Mice lacking secreted IgM (sIgM -/-) antibodies display abnormal splenic B cell development, which results in increased marginal zone and decreased follicular B cell numbers. However, the mechanism by which sIgM exhibit this...
Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B...
Abstract: We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives...
The effect of acute inhibition of both mTORC1 and mTORC2 on metabolism is unknown. A single injection of the mTOR kinase inhibitor, AZD8055, induced a transient, yet marked increase in fat oxidation and insulin resistance in...
Abstract: We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives...
Abstract: We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives...
Abstract: We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives...
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
A measurement of four branching-fraction ratios for three-body decays of $B$
mesons involving two open-charm hadrons in the final state is presented. Run 1
and Run 2 $pp$ collision data are used, recorded by the LHCb experiment...
Assembly of the mitochondrial respiratory chain requires the coordinated synthesis of mitochondrial and nuclear encoded subunits, redox co-factor acquisition, and correct joining of the subunits to form functional complexes. The...
Assembly of the mitochondrial respiratory chain requires the coordinated synthesis of mitochondrial and nuclear encoded subunits, redox co-factor acquisition, and correct joining of the subunits to form functional complexes. The...
Abstract: Measurements of CP observables in B± → D(*)K± and B± → D(*)π± decays are presented, where D(∗) indicates a neutral D or D∗ meson that is an admixture of meson and anti-meson states. Decays of the D(∗) meson to the Dπ0...
Abstract: Measurements of CP observables in B± → D(*)K± and B± → D(*)π± decays are presented, where D(∗) indicates a neutral D or D∗ meson that is an admixture of meson and anti-meson states. Decays of the D(∗) meson to the Dπ0...
Abstract: We report on the calculation of the next-to-leading order QCD corrections to the production of a tt¯ pair in association with two heavy-flavour jets. We concentrate on the di-lepton tt¯ decay channel at the LHC with s...
Abstract: A search is presented for the lepton flavour violating decay B+ → K+μ−τ+ using a sample of proton-proton collisions at centre-of-mass energies of 7, 8, and 13 TeV, collected with the LHCb detector and corresponding to...
Abstract: Measurements of CP observables in B± → DK± and B± → Dπ± decays are presented, where D represents a superposition of D0 and D¯0 states. The D meson is reconstructed in the three-body final states KS0K±π∓ and KS0K∓π±....
Abstract: A search is presented for the lepton flavour violating decay B+ → K+μ−τ+ using a sample of proton-proton collisions at centre-of-mass energies of 7, 8, and 13 TeV, collected with the LHCb detector and corresponding to...
Abstract: A measurement of CP-violating observables is performed using the decays B± → DK± and B± → Dπ±, where the D meson is reconstructed in one of the self-conjugate three-body final states KS0π+π− and KS0K+K− (commonly...
Phosphoinositide-3 kinase (PI3K) signaling is important for the survival of numerous cell types and class IA of PI3K is specifically required for the development of B cells but not for T cell development. Here, we show that...
Abstract: A structure is observed in the B±K∓ mass spectrum in a sample of proton–proton collisions at centre-of-mass energies of 7, 8, and 13 TeV, collected with the LHCb detector and corresponding to a total integrated...
OCA-B (Oct coactivator from B cells) is a B-cell specific coactivator of transcription that acts in conjunction with the ubiquitously expressed activator, OCT-1 or the B cell-restricted OCT-2. OCT-1 or OCT-2 can bind an upstream...
Abstract: Measurements of CP observables in B± → DK± and B± → Dπ± decays are presented, where D represents a superposition of D0 and D¯0 states. The D meson is reconstructed in the three-body final states KS0K±π∓ and KS0K∓π±....
Abstract: A measurement of CP-violating observables is performed using the decays B± → DK± and B± → Dπ±, where the D meson is reconstructed in one of the self-conjugate three-body final states KS0π+π− and KS0K+K− (commonly...
BACKGROUND: Chronic Hepatitis B virus (HBV) infection can lead to the development of chronic hepatitis, cirrhosis and hepatocellular carcinoma. We hypothesized that HBV might accelerate hepatocyte ageing and investigated the...