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The antidiabetic drug lobeglitazone has the potential to inhibit PTP1B activity.
Ruth F Rocha, Tiago Rodrigues, Angela CO Menegatti, Gonçalo JL Bernardes, Hernán Terenzi
May 12, 2020
Protein tyrosine phosphatase 1B (PTP1B) is considered a potential therapeutic target for the treatment of type 2 diabetes mellitus (T2DM), since this enzyme plays a significant role to down-regulate insulin and leptin signalling...
Angela Letourneau Selected as S.C. Professor of the Year
Winthrop University
Jan 01, 0001
Angela Letourneau, professor/chair of Accounting, Finance and Economics, has been selected the S.C. Professor of the Year. Letourneau plans to retire at the end of the academic year.
Published by: Winthrop University
Curriculum Co-Creation
One of the emerging areas is knowledge co-creation, and more specifically, in an educational context, curriculum co-creation. The ability to solicit feedback, reactions, suggestions, and improvements with regards to courses and...
Published by: IGI Global Scientific Publishing
The Co-development of Friends’ Delinquency with Adolescents’ Delinquency and Short-term Mindsets
Abstract: The companions in crime hypothesis suggests that co-offending moderates the link between peer delinquency and adolescent delinquency. However, this hypothesis has rarely been investigated longitudinally. Hence, this...
The Co-development of Friends' Delinquency with Adolescents' Delinquency and Short-term Mindsets
The companions in crime hypothesis suggests that co-offending moderates the link between peer delinquency and adolescent delinquency. However, this hypothesis has rarely been investigated longitudinally. Hence, this study...
Project Management and Education
Angela Even
Jan 01, 2024
The importance of project management in education has become increasingly evident in our evolving technology-ridden lives. Educators are required to manage complex projects involving multiple stakeholders, resources, and...
Published by: IGI Global Scientific Publishing
Mechanochemical co-crystallization
Mechanochemistry integrates mechanical and chemical phenomena to spawn new modes of reactivity, faster reaction kinetics and the discovery of novel materials, in a solvent-free and environmental manner. This simple, yet...
Mechanochemical co-crystallization
Mechanochemistry integrates mechanical and chemical phenomena to spawn new modes of reactivity, faster reaction kinetics and the discovery of novel materials, in a solvent-free and environmental manner. This simple, yet...
Life Lessons of a Co-Teacher
Donna Cherveny
Jan 01, 0001
Co-teaching is a common practice across schools. While research may be present regarding the effects of co-teaching, there is little literature that simply offers the perspective a co-teacher. As a former co-teacher of six...
Published by: Winthrop University
Value co-creation practices and capabilities
The paradigm of value co-creation in business markets is now well established in the marketing literature. However, the practices and capabilities for collaborative value co-creation are less understood, particularly in...
Parasite co-infection
Laboratory studies of pathogens aim to limit complexity in order to disentangle the important parameters contributing to an infection. However, pathogens rarely exist in isolation, and hosts may sustain co-infections with...
Co-designing an intervention to increase uptake of advance care planning in later life following emergency hospitalisation
INTRODUCTION: Despite the potential benefits of advance care planning, uptake in older adults is low. In general, there is a lack of guidance as to how to initiate advance care planning conversations and encourage individuals to...
The lived experience of mental disorders in adolescents
Paolo Fusar-Poli, Andrés Estradé, Cecilia Esposito, René Rosfort, Ilaria Basdonne, Milena Mancini, Giovanni Stanghellini, Jummy Otaiku, Oluwadamilola Olanrele, Lucas Allen, Muskan Lamba, Catherine Alaso, Judy Ieri, Margret Atieno, Yvonne Oluoch, Phides Ireri, Ephraim Tembo, Innocent Zilole, Duncan Nkhoma, Noah Sichone, Candy Siadibbi, Pharidah R.I.O. Sundi, Nyathi Ntokozo, Laura Fusar-Poli, Valentina Floris, Martina M. Mensi, Renato Borgatti, Stefano Damiani, Umberto Provenzani, Ilaria Bonoldi, Joaquim Radua, Kate Cooper, Jae Il Shin, Samuele Cortese, Andrea Danese, Sarah Bendall, Celso Arango, Universitätsmedizin Berlin, Mario Maj
Jun 30, 2024
We provide here the first bottom-up review of the lived experience of mental disorders in adolescents co-designed, co-conducted and co-written by experts by experience and academics. We screened first-person accounts within and...
ADOLESCENTS Anxiety Disorders Attention-deficit/hyperactivity disorder autism spectrum disorders Eating disorders externalizing disorders first-person accounts lived experience mental health care Mood Disorders Psychotic Disorders recovery self-harm behaviors /dk/atira/pure/subjectarea/asjc/2700/2738 name=Psychiatry and Mental health /dk/atira/pure/subjectarea/asjc/2900/2921 name=Phychiatric Mental Health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
The Ins and Outs of Co-teaching
Krystine Blocker
Jan 01, 0001
My journey as an inclusion teacher and the lessons I've learned regarding what works and what does not. Tips for teachers on co-planning, co-teaching and co-assessing as well as strategies to keep all students engaged in...
Published by: Winthrop University
Achieving integrated treatment
Jane Harris, Sonia Dalkin, Lisa Jones, Tom Ainscough, Michelle Maden, Angela Bate, Alex Copello, Gail Gilchrist, Emma Griffith, luke Mitcheson, Harry Sumnall, Elizabeth hughes
Jun 23, 2023
Approximately 30-50% of people with serious mental illness have co-existing drug/alcohol problems (COSMHAD), associated with adverse health/social care outcomes. UK guidelines advocate both co-occurring needs being met within...
Trichotillomania and co-occurring anxiety
$\textit{Background:}$ Trichotillomania appears to be a fairly common disorder, with high rates of co-occurring anxiety disorders. Many individuals with trichotillomania also report that pulling worsens during periods of...
Profiting from innovation through cross-border market co-creation and co-opetition
We study the impact of the new intellectual property (IP) regime, as shaped by international agreements such as the Trade-Related-Aspects-of-IP-Rights (TRIPS), on the competitive positions of emerging country firms and advanced...
The nature of the co-evolutionary process
A business ecosystem is a community that consists of various levels of interdependent firms which co-evolve in an ongoing cycle and constantly renew themselves. Through undertaking an in-depth, qualitative study of multinational...
Call to Action
Angela McCaskill
Jul 01, 2021
Low quality healthcare services can hinder economic and social development, result in premature death and disability, and waste human capital. To compound pre-pandemic healthcare access and equity issues, the quality of care...
Published by: IGI Global Scientific Publishing
Parasite co-infection
Laboratory studies of pathogens aim to limit complexity in order to disentangle the important parameters contributing to an infection. However, pathogens rarely exist in isolation, and hosts may sustain co-infections with...
Co-repressor, co-activator and general transcription factor
At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound repressor proteins to facilitate local histone...
Profiting from innovation through cross-border market co-creation and co-opetition
We study the impact of the new intellectual property (IP) regime, as shaped by international agreements such as the Trade-Related-Aspects-of-IP-Rights (TRIPS), on the competitive positions of emerging country firms and advanced...
Parasite co-infection
Laboratory studies of pathogens aim to limit complexity in order to disentangle the important parameters contributing to an infection. However, pathogens rarely exist in isolation, and hosts may sustain co-infections with...
RETRACTED: Open Innovation in R&D
Breakthrough innovations are crucial drivers of economic progress, often depending on external knowledge sources to complement internal knowledge. Co-patenting is one way to achieve this by implementing open innovation within...
Published by: IGI Global Scientific Publishing
Co-translational assembly orchestrates competing biogenesis pathways.
Maximilian Seidel, Anja Becker, Filipa Pereira, Jonathan JM Landry, Nayara Trevisan Doimo de Azevedo, Claudia M Fusco, Eva Kaindl, Natalie Romanov, Janina Baumbach, Julian D Langer, Erin M Schuman, Kiran Raosaheb Patil, Gerhard Hummer, Vladimir Benes, Martin Beck
Apr 10, 2022
During the co-translational assembly of protein complexes, a fully synthesized subunit engages with the nascent chain of a newly synthesized interaction partner. Such events are thought to contribute to productive assembly, but...
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