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Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2.
Sadam Yaseen, Gregory Demopulos, Thomas Dudler, Munehisa Yabuki, Christi L Wood, W Jason Cummings, Larry W Tjoelker, Teizo Fujita, Steven Sacks, Peter Garred, Peter Andrew, Robert B Sim, Peter J Lachmann, Russell Wallis, Nicholas Lynch, Wilhelm J Schwaeble
Aug 05, 2019
All 3 activation pathways of complement-the classic pathway (CP), the alternative pathway, and the lectin pathway (LP)- converge into a common central event: the cleavage and activation of the abundant third complement...
A farewell to <i>R</i>
The time-dependent reproduction number, Rt, is a key metric used by epidemiologists to assess the current state of an outbreak of an infectious disease. This quantity is usually estimated using...
Andrew Carnegie and the foundations of contemporary entrepreneurial philanthropy
This paper focuses upon the relationship between the business and philanthropic endeavours of world-making entrepreneurs; asking why, how and to what ends these individuals seek to extend their reach in society beyond...
Andrew Carnegie and the foundations of contemporary entrepreneurial philanthropy
This paper focuses upon the relationship between the business and philanthropic endeavours of world-making entrepreneurs; asking why, how and to what ends these individuals seek to extend their reach in society beyond...
R/BHC
BACKGROUND: Although the use of clustering methods has rapidly become one of the standard computational approaches in the literature of microarray gene expression data analysis, little attention has been paid to uncertainty in...
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
Alphonse R. Dochez, 1925
The Rockefeller University
Jan 01, 0001
Alphonse R. Dochez. Etiology of Scarlet Fever
Lecture delivered January 17th, 1925
Posted with permission
Published by: J.B. Lippincott Company
MendelianRandomization v0.5.0
Jim R Broadbent, Christopher N Foley, Andrew J Grant, Amy M Mason, James R Staley, Stephen Burgess
Jan 08, 2021
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have...
Florence R. Sabin, 1915
The Rockefeller University
Jan 01, 0001
Prof. Florence R. Sabin. The Method of Growth of the Lymphatic System
Lecture delivered December 18th, 1915
Published by: J.B. Lippincott Company
Epidemiology, Outcomes and Resource Utilisation in Patients with Carbapenem Non-susceptible Gram-Negative Bacteria in the UK
Simon D Goldenberg, Andrew R Dodgson, Gavin Barlow, Benjamin J Parcell, Lim Jones, Mahableshwar Albur, A Peter R Wilson, David A Enoch, Aleks Marek, Christianne Micallef, Davide Manissero, Christopher Longshaw, Sara Lopes, Karan Gill
Jul 25, 2022
Personality Antecedents of EWoM in Determining Online Customer Purchase Behavior
Electronic word of mouth (EWoM) is similar to the standard word of mouth- the only difference is, the use of Internet as a base in EWoM. By understanding the personality antecedents of EWoM, the consumer buyer beahviour could be...
Published by: IGI Global Scientific Publishing
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
Parasvi S Patel, Karan Joshua Abraham, Kiran Kumar Naidu Guturi, Marie-Jo Halaby, Zahra Khan, Luis Palomero, Brandon Ho, Shili Duan, Jonathan St-Germain, Arash Algouneh, Francesca Mateo, Samah El Ghamrasni, Haithem Barbour, Daniel R Barnes, Jonathan Beesley, Otto Sanchez, Hal K Berman, Grant W Brown, El Bachir Affar, Georgia Chenevix-Trench, Antonis C Antoniou, Cheryl H Arrowsmith, Brian Raught, Miquel Angel Pujana, Karim Mekhail, Anne Hakem, Razqallah Hakem
Feb 15, 2021
Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast and ovarian cancer risk. Given that tumors with these mutations have elevated genomic instability, they exhibit relative vulnerability to certain...
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
Timing the r-process Enrichment of the Ultra-faint Dwarf Galaxy Reticulum II
Abstract
The ultra-faint dwarf galaxy Reticulum II (Ret II) exhibits a unique chemical evolution history, with
Joshua D Simon, Thomas M Brown, Burcin Mutlu-Pakdil, Alexander P Ji, Alex Drlica-Wagner, Roberto J Avila, Clara E Martinez-Vazquez, Ting S Li, Eduardo Balbinot, Keith Bechtol, Anna Frebel, Marla Geha, Terese T Hansen, David J James, Andrew B Pace, M Aguena, O Alves, F Andrade-Oliveira, J Annis, D Bacon, E Bertin, D Brooks, DL Burke, A Carnero Rosell, M Carrasco Kind, J Carretero, M Costanzi, LN Da Costa, J De Vicente, S Desai, P Doel, S Everett, I Ferrero, J Frieman, J Garcia-Bellido, M Gatti, DW Gerdes, D Gruen, RA Gruendl, J Gschwend, G Gutierrez, SR Hinton, DL Hollowood, K Honscheid, K Kuehn, N Kuropatkin, JL Marshall, J Mena-Fernandez, R Miquel, A Palmese, F Paz-Chinchon, MES Pereira, A Pieres, AA Plazas Malagon, M Raveri, M Rodriguez-Monroy, E Sanchez, B Santiago, V Scarpine, I Sevilla-Noarbe, M Smith, E Suchyta, MEC Swanson, G Tarle, C To, M Vincenzi, N Weaverdyck, RD Wilkinson
Feb 10, 2023
Bayesian Spatial Modelling with R-INLA
The principles behind the interface to continuous domain spatial models in the R- INLA software package for R are described. The integrated nested Laplace approximation (INLA) approach proposed by Rue, Martino, and Chopin (2009)...
Bayesian Spatial Modelling with R-INLA
The principles behind the interface to continuous domain spatial models in the R- INLA software package for R are described. The integrated nested Laplace approximation (INLA) approach proposed by Rue, Martino, and Chopin (2009)...
OutbreakTools
Thibaut Jombart, David M Aanensen, Marc Baguelin, Paul Birrell, Simon Cauchemez, Anton Camacho, Caroline Colijn, Caitlin Collins, Anne Cori, Xavier Didelot, Christophe Fraser, Simon Frost, Niel Hens, Joseph Hugues, Michael Höhle, Lulla Opatowski, Andrew Rambaut, Oliver Ratmann, Samuel Soubeyrand, Marc A Suchard, Jacco Wallinga, Rolf Ypma, Neil Ferguson
Jul 17, 2018
The investigation of infectious disease outbreaks relies on the analysis of increasingly complex and diverse data, which offer new prospects for gaining insights into disease transmission processes and informing public health...
Cannabinoids, cannabis and cannabis-based medicine for pain management
Emma Fisher, R Andrew Moore, Alex Fogarty, David Finn, Nanna B. Finnerup, Ian Gilron, Simon Haroutounian, Elliot Krane, Andrew S.C. Rice, Michael Rowbotham, M Wallace, Christopher Eccleston
Jul 31, 2021
ABSTRACT: Cannabinoids, cannabis, and cannabis-based medicines (CBMs) are increasingly used to manage pain, with limited understanding of their efficacy and safety. We summarised efficacy and adverse events (AEs) of these...
Using R and Bioconductor for proteomics data analysis.
This review presents how R, the popular statistical environment and programming language, can be used in the frame of proteomics data analysis. A short introduction to R is given, with special emphasis on some of the features...
Cannabinoids, cannabis and cannabis-based medicine for pain management
Emma Fisher, R Andrew Moore, Alex Fogarty, David Finn, Nanna B. Finnerup, Ian Gilron, Simon Haroutounian, Elliot Krane, Andrew S.C. Rice, Michael Rowbotham, M Wallace, Christopher Eccleston
Jul 31, 2021
ABSTRACT: Cannabinoids, cannabis, and cannabis-based medicines (CBMs) are increasingly used to manage pain, with limited understanding of their efficacy and safety. We summarised efficacy and adverse events (AEs) of these...
A farewell to R
The time-dependent reproduction number, Rt, is a key metric used by epidemiologists to assess the current state of an outbreak of an infectious disease. This quantity is usually estimated using time-series observations on new...
Conrad Russell, Richard Cust, and Andrew Thrush, eds. King James VI/I and His English Parliaments. New York
David L Smith
May 08, 2019
This book is a revised and extended version of the six Trevelyan Lectures that Conrad Russell delivered at Cambridge University in the Lent Term of 1995. Between then and his death in October 2004, Russell developed the lectures...
Orchestrating privacy-protected big data analyses of data from different resources with R and DataSHIELD.
Yannick Marcon, Tom Bishop, Demetris Avraam, Xavier Escriba-Montagut, Patricia Ryser-Welch, Stuart Wheater, Paul Burton, Juan R González
Apr 09, 2021
Combined analysis of multiple, large datasets is a common objective in the health- and biosciences. Existing methods tend to require researchers to physically bring data together in one place or follow an analysis plan and share...
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