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Cleavable linkers in antibody–drug conjugates
This tutorial review summarises the advances in the field of cleavable linker technologies for antibody–drug conjugates (ADCs).
Sulfatase-cleavable linkers for antibody-drug conjugates.
Jonathan D Bargh, Stephen J Walsh, Albert Isidro-Llobet, Soleilmane Omarjee, Jason S Carroll, David R Spring
Feb 05, 2020
Antibody-drug conjugates (ADCs) are a class of targeted drug delivery agents combining the cell-selectivity of monoclonal antibodies (mAbs) and the cytotoxicity of small molecules. These two components are joined by a covalent...
Sulfatase-cleavable linkers for antibody-drug conjugates.
Jonathan D Bargh, Stephen J Walsh, Albert Isidro-Llobet, Soleilmane Omarjee, Jason S Carroll, David R Spring
Jul 28, 2021
Antibody-drug conjugates (ADCs) are a class of targeted drug delivery agents combining the cell-selectivity of monoclonal antibodies (mAbs) and the cytotoxicity of small molecules. These two components are joined by a covalent...
Published by: Chemical science
2002 ALBERT LASKER AWARD
The Rockefeller University
Jan 01, 0001
The Rockefeller University congratulated James E. Darnell Jr, recipient of the 2002 Albert Lasker Award for special achievement in medical science.
Founded in 1945, the Albert Lasker Award recognizes the contributions of...
Published by: The Rockefeller University
Albert Claude, 1948
The Rockefeller University
Jan 01, 0001
Albert Claude. Studies on cells: morphology, chemical constitution, and distributions of biochemical functions.
Lecture delivered January 15th, 1948
Published by: Charles C. Thomas Publisher
IJAGR at the International Medical Symposium Geography 2022 Edinburgh, Scotland
Donald Albert
Jan 01, 2023
Donald Albert (co-Editor-in-Chief) from Sam Houston State University and Dhitinut Ratnapradipa (Associate Editor) from Creighton University participated in the 19th International Medical Symposium Geography (IMGS) from June...
Published by: IGI Global Scientific Publishing
An Effective Emotional Analysis Method of Consumer Comment Text Based on ALBERT-ATBiFRU-CNN
Mei Yang
Dec 21, 2022
To address the challenges of insufficient feature extraction for text sentiment analysis in the e-commerce big data environment, the author proposes a deep learning-based emotion analysis method of consumer comment text....
Published by: IGI Global Scientific Publishing
On
<i>Sanctitatis nova signa</i>
Jose Isidro Belleza
Nov 11, 2022
This paper advances a provisional case denying the attribution of the medieval liturgical sequence Sanctitatis nova signa, written in honor of Saint Francis of Assisi, to Thomas of Celano (died c. 1260), who is best known for...
Football, Mysticism, Thomistic Poetics
Jose Isidro Belleza
Apr 14, 2023
This essay will especially consider the role of the cogitative power and affectivity in the formation of vocal utterances, showing how the Thomistic account of the integration of passion with reason provides a fascinating...
2007 LASKER AWARD
The Rockefeller University
Jan 01, 0001
Ralph M. Steinman, recipient of the 2007 Albert Lasker Award for basic medical research
See Dendritic cells and their immune response
Founded in 1945, the Albert Lasker Award recognizes the contributions of scientists...
Published by: The Rockefeller University
Chinese Named Entity Recognition Method Combining ALBERT and a Local Adversarial Training and Adding Attention Mechanism
For Chinese NER tasks, there is very little annotation data available. To increase the dataset, improve the accuracy of Chinese NER task, and improve the model's stability, the authors propose a method to add local adversarial...
Published by: IGI Global Scientific Publishing
KekuleScope
The application of convolutional neural networks (ConvNets) to harness high-content screening images or 2D compound representations is gaining increasing attention in drug discovery. However, existing applications often require...
EMPLOYEE RECOGNITION
The Rockefeller University
Jan 01, 0001
The Rockefeller University honored Torsten Wiesel, Albert Libchaber, Michael Young, David Allis, Ralph Steinman, Joshua Lederberg, and Jeffrey Ravetch
Published by: The Rockefeller University
Pleading
<i>Nolo Contendere</i>
? Aquinas vs. Bonaventure on Poetry1
Jose Isidro Belleza
Mar 29, 2023
While the story of Thomas Aquinas and Bonaventure of Bagnoregio engaging in a friendly contest, at the behest of Pope Urban IV, to compose the Mass and Office of Corpus Christi is likely a pious fiction, one can still ponder the...
QSAR-derived affinity fingerprints (part 2)
Abstract: Affinity fingerprints report the activity of small molecules across a set of assays, and thus permit to gather information about the bioactivities of structurally dissimilar compounds, where models based on chemical...
Albert Harold Banks
Jarred John Cantu
Apr 01, 2020
One thing is certain for the history of San Antonio; the African American community has had a little spotlight shined on them throughout. Today San Antonio has many different cultures throughout where ideas are all mixed...
San Antonio Albert Harold Banks African American businesses barbershops African American Studies United States History
Published by: Digital Commons @ Texas A&M University-San Antonio
Albert Harold Banks
Jarred John Cantu
Apr 01, 2020
One thing is certain for the history of San Antonio; the African American community has had a little spotlight shined on them throughout. Today San Antonio has many different cultures throughout where ideas are all mixed...
San Antonio Albert Harold Banks African American businesses barbershops African American Studies United States History
Published by: Digital Commons @ Texas A&M University-San Antonio
JEFFREY M. FRIEDMAN
The Rockefeller University
Jan 01, 0001
congratulations to Professor Jeffrey M. Friedman, recipient of the 2010 Albert Lasker Basic Medical Research Award
Published by: The Rockefeller University
QSAR-derived affinity fingerprints (part 2)
Affinity fingerprints report the activity of small molecules across a set of assays, and thus permit to gather information about the bioactivities of structurally dissimilar compounds, where models based on chemical structure...
The Ursinus Weekly, January 10, 1916
University of Pennsylvania society debates Schaff Ursinus victim; Albright victor Death of Albert Vogel College spirit Christian associations Resolutions Inter-group basketball
Ursinus College Collegeville Pennsylvania newspaper Dwight O. Kerr Basketball Schaff literary society YMCA YWCA cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Faculty Members' Documentary Details Spartanburg's Duncan Park Stadium
Winthrop University
Jan 01, 0001
"Duncan Park Stadium: 85 Years of Baseball Memories" will air Oct. 20 and Oct. 24 on ETV. Faculty members Mark Nortz and Albert Bolognese started working on the documentary in January 2010.
Published by: Winthrop University
Modelling ligand selectivity of serine proteases using integrative proteochemometric approaches improves model performance and allows the multi-target dependent interpretation of features.
Qurrat U Ain, Oscar Méndez-Lucio, Isidro Cortés Ciriano, Thérèse Malliavin, Gerard JP van Westen, Andreas Bender
Sep 19, 2014
Albert Harold Banks
Jarred John Cantu
Apr 01, 2020
One thing is certain for the history of San Antonio; the African American community has had a little spotlight shined on them throughout. Today San Antonio has many different cultures throughout where ideas are all mixed...
San Antonio Albert Harold Banks African American businesses barbershops African American Studies United States History
Published by: Digital Commons @ Texas A&M University-San Antonio
QSAR-derived affinity fingerprints (part 2)
Abstract: Affinity fingerprints report the activity of small molecules across a set of assays, and thus permit to gather information about the bioactivities of structurally dissimilar compounds, where models based on chemical...
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