Search
Results: 175
Comparing oncology clinical programs by use of innovative designs and expected net present value optimization
Tom Parke, Olga Marchenko, Vladimir Anisimov, Anastasia Ivanova, Christopher Jennison, Inna Perevozskaya, Guochen Song
Jan 01, 0001
Designing an oncology clinical program is more challenging than designing a single study. The standard approaches have been proven to be not very successful during the last decade; the failure rate of Phase 2 and Phase 3...
Comparing oncology clinical programs by use of innovative designs and expected net present value optimization
Tom Parke, Olga Marchenko, Vladimir Anisimov, Anastasia Ivanova, Christopher Jennison, Inna Perevozskaya, Guochen Song
Jan 01, 0001
Designing an oncology clinical program is more challenging than designing a single study. The standard approaches have been proven to be not very successful during the last decade; the failure rate of Phase 2 and Phase 3...
Translanguaging and Digital Technologies in the Realm of Language Learning
Anastasia Tzirides
Apr 01, 2022
In the globalized world that we live in, people communicate by using not only their primary language, but all the languages they know complemented by the use of multimodal elements, like images, videos, emoticons, memes, and...
Literacy and Language Studies Social Sciences and Humanities Linguistics Education Library and Information Science
Published by: IGI Global Scientific Publishing
Ca2+ Release by IP3 Receptors Is Required to Orient the Mitotic Spindle.
The mitotic spindle distributes chromosomes evenly to daughter cells during mitosis. The orientation of the spindle, guided by internal and external cues, determines the axis of cell division and thereby contributes to tissue...
Translanguaging and Digital Technologies in the Realm of Language Learning
Anastasia Tzirides
May 14, 2021
In the globalized world that we live in, people communicate by using not only their primary language, but all the languages they know complemented by the use of multimodal elements, like images, videos, emoticons, memes, and...
Published by: IGI Global Scientific Publishing
Hysteria: A Collection of Feminist Horror
Anastasia Dziekan
Jan 01, 0001
Horror as a genre holds a unique place in pop culture as a space in which to explore our fears in ways that allow us to embrace and confront them. It is also a genre that relies heavily on tropes and audience familiarity...
horror movies horror films film criticism fiction feminism Creative Writing fiction Film and Media Studies Women's Studies
Published by: Ursinus College
Personalized Mastery-Based Learning Ecosystem
Children differ greatly in what they know and are ready to learn when they enter school. However, when their individual needs are assessed and addressed, even very young children can learn and can greatly surpass grade-level...
K-12 Education Education Learning Assessment and Measurement Social Sciences and Humanities Government and Law
Published by: IGI Global Scientific Publishing
Bend-strength of novel filament wound shear reinforcement
The winding of Fibre Reinforced Polymer (FRP) tows around longitudinal reinforcing bars provides a novel method for the fabrication of reinforcement cages. Complex geometries of internal reinforcement can be fabricated using...
Challenges and Opportunities for the Large-Scale Chemoenzymatic Glycoengineering of Therapeutic N-Glycosylated Monoclonal Antibodies
Variability in the glycosylation profile of therapeutic monoclonal antibodies (mAbs), due to recombinant production technologies, leads to inconsistencies in effector functions and pharmacokinetic properties, both...
Bend-strength of novel filament wound shear reinforcement
The winding of Fibre Reinforced Polymer (FRP) tows around longitudinal reinforcing bars provides a novel method for the fabrication of reinforcement cages. Complex geometries of internal reinforcement can be fabricated using...
Betwixt and Between: an Exploration of Dream Imagery as a Means to Self-Discovery
Anastasia Netrebine
Jan 01, 0001
This body of work is an investigation of the memories and experiences of displacement. As a foreigner, I often find myself in a strange space between the familiar and the unfamiliar. I use various three-dimensional media to...
Published by: Winthrop University
The discovery and maturation of peptide biologics targeting the small G protein Cdc42
George JN Tetley, Natasha P Murphy, Stephane Bonetto, Gabriela Ivanova-Berndt, Jefferson Revell, Helen R Mott, R Neil Cooley, Darerca Owen
Jan 23, 2020
Cdc42 GTPase Kras (KRAS) biologics Cancer cancer therapeutics cell migration Cell Proliferation Cell Signaling cyclic peptide Drug Discovery Nuclear Magnetic Resonance (NMR) peptide conformation Binding Sites Cell Movement Cell Proliferation Cell-Penetrating Peptides Drug Discovery GTP Phosphohydrolases Humans Molecular Structure Neoplasm Invasiveness Neoplasms Peptides Cyclic Signal Transduction cdc42 GTP-Binding Protein ras Proteins
Descriptive Norms and Guilt Aversion
It has been argued that guilt aversion (the desire to meet others’ expectations) and the social norm compliance (the desire to act similarly to other individuals in the same situation) are important drivers of human behavior....
Domain-general and domain-specific computations in single word processing.
Language comprehension relies on a multitude of domain-general and domain-specific cognitive operations. This study asks whether the domain-specific grammatical computations are obligatorily invoked whenever we process...
Penyengat Island Riau Island
Anastasia Wiwik SWASTIWI
Mar 31, 2022
Malay history and culture cannot be separated from the existence of Penyengat Island. This island once had a strategic role. First, Penyengat Island was the fortress of Raja Haji during the war against the Dutch. Second, as the...
Published by: Indonesia Strategic Sustainability
Sandwich groups and (strong) left 3-Engel elements in groups
In this paper we prove a group theoretic analogue of the well known local nilpotence theorem for sandwich Lie algebras due to Kostrikin and Zel’manov [Trudy Mat. Inst. Steklov. 183 (1990), pp. 106–111, 225]. We introduce the...
Sandwich groups and (strong) left 3-Engel elements in groups
In this paper we prove a group theoretic analogue of the well known local nilpotence theorem for sandwich Lie algebras due to Kostrikin and Zel’manov [Trudy Mat. Inst. Steklov. 183 (1990), pp. 106–111, 225]. We introduce the...
LPS-treatment of bovine endometrial epithelial cells causes differential DNA methylation of genes associated with inflammation and endometrial function.
Naveed Jhamat, Adnan Niazi, Yongzhi Guo, Metasu Chanrot, Elena Ivanova, Gavin Kelsey, Erik Bongcam-Rudloff, Göran Andersson, Patrice Humblot
Jun 04, 2021
BACKGROUND: Lipopolysaccharide (LPS) endotoxin stimulates pro-inflammatory pathways and is a key player in the pathological mechanisms involved in the development of endometritis. This study aimed to investigate LPS-induced DNA...
Bovine endometrial epithelial cells Endometritis Implantation Inflammation LPS RRBS Animals Cattle Cells Cultured DNA Methylation Dose-Response Relationship Drug Endometrium Female Gene Expression Profiling Gene Expression Regulation Gene Ontology Gene Regulatory Networks Lipopolysaccharides Promoter Regions Genetic Sequence Analysis DNA
Is seeing believing? The effects of virtual reality on young children’s understanding of possibility and impossibility
This study explored the effects of virtual reality on young children’s understanding of possibility and impossibility. It involved four-year-old children (30 boys and 30 girls) who were randomly allocated to a virtual reality...
Mutable reality and unknowable future
In this dialogue paper, we consider Zellweger and Zenger’s (2021) conceptualization of entrepreneurs as scientists, rooted in pragmatism. While we agree that pragmatism provides a useful but neglected foundation for studying the...
Cancer cell lines show high heritability for motility but not generation time
Tumour evolution depends on heritable differences between cells in traits affecting cell survival or replication. It is well established that cancer cells are genetically and phenotypically heterogeneous; however, the extent to...
Cancer cell lines show high heritability for motility but not generation time
Tumour evolution depends on heritable differences between cells in traits affecting cell survival or replication. It is well established that cancer cells are genetically and phenotypically heterogeneous; however, the extent to...
Is seeing believing? The effects of virtual reality on young children’s understanding of possibility and impossibility
This study explored the effects of virtual reality on young children’s understanding of possibility and impossibility. It involved four-year-old children (30 boys and 30 girls) who were randomly allocated to a virtual reality...
Constraining Baryon-Dark-Matter Scattering with the Cosmic Dawn 21-cm Signal.
The recent detection of an anomalously strong 21-cm signal of neutral hydrogen from cosmic dawn by the EDGES low-band radio experiment can be explained if cold dark matter particles scattered off the baryons draining excess...
|
|< |
< |
1 |