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Results: 8868
Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer.
Elena V Knatko, Cecilia Castro, Maureen Higgins, Ying Zhang, Tadashi Honda, Colin J Henderson, C Roland Wolf, Julian L Griffin, Albena T Dinkova-Kostova
Oct 18, 2021
Heat shock factor 1 is a substrate for p38 mitogen-activated Protein Kinases
Sharadha Dayalan Naidu, Calum Sutherland, Ying Zhang, Ana Risco, Laureano de la Vega, Christopher J Caunt, C James Hastie, Douglas J Lamont, Laura Torrente, Sudhir Chowdhry, Ivor J Benjamin, Stephen M Keyse, Ana Cuenda, Albena T Dinkova-Kostova
Sep 01, 2016
Heat Shock Factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We...
DIA label-free proteomic analysis of murine bone-marrow-derived macrophages.
Christa P Baker, Iain R Phair, Alejandro J Brenes, Abdelmadjid Atrih, Dylan G Ryan, Roland Bruderer, Albena T Dinkova-Kostova, Douglas J Lamont, J Simon C Arthur, Andrew JM Howden
Oct 28, 2022
Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We provide a complete step-by-step protocol describing sample preparation...
Heat shock factor 1 is a substrate for p38 mitogen-activated Protein Kinases
Sharadha Dayalan Naidu, Calum Sutherland, Ying Zhang, Ana Risco, Laureano de la Vega, Christopher J Caunt, C James Hastie, Douglas J Lamont, Laura Torrente, Sudhir Chowdhry, Ivor J Benjamin, Stephen M Keyse, Ana Cuenda, Albena T Dinkova-Kostova
Sep 01, 2016
Heat Shock Factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We...
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response.
Dylan G Ryan, Elena V Knatko, Alva M Casey, Jens L Hukelmann, Sharadha Dayalan Naidu, Alejandro J Brenes, Thanapon Ekkunagul, Christa Baker, Maureen Higgins, Laura Tronci, Efterpi Nikitopolou, Tadashi Honda, Richard C Hartley, Luke AJ O'Neill, Christian Frezza, Angus I Lamond, Andrey Y Abramov, J Simon C Arthur, Doreen A Cantrell, Michael P Murphy, Albena T Dinkova-Kostova
Mar 28, 2022
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH...
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Evanna L Mills, Dylan G Ryan, Hiran A Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P Jedrychowski, Ana SH Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C Runtsch, Martin S King, Joanna F McGouran, Roman Fischer, Benedikt M Kessler, Anne F McGettrick, Mark M Hughes, Richard G Carroll, Lee M Booty, Elena V Knatko, Paul J Meakin, Michael LJ Ashford, Louise K Modis, Gino Brunori, Daniel C Sévin, Padraic G Fallon, Stuart T Caldwell, Edmund RS Kunji, Edward T Chouchani, Christian Frezza, Albena T Dinkova-Kostova, Richard C Hartley, Michael P Murphy, Luke A O'Neill
Jun 13, 2018
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood. Here we show that itaconate is required for the activation of the...
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack.
Zhikai Wang, Philip Moresco, Ran Yan, Jiayun Li, Ya Gao, Daniele Biasci, Min Yao, Jordan Pearson, Jaclyn F Hechtman, Tobias Janowitz, Raza M Zaidi, Matthew J Weiss, Douglas T Fearon
Feb 20, 2022
Cancer immunotherapy frequently fails because most carcinomas have few T cells, suggesting that cancers can suppress T cell infiltration. Here, we show that cancer cells of human pancreatic ductal adenocarcinoma (PDA)...
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signaling in Treg is controversial. Some...
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E Evans, John R Griffiths, Lorenz Poellinger, Ananda W Goldrath, Randall S Johnson
Dec 14, 2016
R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both...
Animals CD8-Positive T-Lymphocytes Cell Differentiation DNA DNA Methylation Dioxygenases Glutarates Histones Homeostasis Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Ketoglutaric Acids Lymphocyte Activation Lysine Mice Oxygen Protein Stability Receptors Antigen T-Cell Von Hippel-Lindau Tumor Suppressor Protein
Cardiac Arrhythmia, CHF, and NSR Classification With NCA-Based Feature Fusion and SVM Classifier
An arrhythmia is an irregular heartbeat that causes abnormal heart rhythms. Manual analysis of electrocardiogram (ECG) signals is not sufficient to quickly detect cardiac arrhythmias. This study proposes a deep learning approach...
Systems & Software Design Computer Science and Information Technology Systems and Software Engineering
Published by: IGI Global Scientific Publishing
Interview with Willie T. "Dub" Massey - OH 138
Willie T. Massey
Jan 01, 0001
In his April 27th, 1981 interview with Phil O'Quinn, Rev. Willie T. "Dub" Massey recollects his involvement in the Civil Rights Movement as one of the Friendship 9 protestors and non-violent activists. Massey retells the...
Friendship nine Friendship 9 Grassroots movement sit-in non-violent protests Rock Hill McCrory's discrimination Segregation Jim Crow NAACP Jail No Bail law
Published by: Winthrop University
Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ
T cells recognize peptides that are bound to MHC molecules on the surface of different types of antigen-presenting cells (APC). Antigen presentation most often is studied using T cells that have undergone priming in situ, or...
Antigen Presentation dendritic cell Immunogenicity major histocompatibility complex restriction t lymphocyte activation
Published by: Rockefeller University
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy.
Marcel P Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C Stinchcombe, Michal A Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S Thommen, Gillian M Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Mar 05, 2023
Tumor-specific T cells are frequently exhausted by chronic antigenic stimulation. We here report on a human antigen-specific ex vivo model to explore new therapeutic options for T cell immunotherapies. T cells generated with...
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