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Net zero adaptation—a review of built environment sustainability assessment tools * * Funded by the UK Engineering and Physical Sciences Research Council, Doctoral Training Studentship.
Abstract: In the context of the built environment there has been a greater focus of research and policy on climate mitigation efforts, compared with adaptation. Buildings designed today will likely need upgrades within their...
Net zero adaptation—a review of built environment sustainability assessment tools
<sup>*</sup>
Abstract
In the context of the built environment there has been a greater focus of research and policy on climate mitigation efforts, compared with adaptation. Buildings designed...
Experimental Tests of a Resistive SFCL Integrated with a Vacuum Interrupter
A resistive superconducting fault-current limiter (SFCL) has been developed using round magnesium diboride (MgB2) wire. The SFCL coil was wound using an interleaved coil arrangement to minimize the total coil...
magnesium diboride Superconducting fault current limiter Vacuum interrupter /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
Experimental Tests of a Resistive SFCL Integrated with a Vacuum Interrupter
A resistive superconducting fault-current limiter (SFCL) has been developed using round magnesium diboride (MgB2) wire. The SFCL coil was wound using an interleaved coil arrangement to minimize the total coil...
magnesium diboride Superconducting fault current limiter Vacuum interrupter /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
Stabilization of Hfq-mediated translational repression by the co-repressor Crc in Pseudomonas aeruginosa.
Ewelina M Malecka, Flavia Bassani, Tom Dendooven, Elisabeth Sonnleitner, Marlena Rozner, Tanino G Albanese, Armin Resch, Ben Luisi, Sarah Woodson, Udo Bläsi
Sep 05, 2021
In Pseudomonas aeruginosa the RNA chaperone Hfq and the catabolite repression control protein (Crc) govern translation of numerous transcripts during carbon catabolite repression. Here, Crc was shown to enhance Hfq-mediated...
Fast operating moving coil actuator for a vacuum interrupter
Xiaoze Pei, Alexander C. Smith, Roger Shuttleworth, Damian S Vilchis-Rodriguez, Mike Barnes
Sep 01, 2017
Vacuum circuit breakers are the dominant technology in medium voltage distribution networks since they are environmentally friendly and maintenance free. It is a challenge to design an actuator for a vacuum circuit breaker...
Fast operating moving coil actuator for a vacuum interrupter
Xiaoze Pei, Alexander C. Smith, Roger Shuttleworth, Damian S Vilchis-Rodriguez, Mike Barnes
Sep 01, 2017
Vacuum circuit breakers are the dominant technology in medium voltage distribution networks since they are environmentally friendly and maintenance free. It is a challenge to design an actuator for a vacuum circuit breaker...
Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
David Gyori, Ee Lyn Lim, Francis M Grant, Dominik Spensberger, Rahul Roychoudhuri, Stephen J Shuttleworth, Klaus Okkenhaug, Len R Stephens, Phillip T Hawkins
Aug 20, 2018
cancer immunotherapy immunology MACROPHAGES oncology T cells Aminopyridines Animals Cell Line Tumor Class I Phosphatidylinositol 3-Kinases Diphtheria Toxin Disease Models Animal Drug Resistance Neoplasm Female Forkhead Transcription Factors Gene Knockout Techniques Humans Lymphocyte Depletion MACROPHAGES Male Mice Mice Transgenic Neoplasms Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Primary Cell Culture Purines Pyrroles Quinazolinones Receptors Granulocyte-Macrophage Colony-Stimulating Factor T-Lymphocytes Regulatory Tumor Microenvironment
PIMMS43 is required for malaria parasite immune evasion and sporogonic development in the mosquito vector.
Chiamaka V Ukegbu, Maria Giorgalli, Sofia Tapanelli, Luisa DP Rona, Amie Jaye, Claudia Wyer, Fiona Angrisano, Andrew M Blagborough, George K Christophides, Dina Vlachou
Aug 12, 2020
After being ingested by a female Anopheles mosquito during a bloodmeal on an infected host, and before they can reach the mosquito salivary glands to be transmitted to a new host, Plasmodium parasites must establish an infection...
complement-like response malaria transmission mosquito innate immunity mosquito population replacement transmission blocking vaccines Animals Anopheles Female host-parasite interactions Humans Immune Evasion Malaria Falciparum Mosquito Vectors Oocysts Plasmodium falciparum Protozoan Proteins Sporozoites
Ursinus College Alumni Journal, March 1961
Richard T. Schellhase, J. William D. Wright, Calvin D. Yost, Roger P. Staiger, Raymond V. Gurzynski, Blanche B. Schultz, Donald L. Helfferich, Frank H Bowles, Harvey R. Vanderslice, Geoffrey Dolman, George Storey, Allan Lake Rice
Jan 01, 0001
The President writes Who gets into college? Mr. Dolman comments Search for certainty Two foreign students sponsored Dr. Miller on TV Announcing an alumni seminar The thousand and second night's tale Student European...
Ursinus College Collegeville Pennsylvania alumni Deaths Marriages college admissions George Meredith Jun Kawashima Eugene H. Miller Lobsang Samden Sandra Motta Harold K. Shilling Robert R. Titus David I. Jacobs Richard H. Henschel wrestling Basketball field hockey track team John Shuttleworth Higher Education Social History United States History
Published by: Ursinus College
Transcript specific regulation of expression influences susceptibility to multiple sclerosis.
Maria Ban, Wenjia Liao, Amie Baker, Alastair Compston, John Thorpe, Paul Molyneux, Mary Fraser, Jyoti Khadake, Joanne Jones, Alasdair Coles, Stephen Sawcer
Dec 19, 2019
Genome-wide association studies (GWAS) have identified over 100 loci containing single nucleotide variants (SNVs) that influence the risk of developing multiple sclerosis (MS). Most of these loci lie in non-coding regulatory...
Structurally graduated collagen scaffolds applied to the ex vivo generation of platelets from human pluripotent stem cell-derived megakaryocytes
Jennifer H Shepherd, Daniel Howard, Amie K Waller, Holly Rebecca Foster, Annett Mueller, Thomas Moreau, Amanda L Evans, Meera Arumugam, Guénaëlle Bouët Chalon, Eleonora Vriend, Natalia Davidenko, Cedric Ghevaert, Serena M Best, Ruth E Cameron
Nov 08, 2018
Bioreactor Bone marrow model Collagen Depth straining Forward programming Human induced pluripotent stem cells interconnectivity Megakaryocytes Parallel flow membrane filter platelets scaffold architecture Settling zones shear flow Biocompatible Materials Bioreactors Blood Platelets Cell Culture Techniques Cells Cultured Collagen Equipment Design Humans Megakaryocytes Pluripotent Stem Cells Thrombopoiesis Tissue Scaffolds
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A. Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G. Boutelle, Eszter Farkas, Jens P. Dreier, Martin Fabricius, C. William Shuttleworth, Andrew Carlson
Jul 22, 2020
Abstract: The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, “What should a clinician do when spreading...
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A. Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G. Boutelle, Eszter Farkas, Jens P. Dreier, Martin Fabricius, C. William Shuttleworth, Andrew Carlson
Jun 06, 2020
Abstract: The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, “What should a clinician do when spreading...
Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function
Amie K Waller, Lajos Lantos, Audrienne Sammut, Burak Salgin, Harriet McKinney, Holly R Foster, Neline Kriek, Jonathan M Gibbins, Simon J Stanworth, Stephen F Garner, Vidheya Venkatesh, Anna Curley, Gusztav Belteki, Cedric Ghevaert
Feb 07, 2019
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G Boutelle, Eszter Farkas, Jens P Dreier, Martin Fabricius, C William Shuttleworth, Andrew Carlson
Jul 29, 2019
The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, "What should a clinician do when spreading depolarizations are...
Cortical Spreading Depression Electroencephalography Intracerebral hemorrhage ischemic stroke outcome Subarachnoid Hemorrhage Traumatic brain injury Brain Injuries Traumatic Cortical Spreading Depression Electrocorticography Electroencephalography Excitatory Amino Acid Antagonists Humans Ketamine Outcome Assessment Health Care Precision Medicine stroke Subarachnoid Hemorrhage
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.
Ya-Hsuan Ho, Raquel Del Toro, José Rivera-Torres, Justyna Rak, Claudia Korn, Andrés García-García, David Macías, Cristina González-Gómez, Alberto Del Monte, Monika Wittner, Amie K Waller, Holly R Foster, Carlos López-Otín, Randall S Johnson, Claus Nerlov, Cedric Ghevaert, William Vainchenker, Fawzia Louache, Vicente Andrés, Simón Méndez-Ferrer
Jun 20, 2019
Hutchinson-Gilford progeria aging Hematopoietic stem cell lymphoid microenvironment myeloid niche Adrenergic Agonists aging aging Premature Animals Bone Marrow Cell Differentiation Cell Encapsulation Cell Proliferation Disease Models Animal Hematopoietic Stem Cells Humans Interleukin-6 Megakaryocytes Mice Myeloid Cells Nitric Oxide Synthase Type I progeria Receptors Adrenergic beta-2 Signal Transduction Stem Cell Niche
BRCA1 and BRCA2 pathogenic sequence variants in women of African origin or ancestry.
Tara M Friebel, Irene L Andrulis, Judith Balmaña, Amie M Blanco, Fergus J Couch, Mary B Daly, Susan M Domchek, Douglas F Easton, William D Foulkes, Patricia A Ganz, Judy Garber, Gord Glendon, Mark H Greene, Peter J Hulick, Claudine Isaacs, Rachel C Jankowitz, Beth Y Karlan, Judy Kirk, Ava Kwong, Annette Lee, Fabienne Lesueur, Karen H Lu, Katherine L Nathanson, Susan L Neuhausen, Kenneth Offit, Edenir I Palmero, Priyanka Sharma, Marc Tischkowitz, Amanda E Toland, Nadine Tung, Elizabeth J van Rensburg, Ana Vega, Jeffrey N Weitzel, Gemo Study Collaborators, Kent F Hoskins, Tara Maga, Michael T Parsons, Lesley McGuffog, Antonis C Antoniou, Georgia Chenevix-Trench, Dezheng Huo, Olufunmilayo I Olopade, Timothy R Rebbeck
May 09, 2019
BRCA1 and BRCA2 (BRCA1/2) pathogenic sequence variants (PSVs) confer elevated risks of multiple cancers. However, most BRCA1/2 PSVs reports focus on European ancestry individuals. Knowledge of the PSV distribution in African...
The Winchcombe meteorite, a unique and pristine witness from the outer solar system.
Ashley J King, Luke Daly, James Rowe, Katherine H Joy, Richard C Greenwood, Hadrien AR Devillepoix, Martin D Suttle, Queenie HS Chan, Sara S Russell, Helena C Bates, James FJ Bryson, Patricia L Clay, Denis Vida, Martin R Lee, Áine O'Brien, Lydia J Hallis, Natasha R Stephen, Romain Tartèse, Eleanor K Sansom, Martin C Towner, Martin Cupak, Patrick M Shober, Phil A Bland, Ross Findlay, Ian A Franchi, Alexander B Verchovsky, Feargus AJ Abernethy, Monica M Grady, Cameron J Floyd, Matthias Van Ginneken, John Bridges, Leon J Hicks, Rhian H Jones, Jennifer T Mitchell, Matthew J Genge, Laura Jenkins, Pierre-Etienne Martin, Mark A Sephton, Jonathan S Watson, Tobias Salge, Katherine A Shirley, Rowan J Curtis, Tristram J Warren, Neil E Bowles, Finlay M Stuart, Luigia Di Nicola, Domokos Györe, Adrian J Boyce, Kathryn MM Shaw, Tim Elliott, Robert CJ Steele, Pavel Povinec, Matthias Laubenstein, David Sanderson, Alan Cresswell, Anthony JT Jull, Ivan Sýkora, Sanjana Sridhar, Richard J Harrison, Francesca M Willcocks, Catherine S Harrison, Daniel Hallatt, Penny J Wozniakiewicz, Mark J Burchell, Luke S Alesbrook, Aishling Dignam, Natasha V Almeida, Caroline L Smith, Brett Clark, Emma R Humphreys-Williams, Paul F Schofield, Luke T Cornwell, Vassilia Spathis, Geraint H Morgan, Mark J Perkins, Richard Kacerek, Peter Campbell-Burns, Francois Colas, Brigitte Zanda, Pierre Vernazza, Sylvain Bouley, Simon Jeanne, Mike Hankey, Gareth S Collins, John S Young, Clive Shaw, Jana Horak, Dave Jones, Nick James, Steve Bosley, Alan Shuttleworth, Paul Dickinson, Ian McMullan, Derek Robson, Andrew RD Smedley, Ben Stanley, Richard Bassom, Mark McIntyre, Adam A Suttle, Richard Fleet, Luc Bastiaens, Míra B Ihász, Sarah McMullan, Sarah J Boazman, Zach I Dickeson, Peter M Grindrod, Annemarie E Pickersgill, Colin J Weir, Fiona M Suttle, Sarah Farrelly, Ieun Spencer, Sheeraz Naqvi, Ben Mayne, Dan Skilton, Dan Kirk, Ann Mounsey, Sally E Mounsey, Sarah Mounsey, Pamela Godfrey, Lachlan Bond, Victoria Bond, Cathryn Wilcock, Hannah Wilcock, Rob Wilcock
Dec 17, 2022
Direct links between carbonaceous chondrites and their parent bodies in the solar system are rare. The Winchcombe meteorite is the most accurately recorded carbonaceous chondrite fall. Its pre-atmospheric orbit and cosmic-ray...
Observing many researchers using the same data and hypothesis reveals a hidden universe of uncertainty.
Nate Breznau, Eike Mark Rinke, Alexander Wuttke, Hung HV Nguyen, Muna Adem, Jule Adriaans, Amalia Alvarez-Benjumea, Henrik K Andersen, Daniel Auer, Flavio Azevedo, Oke Bahnsen, Dave Balzer, Gerrit Bauer, Paul C Bauer, Markus Baumann, Sharon Baute, Verena Benoit, Julian Bernauer, Carl Berning, Anna Berthold, Felix S Bethke, Thomas Biegert, Katharina Blinzler, Johannes N Blumenberg, Licia Bobzien, Andrea Bohman, Thijs Bol, Amie Bostic, Zuzanna Brzozowska, Katharina Burgdorf, Kaspar Burger, Kathrin B Busch, Juan Carlos-Castillo, Nathan Chan, Pablo Christmann, Roxanne Connelly, Christian S Czymara, Elena Damian, Alejandro Ecker, Achim Edelmann, Maureen A Eger, Simon Ellerbrock, Anna Forke, Andrea Forster, Chris Gaasendam, Konstantin Gavras, Vernon Gayle, Theresa Gessler, Timo Gnambs, Amélie Godefroidt, Max Grömping, Martin Groß, Stefan Gruber, Tobias Gummer, Andreas Hadjar, Jan Paul Heisig, Sebastian Hellmeier, Stefanie Heyne, Magdalena Hirsch, Mikael Hjerm, Oshrat Hochman, Andreas Hövermann, Sophia Hunger, Christian Hunkler, Nora Huth, Zsófia S Ignácz, Laura Jacobs, Jannes Jacobsen, Bastian Jaeger, Sebastian Jungkunz, Nils Jungmann, Mathias Kauff, Manuel Kleinert, Julia Klinger, Jan-Philipp Kolb, Marta Kołczyńska, John Kuk, Katharina Kunißen, Dafina Kurti Sinatra, Alexander Langenkamp, Philipp M Lersch, Lea-Maria Löbel, Philipp Lutscher, Matthias Mader, Joan E Madia, Natalia Malancu, Luis Maldonado, Helge Marahrens, Nicole Martin, Paul Martinez, Jochen Mayerl, Oscar J Mayorga, Patricia McManus, Kyle McWagner, Cecil Meeusen, Daniel Meierrieks, Jonathan Mellon, Friedolin Merhout, Samuel Merk, Daniel Meyer, Leticia Micheli, Jonathan Mijs, Cristóbal Moya, Marcel Neunhoeffer, Daniel Nüst, Olav Nygård, Fabian Ochsenfeld, Gunnar Otte, Anna O Pechenkina, Christopher Prosser, Louis Raes, Kevin Ralston, Miguel R Ramos, Arne Roets, Jonathan Rogers, Guido Ropers, Robin Samuel, Gregor Sand, Ariela Schachter, Merlin Schaeffer, David Schieferdecker, Elmar Schlueter, Regine Schmidt, Katja M Schmidt, Alexander Schmidt-Catran, Claudia Schmiedeberg, Jürgen Schneider, Martijn Schoonvelde, Julia Schulte-Cloos, Sandy Schumann, Reinhard Schunck, Jürgen Schupp, Julian Seuring, Henning Silber, Willem Sleegers, Nico Sonntag, Alexander Staudt, Nadia Steiber, Nils Steiner, Sebastian Sternberg, Dieter Stiers, Dragana Stojmenovska, Nora Storz, Erich Striessnig, Anne-Kathrin Stroppe, Janna Teltemann, Andrey Tibajev, Brian Tung, Giacomo Vagni, Jasper Van Assche, Meta van der Linden, Jolanda van der Noll, Arno Van Hootegem, Stefan Vogtenhuber, Bogdan Voicu, Fieke Wagemans, Nadja Wehl, Hannah Werner, Brenton M Wiernik, Fabian Winter, Christof Wolf, Yuki Yamada, Nan Zhang, Conrad Ziller, Stefan Zins, Tomasz Żółtak
Nov 28, 2022
This study explores how researchers' analytical choices affect the reliability of scientific findings. Most discussions of reliability problems in science focus on systematic biases. We broaden the lens to emphasize the...
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants
Daniel R. Barnes, Matti A. Rookus, Lesley McGuffog, Goska Leslie, Thea M. Mooij, Joe Dennis, Nasim Mavaddat, Julian Adlard, Munaza Ahmed, Kristiina Aittomäki, Nadine Andrieu, Irene L. Andrulis, Norbert Arnold, Banu K. Arun, Jacopo Azzollini, Judith Balmaña, Rosa B. Barkardottir, Daniel Barrowdale, Javier Benitez, Pascaline Berthet, Katarzyna Białkowska, Amie M. Blanco, Marinus J. Blok, Bernardo Bonanni, Susanne E. Boonen, Åke Borg, Aniko Bozsik, Angela R. Bradbury, Paul Brennan, Carole Brewer, Joan Brunet, Saundra S. Buys, Trinidad Caldés, Maria A. Caligo, Ian Campbell, Lise Lotte Christensen, Wendy K. Chung, Kathleen B. M. Claes, Chrystelle Colas, Marie-Agnès Collonge-Rame, Jackie Cook, Mary B. Daly, Rosemarie Davidson, Miguel de la Hoya, Robin de Putter, Capucine Delnatte, Peter Devilee, Orland Diez, Yuan Chun Ding, Susan M. Domchek, Cecilia M. Dorfling, Martine Dumont, Ros Eeles, Bent Ejlertsen, Christoph Engel, D. Gareth Evans, Laurence Faivre, Lenka Foretova, Florentia Fostira, Michael Friedlander, Eitan Friedman, Debra Frost, Patricia A. Ganz, Judy Garber, Andrea Gehrig, Anne-Marie Gerdes, Paul Gesta, Sophie Giraud, Gord Glendon, Andrew K. Godwin, David E. Goldgar, Anna González-Neira, Mark H. Greene, Daphne Gschwantler-Kaulich, Eric Hahnen, Ute Hamann, Helen Hanson, Julia Hentschel, Frans B. L. Hogervorst, Maartje J. Hooning, Judit Horvath, Chunling Hu, Peter J. Hulick, Evgeny N. Imyanitov, Claudine Isaacs, Louise Izatt, Angel Izquierdo, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Esther M. John, Vijai Joseph, Beth Y. Karlan, Karin Kast, Marco Koudijs, Torben A. Kruse, Ava Kwong, Yael Laitman, Christine Lasset, Conxi Lazaro, Jenny Lester, Fabienne Lesueur, Annelie Liljegren, Jennifer T. Loud, Jan Lubiński, Phuong L. Mai, Siranoush Manoukian, Véronique Mari, Noura Mebirouk, Hanne E. J. Meijers-Heijboer, Alfons Meindl, Arjen R. Mensenkamp, Austin Miller, Marco Montagna, Emmanuelle Mouret-Fourme, Semanti Mukherjee, Anna Marie Mulligan, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Dieter Niederacher, Finn Cilius Nielsen, Liene Nikitina-Zake, Catherine Noguès, Edith Olah, Olufunmilayo I. Olopade, Kai-Ren Ong, Aoife O’Shaughnessy-Kirwan, Ana Osorio, Claus-Eric Ott, Laura Papi, Sue K. Park, Michael T. Parsons, Inge Sokilde Pedersen, Bernard Peissel, Ana Peixoto, Paolo Peterlongo, Georg Pfeiler, Kelly-Anne Phillips, Karolina Prajzendanc, Miquel Angel Pujana, Paolo Radice, Juliane Ramser, Susan J. Ramus, Johanna Rantala, Gad Rennert, Harvey A. Risch, Mark Robson, Karina Rønlund, Ritu Salani, Hélène Schuster, Leigha Senter, Payal D. Shah, Priyanka Sharma, Lucy E. Side, Christian F. Singer, Thomas P. Slavin, Penny Soucy, Melissa C. Southey, Amanda B. Spurdle, Doris Steinemann, Zoe Steinsnyder, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Yen Tan, Manuel R. Teixeira, Soo Hwang Teo, Darcy L. Thull, Marc Tischkowitz, Silvia Tognazzo, Amanda E. Toland, Alison H. Trainer, Nadine Tung, Klaartje van Engelen, Elizabeth J. van Rensburg, Ana Vega, Jeroen Vierstraete, Gabriel Wagner, Lisa Walker, Shan Wang-Gohrke, Barbara Wappenschmidt, Jeffrey N. Weitzel, Siddhartha Yadav, Xin Yang, Drakoulis Yannoukakos, Dario Zimbalatti, Kenneth Offit, Mads Thomassen, Fergus J. Couch, Rita K. Schmutzler, Jacques Simard, Douglas F. Easton, Georgia Chenevix-Trench, Antonis C. Antoniou, Antonis Antoniou, Douglas Easton, Lucy Side, Amanda Spurdle, Marinus Blok, Frans Hogervorst, Maartje Hooning, Arjen Mensenkamp, Hanne Meijers-Heijboer, Matti Rookus, Klaartje van Engelen
Feb 12, 2021
Abstract: Purpose: We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. Methods...
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants
Daniel R. Barnes, Matti A. Rookus, Lesley McGuffog, Goska Leslie, Thea M. Mooij, Joe Dennis, Nasim Mavaddat, Julian Adlard, Munaza Ahmed, Kristiina Aittomäki, Nadine Andrieu, Irene L. Andrulis, Norbert Arnold, Banu K. Arun, Jacopo Azzollini, Judith Balmaña, Rosa B. Barkardottir, Daniel Barrowdale, Javier Benitez, Pascaline Berthet, Katarzyna Białkowska, Amie M. Blanco, Marinus J. Blok, Bernardo Bonanni, Susanne E. Boonen, Åke Borg, Aniko Bozsik, Angela R. Bradbury, Paul Brennan, Carole Brewer, Joan Brunet, Saundra S. Buys, Trinidad Caldés, Maria A. Caligo, Ian Campbell, Lise Lotte Christensen, Wendy K. Chung, Kathleen B. M. Claes, Chrystelle Colas, Marie-Agnès Collonge-Rame, Jackie Cook, Mary B. Daly, Rosemarie Davidson, Miguel de la Hoya, Robin de Putter, Capucine Delnatte, Peter Devilee, Orland Diez, Yuan Chun Ding, Susan M. Domchek, Cecilia M. Dorfling, Martine Dumont, Ros Eeles, Bent Ejlertsen, Christoph Engel, D. Gareth Evans, Laurence Faivre, Lenka Foretova, Florentia Fostira, Michael Friedlander, Eitan Friedman, Debra Frost, Patricia A. Ganz, Judy Garber, Andrea Gehrig, Anne-Marie Gerdes, Paul Gesta, Sophie Giraud, Gord Glendon, Andrew K. Godwin, David E. Goldgar, Anna González-Neira, Mark H. Greene, Daphne Gschwantler-Kaulich, Eric Hahnen, Ute Hamann, Helen Hanson, Julia Hentschel, Frans B. L. Hogervorst, Maartje J. Hooning, Judit Horvath, Chunling Hu, Peter J. Hulick, Evgeny N. Imyanitov, Claudine Isaacs, Louise Izatt, Angel Izquierdo, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Esther M. John, Vijai Joseph, Beth Y. Karlan, Karin Kast, Marco Koudijs, Torben A. Kruse, Ava Kwong, Yael Laitman, Christine Lasset, Conxi Lazaro, Jenny Lester, Fabienne Lesueur, Annelie Liljegren, Jennifer T. Loud, Jan Lubiński, Phuong L. Mai, Siranoush Manoukian, Véronique Mari, Noura Mebirouk, Hanne E. J. Meijers-Heijboer, Alfons Meindl, Arjen R. Mensenkamp, Austin Miller, Marco Montagna, Emmanuelle Mouret-Fourme, Semanti Mukherjee, Anna Marie Mulligan, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Dieter Niederacher, Finn Cilius Nielsen, Liene Nikitina-Zake, Catherine Noguès, Edith Olah, Olufunmilayo I. Olopade, Kai-Ren Ong, Aoife O’Shaughnessy-Kirwan, Ana Osorio, Claus-Eric Ott, Laura Papi, Sue K. Park, Michael T. Parsons, Inge Sokilde Pedersen, Bernard Peissel, Ana Peixoto, Paolo Peterlongo, Georg Pfeiler, Kelly-Anne Phillips, Karolina Prajzendanc, Miquel Angel Pujana, Paolo Radice, Juliane Ramser, Susan J. Ramus, Johanna Rantala, Gad Rennert, Harvey A. Risch, Mark Robson, Karina Rønlund, Ritu Salani, Hélène Schuster, Leigha Senter, Payal D. Shah, Priyanka Sharma, Lucy E. Side, Christian F. Singer, Thomas P. Slavin, Penny Soucy, Melissa C. Southey, Amanda B. Spurdle, Doris Steinemann, Zoe Steinsnyder, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Yen Tan, Manuel R. Teixeira, Soo Hwang Teo, Darcy L. Thull, Marc Tischkowitz, Silvia Tognazzo, Amanda E. Toland, Alison H. Trainer, Nadine Tung, Klaartje van Engelen, Elizabeth J. van Rensburg, Ana Vega, Jeroen Vierstraete, Gabriel Wagner, Lisa Walker, Shan Wang-Gohrke, Barbara Wappenschmidt, Jeffrey N. Weitzel, Siddhartha Yadav, Xin Yang, Drakoulis Yannoukakos, Dario Zimbalatti, Kenneth Offit, Mads Thomassen, Fergus J. Couch, Rita K. Schmutzler, Jacques Simard, Douglas F. Easton, Georgia Chenevix-Trench, Antonis C. Antoniou, Antonis Antoniou, Douglas Easton, Lucy Side, Amanda Spurdle, Marinus Blok, Frans Hogervorst, Maartje Hooning, Arjen Mensenkamp, Hanne Meijers-Heijboer, Matti Rookus, Klaartje van Engelen
Sep 29, 2020
Abstract: Purpose: We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. Methods...
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants.
Daniel R Barnes, Matti A Rookus, Lesley McGuffog, Goska Leslie, Thea M Mooij, Joe Dennis, Nasim Mavaddat, Julian Adlard, Munaza Ahmed, Kristiina Aittomäki, Nadine Andrieu, Irene L Andrulis, Norbert Arnold, Banu K Arun, Jacopo Azzollini, Judith Balmaña, Rosa B Barkardottir, Daniel Barrowdale, Javier Benitez, Pascaline Berthet, Katarzyna Białkowska, Amie M Blanco, Marinus J Blok, Bernardo Bonanni, Susanne E Boonen, Åke Borg, Aniko Bozsik, Angela R Bradbury, Paul Brennan, Carole Brewer, Joan Brunet, Saundra S Buys, Trinidad Caldés, Maria A Caligo, Ian Campbell, Lise Lotte Christensen, Wendy K Chung, Kathleen BM Claes, Chrystelle Colas, GEMO Study Collaborators, EMBRACE Collaborators, Marie-Agnès Collonge-Rame, Jackie Cook, Mary B Daly, Rosemarie Davidson, Miguel de la Hoya, Robin de Putter, Capucine Delnatte, Peter Devilee, Orland Diez, Yuan Chun Ding, Susan M Domchek, Cecilia M Dorfling, Martine Dumont, Ros Eeles, Bent Ejlertsen, Christoph Engel, D Gareth Evans, Laurence Faivre, Lenka Foretova, Florentia Fostira, Michael Friedlander, Eitan Friedman, Debra Frost, Patricia A Ganz, Judy Garber, Andrea Gehrig, Anne-Marie Gerdes, Paul Gesta, Sophie Giraud, Gord Glendon, Andrew K Godwin, David E Goldgar, Anna González-Neira, Mark H Greene, Daphne Gschwantler-Kaulich, Eric Hahnen, Ute Hamann, Helen Hanson, Julia Hentschel, Frans BL Hogervorst, Maartje J Hooning, Judit Horvath, Chunling Hu, Peter J Hulick, Evgeny N Imyanitov, kConFab Investigators, HEBON Investigators, GENEPSO Investigators, Claudine Isaacs, Louise Izatt, Angel Izquierdo, Anna Jakubowska, Paul A James, Ramunas Janavicius, Esther M John, Vijai Joseph, Beth Y Karlan, Karin Kast, Marco Koudijs, Torben A Kruse, Ava Kwong, Yael Laitman, Christine Lasset, Conxi Lazaro, Jenny Lester, Fabienne Lesueur, Annelie Liljegren, Jennifer T Loud, Jan Lubiński, Phuong L Mai, Siranoush Manoukian, Véronique Mari, Noura Mebirouk, Hanne EJ Meijers-Heijboer, Alfons Meindl, Arjen R Mensenkamp, Austin Miller, Marco Montagna, Emmanuelle Mouret-Fourme, Semanti Mukherjee, Anna Marie Mulligan, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Dieter Niederacher, Finn Cilius Nielsen, Liene Nikitina-Zake, Catherine Noguès, Edith Olah, Olufunmilayo I Olopade, Kai-Ren Ong, Aoife O'Shaughnessy-Kirwan, Ana Osorio, Claus-Eric Ott, Laura Papi, Sue K Park, Michael T Parsons, Inge Sokilde Pedersen, Bernard Peissel, Ana Peixoto, Paolo Peterlongo, Georg Pfeiler, Kelly-Anne Phillips, Karolina Prajzendanc, Miquel Angel Pujana, Paolo Radice, Juliane Ramser, Susan J Ramus, Johanna Rantala, Gad Rennert, Harvey A Risch, Mark Robson, Karina Rønlund, Ritu Salani, Hélène Schuster, Leigha Senter, Payal D Shah, Priyanka Sharma, Lucy E Side, Christian F Singer, Thomas P Slavin, Penny Soucy, Melissa C Southey, Amanda B Spurdle, Doris Steinemann, Zoe Steinsnyder, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Yen Tan, Manuel R Teixeira, Soo Hwang Teo, Darcy L Thull, Marc Tischkowitz, Silvia Tognazzo, Amanda E Toland, Alison H Trainer, Nadine Tung, Klaartje van Engelen, Elizabeth J van Rensburg, Ana Vega, Jeroen Vierstraete, Gabriel Wagner, Lisa Walker, Shan Wang-Gohrke, Barbara Wappenschmidt, Jeffrey N Weitzel, Siddhartha Yadav, Xin Yang, Drakoulis Yannoukakos, Dario Zimbalatti, Kenneth Offit, Mads Thomassen, Fergus J Couch, Rita K Schmutzler, Jacques Simard, Douglas F Easton, Georgia Chenevix-Trench, Antonis C Antoniou, Consortium of Investigators of Modifiers of BRCA and BRCA2
May 27, 2020
PURPOSE: We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. METHODS...
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