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Beliefs in Online Professional Learning in Early Mathematics Teaching and Their Effects on Course Engagement
This study focused on the effects of an early math online professional learning course offered to preschool teachers. The course was designed to inform participants' knowledge of developmental progressions and promote daily...
Published by: IGI Global Scientific Publishing
The storage stability of biocrude obtained by the hydrothermal liquefaction of microalgae
Hydrothermal liquefaction (HTL) is a promising technology that can produce biocrude oil from wet biomass. The biocrudes, while generally acknowledged to be more stable than pyrolysis oils, are still thought to degrade...
Diffusion MRI approaches for investigating microstructural complexity in a rat model of traumatic brain injury.
Karthik Chary, Eppu Manninen, Jade Claessens, Alonso Ramirez-Manzanares, Olli Gröhn, Alejandra Sierra
Feb 09, 2023
Our study explores the potential of conventional and advanced diffusion MRI techniques including diffusion tensor imaging (DTI), and single-shell 3-tissue constrained spherical deconvolution (SS3T-CSD) to investigate complex...
The storage stability of biocrude obtained by the hydrothermal liquefaction of microalgae
Hydrothermal liquefaction (HTL) is a promising technology that can produce biocrude oil from wet biomass. The biocrudes, while generally acknowledged to be more stable than pyrolysis oils, are still thought to degrade...
Metabolic imaging with hyperpolarized [1-13C] pyruvate in patient-derived preclinical mouse models of breast cancer.
13C nuclear spin hyperpolarization can increase the sensitivity of detection in an MRI experiment by more than 10,000-fold. 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C label exchange between...
Deciphering the role of miR-71 in Echinococcus multilocularis early development in vitro.
Matías Gastón Pérez, Markus Spiliotis, Natalia Rego, Natalia Macchiaroli, Laura Kamenetzky, Nancy Holroyd, Marcela Alejandra Cucher, Klaus Brehm, Mara Cecilia Rosenzvit
Jan 13, 2020
Echinococcosis represents a major public health problem worldwide and is considered a neglected disease by the World Health Organization. The etiological agents are Echinococcus tapeworms, which display elaborate developmental...
Enhancing the stability and efficiency of MAPbI3 perovskite solar cells by theophylline-BF4 - alkaloid derivatives, a theoretical-experimental approach.
Measurement and analysis of air quality in temporary shelters on three continents
Dima Albadra, N Kuchai, Alejandra Acevedo De Los Ríos, Daniel Rondinel-Oviedo, David Coley, Carla Florbela Ferreira Pinto Da Silva, Chetas Rana, Keith Mower, Andy Dengel, Dan Maskell, Richard Ball
Nov 30, 2020
Millions of displaced people are housed in shelters that generally consist of a single room, meaning that activities including cooking, sleeping and socialising all take place in the same space. Therefore, indoor air quality can...
Intersect-then-combine approach
Maurizio Callari, Stephen-John Sammut, Leticia De Mattos-Arruda, Alejandra Bruna, Oscar M Rueda, Suet-Feung Chin, Carlos Caldas
May 05, 2017
Bioinformatic analysis of genomic sequencing data to identify somatic mutations in cancer samples is far from achieving the required robustness and standardisation. In this study we generated a whole exome sequencing benchmark...
BWA Filtering Mutect2 NA12878 Novoalign Platinum genome Somatic mutation Strelka Variant calling Whole exome sequencing Algorithms Computational Biology DNA Neoplasm Exome Genome Human Humans INDEL Mutation Mutation Neoplasms Polymorphism Single Nucleotide Sensitivity and Specificity Sequence Analysis DNA
Measurement and analysis of air quality in temporary shelters on three continents
Dima Albadra, N Kuchai, Alejandra Acevedo De Los Ríos, Daniel Rondinel-Oviedo, David Coley, Carla Florbela Ferreira Pinto Da Silva, Chetas Rana, Keith Mower, Andy Dengel, Dan Maskell, Richard Ball
Nov 30, 2020
Millions of displaced people are housed in shelters that generally consist of a single room, meaning that activities including cooking, sleeping and socialising all take place in the same space. Therefore, indoor air quality can...
Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome.
Ana Tufegdzic Vidakovic, Oscar M Rueda, Stephin J Vervoort, Ankita Sati Batra, Mae Akilina Goldgraben, Santiago Uribe-Lewis, Wendy Greenwood, Paul J Coffer, Alejandra Bruna, Carlos Caldas
Oct 21, 2015
Binding Sites Cell Line Tumor DNA DNA Methylation Epigenesis Genetic Histones Humans Neoplastic Stem Cells Promoter Regions Genetic Protein Binding RNA Interference RNA Small Interfering Signal Transduction Smad2 Protein Smad3 Protein Trans-Activators Transcription Factors Transforming Growth Factor beta
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells.
Cesar L Cuevas-Velazquez, Tamara Vellosillo, Karina Guadalupe, Hermann Broder Schmidt, Feng Yu, David Moses, Jennifer AN Brophy, Dante Cosio-Acosta, Alakananda Das, Lingxin Wang, Alexander M Jones, Alejandra A Covarrubias, Shahar Sukenik, José R Dinneny
Nov 22, 2021
Cell homeostasis is perturbed when dramatic shifts in the external environment cause the physical-chemical properties inside the cell to change. Experimental approaches for dynamically monitoring these intracellular effects are...
Arabidopsis Arabidopsis Proteins Binding Sites Biosensing Techniques Cell Line Tumor Escherichia coli Fluorescence Resonance Energy Transfer Gene Expression Humans Intrinsically Disordered Proteins Kinetics Models Molecular Molecular Chaperones Osmolar Concentration Osmotic Pressure Osteoblasts Protein Binding Protein Conformation Protein Interaction Domains and Motifs Recombinant Proteins Saccharomyces cerevisiae Thermodynamics water
Human cell transformation by combined lineage conversion and oncogene expression.
Biswajyoti Sahu, Päivi Pihlajamaa, Kaiyang Zhang, Kimmo Palin, Saija Ahonen, Alejandra Cervera, Ari Ristimäki, Lauri A Aaltonen, Sampsa Hautaniemi, Jussi Taipale
Sep 09, 2021
SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis.
Stephin J Vervoort, Ana Rita Lourenço, Ana Tufegdzic Vidakovic, Enric Mocholi, José L Sandoval, Oscar M Rueda, Cynthia Frederiks, Cornelieke Pals, Janneke GC Peeters, Carlos Caldas, Alejandra Bruna, Paul J Coffer
Dec 13, 2018
Expression of the transcription factor SOX4 is often elevated in human cancers, where it generally correlates with tumor-progression and poor-disease outcome. Reduction of SOX4 expression results in both diminished...
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.
Zheng Xue, Daniel J Vis, Alejandra Bruna, Tonci Sustic, Sake van Wageningen, Ankita Sati Batra, Oscar M Rueda, Evert Bosdriesz, Carlos Caldas, Lodewyk FA Wessels, René Bernards
Apr 29, 2019
Activation of the mitogen-activated protein kinase (MAPK) pathway is frequent in cancer. Drug development efforts have been focused on kinases in this pathway, most notably on RAF and MEK. We show here that MEK inhibition...
Animals Benzimidazoles Breast Neoplasms Cell Line Tumor Colonic Neoplasms Drug Resistance Neoplasm Female Heterografts Humans Loss of Function Mutation MAP Kinase Kinase 4 MAP Kinase Kinase Kinase 1 MAP Kinase Signaling System Male Mice Inbred BALB C Mice Nude Mitogen-Activated Protein Kinase Kinases Prostatic Neoplasms Protein Kinase Inhibitors
Nonalcoholic and Alcoholic Beverage Intakes by Adults across 5 Upper-Middle- and High-Income Countries.
Lana Vanderlee, Christine M White, Sharon I Kirkpatrick, Vicki L Rynard, Alejandra Jáuregui, Jean Adams, Gary Sacks, David Hammond
Nov 12, 2020
adults Alcohol beverage consumption diet beverage consumption international comparisons noncaloric sweetener Sugar-sweetened beverages sugary drinks Adolescent Adult Aged Alcohol Drinking Alcoholic Beverages Developed Countries Diet Surveys Female Humans Income Male Middle Aged Surveys and Questionnaires Young Adult
A survey of best practices for RNA-seq data analysis.
Ana Conesa, Pedro Madrigal, Sonia Tarazona, David Gomez-Cabrero, Alejandra Cervera, Andrew McPherson, Michał Wojciech Szcześniak, Daniel J Gaffney, Laura L Elo, Xuegong Zhang, Ali Mortazavi
Jan 13, 2016
Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts.
Maurizio Callari, Ankita Sati Batra, Rajbir Nath Batra, Stephen Sammut, Wendy Greenwood, Harry Clifford, Colin Hercus, Suet-Feung Chin, Alejandra Bruna, Oscar M Rueda, Carlos Caldas
Mar 08, 2018
Background - Patient-Derived Tumour Xenografts (PDTXs) have emerged as the pre-clinical models that best represent clinical tumour diversity and intra-tumour heterogeneity. The molecular characterization of PDTXs using...
Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.
Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas
Jul 31, 2019
BRCA1 BRCA2 DNA damage responses alkylating agents cisplatin Animals BRCA1 Protein BRCA2 Protein Cell Line Tumor Chlorambucil Cricetinae Drug Delivery Systems Drug Resistance Neoplasm Humans Leukemia Lymphocytic Chronic B-Cell Male Mice Mice SCID Peroxisome Proliferator-Activated Receptors Phthalazines Piperazines Xenograft Model Antitumor Assays
Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells
Zijian Fang, Shiqian Chen, Yusman Manchanda, Stavroula Bitsi, Philip Pickford, Alessia David, Maria M. Shchepinova, Ivan R. Corrêa Jr, David J. Hodson, Johannes Broichhagen, Edward W. Tate, Frank Reimann, Victoria Salem, Guy A. Rutter, Tricia Tan, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Nov 10, 2020
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic...
MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer.
Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio
Nov 25, 2022
The telomeric repeat-binding factor 2 (TRF2) is a telomere-capping protein that plays a key role in the maintenance of telomere structure and function. It is highly expressed in different cancer types, and it contributes to...
Landscape of G-quadruplex DNA structural regions in breast cancer.
Robert Hänsel-Hertsch, Angela Simeone, Abigail Shea, Winnie WI Hui, Katherine G Zyner, Giovanni Marsico, Oscar M Rueda, Alejandra Bruna, Alistair Martin, Xiaoyun Zhang, Santosh Adhikari, David Tannahill, Carlos Caldas, Shankar Balasubramanian
Jun 30, 2020
CyanoGate
Ravendran Vasudevan, Grant AR Gale, Alejandra A Schiavon, Anton Puzorjov, John Malin, Michael D Gillespie, Konstantinos Vavitsas, Valentin Zulkower, Baojun Wang, Christopher J Howe, David J Lea-Smith, Alistair J McCormick
Mar 14, 2019
Recent advances in synthetic biology research have been underpinned by an exponential increase in available genomic information and a proliferation of advanced DNA assembly tools. The adoption of plasmid vector assembly...
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