerre Haase, Thilo Hagendorff, Eleanore Hickman, Elisabeth Hildt, Sune Holm, Pedro Kringen, Ulrich Kühne, Adriano Lucieri, Vince I Madai, Pedro A Moreno-Sánchez, Oriana Medlicott, Matiss Ozols, Eberhard Schnebel, Andy Spezzatti, Jesmin Jahan Tithi, Steven Umbrello, Dennis Vetter, Holger Volland, Magnus Westerlund, Renee Wurth
Jul 28, 2021
Animal vocal sequences
Arik Kershenbaum, Ann E Bowles, Todd M Freeberg, Dezhe Z Jin, Adriano R Lameira, Kirsten Bohn
Oct 03, 2014
Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons.
Elizabeth Bilsland, Tatyana A Tavella, Renata Krogh, Jamie E Stokes, Annabelle Roberts, James Ajioka, David R Spring, Adriano D Andricopulo, Fabio TM Costa, Stephen G Oliver
Sep 20, 2018
BACKGROUND: Violacein is a deep violet compound that is produced by a number of bacterial species. It is synthesized from tryptophan by a pathway that involves the sequential action of 5 different enzymes (encoded by genes vioA...
Antiparasitic Deoxyviolacein Escherichia coli Plasmodium falciparum Synthetic operon Trypanosoma cruzi Violacein Animals Antimalarials Antineoplastic Agents COS Cells Chlorocebus aethiops Escherichia coli Hep G2 Cells Humans Indole Alkaloids Indoles Metabolic Engineering Operon Plasmids Plasmodium falciparum Spiro Compounds Trypanocidal Agents Trypanosoma cruzi
The effect of ozone gas sterilization on the properties and cell compatibility of electrospun polycaprolactone scaffolds
Carolina Rediguieri, Paul De Bank, Maria Helena Ambrosio Zanin, Patrícia Leo, Natalia Neto Pereira Cerize, Adriano Marim de Oliveira, Terezinha Pinto
Jul 30, 2017
The growing area of tissue engineering has the potential to alleviate the shortage of tissues and organs for transplantation, and electrospun biomaterial scaffolds are extremely promising devices for translating engineered...
Brain metabolic changes across King's stages in amyotrophic lateral sclerosis
Antonio Canosa, Andrea Calvo, Cristina Moglia, Umberto Manera, Rosario Vasta, Francesca Di Pede, Sara Cabras, Davide Nardo, Vincenzo Arena, Maurizio Grassano, Fabrizio D'Ovidio, Koen Van Laere, Philip Van Damme, Marco Pagani, Adriano Chiò
Oct 01, 2020
PURPOSE: To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King's staging system, using brain 18F-2-fluoro-2-deoxy-D-glucose-PET (18F-FDG-PET). METHODS: Three hundred ninety ALS...
Brain metabolic changes across King’s stages in amyotrophic lateral sclerosis
Antonio Canosa, Andrea Calvo, Cristina Moglia, Umberto Manera, Rosario Vasta, Francesca Di Pede, Sara Cabras, Davide Nardo, Vincenzo Arena, Maurizio Grassano, Fabrizio D’Ovidio, Koen Van Laere, Philip Van Damme, Marco Pagani, Adriano Chiò
Apr 12, 2021
Abstract: Purpose: To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King’s staging system, using brain 18F-2-fluoro-2-deoxy-d-glucose-PET (18F-FDG-PET). Methods: Three hundred...
The effect of ozone gas sterilization on the properties and cell compatibility of electrospun polycaprolactone scaffolds
Carolina Rediguieri, Paul De Bank, Maria Helena Ambrosio Zanin, Patrícia Leo, Natalia Neto Pereira Cerize, Adriano Marim de Oliveira, Terezinha Pinto
Jul 30, 2017
The growing area of tissue engineering has the potential to alleviate the shortage of tissues and organs for transplantation, and electrospun biomaterial scaffolds are extremely promising devices for translating engineered...
Kiloparsec-scale gaseous clumps and star formation at z = 5–7
Built environment and physical activity
Inácio Crochemore Mohnsam da Silva, Adriano Akira Hino, Adalberto Lopes, Ulf Ekelund, Soren Brage, Helen Gonçalves, Ana B Menezes, Rodrigo Siqueira Reis, Pedro Curi Hallal
Dec 04, 2017
BACKGROUND: Physical activity is likely to be determined as a complex interplay between personal, interpersonal, and environmental factors. Studying the built environment involves expanding the focus from the individual...
Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)).
Kristina A Ganzinger, Priyanka Narayan, Seema S Qamar, Laura Weimann, Rohan T Ranasinghe, Adriano Aguzzi, Christopher M Dobson, James McColl, Peter St George-Hyslop, David Klenerman
Aug 22, 2014
Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment.
Peter J Eastmond, Holly M Astley, Kate Parsley, Sylvain Aubry, Ben P Williams, Guillaume N Menard, Christian P Craddock, Adriano Nunes-Nesi, Alisdair R Fernie, Julian M Hibberd
Apr 17, 2015
Built environment and physical activity
Inácio C da Silva, Adriano A Hino, Adalberto Lopes, Ulf Ekelund, Soren Brage, Helen Gonçalves, Ana B Menezes, Rodrigo S Reis, Pedro C Hallal
Jul 04, 2017
Abstract
Background
Physical activity is likely to be determined as a complex interplay between personal, interpersonal, and environmental factors. Studying the built environment...
Brain metabolic changes across King’s stages in amyotrophic lateral sclerosis
Antonio Canosa, Andrea Calvo, Cristina Moglia, Umberto Manera, Rosario Vasta, Francesca Di Pede, Sara Cabras, Davide Nardo, Vincenzo Arena, Maurizio Grassano, Fabrizio D’Ovidio, Koen Van Laere, Philip Van Damme, Marco Pagani, Adriano Chiò
Oct 07, 2021
Abstract: Purpose: To assess the brain metabolic correlates of the different regional extent of ALS, evaluated with the King’s staging system, using brain 18F-2-fluoro-2-deoxy-d-glucose-PET (18F-FDG-PET). Methods: Three hundred...
Genetic screening in sporadic ALS and FTD.
Martin R Turner, Ammar Al-Chalabi, Adriano Chio, Orla Hardiman, Matthew C Kiernan, Jonathan D Rohrer, James Rowe, William Seeley, Kevin Talbot
Nov 29, 2017
The increasing complexity of the genetic landscape in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) presents a significant resource and physician training challenge. At least 10% of those diagnosed with...
MFN2 mutations in Charcot-Marie-Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics.
Delfina Larrea, Marta Pera, Adriano Gonnelli, Rubén Quintana-Cabrera, H Orhan Akman, Cristina Guardia-Laguarta, Kevin R Velasco, Estela Area-Gomez, Federica Dal Bello, Diego De Stefani, Rita Horvath, Michael E Shy, Eric A Schon, Marta Giacomello
Jun 28, 2019
Charcot-Marie-Tooth disease (CMT) type 2A is a form of peripheral neuropathy, due almost exclusively to dominant mutations in the nuclear gene encoding the mitochondrial protein mitofusin-2 (MFN2). However, there is no...
Scaling analysis reveals the mechanism and rates of prion replication in vivo.
Georg Meisl, Timothy Kurt, Itzel Condado-Morales, Cyrus Bett, Silvia Sorce, Mario Nuvolone, Thomas CT Michaels, Daniel Heinzer, Merve Avar, Samuel IA Cohen, Simone Hornemann, Adriano Aguzzi, Christopher M Dobson, Christina J Sigurdson, Tuomas PJ Knowles
Feb 15, 2021
Prions consist of pathological aggregates of cellular prion protein and have the ability to replicate, causing neurodegenerative diseases, a phenomenon mirrored in many other diseases connected to protein aggregation, including...
Functional characterisation of human pulmonary monocyte-like cells in lipopolysaccharide-mediated acute lung inflammation.
Mairi Brittan, Laura C Barr, Niall Anderson, Andrew Conway Morris, Rodger Duffin, John A Marwick, Fiona Rossi, Shonna Johnson, Kev Dhaliwal, Nikhil Hirani, Adriano G Rossi, A John Simpson
Jun 26, 2020
BACKGROUND: We have previously reported the presence of novel subpopulations of pulmonary monocyte-like cells (PMLC) in the human lung; resident PMLC (rPMLC, HLA-DR(+)CD14(++)CD16(+)cells) and inducible PMLC (iPMLC...
A conformational switch controlling the toxicity of the prion protein.
Karl Frontzek, Marco Bardelli, Assunta Senatore, Anna Henzi, Regina R Reimann, Seden Bedir, Marika Marino, Rohanah Hussain, Simon Jurt, Georg Meisl, Mattia Pedotti, Federica Mazzola, Giuliano Siligardi, Oliver Zerbe, Marco Losa, Tuomas Knowles, Asvin Lakkaraju, Caihong Zhu, Petra Schwarz, Simone Hornemann, Matthew G Holt, Luca Simonelli, Luca Varani, Adriano Aguzzi
Aug 12, 2022
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma.
Matthias M Schneider, Marc Emmenegger, Catherine K Xu, Itzel Condado Morales, Georg Meisl, Priscilla Turelli, Chryssa Zografou, Manuela R Zimmermann, Beat M Frey, Sebastian Fiedler, Viola Denninger, Raphaël PB Jacquat, Lidia Madrigal, Alison Ilsley, Vasilis Kosmoliaptsis, Heike Fiegler, Didier Trono, Tuomas PJ Knowles, Adriano Aguzzi
Jan 10, 2022
Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome.
David A Dorward, Christopher D Lucas, Mary K Doherty, Gavin B Chapman, Emma J Scholefield, Andrew Conway Morris, Jennifer M Felton, Tiina Kipari, Duncan C Humphries, Calum T Robb, A John Simpson, Phillip D Whitfield, Christopher Haslett, Kevin Dhaliwal, Adriano G Rossi
Aug 17, 2017
BACKGROUND: Acute respiratory distress syndrome (ARDS) is an often fatal neutrophil-dominant lung disease. Although influenced by multiple proinflammatory mediators, identification of suitable therapeutic candidates remains...
ARDS innate immunity Neutrophil Biology Animals Bronchoalveolar Lavage Fluid Chemotaxis Leukocyte Chromatography High Pressure Liquid Disease Models Animal Flow Cytometry Humans Mice Mitochondria Neutrophil Activation Neutrophils Receptors Formyl Peptide Respiratory Distress Syndrome Tandem Mass Spectrometry
An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation.
Merve Avar, Daniel Heinzer, Alana M Thackray, Yingjun Liu, Marian Hruska-Plochan, Stefano Sellitto, Elke Schaper, Daniel P Pease, Jiang-An Yin, Asvin Kk Lakkaraju, Marc Emmenegger, Marco Losa, Andra Chincisan, Simone Hornemann, Magdalini Polymenidou, Raymond Bujdoso, Adriano Aguzzi
Oct 18, 2022
Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2.
Viola Denninger, Catherine K Xu, Georg Meisl, Alexey S Morgunov, Sebastian Fiedler, Alison Ilsley, Marc Emmenegger, Anisa Y Malik, Monika A Piziorska, Matthias M Schneider, Sean RA Devenish, Vasilis Kosmoliaptsis, Adriano Aguzzi, Heike Fiegler, Tuomas PJ Knowles
Apr 29, 2022
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