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Attitudes of Costa Rican individuals towards donation of personal genetic data for research.
Gabriela Chavarria-Soley, Fernanda Francis-Cartin, Fabiola Jimenez-Gonzalez, Alejandro Ávila-Aguirre, Maria Jose Castro-Gomez, Lauren Robarts, Anna Middleton, Henriette Raventós
Mar 18, 2021
Aim: We explore attitudes from the public in Costa Rica regarding willingness to donate DNA data for research. Materials & methods: A total of 224 Costa Rican individuals answered the anonymous online survey 'Your DNA, Your...
Attitudes of Costa Rican individuals towards donation of personal genetic data for research
Gabriela Chavarria-Soley, Fernanda Francis-Cartin, Fabiola Jimenez-Gonzalez, Alejandro Ávila-Aguirre, Maria Jose Castro-Gomez, Lauren Robarts, Anna Middleton, Henriette Raventós
Feb 12, 2021
Aim: We explore attitudes from the public in Costa Rica regarding willingness to donate DNA data for research. Materials & methods: A total of 224 Costa Rican individuals answered the anonymous online survey ‘Your DNA, Your...
Attitudes of Costa Rican individuals towards donation of personal genetic data for research
Gabriela Chavarria-Soley, Fernanda Francis-Cartin, Fabiola Jimenez-Gonzalez, Alejandro Ávila-Aguirre, Maria Jose Castro-Gomez, Lauren Robarts, Anna Middleton, Henriette Raventós
Feb 26, 2021
Aim: We explore attitudes from the public in Costa Rica regarding willingness to donate DNA data for research. Materials & methods: A total of 224 Costa Rican individuals answered the anonymous online survey ‘Your DNA, Your...
Los Matices Varios del Feminismo en las Comunidades Indígenas de América Latina: Yorkín, Costa Rica y Santa Anita, Guatemala
Roseangela G Hartford
Jan 01, 0001
This project investigates gender constructs and the complex assigned gender roles in settings of female indigenous leadership in Latin America. It examines two distinct indigenous communities, including the BriBri society in...
indigenous peoples Guatemala feminism masculine domination Femininity Costa Rica leadership Arts and Humanities Feminist, Gender, and Sexuality Studies Latin American Studies Leadership Studies Spanish and Portuguese Language and Literature
Published by: Ursinus College
Public Security Sentiment Analysis on Social Web
This article presents (1) the results of a literature review on social web mining and sentiment analysis on public security; (2) the idea of a framework for the analytical process involved in the literature review themes; and...
Published by: IGI Global Scientific Publishing
A Multi-Criteria Decision-Making Model for Selecting a Maturity Model
This paper proposes a decision model for a maturity model choice problem via the multiple-criteria decision analysis method. The authors implemented the model in FITradeoff decision support system to select a project management...
Published by: IGI Global Scientific Publishing
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.
Neurons rely on mitochondria as their preferred source of energy. Mutations in PINK1 and PARKIN cause neuronal death in early-onset Parkinson's disease (PD), thought to be due to mitochondrial dysfunction. In Drosophila pink1...
Activating Transcription Factor 4 Animals Drosophila Drosophila Proteins Folic Acid Glycine Hydroxymethyltransferase Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Mutagenesis Neuroprotection Parkinson Disease Phenotype Protein Serine-Threonine Kinases RNA Interference RNA Small Interfering Ubiquitin-Protein Ligases Up-Regulation
Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin.
Juan Garrido-Maraver, Ivana Celardo, Ana C Costa, Susann Lehmann, Samantha HY Loh, L Miguel Martins
Feb 27, 2019
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
Geometric general solution to the U(1) anomaly equations
Abstract: Costa et al. [Phys. Rev. Lett.123 (2019) 151601] recently gave a general solution to the anomaly equations for n charges in a U(1) gauge theory. ‘Primitive’ solutions of chiral fermion charges were parameterised and it...
Phosphoinositide 3-kinase beta controls replication factor C assembly and function.
Javier Redondo-Muñoz, María Josefa Rodríguez, Virginia Silió, Vicente Pérez-García, José María Valpuesta, Ana C Carrera
Apr 16, 2019
Genomic integrity is preserved by the action of protein complexes that control DNA homeostasis. These include the sliding clamps, trimeric protein rings that are arranged around DNA by clamp loaders. Replication factor C (RFC)...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways
Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C. Costa, Samantha H. Y. Loh, L. Miguel Martins
Apr 29, 2021
In Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson’s disease caused by...
Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways.
Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C Costa, Samantha HY Loh, L Miguel Martins
Jul 20, 2021
In Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson's disease caused by...
Drosophila Drosophila protein kinase RNA (PKR)-like ER kinase (dPerk) ER stress activating transcription factor 4 (ATF4) Unfolded Protein Response Activating Transcription Factor 4 Animals Cell Cycle Proteins Computational Biology Drosophila Proteins Drosophila melanogaster Endoplasmic Reticulum Endoplasmic reticulum stress Eukaryotic Initiation Factor-2 HEAT-SHOCK PROTEINS Mitochondria Neurodegenerative Diseases Phosphorylation Protein Processing Post-Translational Protein Serine-Threonine Kinases Proteomics Signal Transduction Transcription Factors Transcriptome Ubiquitin-Protein Ligases Unfolded Protein Response eIF-2 Kinase
Geometric general solution to the U(1) anomaly equations
Abstract: Costa et al. [Phys. Rev. Lett.123 (2019) 151601] recently gave a general solution to the anomaly equations for n charges in a U(1) gauge theory. ‘Primitive’ solutions of chiral fermion charges were parameterised and it...
Circulating vitamin C and digestive system cancers
Susanna C Larsson, Amy M Mason, Mathew Vithayathil, Paul Carter, Siddhartha Kar, Ju-Sheng Zheng, Stephen Burgess
Sep 20, 2022
BACKGROUND & AIMS: Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to...
Breast cancer management pathways during the COVID-19 pandemic
Rajiv V Dave, Baek Kim, Alona Courtney, Rachel O'Connell, Tim Rattay, Vicky P Taxiarchi, Jamie J Kirkham, Elizabeth M Camacho, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Ramsey I Cutress, Ashu Gandhi, Cliona C Kirwan, B-MaP-C study collaborative
Apr 14, 2021
BACKGROUND: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. METHODS: This...
Geometric general solution to the U(1) anomaly equations
Abstract: Costa et al. [Phys. Rev. Lett.123 (2019) 151601] recently gave a general solution to the anomaly equations for n charges in a U(1) gauge theory. ‘Primitive’ solutions of chiral fermion charges were parameterised and it...
Presence of anti-eukaryotic initiation factor-2B, anti-RuvBL1/2 and anti-synthetase antibodies in patients with anti-nuclear antibody negative systemic sclerosis
John D Pauling, Gloria Salazar, Hui Lu, Zoe E Betteridge, Shervin Assassi, Maureen D Mayes, Neil J McHugh
Apr 01, 2018
Objectives: Autoantibodies targeting ubiquitously expressed nuclear antigens can be identified in most patients with SSc. Cytoplasmic autoantibodies (in otherwise ANA-negative sera) targeting eukaryotic initiation factor-2B...
Controlled masking and targeted release of redox-cycling ortho-quinones via a C-C bond-cleaving 1,6-elimination.
Lavinia Dunsmore, Claudio D Navo, Julie Becher, Enrique Gil de Montes, Ana Guerreiro, Emily Hoyt, Libby Brown, Viviane Zelenay, Sigitas Mikutis, Jonathan Cooper, Isaia Barbieri, Stefanie Lawrinowitz, Elise Siouve, Esther Martin, Pedro R Ruivo, Tiago Rodrigues, Filipa P da Cruz, Oliver Werz, George Vassiliou, Peter Ravn, Gonzalo Jiménez-Osés, Gonçalo JL Bernardes
Aug 01, 2022
Natural products that contain ortho-quinones show great potential as anticancer agents but have been largely discarded from clinical development because their redox-cycling behaviour results in general systemic toxicity. Here we...
Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation.
An altered response to DNA damage is commonly associated with genomic instability, a hallmark of cancer. Fumarate hydratase (FH) was recently characterised as a DNA repair factor required in non-homologous end-joining (NHEJ)...
Measuring Medical Students' Empathy
Patrício Costa, Marco Antonio de Carvalho-Filho, Marcelo Schweller, Pia Thiemann, Ana Salgueira, John Benson, Manuel João Costa, Thelma Quince
Jan 23, 2019
PURPOSE: Understanding medical student empathy is important to future patient care; however, the definition and development of clinical empathy remain unclear. The authors sought to examine the underlying constructs of two of...
Controlled masking and targeted release of redox-cycling ortho-quinones via a C-C bond-cleaving 1,6-elimination.
Lavinia Dunsmore, Claudio D Navo, Julie Becher, Enrique Gil de Montes, Ana Guerreiro, Emily Hoyt, Libby Brown, Viviane Zelenay, Sigitas Mikutis, Jonathan Cooper, Isaia Barbieri, Stefanie Lawrinowitz, Elise Siouve, Esther Martin, Pedro R Ruivo, Tiago Rodrigues, Filipa P da Cruz, Oliver Werz, George Vassiliou, Peter Ravn, Gonzalo Jiménez-Osés, Goncalo Lopes Bernardes
Jul 05, 2022
Natural products that contain ortho-quinones show great potential as anticancer agents but have been largely discarded from clinical development because their redox-cycling behaviour results in general systemic toxicity. Here we...
The ALPINE–ALMA [C ii] Survey
Abstract
We present the radio properties of 66 spectroscopically confirmed normal star-forming galaxies (SFGs) at 4.4 < z < 5.9 in the COSMOS field...
Lu Shen, Brian C Lemaux, Lori M Lubin, Guilin Liu, Matthieu Béthermin, Médéric Boquien, Olga Cucciati, Olivier Le Fèvre, Margherita Talia, Daniela Vergani, Gianni Zamorani, Andreas L Faisst, Michele Ginolfi, Carlotta Gruppioni, Gareth C Jones, Sandro Bardelli, Nimish Hathi, Anton M Koekemoer, Michael Romano, Daniel Schaerer, Elena Zucca, Wenjuan Fang, Ben Forrest, Roy Gal, Denise Hung, Ekta A Shah, Priti Staab, Brittany Vanderhoof, Eduardo Ibar
Aug 24, 2022
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