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The major barriers to evidence-informed conservation policy and possible solutions.
David C Rose, William J Sutherland, Tatsuya Amano, Juan P González-Varo, Rebecca J Robertson, Benno I Simmons, Hannah S Wauchope, Eszter Kovacs, América Paz Durán, Alice BM Vadrot, Weiling Wu, Maria P Dias, Martina MI Di Fonzo, Sarah Ivory, Lucia Norris, Matheus Henrique Nunes, Tobias Ochieng Nyumba, Noa Steiner, Juliet Vickery, Nibedita Mukherjee
Jul 17, 2018
Conservation policy decisions can suffer from a lack of evidence, hindering effective decision-making. In nature conservation, studies investigating why policy is often not evidence-informed have tended to focus on Western...
Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice.
Alexi Crosby, Mark R Toshner, Mark R Southwood, Elaine Soon, Benjamin J Dunmore, Emily Groves, Stephen Moore, Penny Wright, Katrin Ottersbach, Cavan Bennett, Jose Guerrero, Cedric Ghevaert, Nicholas W Morrell
Nov 15, 2018
Increasing evidence suggests that patients with pulmonary arterial hypertension (PAH) demonstrate abnormalities in the bone marrow (BM) and hematopoietic progenitor cells. In addition, PAH is associated with myeloproliferative...
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling.
Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot
Nov 30, 2020
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How glycolysis and its major byproduct lactate are triggered in bone marrow (BM) neutrophils and...
Neuronal regulation of bone marrow stem cell niches.
The bone marrow (BM) is the primary site of postnatal hematopoiesis and hematopoietic stem cell (HSC) maintenance. The BM HSC niche is an essential microenvironment which evolves and responds to the physiological demands of...
Exploring Totalitarian Elements of Artificial Intelligence in Higher Education With Hannah Arendt
Alice Watanabe
Jan 01, 2023
From the perspective of political philosophy, this article examines the extent to which artificial intelligence (AI) applications in higher education contain totalitarian elements. Drawing on the theoretical considerations of...
Published by: IGI Global Scientific Publishing
Human Bone Marrow Mesenchymal Stromal Cell-Derived CXCL12, IL-6 and GDF-15 and Their Capacity to Support IgG-Secreting Cells in Culture Are Divergently Affected by Doxorubicin
Various subsets of bone marrow mesenchymal stromal cells (BM MSCs), including fibroblasts, endothelial, fat and reticular cells, are implicated in the regulation of the hematopoietic microenvironment and the survival of...
Gintare Lasaviciute, Anna Höbinger, Dorina Ujvari, Daniel Salamon, Aisha Yusuf, Mikael Sundin, Eva Sverremark-Ekström, Rayan Chikhi, Anna Nilsson, Shanie Saghafian-Hedengren
Mar 15, 2021
Hematology Cancer Stem Cell Research - Nonembryonic - Non-Human Stem Cell Research - Nonembryonic - Human Stem Cell Research Pediatric Regenerative Medicine Transplantation 2 Aetiology 5.2 Cellular and gene therapies 5 Development of treatments and therapeutic interventions 2.1 Biological and endogenous factors Cancer Inflammatory and immune system
Proximate Breast Cancer Factors Using Data Mining Classification Techniques
Breast cancer is the most common of all cancers and is the leading cause of cancer deaths in women worldwide. The classification of breast cancer data can be useful to predict the outcome of some diseases or discover the genetic...
Published by: IGI Global Scientific Publishing
Hematopoietic stem and progenitor cells outside the bone marrow
Bone marrow (BM) is the primary site of adult blood production, hosting the majority of all hematopoietic stem and progenitor cells (HSPCs). Rare HSPCs are also found outside of the BM at steady state. In times of large...
Burmeister Named Acting Chair for Department of Art and Design
Winthrop University
Jan 01, 0001
For the next academic year, Alice Burmeister, art history, will be acting chair of the Department of Art and Design. Burmeister, associate professor of art history, came to Winthrop in 1997.
Published by: Winthrop University
Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance.
Karin Golan, Anju Kumari, Orit Kollet, Eman Khatib-Massalha, Mohana Devi Subramaniam, Zulma S Ferreira, Francesca Avemaria, Sylwia Rzeszotek, Andrés García-García, Stephanie Xie, Eugenia Flores-Figueroa, Shiri Gur-Cohen, Tomer Itkin, Aya Ludin-Tal, Hassan Massalha, Biana Bernshtein, Andrzej K Ciechanowicz, Alexander Brandis, Tevie Mehlman, Suditi Bhattacharya, Mayla Bertagna, Hui Cheng, Ekaterina Petrovich-Kopitman, Tomasz Janus, Nathali Kaushansky, Tao Cheng, Irit Sagi, Mariusz Z Ratajczak, Simón Méndez-Ferrer, John E Dick, Regina P Markus, Tsvee Lapidot
Nov 20, 2018
Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic stem cells (LT-HSCs), with intensive daily production...
TNF Bone Marrow differentiation and egress hematopoietic stem and progenitor cells light and darkness maintenance and retention melatonin Norepinephrine stem cell repopulation potential vascular permeability Animals Cell Differentiation Cells Cultured Darkness Epigenesis Genetic Hematopoietic Stem Cells LIGHT Mice Mice Inbred C57BL Transcription Factors
Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1.
Cell migration relies on coordinated activity of chemotactic and guidance receptors. Here, we report a specific role for the RNA-binding protein ZFP36L1 in limiting the abundance of molecules involved in the homing of...
Animals Antibody-Producing Cells Antigens B-Lymphocytes Base Sequence Bone Marrow Butyrate Response Factor 1 Cell Count Cell Death Cell Membrane Cell Movement G-Protein-Coupled Receptor Kinase 2 Gene Expression Regulation Germinal Center Immunization Integrins Lysophospholipids Mice Inbred C57BL Receptors CXCR4 Receptors G-Protein-Coupled Signal Transduction Sphingosine Sphingosine-1-Phosphate Receptors Spleen
College of Visual and Performing Arts Will Have Interim Dean During Fall
Winthrop University
Jan 01, 0001
Alice Burmeister will oversee the four departments of Music, Fine Arts, Design and Theatre and Dance. Dean Elizabeth "Libby" Patenaude remains on medical leave.
Published by: Winthrop University
Missing Link of the Health Information Exchange Loop
Since 2004, the services of the Florida Health Information Exchange (HIE) have grown, and in 2011, the state contracted with Harris Corporation to provide some basic services to the Florida health care industry and provide...
Published by: IGI Global Scientific Publishing
Future Sustainability of the Florida Health Information Exchange
Florida began the journey to health information connectivity in 2004 under Governor Jeb Bush. Initially these efforts were funded by grants, but due to the downturn in the economy, the state was unable to support growth in 2008....
Published by: IGI Global Scientific Publishing
Knowledge-Concealing Evidencing of Knowledge About a Quantum State.
Bob has a black box that emits a single pure state qudit which is, from his perspective, uniformly distributed. Alice wishes to give Bob evidence that she has knowledge about the emitted state while giving him little or no...
Laminin Levels Regulate Tissue Migration and Anterior-Posterior Polarity during Egg Morphogenesis in Drosophila.
María C Díaz de la Loza, Alfonsa Díaz-Torres, Federico Zurita, Alicia E Rosales-Nieves, Emad Moeendarbary, Kristian Franze, María D Martín-Bermudo, Acaimo González-Reyes
Mar 28, 2018
Basement membranes (BMs) are specialized extracellular matrices required for tissue organization and organ formation. We study the role of laminin and its integrin receptor in the regulation of tissue migration during Drosophila...
Proximate Breast Cancer Factors Using Data Mining Classification Techniques
Breast cancer is the most common of all cancers and is the leading cause of cancer deaths in women worldwide. The classification of breast cancer data can be useful to predict the outcome of some diseases or discover the genetic...
Medicine and Healthcare Medical Technologies Medical Informatics Computer Science and Information Technology Physical Sciences and Engineering
Published by: IGI Global Scientific Publishing
Healthcare Professionals' Perceptions of Factors That Could Inform Adherence Interventions for Postnatal Depression Treatments
Interventions for postnatal depression (PND) have been widely researched, but little is known about techniques to improve poor adherence to treatment and sustained outcomes. To explore healthcare professionals' experience, a...
Published by: IGI Global Scientific Publishing
Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes.
Andrés García-García, Claudia Korn, María García-Fernández, Olivia Domingues, Javier Villadiego, Daniel Martín-Pérez, Joan Isern, José A Bejarano-García, Jacques Zimmer, José A Pérez-Simón, Juan J Toledo-Aral, Tatiana Michel, Matti S Airaksinen, Simón Méndez-Ferrer
Dec 07, 2018
Hematopoietic stem and progenitor cells (HSPCs) and leukocytes circulate between the bone marrow (BM) and peripheral blood following circadian oscillations. Autonomic sympathetic noradrenergic signals have been shown to regulate...
Animals Bone Marrow Cells Cell Adhesion Cell Movement Cells Cultured Chemotaxis Cholinergic Agents Circadian Rhythm Endothelium Vascular Female Glial Cell Line-Derived Neurotrophic Factor Receptors Hematopoietic Stem Cells Leukocytes Male Mice Mice Inbred C57BL Mice Knockout Parasympathetic Nervous System Receptors Adrenergic beta-2 Receptors Adrenergic beta-3 Receptors G-Protein-Coupled sympathetic nervous system
Molecular interactome between HSCs and their niches.
Simón Méndez-Ferrer
Nov 18, 2019
Because hematopoietic stem cells (HSCs) were found to require a bone marrow (BM) habitat for long-term function, many studies have attempted to dissect key cellular and molecular interactions between HSCs and their BM...
Spermatogonia Loss Correlates with LAMA 1 Expression in Human Prepubertal Testes Stored for Fertility Preservation
Magdalena Kurek, Elisabet Åkesson, Masahito Yoshihara, Elizabeth Oliver, Yanhua Cui, Martin Becker, João Pedro Alves-Lopes, Ragnar Bjarnason, Patrik Romerius, Mikael Sundin, Ulrika Norén Nyström, Cecilia Langenskiöld, Hartmut Vogt, Lars Henningsohn, Cecilia Petersen, Olle Söder, Jingtao Guo, Rod T. Mitchell, Kirsi Jahnukainen, Jan-Bernd Stukenborg
Jan 29, 2021
Fertility preservation for male childhood cancer survivors not yet capable of producing mature spermatozoa, relies on experimental approaches such as testicular explant culture. Although the first steps in somatic maturation can...
Mobile Health and Telemedicine
In 2016, the U.S. Government health expenditures reached $3.35 trillion and the cost per person stood at $10,345. Health is seen as impacting both one's quality of life and finances. The Affordable Care Act (ACA) (2008 - 2016)...
Published by: IGI Global Scientific Publishing
Schechter’s eye for the extraordinary
BM Outhwaite
Apr 21, 2017
Schechter’s eye for the extraordinary
Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.
Larissa S Carnevalli, Roberta Scognamiglio, Nina Cabezas-Wallscheid, Susann Rahmig, Elisa Laurenti, Kohei Masuda, Lars Jöckel, Andrea Kuck, Stefanie Sujer, Apostolos Polykratis, Miriam Erlacher, Manolis Pasparakis, Marieke AG Essers, Andreas Trumpp
Aug 28, 2020
The serine protease granzyme B (GzmB) is stored in the granules of cytotoxic T and NK cells and facilitates immune-mediated destruction of virus-infected cells. In this study, we use genetic tools to report novel roles for GzmB...
Animals Apoptosis Bone Marrow Cell Proliferation Colony-Forming Units Assay DNA Primers Drug Therapy Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorouracil Gene Expression Regulation Granzymes Hematopoietic Stem Cells Immunohistochemistry Lipopolysaccharides Mice Mice Inbred C57BL Mice Knockout Microarray Analysis Mitochondria Real-Time Polymerase Chain Reaction Signal Transduction Stress Physiological
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