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PI3Kδ and primary immunodeficiencies.
Primary immunodeficiencies are inherited disorders of the immune system, often caused by the mutation of genes required for lymphocyte development and activation. Recently, several studies have identified gain-of-function...
Animals Cell Differentiation Cellular Senescence Enzyme Activation Gene Expression Regulation Humans Immune System Immunity Immunologic Deficiency Syndromes Lymphocyte Activation Lymphocytes Molecular Targeted Therapy Mutation Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Protein Subunits Signal Transduction
Priming and de-priming of neutrophil responses in vitro and in vivo.
Review of: Projects in Linguistics: A Practical Research Guide to Researching Language, by Alison Wray, Kate Trott and Aileen Bloomer. London
Robert Fink
Jul 18, 2013
Review of: Projects in Linguistics: A Practical Research Guide to Researching Language, by Alison Wray, Kate Trott and Aileen Bloomer. London: Arnold, 1998. Pp xv, 303. Can $38.50.
Published by: Atlantic Provinces Linguistic Association
Review of: Projects in Linguistics: A Practical Research Guide to Researching Language, by Alison Wray, Kate Trott and Aileen Bloomer. London
Robert Fink
Jul 18, 2013
Review of: Projects in Linguistics: A Practical Research Guide to Researching Language, by Alison Wray, Kate Trott and Aileen Bloomer. London: Arnold, 1998. Pp xv, 303. Can $38.50.
Published by: Atlantic Provinces Linguistic Association
Role of unfolded proteins in lung disease.
Kirsty L Bradley, Clare A Stokes, Stefan J Marciniak, Lisa C Parker, Alison M Condliffe
Oct 26, 2020
The lungs are exposed to a range of environmental toxins (including cigarette smoke, air pollution, asbestos) and pathogens (bacterial, viral and fungal), and most respiratory diseases are associated with local or systemic...
The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host.
Neutrophils are key effector cells of innate immunity, rapidly recruited to defend the host against invading pathogens. Neutrophils may kill pathogens intracellularly, following phagocytosis, or extracellularly, by degranulation...
Role of unfolded proteins in lung disease
Kirsty L Bradley, Clare A Stokes, Stefan J Marciniak, Lisa C Parker, Alison M Condliffe
Oct 21, 2020
The lungs are exposed to a range of environmental toxins (including cigarette smoke, air pollution, asbestos) and pathogens (bacterial, viral and fungal), and most respiratory diseases are associated with local or systemic...
Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.
Sarah R Walmsley, Cristin Print, Neda Farahi, Carole Peyssonnaux, Randall S Johnson, Thorsten Cramer, Anastasia Sobolewski, Alison M Condliffe, Andrew S Cowburn, Nicola Johnson, Edwin R Chilvers
Mar 13, 2020
Neutrophils are key effector cells of the innate immune response and are required to migrate and function within adverse microenvironmental conditions. These inflammatory sites are characterized by low levels of oxygen and...
Animals Apoptosis Blotting Western Cell Survival Chemokine CCL4 Cytokines DNA Primers DNA-Binding Proteins Enzyme-Linked Immunosorbent Assay Gliotoxin Humans Hypoxia Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1 alpha Subunit Macrophage Inflammatory Proteins Mice Mice Knockout Mixed Function Oxygenases NF-kappa B p50 Subunit Neutrophils Nuclear Proteins Oligonucleotide Array Sequence Analysis Oligonucleotides Polymerase Chain Reaction Protein Binding Repressor Proteins Sesquiterpenes Transcription Factors
Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit.
Charlotte Summers, Nanak R Singh, Linda Worpole, Rosalind Simmonds, Judith Babar, Alison M Condliffe, Kevin E Gunning, Andrew J Johnston, Edwin R Chilvers
Aug 14, 2017
Jatinder K Juss, David House, Augustin Amour, Malcolm Begg, Jurgen Herre, Daniel ML Storisteanu, Kim Hoenderdos, Glyn Bradley, Mark Lennon, Charlotte Summers, Edith M Hessel, Alison Condliffe, Edwin R Chilvers
Apr 29, 2016
acute respiratory distress syndrome neutrophil function phosphoinositide 3-kinase Bronchoalveolar Lavage Fluid CD11b Antigen Cytokines Female Flow Cytometry Gene Expression Profiling Humans L-Selectin Male Middle Aged Neutrophils Oligonucleotide Array Sequence Analysis Phenotype Phosphoinositide-3 Kinase Inhibitors Respiratory Distress Syndrome
Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung.
Chrystalla Loutsios, Neda Farahi, Rosalind Simmonds, Ian Cullum, Daniel Gillett, Chandra Solanki, Kishor Solanki, John Buscombe, Alison M Condliffe, A Mike Peters, Edwin R Chilvers
Nov 19, 2015
Voice Professor Plans Program of Inspirational Songs
Winthrop University
Jan 01, 0001
Her performance on Feb. 21 will feature the works of such important 16th-, 17th-, 18th- and 19th-century composers. Jennifer Corbell Hough, soprano; Craig Estep, counter tenor; dancer Alison Cook; and pianist/harpsichordist...
Published by: Winthrop University
Neutrophil GM-CSF receptor dynamics in acute lung injury.
Silvia De Alessandris, G John Ferguson, Alison J Dodd, Jatinder K Juss, Abhinandan Devaprasad, Siân Piper, Owen Wyatt, Helen Killick, Dominic J Corkill, E Suzanne Cohen, Aridaman Pandit, Timothy RDJ Radstake, Rosalind Simmonds, Alison M Condliffe, Matthew A Sleeman, Andrew S Cowburn, Donna K Finch, Edwin R Chilvers
May 07, 2019
GM-CSF is important in regulating acute, persistent neutrophilic inflammation in certain settings, including lung injury. Ligand binding induces rapid internalization of the GM-CSF receptor (GM-CSFRα) complex, a process...
LPS Alveolar Apoptosis Inflammation signaling Acute Lung Injury Adult Animals Cell Line Tumor Cytokine Receptor Common beta Subunit Disease Models Animal Female Gene Expression Regulation Humans Lipopolysaccharides Male Mice Mice Inbred BALB C Mice Transgenic Neutrophils Pulmonary Alveoli Receptors Granulocyte-Macrophage Colony-Stimulating Factor Time Factors
Popular Antebellum Clothing Exhibit Returns to Pettus Archives
Winthrop University
Jan 01, 0001
The exhibit will be on display until March 29. Alison Boulton will give a lecture Tuesday, March 5 at 7 p.m. at Louise Pettus Archives and Special Collections. It is a free cultural event.
Published by: Winthrop University
Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.
Lisa C Willcocks, Paul A Lyons, Menna R Clatworthy, James I Robinson, Wanling Yang, Stephen A Newland, Vincent Plagnol, Naomi N McGovern, Alison M Condliffe, Edwin R Chilvers, Dwomoa Adu, Elaine C Jolly, Richard Watts, Yu Lung Lau, Ann W Morgan, Gerard Nash, Kenneth GC Smith
Jun 28, 2018
Copy number (CN) variation (CNV) has been shown to be common in regions of the genome coding for immune-related genes, and thus impacts upon polygenic autoimmunity. Low CN of FCGR3B has recently been associated with systemic...
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.
Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, Rafeah Alam, Valentina Carbonaro, Jonathan Clark, Srividya Sriskantharajah, Glyn Bradley, Alex G Richter, Edward Banham-Hall, Menna R Clatworthy, Sergey Nejentsev, J Nicole Hamblin, Edith M Hessel, Alison M Condliffe, Klaus Okkenhaug
Oct 10, 2018
Animals Antigens CD19 B-Lymphocytes Class I Phosphatidylinositol 3-Kinases Enzyme Activation Female Gene Knock-In Techniques Genotype Humans Interleukin-10 Lung Male Mice Mice Inbred C57BL Neutrophils Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Pneumococcal Infections Signal Transduction Species Specificity Streptococcus pneumoniae
The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host
Neutrophils are key effector cells of innate immunity, rapidly recruited to defend the host against invading pathogens. Neutrophils may kill pathogens intracellularly, following phagocytosis, or extracellularly, by degranulation...
Meeting CanMEDS objective through global health education at MUN
Background The academic and practical benefit of global health education have been recognized and endorsed by the Association of Faculties of Medicine in Canada (AFMC) and articulated by the AFMC Resource Group (2011). Clinical...
Meeting CanMEDS objective through global health education at MUN
Background The academic and practical benefit of global health education have been recognized and endorsed by the Association of Faculties of Medicine in Canada (AFMC) and articulated by the AFMC Resource Group (2011). Clinical...
In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients.
Neda Farahi, Chrystalla Loutsios, Nicola Tregay, Adam KA Wright, Rachid Berair, Laurence SC Lok, Daniel Gillett, Ian Cullum, Rosalind P Simmonds, Charlotte Summers, Anna Wong, Chandra K Solanki, John Buscombe, Pee Hwee Pang, Arthikkaa Thavakumar, A Michael Peters, Christopher E Brightling, Alison M Condliffe, Edwin R Chilvers
Oct 15, 2018
Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice.
Wei Li, Lu Long, Xudong Yang, Zhen Tong, Mark Southwood, Ross King, Paola Caruso, Paul D Upton, Peiran Yang, Geoffrey A Bocobo, Ivana Nikolic, Angelica Higuera, Richard M Salmon, He Jiang, Katharine M Lodge, Kim Hoenderdos, Rebecca M Baron, Paul B Yu, Alison M Condliffe, Charlotte Summers, Sussan Nourshargh, Edwin R Chilvers, Nicholas W Morrell
Nov 26, 2020
Rationale: Pulmonary endothelial permeability contributes to the high-permeability pulmonary edema that characterizes acute respiratory distress syndrome. Circulating BMP9 (bone morphogenetic protein 9) is emerging as an...
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