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Results: 764
TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response.
Raquel Espín-Palazón, Alicia Martínez-López, Francisco J Roca, Azucena López-Muñoz, Sylwia D Tyrkalska, Sergio Candel, Diana García-Moreno, Alberto Falco, José Meseguer, Amparo Estepa, Victoriano Mulero
May 13, 2019
TNFα is a pleiotropic pro-inflammatory cytokine with a key role in the activation of the immune system to fight viral infections. Despite its antiviral role, a few viruses might utilize the host produced TNFα to their benefit....
Buying Through Social Platforms
Social platforms are currently encountering a set of burning issues: low ad conversion rates, cross-channel free-riding phenomena, lack of monetary incentives to retain premium content creators, etc. Direct purchase behaviors...
Published by: IGI Global Scientific Publishing
Tail-regression estimator for heavy-tailed distributions of known tail indices and its application to continuum quantum Monte Carlo data.
Standard statistical analysis is unable to provide reliable confidence intervals on expectation values of probability distributions that do not satisfy the conditions of the central limit theorem. We present a regression-based...
Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization.
Laura Formentini, Fulvio Santacatterina, Cristina Núñez de Arenas, Konstantinos Stamatakis, David López-Martínez, Angela Logan, Manuel Fresno, Ron Smits, Michael P Murphy, José M Cuezva
Aug 17, 2017
Mitochondria are signaling hubs in cellular physiology that play a role in inflammatory diseases. We found that partial inhibition of the mitochondrial ATP synthase in the intestine of transgenic mice triggers an...
ATP synthase Cytokines innate immunity Animals Cells Cultured Colitis Ulcerative Immunity Innate Intestines Macrophage Activation MACROPHAGES Mice Mice Inbred C57BL Mitochondria Mitochondrial Proton-Translocating ATPases NF-kappa B Phenotype Proto-Oncogene Proteins c-akt Reactive Oxygen Species STAT3 Transcription Factor Signal Transduction TOR Serine-Threonine Kinases
Neural Population Dynamics Underlying Encoding of Time in the Cortico-Striatal Circuit
Francisca Martínez Traub
Jan 01, 0001
Interval timing, the ability to accurately measure elapsed time between events, is critical for generating appropriate behavioral responses. Research conducted over the past decades has implicated the cortico-striatal-thalamic...
Published by: Rockefeller University
REACT study protocol
Alicia Joanne Smith, Laura Moreno-López, Eugenia Davidson, Maria Dauvermann, Sofia Orellana, Emma Soneson, Konstantinos Ioannidis, Muzaffer Kaser, Anne-Laura van Harmelen
Feb 01, 2021
INTRODUCTION: COVID-19-related social isolation and stress may have significant mental health effects, including post-traumatic stress, anxiety and depression. These factors are thought to disproportionately affect populations...
Ensuring Virtual Success
Very few academic programs in pre-service teacher education include opportunities for current and future K-12 educators to develop the necessary skills to teach in an online setting. While limited research has been done related...
Published by: IGI Global Scientific Publishing
G-quadruplexes are transcription factor binding hubs in human chromatin
Jochen Spiegel, Sergio Martínez Cuesta, Santosh Adhikari, Robert Hänsel-Hertsch, David Tannahill, Shankar Balasubramanian
Apr 23, 2021
Abstract: Background: The binding of transcription factors (TF) to genomic targets is critical in the regulation of gene expression. Short, double-stranded DNA sequence motifs are routinely implicated in TF recruitment, but many...
Omar Khayyam’s Epicureanism
This translation appears as the following chapter in:
Omar Khayyam’s Epicureanism: The Spanish Translations of Rubaiyats (1904-1930). Peripheral Transmodernities: South-to-South Dialogues Between the Luso-Hispanic World and “the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Omar Khayyam’s Epicureanism
This translation appears as the following chapter in:
Omar Khayyam’s Epicureanism: The Spanish Translations of Rubaiyats (1904-1930). Peripheral Transmodernities: South-to-South Dialogues Between the Luso-Hispanic World and “the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Omar Khayyam’s Epicureanism
This translation appears as the following chapter in:
Omar Khayyam’s Epicureanism: The Spanish Translations of Rubaiyats (1904-1930). Peripheral Transmodernities: South-to-South Dialogues Between the Luso-Hispanic World and “the...
Published by: Digital Commons @ Texas A&M University-San Antonio
G-quadruplexes are transcription factor binding hubs in human chromatin.
Jochen Spiegel, Sergio Martínez Cuesta, Santosh Adhikari, Robert Hänsel-Hertsch, David Tannahill, Shankar Balasubramanian
Mar 26, 2021
Contextual Considerations for Eco-Behavioral Change Among Aquatic Recreationists
This chapter draws from Australian studies to explore policies associated with behavioral interventions for environmental stewardship. Each case focuses on attempts to influence the eco-behaviors of recreational users of aquatic...
Policy & Reform Government and Law Public and Sector Management Social Sciences and Humanities Medicine and Healthcare
Published by: IGI Global Scientific Publishing
<i>RAD51D</i> Aberrant Splicing in Breast Cancer
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Víctor Lorca, Alicia Gómez-Sanz, Sara Carvalho, Jamie Allen, Mar Infante, Pedro Pérez-Segura, Conxi Lázaro, Douglas F Easton, Peter Devilee, Maaike P G Vreeswijk, Miguel de la Hoya, Eladio A Velasco
Aug 02, 2021
RAD51D loss-of-function variants increase lifetime risk of breast and ovarian cancer. Splicing disruption is a frequent pathogenic mechanism associated with variants in susceptibility genes. Herein, we have assessed the...
Breast Cancer ovarian cancer susceptibility genes ESE ESS VUS aberrant splicing minigene RAD51D clinical interpretation
Published by: Cancers
RAD51D Aberrant Splicing in Breast Cancer
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Víctor Lorca, Alicia Gómez-Sanz, Sara Carvalho, Jamie Allen, Mar Infante, Pedro Pérez-Segura, Conxi Lázaro, Douglas F Easton, Peter Devilee, Maaike PG Vreeswijk, Miguel de la Hoya, Eladio A Velasco
Jul 08, 2021
RAD51D loss-of-function variants increase lifetime risk of breast and ovarian cancer. Splicing disruption is a frequent pathogenic mechanism associated with variants in susceptibility genes. Herein, we have assessed the splicing...
Missing the missing values
Abstract: Nowadays, there is an increasing concern in machine learning about the causes underlying unfair decision making, that is, algorithmic decisions discriminating some groups over others, especially with groups that are...
Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance
N Martínez-Sánchez, P Seoane-Collazo, C Contreras, L Varela, J Villarroya, E Rial-Pensado, X Buqué, I Aurrekoetxea, TC Delgado, R Vázquez-Martínez, I González-García, J Roa, AJ Whittle, B Gomez-Santos, V Velagapudi, YCL Tung, DA Morgan, PJ Voshol, PB Martínez de Morentin, T López-González, L Liñares-Pose, F Gonzalez, K Chatterjee, T Sobrino, G Medina-Gómez, RJ Davis, N Casals, M Orešič, AP Coll, A Vidal-Puig, J Mittag, M Tena-Sempere, MM Malagón, C Diéguez, ML Martínez-Chantar, P Aspichueta, K Rahmouni, R Nogueiras, G Sabio, F Villarroya, M López
Aug 09, 2017
Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) through the parasympathetic...
AMPK bat ER stress JNK1 SF1 VMH Autonomic Nervous System Ceramides Liver Thyroid Hormones Adipose Tissue Brown Animals Energy Metabolism Hypothalamus Lipid Metabolism Liver Male Mice Inbred C57BL Mitogen-Activated Protein Kinase 8 Rats Rats Sprague-Dawley Signal Transduction Thermogenesis Thyroid Hormones Triiodothyronine
QSAR Analysis for the Inhibition of the Mutagenic Activity by Anthocyanin Derivatives
Flavonoid compounds modulate the cytochrome P450 3A4 enzyme activity and inhibit the mutagenic activity of mammalian cells, preventing carcinogen activation and cellular DNA damage. In this work, the quantitative...
Published by: IGI Global Scientific Publishing
Business Intelligence Tools for a Digital Services Company in Peru, 2022
The objective is to propose the use of the business intelligence tool Microsoft Power BI to contribute to the best decision making in the digital services company; there are deficiencies in the ERP integrator system currently...
Published by: IGI Global Scientific Publishing
Nutritional Labelling and Purchase Intention
With the aim of preventing malnutrition, it has been proposed to provide information to consumers about the nutritional content of food using labelling on packages to promote healthier eating habits. Since the way in which the...
Published by: IGI Global Scientific Publishing
Crystallization processes in bi-component thin film depositions:
The kinetic Monte Carlo (KMC) method is a powerful and simple tool to simulate the growth of thin films by deposition. However, one of its major drawbacks is the artificial order induced by the use of regular lattices. An...
Crystallization kinetic Monte Carlo Nanocomposite Polycrystal Thin film deposition /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/3100/3110 name=Surfaces and Interfaces
Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner.
Mar Quiñones, René Hernández-Bautista, Daniel Beiroa, Violeta Heras, Francisco L Torres-Leal, Brian YH Lam, Ana Senra, Johan Fernø, Alicia García Gómez-Valadés, Markus Schwaninger, Vincent Prevot, Giles Yeo, Marc Claret, Miguel López, Carlos Diéguez, Omar Al-Massadi, Ruben Nogueiras
Apr 26, 2021
Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuin homologs of the yeast Sir2 gene that has emerged as an important player in the regulation of energy metabolism in peripheral tissues. However, its role in the hypothalamus...
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