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Results: 65
The jellification of north temperate lakes.
Adam Jeziorski, Andrew J Tanentzap, Norman D Yan, Andrew M Paterson, Michelle E Palmer, Jennifer B Korosi, James A Rusak, Michael T Arts, Wendel Bill Keller, Ron Ingram, Allegra Cairns, John P Smol
Nov 06, 2014
Tutankhamen, Egyptomania, and Temporal Enchantment in Interwar Britain.
Allegra Fryxell
Sep 29, 2018
In 1923 or thereabouts, Britain fell under the ‘Tut-ankh-amen spell’. Howard Carter and Lord Carnarvon’s discovery of Tutankhamen’s tomb in 1922 prompted a new wave of popular interest in ancient Egypt that suffused British...
How are we evaluating the cost-effectiveness of companion biomarkers for targeted cancer therapies? A systematic review
Abstract: Background: Despite the increasing economic assessment of biomarker-guided therapies, no clear agreement exists whether existing methods are sufficient or whether different methods might produce different...
Scenario analysis to support decision making in addressing wicked problems
This paper provides a review and evaluation of the use of scenario methods from the Intuitive Logics (IL) school to address so-called ‘wicked problems’. Scenario planning has been widely advocated by its practitioners and its...
Decision making. Intuitive logics scenarios Soft OR methods Wicked problems /dk/atira/pure/subjectarea/asjc/1700/1700 name=General Computer Science /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research /dk/atira/pure/subjectarea/asjc/1800/1802 name=Information Systems and Management
Psychopathologies of time
Allegra RP Fryxell
Apr 16, 2019
Variability and Reproducibility of Directed and Undirected Functional MRI Connectomes in the Human Brain.
Allegra Conti, Andrea Duggento, Maria Guerrisi, Luca Passamonti, Iole Indovina, Nicola Toschi
Jul 05, 2019
A decision-analysis-based framework for analyzing stakeholder behaviour in scenario planning
Scenario planning is a method widely used by strategic planners to address uncertainty about the future. However, current methods either fail to address the future behaviour and impact of stakeholders or they treat the role of...
Lower Functional Connectivity in Vestibular-Limbic Networks in Individuals With Subclinical Agoraphobia.
Iole Indovina, Allegra Conti, Francesco Lacquaniti, Jeffrey P Staab, Luca Passamonti, Nicola Toschi
Jul 29, 2019
A decision-analysis-based framework for analyzing stakeholder behaviour in scenario planning
Scenario planning is a method widely used by strategic planners to address uncertainty about the future. However, current methods either fail to address the future behaviour and impact of stakeholders or they treat the role of...
Heritability of human "directed" functional connectome.
Maria Giovanna Bianco, Andrea Duggento, Salvatore Nigro, Allegra Conti, Nicola Toschi, Luca Passamonti
Mar 29, 2023
INTRODUCTION: The functional connectivity patterns in the brain are highly heritable; however, it is unclear how genetic factors influence the directionality of such "information flows." Studying the "directionality" of the...
How are we evaluating the cost-effectiveness of companion biomarkers for targeted cancer therapies? A systematic review.
BACKGROUND: Despite the increasing economic assessment of biomarker-guided therapies, no clear agreement exists whether existing methods are sufficient or whether different methods might produce different cost-effectiveness...
biomarker Cancer Companion biomarker Companion diagnostic cost-effectiveness economic evaluation health economics oncology Precision Medicine Systematic review targeted therapy Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Cost-Benefit Analysis Humans Molecular Targeted Therapy Neoplasms Precision Medicine Prognosis ROC Curve Survival Rate
Scenario analysis to support decision making in addressing wicked problems
This paper provides a review and evaluation of the use of scenario methods from the Intuitive Logics (IL) school to address so-called ‘wicked problems’. Scenario planning has been widely advocated by its practitioners and its...
Decision making. Intuitive logics scenarios Soft OR methods Wicked problems /dk/atira/pure/subjectarea/asjc/1700/1700 name=General Computer Science /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1800/1803 name=Management Science and Operations Research /dk/atira/pure/subjectarea/asjc/1800/1802 name=Information Systems and Management
Semantic City Planning Systems (SCPS)
This review focuses on recent research literature on the use of Semantic Web Technologies (SWT) in city planning. The review foregrounds representational, evaluative, projective, and synthetical meta-practices as...
Is subarctic forest advance able to keep pace with climate change?
W Gareth Rees, Annika Hofgaard, Stéphane Boudreau, David M Cairns, Karen Harper, Steven Mamet, Ingrid Mathisen, Zuzanna Swirad, Olga Tutubalina
Apr 06, 2020
Global reorganisation of $\textit{cis}$-regulatory units upon lineage commitment of human embryonic stem cells
P Freire-Pritchett, S Schoenfelder, C Várnai, SW Wingett, J Cairns, AJ Collier, R García-Vílchez, M Furlan-Magaril, CS Osborne, P Fraser, PJ Rugg-Gunn, M Spivakov
Jun 15, 2017
Diagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests
Jennifer L J Heaney, John P Campbell, Anne E Griffin, Jane Birtwistle, Meena Shemar, J Anthony Child, Walter M Gregory, David A Cairns, Gareth J Morgan, Graham H Jackson, Mark T Drayson
Jul 11, 2017
This study aims to guide the integration of serum free light chain (sFLC) tests into clinical practice, including a new rapid test (Seralite(®) ). Blood and urine analysis from 5573 newly diagnosed myeloma patients identified...
Diagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests
Jennifer L J Heaney, John P Campbell, Anne E Griffin, Jane Birtwistle, Meena Shemar, J Anthony Child, Walter M Gregory, David A Cairns, Gareth J Morgan, Graham H Jackson, Mark T Drayson
Jul 11, 2017
This study aims to guide the integration of serum free light chain (sFLC) tests into clinical practice, including a new rapid test (Seralite(®) ). Blood and urine analysis from 5573 newly diagnosed myeloma patients identified...
Recipient Comorbidity and Survival Outcomes After Kidney Transplantation
Diana A Wu, Matthew L Robb, John LR Forsythe, Clare Bradley, John Cairns, Heather Draper, Christopher Dudley, Rachel J Johnson, Wendy Metcalfe, Rommel Ravanan, Paul Roderick, Charles RV Tomson, Christopher JE Watson, J Andrew Bradley, Gabriel C Oniscu
Sep 09, 2019
BACKGROUND: Comorbidity is increasingly common in kidney transplant recipients, yet the implications for transplant outcomes are not fully understood. We analyzed the relationship between recipient comorbidity and survival...
Adolescent Adult Aged Cerebrovascular Disorders Chronic Disease Comorbidity Female Graft Rejection Graft Survival Heart Failure Humans Kidney Failure Chronic Kidney Transplantation Liver Diseases Male Middle Aged obesity peripheral vascular diseases Prospective Studies Registries Risk Assessment Risk Factors Transplant Recipients Treatment Outcome United Kingdom Young Adult
Long-term follow-up of a combined rituximab and cyclophosphamide regimen in renal anti-neutrophil cytoplasm antibody-associated vasculitis.
Stephen P McAdoo, Nicholas Medjeral-Thomas, Seerapani Gopaluni, Anisha Tanna, Nicholas Mansfield, Jack Galliford, Megan Griffith, Jeremy Levy, Thomas D Cairns, David Jayne, Alan D Salama, Charles D Pusey
Sep 08, 2018
Background. Current guidelines advise that rituximab or cyclophosphamide should be used for the treatment of organthreatening disease in anti-neutrophil cytoplasm antibody
(ANCA)-associated vasculitis (AAV), although few...
Adolescent Adult Aged Aged 80 and over Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antineoplastic Combined Chemotherapy Protocols Azathioprine Case-Control Studies Cohort Studies cyclophosphamide Disease Progression Female Follow-Up Studies Glomerular Filtration Rate Humans Kidney Diseases Kidney Failure Chronic Male Middle Aged Prognosis Remission Induction Rituximab Survival Rate Young Adult
p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.
Ivano Amelio, Mara Mancini, Varvara Petrova, Rob A Cairns, Polina Vikhreva, Sara Nicolai, Alberto Marini, Alexey A Antonov, John Le Quesne, Juvenal D Baena Acevedo, Kate Dudek, Gabriella Sozzi, Ugo Pastorino, Richard A Knight, Tak W Mak, Gerry Melino
Dec 04, 2018
HIF SWI/SNF Chromatin architecture microenvironment p53 Animals Carcinoma Non-Small-Cell Lung Cell Hypoxia Cell Line Tumor Extracellular Matrix Genes p53 Heterografts Humans Hypoxia-Inducible Factor 1 Lung Neoplasms Mice Mice Inbred BALB C Mice Nude Mutation Transcriptional Activation Tumor Microenvironment Tumor Suppressor Protein p53
A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis.
Ruth J Pepper, Stephen P McAdoo, Sarah M Moran, Dearbhla Kelly, Jennifer Scott, Sally Hamour, Aine Burns, Megan Griffith, Jack Galliford, Jeremy B Levy, Thomas D Cairns, Seerapani Gopaluni, Rachel B Jones, David Jayne, Mark A Little, Charles D Pusey, Alan D Salama
May 06, 2019
Objectives: Glucocorticoids (GCs) are a mainstay of treatment for patients with ANCA-associated vasculitis (AAV) but are associated with significant adverse effects. Effective remission induction in severe AAV using extremely...
Introduction to the special column
Communication is the glue that holds societies together, and many of the benefits that social species gain from living in groups rely on intra-group communication. We might expect that highly social species with more to...
Response comparison of multiple myeloma and monoclonal gammopathy of undetermined significance to the same anti-myeloma therapy
John P Campbell, Jennifer L J Heaney, Sankalp Pandya, Zaheer Afzal, Martin F Kaiser, Roger G Owen, J Anthony Child, David A Cairns, Walter M Gregory, Gareth J Morgan, Graham H Jackson, Chris M Bunce, Mark T Drayson
Dec 31, 2017
Background
Multiple myeloma is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS), which is usually only treated by a form of anti-multiple myeloma therapy if it is causing substantial disease...
Multiple myeloma is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS), which is usually only treated by a form of anti-multiple myeloma therapy if it is causing substantial disease...
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