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Pathophysiology, causes and genetics of paediatric and adult bronchiectasis.
Bronchiectasis has historically been considered to be irreversible dilatation of the airways, but with modern imaging techniques it has been proposed that 'irreversible' be dropped from the definition. The upper limit of normal...
Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis.
Cystic fibrosis (CF) is progressive genetic disease that predisposes lungs and other organs to multiple long-lasting microbial infections. Pseudomonas aeruginosa is the most prevalent and deadly pathogen among these microbes....
Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation.
Inflammation-related progressive lung destruction is the leading causes of premature death in cystic fibrosis (CF), a genetic disorder caused by a defective cystic fibrosis transmembrane conductance regulator (CFTR). However...
CFTR Tanshione IIA Apoptosis Cystic Fibrosis neutrophil reverse migration neutrophilic inflammation tissue repair Zebrafish Animals Animals Genetically Modified Cystic Fibrosis Transmembrane Conductance Regulator Immunity Innate Inflammation Neutrophil Infiltration Wound Healing Zebrafish Zebrafish Proteins
Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19.
Bridget P Bannerman, Jorge Júlvez, Alexandru Oarga, Tom L Blundell, Pablo Moreno, R Andres Floto
Sep 08, 2021
Humans Drug Evaluation Preclinical Computational Biology Models Biological Pandemics Drug development covid-19 SARS-CoV-2
Published by: Life science alliance
Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19.
Bridget P Bannerman, Jorge Júlvez, Alexandru Oarga, Tom L Blundell, Pablo Moreno, R Andres Floto
Oct 18, 2021
The coronavirus disease 2019 (COVID-19) pandemic caused by the new coronavirus (SARS-CoV-2) is currently responsible for more than 3 million deaths in 219 countries across the world and with more than 140 million cases. The...
The Impact of Hospital-Ward Ventilation on Airborne-Pathogen Exposure.
Nicola Mingotti, Dorothy Grogono, Gennaro Dello Ioio, Martin Curran, Kathryn Barbour, Marlene Taveira, Josie Rudman, Charles S Haworth, R Andres Floto, Andrew W Woods
Nov 09, 2020
Mutations in the MAB_2299c TetR Regulator Confer Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus.
Matthias Richard, Ana Victoria Gutiérrez, Albertus Viljoen, Daniela Rodriguez-Rincon, Françoise Roquet-Baneres, Mickael Blaise, Isobel Everall, Julian Parkhill, R Andres Floto, Laurent Kremer
May 16, 2019
New therapeutic approaches are needed against Mycobacterium abscessus, a respiratory mycobacterial pathogen that evades efforts to successfully treat infected patients. Clofazimine and bedaquiline, two drugs used for the...
EMSA MmpL Mycobacterium abscessus TetR regulator bedaquiline clofazimine drug resistance mechanisms efflux pumps Antitubercular Agents Clofazimine Diarylquinolines Drug Resistance Multiple Bacterial Genome Bacterial Humans Membrane Transport Proteins Microbial Sensitivity Tests Mycobacterium abscessus Tetracycline Resistance Trans-Activators Tuberculosis Multidrug-Resistant whole genome sequencing
Which microbial factors really are important in Pseudomonas aeruginosa infections?
Audrey Crousilles, Eve Maunders, Sean Bartlett, Catherine Fan, Emem-Fong Ukor, Yassmin Abdelhamid, Ysobel Baker, Andres Floto, David R Spring, Martin Welch
Aug 19, 2015
Structure-guided fragment-based drug discovery at the synchrotron
Sherine E Thomas, Patrick Collins, Rory Hennell James, Vitor Mendes, Sitthivut Charoensutthivarakul, Chris Radoux, Chris Abell, Anthony G Coyne, R Andres Floto, Frank von Delft, Tom L Blundell
Apr 03, 2019
Mycobacterium abscessus SAICAR synthetase (PurC) Fragment-based drug discovery Structure-guided synchrotron Bacterial Proteins Binding Sites Drug Discovery High-Throughput Screening Assays History 20th Century History 21st Century Humans Models Molecular Mycobacterium abscessus Peptide Fragments Peptide Synthases Synchrotrons
Increased Virulence of Outer Membrane Porin Mutants of Mycobacterium abscessus.
Vinicius CN de Moura, Deepshikha Verma, Isobel Everall, Karen P Brown, Juan M Belardinelli, Crystal Shanley, Megan Stapleton, Julian Parkhill, R Andres Floto, Diane J Ordway, Mary Jackson
Aug 23, 2021
Chronic pulmonary infections caused by non-tuberculous mycobacteria of the Mycobacterium abscessus complex (MABSC) are emerging as a global health problem and pose a threat to susceptible individuals with structural lung disease...
Producing polished prokaryotic pangenomes with the Panaroo pipeline.
Gerry Tonkin-Hill, Neil MacAlasdair, Christopher Ruis, Aaron Weimann, Gal Horesh, John A Lees, Rebecca A Gladstone, Stephanie Lo, Christopher Beaudoin, R Andres Floto, Simon DW Frost, Jukka Corander, Stephen D Bentley, Julian Parkhill
Aug 03, 2020
Population-level comparisons of prokaryotic genomes must take into account the substantial differences in gene content resulting from horizontal gene transfer, gene duplication and gene loss. However, the automated annotation of...
R/BHC
BACKGROUND: Although the use of clustering methods has rapidly become one of the standard computational approaches in the literature of microarray gene expression data analysis, little attention has been paid to uncertainty in...
Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions
Sherine E Thomas, William J McCarthy, Jamal El Bakali, Karen P Brown, So Yeon Kim, Michal Blaszczyk, Vítor Mendes, Chris Abell, R Andres Floto, Anthony G Coyne, Tom L Blundell
Jun 14, 2022
Anti-microbial resistance is a rising global healthcare concern that needs urgent attention as growing number of infections become difficult to treat with the currently available antibiotics. This is particularly true for...
Producing polished prokaryotic pangenomes with the Panaroo pipeline
Gerry Tonkin-Hill, Neil MacAlasdair, Christopher Ruis, Aaron Weimann, Gal Horesh, John A. Lees, Rebecca A. Gladstone, Stephanie Lo, Christopher Beaudoin, R. Andres Floto, Simon D.W. Frost, Jukka Corander, Stephen D. Bentley, Julian Parkhill
Jul 22, 2020
Abstract: Population-level comparisons of prokaryotic genomes must take into account the substantial differences in gene content resulting from horizontal gene transfer, gene duplication and gene loss. However, the automated...
Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae.
Brief Sensory Deprivation Triggers Cell Type-Specific Structural and Functional Plasticity in Olfactory Bulb Neurons.
Elisa Galliano, Christiane Hahn, Lorcan P Browne, Paula R Villamayor, Candida Tufo, Andres Crespo, Matthew S Grubb
Dec 03, 2020
Can alterations in experience trigger different plastic modifications in neuronal structure and function, and if so, how do they integrate at the cellular level? To address this question, we interrogated circuitry in the mouse...
Mycobacterium abscessus pathogenesis identified by phenogenomic analyses.
Lucas Boeck, Sophie Burbaud, Marcin Skwark, Will H Pearson, Jasper Sangen, Andreas W Wuest, Eleanor KP Marshall, Aaron Weimann, Isobel Everall, Josephine M Bryant, Sony Malhotra, Bridget P Bannerman, Katrin Kierdorf, Tom L Blundell, Marc S Dionne, Julian Parkhill, R Andres Floto
Sep 25, 2022
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