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Results: 208
Population-scale proteome variation in human induced pluripotent stem cells.
Bogdan Andrei Mirauta, Daniel D Seaton, Dalila Bensaddek, Alejandro Brenes, Marc Jan Bonder, Helena Kilpinen, HipSci Consortium, Oliver Stegle, Angus I Lamond
Nov 02, 2020
Human disease phenotypes are driven primarily by alterations in protein expression and/or function. To date, relatively little is known about the variability of the human proteome in populations and how this relates to...
deleterious variants Genetics Genomics human Induced Pluripotent Stem Cells Proteomics Adolescent Adult Aged Child Child Preschool Disease Female genetic variation Genetics Population Genotype Humans Induced Pluripotent Stem Cells Infant Infant Newborn Male Middle Aged Phenotype Proteome Proteomics Quantitative Trait Loci RNA Messenger Transcriptome Young Adult
DIA label-free proteomic analysis of murine bone-marrow-derived macrophages.
Christa P Baker, Iain R Phair, Alejandro J Brenes, Abdelmadjid Atrih, Dylan G Ryan, Roland Bruderer, Albena T Dinkova-Kostova, Douglas J Lamont, J Simon C Arthur, Andrew JM Howden
Oct 28, 2022
Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We provide a complete step-by-step protocol describing sample preparation...
The Impact of Atmosphere on the Local Luminescence Properties of Metal Halide Perovskite Grains.
Metal halide perovskites are exceptional candidates for inexpensive yet high-performing optoelectronic devices. Nevertheless, polycrystalline perovskite films are still limited by nonradiative losses due to charge carrier trap...
Active Blended Learning
This chapter focuses on the joint implementation of blended learning and active learning. The authors analysed 152 institutional websites containing definitions of these concepts. Blended learning is commonly, though arguably...
Published by: IGI Global Scientific Publishing
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response.
Dylan G Ryan, Elena V Knatko, Alva M Casey, Jens L Hukelmann, Sharadha Dayalan Naidu, Alejandro J Brenes, Thanapon Ekkunagul, Christa Baker, Maureen Higgins, Laura Tronci, Efterpi Nikitopolou, Tadashi Honda, Richard C Hartley, Luke AJ O'Neill, Christian Frezza, Angus I Lamond, Andrey Y Abramov, J Simon C Arthur, Doreen A Cantrell, Michael P Murphy, Albena T Dinkova-Kostova
Mar 28, 2022
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH...
Design Thinking and Compliance as Drivers for Decision Support System Adoption in Agriculture
To respond to increasing demands for good agricultural practices (GAP) and food safety, governments globally are introducing stringent regulations to govern agricultural compliance that affect production, storage, and sales...
Published by: IGI Global Scientific Publishing
COVID-19 Mitigation Measures and Their Impact on Subjective Wellbeing
This study assesses the actual magnitude and scope of the impacts of the COVID-19 mitigation measures at the individual level, with special interest in subjective well-being (SWB), its relevance and how these negative effects...
Published by: IGI Global Scientific Publishing
Neural Mechanisms that Control an Innate Foraging Behavior in Caenorhabditis Elegans
Alejandro Lopez-Cruz
Jan 01, 0001
The ability to efficiently locate food is critical for survival. Thus, animals modify their foraging patterns based on recent experience and current conditions to increase their likelihood of finding food. One highly conserved...
Published by: Rockefeller University
On the Interactions of Augmin with Microtubules and the Mechanics of the Cross-Linker PRC1
Alejandro Dottore
Jan 01, 0001
Cell division in eukaryotes requires the assembly and maintenance of a structure, the bipolar spindle, self-organized from microtubules and their associated proteins. A multitude of components have been identified to be involved...
Published by: Rockefeller University
The infrastructures of internal colonialism:
Alejandro De Coss-Corzo
May 01, 2023
This article explores the relation between infrastructures, labour and internal colonialism in Lerma, Mexico. Drawing on archival and ethnographic research of two hydraulic projects there, the article argues that infrastructures...
The infrastructures of internal colonialism:
Alejandro De Coss-Corzo
May 01, 2023
This article explores the relation between infrastructures, labour and internal colonialism in Lerma, Mexico. Drawing on archival and ethnographic research of two hydraulic projects there, the article argues that infrastructures...
The Impact of Phase Retention on the Structural and Optoelectronic Properties of Metal Halide Perovskites.
Anna Osherov, Eline M Hutter, Krzysztof Galkowski, Roberto Brenes, Duncan K Maude, Robin J Nicholas, Paulina Plochocka, Vladimir Bulović, Tom J Savenije, Samuel D Stranks
Aug 16, 2017
The extent to which the soft structural properties of metal halide perovskites affect their optoelectronic properties is unclear. X-ray diffraction and micro-photoluminescence measurements are used to show that there is a...
Genetic diversity of Phytophthora infestans in the Northern Andean region.
Brain-to-Brain Coupling in the Gamma-Band as a Marker of Shared Intentionality
Cooperation and competition are two ways of social interaction keys to life in society. Recent EEG-based hyperscanning studies reveal that cooperative and competitive interactions induce an increase in interbrain coupling....
Joint recording of EEG and audio signals in hyperscanning and pseudo-hyperscanning experiments.
Hyperscanning is an emerging technique that allows for the study of brain similarities between interacting individuals. This methodology has powerful implications for understanding the neural basis of joint actions, such as...
Non-axisymmetric complete flow conditioning gauzes
Abstract: This paper presents a novel methodology for the design of a gauze that produces distributions of stagnation pressure, swirl angle, pitch angle and turbulence intensity, tailored in both the radial and circumferential...
Enhancing Preoperative Planning in Orthopedic Trauma Surgery Using a Presentation Software.
Preoperative planning (PP) is critical to ensure a successful outcome in orthopaedic trauma surgery. Since it was first described thirty years ago, no modifications have been made to the original preoperative planning (OPP)...
Data-Efficient Neural Network for Track Profile Modelling in Cold Spray Additive Manufacturing
Cold spray is emerging as an additive manufacturing technique, particularly advantageous when high production rate and large build sizes are in demand. To further accelerate technology’s industrial maturity, the problem of...
Lack of detectable neoantigen depletion signals in the untreated cancer genome.
Somatic mutations can result in the formation of neoantigens, immunogenic peptides that are presented on the tumor cell surface by HLA molecules. These mutations are expected to be under negative selection pressure, but the...
Non-axisymmetric complete flow conditioning gauzes
Abstract: This paper presents a novel methodology for the design of a gauze that produces distributions of stagnation pressure, swirl angle, pitch angle and turbulence intensity, tailored in both the radial and circumferential...
Carotenoid-dependent plumage coloration is associated with reduced male care in passerine birds
The immense diversity of plumage coloration exhibited by birds is the result of either pigments deposited in the feathers or microstructural arrangements of feather barbules. Some of the most common pigments are carotenoids...
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