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Blockade of chemokine-induced signalling inhibits CCR5-dependent HIV infection in vitro without blocking gp120/CCR5 interaction.
BACKGROUND: Cellular infection with human immunodeficiency virus (HIV) both in vitro and in vivo requires a member of the chemokine receptor family to act as a co-receptor for viral entry. However, it is presently unclear to...
Wrapping up the bad news
Calcium-Binding Proteins Cell Cycle Proteins Endosomal Sorting Complexes Required for Transport HIV Infections HIV-1 Host-Pathogen Interactions Humans Nedd4 Ubiquitin Protein Ligases Protein Processing Post-Translational Proteolysis Ubiquitin-Protein Ligases Virus Assembly Virus Release gag Gene Products Human Immunodeficiency Virus
The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle.
Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT) system, which is classically associated with sorting and downgrading...
The molecular biology of feline immunodeficiency virus (FIV).
Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-like illness in domestic cats. It is highly prevalent in several endangered feline species. In domestic cats FIV infection is a valuable...
A new method for detecting signal regions in ordered sequences of real numbers, and application to viral genomic data.
We present a fast, robust and parsimonious approach to detecting signals in an ordered sequence of numbers. Our motivation is in seeking a suitable method to take a sequence of scores corresponding to properties of positions in...
DDX5 potentiates HIV-1 transcription as a co-factor of Tat.
BACKGROUND: HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was recently...
Evaluating RNA Structural Flexibility
Our understanding of RNA structure has lagged behind that of proteins and most other biological polymers, largely because of its ability to adopt multiple, and often very different, functional conformations within a single...
Persistence of Imported Malaria Into the United Kingdom
BACKGROUND: The United Kingdom documented a decline of >30% in imported cases of malaria annually between 1996 and 2003; however, there are still approximately 1700 cases and 5-10 deaths each year. Prophylaxis health messages...
imported Malaria Risk Factors Adolescent Adult Age Factors Aged Aged 80 and over Child Child Preschool Communicable Diseases Imported Female Humans Infant Malaria Male Middle Aged Plasmodium Population Surveillance Retrospective Studies Risk Factors Seasons Sex Factors Travel United Kingdom Young Adult
ML-SIM
Structured illumination microscopy (SIM) has become an important technique for optical super-resolution imaging because it allows a doubling of image resolution at speeds compatible with live-cell imaging. However, the...
Published by: Biomedical optics express
ML-SIM
Structured illumination microscopy (SIM) has become an important technique for
optical super-resolution imaging because it allows a doubling of image resolution at speeds
compatible with live-cell imaging. However, the...
Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage.
No evidence of ongoing evolution in replication competent latent HIV-1 in a patient followed up for two years.
Hoi Ping Mok, Nicholas J Norton, Jack C Hirst, Axel Fun, Mikaila Bandara, Mark R Wills, Andrew ML Lever
May 01, 2018
The persistence of infected T cells harbouring intact HIV proviruses is the barrier to the eradication of HIV. This reservoir is stable over long periods of time despite antiretroviral therapy. There has been controversy on...
Promoter optimisation of lentiviral vectors for efficient insulin gene expression in canine mesenchymal stromal cells
Pratigya Gautam, Asha Recino, Robert D Foale, Jing Zhao, Shu Uin Gan, Maja Wallberg, Roy Calne, Andrew ML Lever
Oct 20, 2016
Diabetes gene therapy Insulin Lentivirus mesenchymal stromal cells Animals Bone Marrow Cells Cell Line Tumor Cells Cultured Dogs Gene Expression Gene Transfer Techniques Genetic Therapy Genetic Vectors HEK293 Cells Hepatocytes Humans Insulin Insulin-Secreting Cells Lentivirus Mesenchymal Stem Cells Proinsulin Promoter Regions Genetic
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